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To metabolomics and beyond:a technological portfolio to investigate cancer metabolism

Signal Transduction and Targeted Therapy 2023年第4期8卷 1721-1742页

作者： Federica Danzi Raffaella Pacchiana andrea Mafficini Maria TScupoli Aldo Scarpa Massimo Donadelli Alessandra Fiore Department of Neurosciences Biomedicine and Movement SciencesSection of BiochemistryUniversity of VeronaVeronaItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly Department of Neurosciences Biomedicine and Movement SciencesBiology and Genetics SectionUniversity of VeronaVeronaItaly ARC-NET Research Centre University and Hospital Trust of VeronaVeronaItaly

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support tumour initiation, progression,metastasis and resistance to therapies. These reprogrammed activities include a complete rewiring of the bioenergetic, biosyntheticand redox status to sustain the increased energetic demand of the cells. Over the last decades, the cancer metabolism field hasseen an explosion of new biochemical technologies giving more tools than ever before to navigate this complexity. Within a cell ora tissue, the metabolites constitute the direct signature of the molecular phenotype and thus their profiling has concrete clinicalapplications in oncology. Metabolomics and fluxomics, are key technological approaches that mainly revolutionized the fieldenabling researchers to have both a qualitative and mechanistic model of the biochemical activities in cancer. Furthermore, theupgrade from bulk to single-cell analysis technologies provided unprecedented opportunity to investigate cancer biology at cellularresolution allowing an in depth quantitative analysis of complex and heterogenous diseases. More recently, the advent offunctional genomic screening allowed the identification of molecular pathways, cellular processes, biomarkers and noveltherapeutic targets that in concert with other technologies allow patient stratification and identification of new treatmentregimens. This review is intended to be a guide for researchers to cancer metabolism, highlighting current and emergingtechnologies, emphasizing advantages, disadvantages and applications with the potential of leading the development ofinnovative anti-cancer therapies.

关键词： metabolism qualitative beyond

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Publishing Eurac Research data on the GEOSS Platform

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Big Earth Data 2023年第2期7卷 428-450页

作者： Roberto Roncella Bartolomeo Ventura andrea Vianello Enrico Boldrini Mattia Santoro Paolo Mazzetti Stefano Nativi National Research Council of Italy-Institute of Atmospheric Pollution Research Division of Florence-Via Madonna del Piano 10FlorenceItaly Institute for Earth Observation Eurac Research-Viale Druso 1BozenItaly Center for Sensing Solution Eurac Research-Viale Druso 1BozenItaly

This paper is the third of a series that introduces some of the main dataset resources presently shared through the GEOSS Platform. The GEOSS Platform is a brokering infrastructure that brokers more than 190 autonomous information systems and data catalogs;it was created to provide the technological tool to implement the Global Earth Observation System of Systems (GEOSS). This manuscript focuses on the analysis of Eurac Research datasets and illustrates the data publishing process to enroll the Eurac Research Data Provider to the GEOSS Platform through the administrative and technical registrations. The study provides an analysis of the GEOSS user searches for Eurac Research data in order to understand the main use of datasets of an important Data Provider.

关键词： GEOSS data interoperability data sharing Eurac Research Earth observation

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Towards a standardisation for digital inputs and outputs of protection functions in IEC 60255 series

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Protection and Control of Modern Power Systems 2022年第1期7卷 382-392页

作者： Volker Leitloff Hao Chen Dehui Chen andrea Bonetti Lei Xu Ahmed Mohamed Carl Byman French Transmission Network Operator Rte ParisFrance State Grid Jiangsu Electric Power Co. Ltd.NanjingChina State Grid Electric Power Institute NanjingChina Royal Institute of Technology StockholmSweden NR Elec-tric Co. Ltd.NanjingChina Scottish and Southern Energy Network(SSEN) GlasgowUK Hitachi Energy VästeråsSweden.

Fully digitalized substations using IEC 61850 process bus are being introduced all over the *** utilities have featured pilot projects,demonstrators or even industrial scale deployment of these Fully Digital Protection,Auto-mation and Control Systems(FD-PACS).Product standards such as profiles for Instrument Transformers have been developed and published(IEC 61869-6 and IEC 61869-9 by TC 38-Instrument Transformers).This raises the question about the standards for digitally interfaced protection *** 2016,IEC TC 95(Measuring relays and protection equipment)charged a working group to investigate this subject and to elaborate recommendations concerning requirements and testing of protection IED with digital inputs and outputs for protection standards(IEC 60255-1xx series).For protection functions,publisher/subscriber based data streams are supposed to comply with IEC 61850 and IEC 61869 *** holds in particular for Sampled Values(SV)representing energising inputs of the protection function,and is also applicable to Generic Object Oriented Substation Event(GOOSE)which can be used for input or output of protection *** attributes of published data depend on the operational and connection status of the function and the hosting *** addition,protection functions have to take into account the information regarding the time synchronisation of the received SV and other *** paper gives an overview of these features and the proposed way to take them into account in the IEC 60255 standard *** describes the progress of WG 2 and relates it to existing standardization documents.

