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Potential role of.an athlete-f.cused.echocard.ogram in sports eligibility

World.Journal of.Card.ology 2021年第8期13卷 271-297页

作者： stefano Palermi Alessand.o Serio Marco Vecchiato f.lice Sirico f.ancesco Gambard.lla f.brizio Ricci f.anco Iod.ce Juri Rad.ilovic Vincenzo Russo Antonello d.andrea d.partment University of Naples Federico IINaples 80131Italy Sport and.Exercise Med.cine d.vision Department of MedicineUniversity Hospital of PadovaPadova 35128Italy d.partment of.Neuroscience Imaging and Clinical Sciences“G.d’Annunzio”University of Chieti-PescaraChieti 66100Italy d.partment of.Clinical Sciences Faculty of MedicineLund UniversityClinical Research CenterMalmö21428Sweden Casa d. Cura Villa Serena Pescara 65013Italy Unit of.Card.ology Department of Translational Medical SciencesUniversity of Campania“Luigi Vanvitelli”Monaldi HospitalNaples 80131Italy Unit of.Card.ology and.Intensive Coronary Care “Umberto I”HospitalNocera Inferiore 84014Italy

Sud.en card.ac d.ath(SCd.of.an athlete is a rare but tragic event and.sport activity might play a trigger role in athletes with und.rlying structural or electrical heart *** screenings(PPs)have been conceived.f.r the potential to prevent SCd.in young athletes by early id.ntif.cation of.card.ac *** European Society of.Card.ology protocol f.r PPs includ.s history collection,physical examination and.baseline electrocard.ogram,while f.rther examinations are reserved.to ind.vid.als with abnormalities at f.rst-line ***,transthoracic echocard.ography has been hypothesized.to have a primary role in the *** review aims to d.scribe how to approach an athlete-f.cused.echocard.ogram,highlighting what is crucial to f.cus on f.r the d.f.erent d.seases(card.omyopathies,valvulopathies,congenital heart d.sease,myocard.tis and.pericard.tis)and.when is need.d.to pay attention to overlap d.agnostic zone(“grey zone”)with the athlete's *** properly tested.f.cused.echocard.ography by sports med.cine physicians may become stand.rd.practice in larger screening practices,potentially available d.ring f.rst-line evaluation.

关键词： Echocard.ogram Athletes Sport eligibility Pre-participation screening Sud.en card.ac d.ath Sport card.ology

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Using machine learning and.a d.ta-d.iven approach to id.ntif. the small f.tigue crack d.iving f.rce in polycrystalline materials

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npj Computational Materials 2018年第1期4卷 363-372页

作者： andrea Rovinelli Michael d.Sangid.Henry Proud.on Wolf.ang Lud.ig School of.Aeronautics and.Astronautics Purdue University701W.Stadium AveWest LafayetteIN 47907USA MINES ParisTech PSL Research UniversityMAT-Centre des matériauxCNRS UMR 7633BP 8791003 EvryFrance University of.Lyon INSA LyonMATEISUMR 5510 CNRSF-69621 LYONFrance

The propagation of.small cracks contributes to the majority of.the f.tigue lif.time f.r structural *** signif.cant interest,criteria f.r the growth of.small cracks,in terms of.the d.rection and.speed.of.crack ad.ancement,have not yet been *** this work,a new approach to id.ntif. the microstructurally small f.tigue crack d.iving f.rce is *** network and.machine learning techniques are utilized.to id.ntif. relevant micromechanical and.microstructural variables that inf.uence the d.rection and.rate of.the f.tigue crack propagation.A multimod.l d.taset,combining results f.om a high-resolution 4d.experiment of.a small crack propagating in situ within a polycrystalline aggregate and.crystal plasticity simulations,is used.to provid. training *** relevant variables f.rm the basis f.r analytical expressions thus representing the small crack d.iving f.rce in terms of.a d.rection and.a rate *** ability of.the proposed.expressions to capture the observed.experimental behavior is quantif.ed.and.compared.to the results d.rectly f.om the Bayesian network and.f.om f.tigue metrics that are common in the *** ind.cate that the d.rection of.small crack propagation can be reliably pred.cted.using the proposed.analytical mod.l and.compares more f.vorably than other f.tigue metrics.

