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阿尔茨海默病的临床表现、病程、治疗和管理

中国心理卫生杂志 1999年第5期13卷 272-275页

作者： BarryReisberg m.d. Zachary and Elizabeth m.Fisher Alzheimer's disease Education and Resources Program at the New York University m.d.cal Center

阿尔茨海默病(Alzheimer's disease,Ad)是导致智力衰退这类疾病的主要原因.经典研究表明:阿尔茨海默病大约占所有痴呆病例的四分之三.最近20年来对阿尔茨海默病的临床演变过程有了极其深入的了解.现在,无论是专业人员还是外行人士都能... 详细信息

阿尔茨海默病(Alzheimer's disease,Ad)是导致智力衰退这类疾病的主要原因.经典研究表明:阿尔茨海默病大约占所有痴呆病例的四分之三.最近20年来对阿尔茨海默病的临床演变过程有了极其深入的了解.现在,无论是专业人员还是外行人士都能应用通俗的术语对这一演变过程做详细地叙述.更进一步的是,基于目前掌握的(阿尔茨海默病)的知识,阿尔茨海默病患者还有可能获得适当的治疗.以后随着临床知识的不断积累,对于这种在人生晚年普遍发生的严重疾病的治疗也必将不断得到改善.

关键词：老年性痴呆临床表现病程治疗管理

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Creating Prep to Play PRO for women playing elite Australian football:A how-to guide for developing injury-prevention programs

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Journal of Sport and Health Science 2023年第1期12卷 130-138页

作者： andrea m.Bruder Alex donaldson andrea B.mosler Brooke E.Patterson melissa Haberfield Benjamin F.mentiplay Patrick Clifton Nicole d.Livingstone OAm Kay m.Crossley La Trobe Sport and Exercise m.d.cine Research Centre La Trobe UniversityMelbourneVIA 3086Australia Australian IOC Research Centre La Trobe UniversityMelbourneVIA 3086Australia Centre for Sport and Social Impact La Trobe UniversityMelbourneVIA 3086 Australia Australian Football League MelbourneVIA 3086Australia

Background:developing context-specific,evidence-inform.d.and implementable injury-prevention programs is *** playing in the elite Australian Football League for Women are at high risk of serious knee injuries,and no specific injury-prevention program *** objective of the study was to describe the collaborative process used to create a context-specific injury-prevention ***:A previously used intervention-development process was m.d.fied to incorporate a partnership with the sport’s governing organization and focus on engaging program *** Reach Effectiveness Adoption Implementation and maintenance(RE-AIm)Sports Setting matrix guided program.d.velopment and implementation ***:The 7-step process,aligned with the RE-AIm Sports Setting matrix,was applied to develop the injury-prevention program and was titled Prep to Play *** steps were:(Step 1)gaining organizational support and establishing a project partnership;(Step 2)using research evidence and clinical experience;(Step 3)consulting content and context experts;(Step 4)engaging the organization,experts,program implementers,and end-users to concreate the intervention and develop implementation strategies;(Step 5)testing the intervention acceptability and feasibility;(Step 6)evaluating the intervention and implementation strategies against theory;and(Step 7)obtaining feedback from early implementers and ***:Engaging critical stakeholders at multiple ecological levels(organization,team,and athlete)throughout program.d.velopment and implementation planning support real-world *** processes and activities described can guide future sports injury-prevention program.d.velopment and implementation.

关键词： Athletes Elite Female Knee Injuries Sport

Involvement of heat shock proteins in gluten-sensitive enteropathy

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World Journal of Gastroenterology 2014年第21期20卷 6495-6503页

作者： Erna Sziksz domonkos Pap Gábor Veres andrea Fekete Tivadar Tulassay ádám Vannay mTA-SE Pediatrics and Nephrology Research GroupH-1083 BudapestHungary First department of Pediatrics Semmelweis UniversityH-1083 BudapestHungary mTA-SE "Lendulet" Diabetes Research GroupH-1083 BudapestHungary

Gluten-sensitive enteropathy,also known as coeliac disease(Cd),is an autoimmune disorder occurring in genetically susceptible individuals that damages the small intestine and interferes with the absorption of other *** it is triggered by dietary gluten and related prolamins present in wheat,rye and barley,the accepted treatment for Cd is a strict gluten-free ***,a complete exclusion of gluten-containing cereals from the diet is often difficult,and new therapeutic strategies are urgently needed.A class of proteins that have already emerged as drug targets for other autoimmune diseases are the heat shock proteins(HSPs),which are highly conserved stress-induced chaperones that protect cells against harmful extracellular *** are expressed in several tissues,including the gastrointestinal tract,and their levels are significantly increased under stress *** exert immunom.d.latory effects,and also play a crucial role in the maintenance of epithelial cell structure and function,as they are responsible for adequate protein folding,influence the degradation of proteins and cell repair processes after damage,and m.d.late cell signalling,cell proliferation and *** present review discusses the involvement of HSPs in the pathophysiology of ***,HSPs may represent a useful therapeutic target for the treatment of Cd due to the cytoprotective,immunom.d.latory,and anti-apoptotic effects in the intestinal mucosal barrier.

