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Methods and approaches to disease mechanisms using systems kinomics

Synthetic and Systems Biotechnology 2018年第1期3卷 34-43页

作者： Alicia Berard andrea kroeker Peter McQueen Kevin M.Coombs Department of Medical Microbiology University of ManitobaWinnipegR3E 0J9Canada JC Wilt Infectious Diseases Research Centre Public Health Agency of CanadaWinnipegCanada Canadian Food Inspection Agency WinnipegCanada

All cellular functions,ranging from regular cell maintenance and homeostasis,specialized functions specific to cellular types,or generating responses due to external stimulus,are mediated by proteins within the *** of these proteins allows the cell to alter its behavior under different circumstances.A major mechanism of protein regulation is utilizing protein kinases and phosphatases;enzymes that catalyze the transfer of phosphates between substrates[1].Proteins involved in phosphate signaling are well studied and include kinases and phosphatases that catalyze opposing reactions regulating both structure and function of the *** is the study of kinases,phosphatases and their targets,and has been used to study the functional changes in numerous diseases and infectious diseases with aims to delineate the cellular functions *** the phosphate signaling pathways changed by certain diseases or infections can lead to novel therapeutic ***,a daunting 518 putative protein kinase genes have been identified[2],indicating that this protein family is very large and *** which enzymes are specific to a particular disease can be a laborious *** this review,we will provide information on large-scale systems biology methodologies that allow global screening of the kinome to more efficiently identify which kinase pathways are pertinent for further study.

关键词： diseases homeostasis utilizing

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Systems biology unravels interferon responses to respiratory virus infections

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World Journal of Biological Chemistry 2014年第1期5卷 12-25页

作者： andrea L kroeker Kevin M Coombs Department of Physiology University of Manitoba Department of Microbiology University of Manitoba

Interferon production is an important defence against viral replication and its activation is an attractive therapeutic target. However, it has long been known that viruses perpetually evolve a multitude of strategies to evade these host immune responses. In recent years there has been an explosion of information on virusinduced alterations of the host immune response that have resulted from data-rich omics technologies. Unravelling how these systems interact and determining the overall outcome of the host response to viral infection will play an important role in future treatment and vaccine development. In this review we focus primarily on the interferon pathway and its regulation as well as mechanisms by which respiratory RNA viruses interfere with its signalling capacity.

关键词： Respiratory virus Interferon Systems biology Proteomics Genomics Innate immunity

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