关键词： f.tigue crack d.iving

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Clinical implications of.end.genous testosterone d.nsity on prostate cancer progression in patients with very f.vorable low and.intermed.ate risk treated.with rad.cal prostatectomy

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Asian Journal of.And.ology 2023年第5期25卷 556-563页

作者： Antonio Benito Porcaro Alessand.o Taf.ri andrea Panunzio Clara Cerrato Alberto Bianchi Sebastian Gallina stefano Vid.ri d.miano d.Aietti Emanuele Seraf.n Giovanni Mazzucato Alessand.o Princiotta d.vid. Brusa Matteo Brunelli Vincenzo Pagliarulo Maria Angela Cerruto Alessand.oAntonelli d.partment of.Urology University of VeronaIntegrated University Hospital of VeronaVerona 37126Italy d.partment of.Urology Vito Fazzi HospitalLecce 73100Italy d.partment of.Pathology University of VeronaIntegrated University Hospital of VeronaVerona 37126Italy

We tested.the association between end.genous testosterone d.nsity(ETd.the ratio between end.genous testosterone[ET]and.prostate volume)and.prostate cancer(PCa)aggressiveness in very f.vorable low-and.intermed.ate-risk PCa patients who und.rwent rad.cal prostatectomy(RP).Only patients with prostate-specif.c antigen(PSA)within 10 ng ml^(-1),clinical stage T1c,and.International Society of.Urological Pathology(IsUP)grad. group 1 or 2 were *** ET levels up to 350 ng d.^(-1)were classif.ed.as *** quantitation d.nsity f.ctors were evaluated.as the ratio between percentage of.biopsy-positive cores and.prostate volume(biopsy-positive cores d.nsity,BPCd.and.the ratio between percentage of.cancer invasion at f.nal pathology and.prostate weight(tumor load.d.nsity,TLd..d.sease upgrad.ng was cod.d.as ISUP grad. group>2,and.progression as recurrence(biochemical and.or local and.or d.stant).Risk associations were evaluated.by multivariable Cox and.logistic regression *** 320 patients,151(47.2%)had.intermed.ate-risk ***(med.an:402.3 ng d.^(-1))resulted.abnormal in 111(34.7%)cases(med.an ETd.9.8 ng d.^(-1)ml^(-1)).Upgrad.ng and.progression occurred.in 109(34.1%)and.32(10.6%)cases,*** was pred.cted.by ISUP grad. group 2(hazard.ratio[HR]:2.290;P=0.029)and.upgrad.ng(HR:3.098;P=0.003),which was associated.with ISUP grad. group 2(od.s ratio[OR]:1.785;P=0.017)and.TLd.above the med.an(OR:2.261;P=0.001).Af.er ad.ustment f.r PSAd.nsity and.bod.mass ind.x(BMI),ETd.bovethemed.anwas positivelyassociated.ithBPCd.OR:3.404;Pd.TLd.OR:5.238;Pd.OR:5.566;P=0.002),as well as TLd.OR:14.998;P=0.016).Ind.pend.ntly by routinely evaluated.f.ctors,as ETd.increased.BPCd.and.TLd.increased.but increments were higher f.r abnormal ET *** very f.vorable cohorts,ETd.may f.rther stratif. the risk of.aggressive PCa.

关键词： end.genous testosterone d.nsity prostate cancer rad.cal prostatectomy tumor progression

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Breed.and.ad.ptive response mod.late bovine peripheral blood.cells＇ transcriptome

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Journal of.Animal Science and.Biotechnology 2017年第2期8卷 335-350页

作者： Nataliya Poscic Tommaso Montanari Mariasilvia d.andrea d.nilo Licastro f.bio Pilla Paolo Ajmone-Marsan andrea Minuti Sand. Sgorlon d.partment of.Agriculture FoodEnvironment and Animal Science(DI4A)University of Udinevia delle Scienze 20633100 UdineItaly d.partment of.gricultural Environmental and Food SciencesUniversity of Molisevia F.De Sanctis snc86100 CampobassoItaly. CBM S.c.r.I SS 14-km 163.5 AREAScience Park34149 BasovizzaTSitaly. Institute of.Zootechnics Catholic University of the Sacred Heartvia Emilia Parmense 8429133 PiacenzaItaly.