关键词： Process bus Protection function Digital interface SAMU LPIT Standards IEC 61850

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Endoscopic ultrasound fine-needle biopsy vs fine-needle aspiration for lymph nodes tissue acquisition:a systematic review and meta-analysis

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Gastroenterology Report 2022年第1期10卷 544-551页

作者： Antonio Facciorusso Stefano Francesco Crino Paraskevas Gkolfakis Daryl Ramai andrea Lisotti Ioannis S Papanikolaou Benedetto Mangiavillano Ilaria Tarantino andrea Anderloni Carlo Fabbri Konstantinos Triantafyllou Pietro Fusaroli Gastroenterology Unit Department of Surgical and Medical SciencesUniversity of FoggiaFoggiaItaly Department of Medicine Gastroenterology and Digestive Endoscopy UnitThe Pancreas InstituteUniversity Hospital of VeronaVeronaItaly Department of Gastroenterology Hepatopancreatologyand Digestive OncologyCUB Erasme HospitalUniversite Libre de Bruxelles(ULB)BrusselsBelgium Gastroenterology and Hepatology University of Utah HealthSalt Lake CityUTUSA Gastroenterology Unit Hospital of ImolaUniversity of BolognaImolaItaly Hepatogastroenterology Unit Second Department of Internal Medicine-PropaedeuticMedical SchoolNational and Kapodistrian University of Athens‘Attikon’University General HospitalAthensGreece Gastrointestinal Endoscopy Unit Humanitas Mater DominiCastellanzaVareseItaly Endoscopy Service Department of Diagnostic and Therapeutic ServicesIRCCS-ISMETTPalermoItaly Digestive Endoscopy Unit Humanitas Clinical and Research Center—IRCCSRozzanoMilanoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsAUSL RomagnaForlì-CesenaItaly

Background:Endoscopic ultrasound(EUS)-guided tissue acquisition represents the choice of methods for suspected lymph nodes(LNs)located next to the gastrointestinal *** study aimed to compare the pooled diagnostic performance of EUS-guided fine-needle biopsy(EUS-FNB)and fine-needle aspiration(EUS-FNA)for LNs ***:We searched PubMed/MedLine and Embase databases through August *** outcome was diagnostic accuracy;secondary outcomes were sensitivity,specificity,sample adequacy,optimal histological core procurement,number of passes,and adverse *** performed a pairwise meta-analysis using a random-effects *** results are presented as odds ratio(OR)or mean difference along with 95%confidence interval(CI).Results:We identified nine studies(1,276 patients)in this *** these patients,66.4%were male;the median age was 67 *** accuracy was not significantly different between the two approaches(OR,1.31;95%CI,0.81–2.10;P=0.270).The accuracy of EUS-FNB was significantly higher when being performed with newer end-cutting needles(OR,1.87;95%CI,1.17–3.00;P=0.009)and in abdominal LNs(OR,2.48;95%CI,1.52–4.05;P<0.001)than that of *** difference in terms of sample adequacy was observed between the two approaches(OR,1.40;95%CI,0.46–4.26;P=0.550);however,histological core procurement and diagnostic sensitivity with EUS-FNB were significantly higher than those with EUS-FNA(OR,6.15;95%CI,1.51–25.07;P=0.010 and OR,1.87;95%CI,1.27–2.74,P=0.001).The number of needle passes needed was significantly lower in the EUS-FNB group than in the EUS-FNA group(mean difference,-0.54;95%CI,-0.97 to -0.12;P=0.010).Conclusions EUS-FNA and EUS-FNB perform similarly in LN sampling;however,FNB performed with end-cutting needles outperformed FNA in terms of diagnostic accuracy.