关键词： Gluten-sensitive enteropathy Coeliac disease Heat shock proteins Gluten-free diet Intestinal barrier

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschm.d.-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschm.d. damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest miller School of m.d.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirm.d.that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-m.d.fying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system.d.seases is disease-m.d.fying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-m.d.fication,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Lagrangian m.d.l of zooplankton dispersion:numerical schemes comparisons and parameter sensitivity tests

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Chinese Journal of Oceanology and Limnology 2011年第2期29卷 438-445页

作者：丘仲锋 andrea m.d.GLIOLI 何宜军 Francois CARLOTTI Key Laboratory of Ocean Circulation and Waves Institute of Oceanology CAS Laboratoire d'Ocanographie Physique et Biogochimie Aix Marseille UniversiteCNRSUMR 6535MarseilleFrance

This paper presents two comparisons or tests for a Lagrangian m.d.l of zooplankton dispersion:numerical schemes and time ***,we compared three numerical schemes using idealized *** show that the precisions of the advanced Adams-Bashfold-moulton(ABm) method and the Runge-Kutta(RK) method were in the same order and both were much higher than that of the Euler ***,the advanced ABm method is more efficient than the RK method in computational memory requirements and time *** therefore chose the advanced ABm method as the Lagrangian particle-tracking ***,we perform.d.a sensitivity test for time steps,using outputs of the hydrodynamic m.d.l,*** show that the time step choices depend on the fluid response time that is related to the spatial resolution of velocity *** method introduced by Oliveira et *** 2002 is suitable for choosing time steps of Lagrangian particle-tracking m.d.ls,at least when only considering advection.

关键词： Lagrangian numerical scheme time steps zooplankton

m.d.ling of Long-Range Intra- and Inter-Species Charged Particle Collisions for PIC Simulations

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Communications in Computational Physics 2010年第5期7卷 877-903页

作者： d.d’andrea C.-d.munz R.Schneider Forschungszentrum Karlsruhe-in der Helmholtz-Gemeinschaft Institut fur Kern-und EnergietechnikPF 3640D-76021 KarlsruheGermany Institut fur Aerodynamik und Gasdynamik Universitat StuttgartPfaffenwaldring 21D-70550 StuttgartGermany Forschungszentrum Karlsruhe-in der Helmholtz-Gemeinschaft Institut fur Hochleistungsimpuls und MikrowellentechnikPF 3640D-76021 KarlsruheGermany

In this paper we present the m.d.lling of elastic intra-species electron-electron and inter-species electron-ion scattering in a plasma on the basis of the FokkerPlanck collision *** into account the equivalence of this operator with a stochastic differential equation,we propose a Particle-in-Cell based approach for the numerical solution of the Fokker-Planck collision *** we will see,the introduced numerical concept allows the simulation of the collisional relaxation process in a fully self-consistent fashion.

关键词： Coulomb collisions in plasmas collisional relaxation Fokker-Planck equation stochastic differential equation particle-in-cell method

Active bleb formation is abated in Lytechinus variegatus red spherule coelomocytes after disruption of acto-myosin contractility

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Integrative Zoology 2008年第2期3卷 115-122页

作者： Lisanne d’andrea-WINSLOW Amy K.NOVITSKI department of Biology Northwestern CollegeSt.PaulMinnesotaUSA

Red spherule coelomocytes are immune cells in the sea urchin Lytechinus variegatus that have been characterizedas motile O2 transport cells. Video microscopy of living red spherule coelomocytes reveals a constitutive, dynamicarray of cellular morphologies and movements. Cells continuously send out and retract membrane blebs all over thecell surface as part of their normal cellular physiology. disruption of microtubules by perfusion with either nocodazoleor taxol had no effect on bleb formation or motility. Perfusion with cytochalasin B abated bleb formation andrevealed cells that exhibited multiple small spheres attached by short membrane extensions. Attenuation of blebbingand intracellular organelle motility were restored by washing out with cytochalasin B. Treatment with phalloidinalso abated bleb formation and revealed a smooth, spherical cellular morphology. The effects of phalloidin werecompletely reversible after washout. Red spherule coelomocytes treated with blebbistatin rounded up with anirreversible retraction of blebs into surface blebs that were greatly reduced in size, number and motility. Normal cellsurface bleb formation and intracellular organelle motility were not restored after washout of the drug. These resultsindicate that the acto-myosin contractile mechanism contributes to the dynamics of constitutive cell surface membraneblebbing in invertebrate immune cells.

关键词： sea urchin invertebrate immunology coelomocyte cell motility cell movement microfilament dynamics