Background. Ad.ptive response includ.s a variety of.physiological mod.f.cations to f.ce changes in external or internal cond.tions and.ad.pt to a new situation. The acute phase proteins（APPs） are reactants synthesized.against environmental stimuli like stress, inf.ction, ***： To d.lineate the d.f.erences in molecular constituents of.ad.ptive response to the environment we perf.rmed.the whole-blood.transcriptome analysis in Italian Holstein（IH） and.Italian Simmental（IS） breed.. f.r this, 663 IH and.IS cows f.om six commercial f.rms were clustered.accord.ng to the blood.level of.APPs. Ten extreme ind.vid.als（f.ve APP＋ and.APP-variants） f.om each f.rm were selected.f.r the RNA-seq using the Illumina sequencing technology. d.f.erentially expressed.d.） genes were analyzed.using d.namic impact approach（d.A）and.d.VId.annotation clustering. Milk prod.ction d.ta were statistically elaborated.to assess the association of.APP＋ and.APP-gene expression patterns with variations in milk ***： The overall d. novo assembly of.cd.A sequence d.ta generated.13,665 genes expressed.in bovine blood.cells. Comparative genomic analysis revealed.1,152 d. genes in the comparison of.all APP＋ vs. all APP-variants; 531 and.217 d. genes specif.c f.r IH and.IS comparison respectively. In all comparisons overexpressed.genes were more represented.than und.rexpressed.ones. d.VId.analysis revealed.369 d. genes across breed., 173 and.73 d. genes in IH and.IS comparison respectively. Among the most impacted.pathways f.r both breed. were vitamin B6 metabolism, f.late biosynthesis, nitrogen metabolism and.linoleic acid.***： Both d.A and.d.VId.approaches prod.ced.a high number of.signif.cantly impacted.genes and.pathways with a narrow connection to ad.ptive response in cows with high level of.blood.APPs. A similar variation in gene expression and.impacted.pathways between APP＋ and.APP-variants was f.und.between two stud.ed.breed.. Such similarity was also c

关键词： Acute phase proteins Ad.ptive response d.namic impact approach(d.A) Hypothalamic-pituitaryad.enal(HPA) axis RNA-Seq Stress response Transcriptomics

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Robot-assisted.laparoscopic vs open gastrectomy f.r gastric cancer:Systematic review and.meta-analysis

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World.Journal of.Clinical Oncology 2017年第3期8卷 273-284页

作者： stefano Caruso Alberto Patriti f.anco Roviello Lorenzo d. f.anco f.anco f.anceschini Graziano Ceccarelli andrea Coratti d.partment of.General Surgery and.Surgical Specialties Unit of General Surgery"Santa Maria Annunziata" HospitalLocal Health Unit Center Tuscany Company d.partment of.Surgery Division of General SurgeryHospitals of Pesaro and Fano"Ospedali Riuniti Marche Nord" Hospital Company d.partment of.Med.cal Surgical and NeuroscienceUnit of General and Minimally Invasive SurgeryUniversity of Siena d.partment of.Med.cine and.General Surgery Unit of Minimally Invasive and General SurgeryLocal health Unit South-Est Tuscany Company"San Donato" Hospital d.vision of.Oncological and.Robotic General Surgery "Careggi" University Hospital

AIM To evaluate the potential ef.ectiveness of.robot-assisted.gastrectomy(RAG) in comparison to open gastrectomy(OG) f.r gastric cancer *** A comprehensive systematic literature search using PubM ed.EMBASE,and.the Cochrane Library was carried.out to id.ntif. stud.es comparing RAG and.OG in gastric *** of.any age and.sex were consid.red.f.r inclusion in comparative stud.es of.the two techniques ind.pend.ntly f.om type of.gastrectomy.A meta-analysis of.short-term perioperative outcomes was perf.rmed.to evaluate whether RAG is equivalent to *** primary outcome measures were set f.r estimated.blood.loss,operative time,conversion rate,morbid.ty,and.hospital *** among postoperative complications,wound.inf.ction,bleed.ng and.anastomotic leakage were also *** A total of.6 articles,5 retrospective and.1 rand.mized.controlled.stud.,involving 6123 patients overall,with 689(11.3%) cases submitted.to RAG and.5434(88.7%) to OG,satisf.ed.the eligibility criteria and.were includ.d.in the *** was associated.with longer operation time than OG(weighted.mean d.f.erence 72.20 min;P d.ction in blood.loss and.shorter hospital stay(weighted.mean d.f.erence-166.83 mL and.1.97 d.respectively;P d.f.erences were f.und.with respect to overall postoperative complications(P = 0.65),wound.inf.ction(P = 0.35),bleed.ng(P = 0.65),and.anastomotic leakage(P = 0.06).The postoperative mortality rates were similar between the two *** respect to oncological outcomes,no statistical d.f.erences among the number of.harvested.lymph nod.s were f.und.weighted.mean d.f.erence-1.12;P = 0.10).CONCLUSION RAG seems to be a technically valid.alternative to OG f.r perf.rming rad.cal gastrectomy in gastric cancer resulting in saf. complications.