关键词： EUS FNA FNB cancer metastases lymphoma

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Integration and implementation of precision medicine in the multifaceted inflammatory bowel disease

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世界胃肠病学杂志:英文版 2023年第36期29卷 5211-5225页

作者： Gowthami Sai Kogilathota Jagirdhar Jose Andres Perez andrea Belen Perez Salim Surani Department of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Department of Medicine Saint Francis Health SystemsTulsaOK 74133United States Department of Research Columbia UniversityNew YorkNY 10027United States Department of Medicine and Pharmacology Texas A&M UniversityCollege StationTX 77413United States

Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and *** medicine has the potential to play a crucial role in managing IBD by tailoring treatment plans based on the heterogeneity of clinical and temporal variability of *** medicine is a population-based approach to managing IBD by integrating environmental,genomic,epigenomic,transcriptomic,proteomic,and metabolomic *** is a recent and rapidly developing *** widespread adoption of precision medicine worldwide has the potential to result in the early detection of diseases,optimal utilization of healthcare resources,enhanced patient outcomes,and,ultimately,improved quality of life for individuals with *** precision medicine is promising in terms of better quality of patient care,inadequacies exist in the ongoing *** is discordance in study conduct,and data collection,utilization,interpretation,and *** review aims to describe the current literature on precision medicine,its multiomics approach,and future directions for its application in IBD.

关键词： Precision medicine Multiomics Inflammatory bowel disease Crohn’s disease Ulcerative colitis Data integration

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eHealth,telehealth,and telemedicine in the management of the COVID-19 pandemic and beyond:Lessons learned and future perspectives

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World Journal of Clinical Cases 2022年第8期10卷 2363-2368页

作者： andrea Giacalone Luca Marin Massimiliano Febbi Thomas Franchi Marcos Roberto Tovani-Palone Department of Industrial Engineering Technologies for Sports Medicine and RehabilitationUniversity of Rome Tor VergataRome 00133Italy Department of Research Asomi College of SciencesMarsa MRS 19112Malta The Medical School The University of SheffieldSheffield S102RXUnited Kingdom Department of Pathology and Legal Medicine Ribeirão Preto Medical SchoolUniversity of São PauloRibeirão Preto 14049-900Brazil

In this article,we discuss evidence supporting the effective implementation of e Health,telehealth,and telemedicine during the coronavirus disease 2019 pandemic,with a view towards its permanent future integration in *** performed a literature search for articles describing the use of telehealth/telemedicine in the pandemic context using five *** articles selected describe the use of telemedicine as its advantages in terms of practicality and *** synthesis of articles is applicable to high-,middle-and lowincome *** of the notable benefits include breaking down geographical and time barriers,reducing waiting lists and crowding in healthcare facilities,and saving on national healthcare ***,there are a number of difficulties with the widespread implementation of telemedicine services that mainly relate to bureaucratic and regulatory ***,it is also important to make healthcare professionals and providers aware of the limits of this tool to avoid potential cases of *** in turn will have to be made aware of and be educated on the use of this new healthcare modality before it is accepted by *** the current socio-economic climate,it is therefore essential to implement a telehealth model aimed at efficiency and continuity of healthcare,as well as leading to an improvement in the quality of life of patients,whilst optimising existing resources and reducing *** that regard,the adoption of e Health,telehealth,and telemedicine services should be considered highly timely,despite current existing limitations.

关键词： eHealth Telehealth Telemedicine Coronavirus disease 2019 Pandemics Delivery of healthcare

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Examining the interplay between artificial intelligence and the agri-food industry

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Artificial Intelligence in Agriculture 2022年第1期6卷 111-128页

作者： Abderahman Rejeb Karim Rejeb Suhaiza Zailani John G.Keogh andrea Appolloni Department of Management and Law Faculty of EconomicsUniversity of Rome Tor VergataVia Columbia2Rome 00133Italy Faculty of Sciences of Bizerte University of CarthageTunisTunisia Department of Management Faculty of Business and EconomicsUniversity MalayaKuala Lumpur50203Malaysia Henley Business School University of ReadingGreenlandsHenley-on-Thames RG93AUUK

Artificial intelligence(AI)has advanced at an astounding rate and transformed numerous economic ***,a comprehensive understanding of how AI can improve the agri-food industry is *** addition,there is a notable dearth of research on AI that investigates the influence of AI on agri-food resources and educates practitioners on the significance of knowledge-based and smart *** utilised bibliometric analysis to investigate the present state of the art and emerging trends in the relationship between AI and the agri-food *** research identified three distinct growth phases and the most prevalent AI strategies in the *** addition,we analysed key trends and offered researchers and practitioners insightful recommendations for future *** resource-based view(RBV)as the theoretical lens,this study established a framework emphasising the long-term effects of AI on various agri-food resources and proposed several research *** addition,AI-related obstacles have been identified and categorised into four major ***,the originality of the article lies in its numerous research suggestions and recommendations for advancing the AI field in the agri-food industry.

关键词： Artificial intelligence Agriculture Farming Machine learning Deep learning Bibliometric analysis Resource-based view

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Developments in diagnosis and management of post-liver transplantation biliary complications:the radiologist’s perspective

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 457-461页

作者： Paolo Marra Pietro andrea Bonaffini Davide Ippolito Sandro Sironi Department of Radiology Papa Giovanni XXIII HospitalBergamoItaly School of Medicine University of Milano-BicoccaMilanItaly Department of Diagnostic Radiology San Gerardo HospitalMonzaItaly

Biliary complications are the most common source of morbidity after liver transplantation as they may occur in up to 45%of patients(1).The review by Magro et al.(2)provides comprehensive insights on this topic and offers a cue for in-depth remarks form a radiological perspective regarding both diagnostic and interventional ***(US)-based techniques,including B-mode and color-Doppler,are the milestone of post-transplant *** assessment of graft vascularization is crucial since many biliary complications are supposed to be induced by arterial *** this regard,however,it must be emphasized that US imaging is hampered by a limited panoramic view,especially in difficult abdomens,therefore it is not possible to rely exclusively on this technique.

关键词： diagnosis complications graft

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Use of anticoagulation reversal therapy in the emergency department:a single-center real-life retrospective study

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World Journal of Emergency Medicine 2023年第1期14卷 56-58页

作者： Jacopo Davide Giamello andrea Pisano Fabrizio Corsini Remo Melchio Luca Bertolaccini Enrico Lupia Giuseppe Lauria School of Emergency Medicine University of TurinTurin 10100Italy Department of Emergency Medicine Santa Croce e Carle HospitalCuneo 12100Italy Department of Internal Medicine Santa Croce e Carle HospitalCuneo 12100Italy Department of Thoracic Surgery IEOEuropean Institute of Oncology IRCCSMilan 20141Italy Department of Emergency Medicine Cittàdella Salute e della Scienza HospitalTurin 10126Italy Department of Medical Sciences University of TurinTurin 10100Italy

The incidence of atrial fibrillation(AF)and deep vein thrombosis/pulmonary embolism(DVT/PE)has increased in the last decades as a consequence of global aging and th refinement of diagnostic techniques;thus,the consumption o anticoagulant drugs has increased significantly.[1,2]Prescription of direct oral anticoagulants(DOACs)have overtaken thos of vitamin K antagonists(VKA)since the mid-2010s.[3]Consequently,the incidence of these drugs’side effects has also increased;the most relevant side effect in terms of morbidity and mortality is *** addition to critically ill bleeding patients,another indication of anticoagulant reversal therapy is the need for emergency surgery or for a procedure with high risk of bleeding.

关键词： drugs vitamin mortality

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Refrigerated and frozen storage impact aronia berry quality

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Food Production, Processing and Nutrition 2022年第1期4卷 13-24页

作者： Erica S.King andrea Noll Susan Glenn Bradley W.Bolling Department of Food Science University of Wisconsin-Madison1605 Linden Dr.MadisonWI53706USA Department of Statistics Medical Sciences CenterUniversity of Wisconsin-Madison1300 University Ave Rm 1220MadisonWI53706USA

Postharvest storage of many freshly picked berries affects polyphenol and sugar content. However, little is known about the impact of refrigerated and frozen storage on aronia berry composition. Therefore, the objective of this study was to characterize how storage at 4 ± 2 °C and − 20 ± 2 °C, and temperature cycles affect aronia berry polyphenols, total solid content, pH, titratable acidity, polyphenol oxidase (PPO) activity, sugar content, acid content, color, and cell structure. Refrigerated storage reduced proanthocyanidins (21%), anthocyanins (36%), and total phenols (21%) after 12 weeks. Frozen storage increased polyphenols in the first 6 mo. of frozen storage but then decreased polyphenols at mo. 8 to levels similar to initial values. Frozen temperature cycling reduced anthocyanins 18% but did not affect total phenols or proanthocyanidins. Scanning electron microscopy analysis indicated temperature cycling induced cell damage, shrinking, and fusion. This disruption led to the release of anthocyanins inside the berry tissue. PPO activity did not significantly correlate with the decrease in polyphenol content during storage. °Brix did not significantly change during refrigeration and frozen storage but did during the 12th temperature cycle. Aronia berries’ pH and titratable acidity were affected more by refrigeration than frozen and temperature storage. The pH increased by 4% during refrigeration, and titratable acidity decreased by 17% at 12 weeks. In conclusion, refrigerated storage results in a modest reduction of aronia berry polyphenols, but absolute extractable polyphenols are stable for up to 8 months of frozen storage.

关键词： Aronia berry Polyphenols Storage Refrigeration Sugars Acids Frozen

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