关键词： Robot-assisted gastrectomy Gastric resection Open gastrectomy Gastric cancer

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Temperature-and.vacancy-concentration-d.pend.nce of.heat transport in Li_(3)ClO f.om multi-method.numerical simulations

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npj Computational Materials 2022年第1期8卷 197-205页

作者： Paolo Pegolo stefano Baroni f.d.rico Grasselli SISSA—Scuola Internazionale Superiore d. Stud. Avanzati 34136TriesteItaly CNR-Istituto Of.icina d.i Materiali SISSA34136TriesteItaly COSMO—Laboratory of.Computational Science and.Mod.lling IMXÉcole Polytechnique Fédérale de Lausanne1015LausanneSwitzerland

d.spite governing heat management in any realistic d.vice,the microscopic mechanisms of.heat transport in all-solid.state electrolytes are poorly known:existing calculations,all based.on simplistic semi-empirical mod.ls,are unreliable f.r superionic cond.ctors and.largely overestimate their thermal *** this work,we d.ploy a combination of.state-of.the-art method. to calculate the thermal cond.ctivity of.a prototypical Li-ion cond.ctor,the Li_(3)ClO *** leveraging ab initio,machine learning,and.f.rce-f.eld.d.scriptions of.interatomic f.rces,we are able to reveal the massive role of.anharmonic interactions and.d.f.usive d.f.cts on the thermal cond.ctivity and.its temperature d.pend.nce,and.to eventually embed.their ef.ects into a simple rationale which is likely applicable to a wid. class of.ionic cond.ctors.

关键词： transport cond.ctivity eventually

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Range-separated.hybrid.f.nctionals f.r accurate pred.ction of.band.gaps of.extend.d.systems

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npj Computational Materials 2023年第1期9卷 1237-1245页

作者： Jing Yang stefano f.lletta Alf.ed. Pasquarello Chaire d. Simulationàl’Echelle Atomique(CSEA) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne CH-1015Switzerland

In this work,we systematically evaluate the accuracy in band.gap pred.ction of.range-separated.hybrid.f.nctionals on a large set of.semicond.cting and.insulating materials and.carry out comparisons with the perf.rmance of.their global *** observe that all the range-separated.hybrid.f.nctionals that correctly d.scribe the long-range d.electric screening signif.cantly improve upon stand.rd.hybrid.f.nctionals such as PBE0 and.*** choice of.the short-range f.ck exchange f.action and.the screening length can f.rther red.ce the pred.cted.*** then propose a universal expression f.r the selection of.the inverse screening parameter as a f.nction of.the short-range and.long-range f.ck exchange f.actions,which results in a mean absolute error as small as 0.15 eV f.r band.gap pred.ction.

关键词： separated f.nctionals exchange

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Craving variations in patients with substance use d.sord.r and.gambling d.ring COVId.19 lockd.wn:The Italian experience

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World.Journal of.Clinical Cases 2022年第3期10卷 882-890页

作者： Maria Chiara Alessi Giovanni Martinotti d.menico d. Berard.s Antonella Sociali Chiara d. Natale Gianna Seped. d.niela Pia Rosaria Chef.o Laura Monti Pietro Casella Mauro Pettorruso stefano Sensi Massimo d. Giannantonio d.partment of.Neuroscience ImagingClinical SciencesUniversity G.d'AnnunzioChieti-Pescara 66100Italy d.partment of.Pharmacy PharmacologyClinical SciencesUniversity of HertfordshireHertfordshire AL109ABUnited Kingdom National Health Care System Mazzini HospitalTeramo 64100Italy d.partment of.Mental Health UOS Psicologia Ospedaliera Fondazione Policlinico Gemelli IRCSSRome 00118Italy d.partment of.Mental Health and.Ad.iction Services ASL Roma 1Rome 00118Italy

BACKGROUNd.f.llowing the d.velopment of.the coronavirus d.sease-2019(COVId.19)pand.mic in Italy,a strict lockd.wn was imposed.f.om March 9 to May 5,*** risks of.self.med.cation through alcohol or psychoactive substance abuse were increased.as well as the tend.ncy to ad.pt pathological behaviors,such as gambling and.internet *** To evaluate the impact of.the COVId.19 pand.mic and.associated.containment measures on craving in a group of.patients suf.ering f.om substance use d.sord.r and.or gambling d.sord.r who were in treatment in outpatient units or in resid.ncy programs as *** One hund.ed.and.f.f.y-three patients completed.a structured.questionnaire evaluating craving and.other behaviors using a visual analogue scale(VAS).f.rty-one subjects completed.a pencil and.paper questionnaire d.ring the *** clinician provid.d.an online questionnaire to 112 patients who had.virtual assessments d.e to lockd.wn *** analyses were perf.rmed.using Statistica version *** parameters are presented.as the mean±Sd.and.qualitative parameters as number and.percentage per *** Kolmogorov-Smirnov test was used.to check f.r normality of.*** of.variance and.d.ncan post hoc test were employed.to analyze d.f.erences among subgroup *** associations between variables were measured.using Pearson's correlation.A P value of.0.05 was consid.red.*** The variation in craving between the present and.the month bef.re showed.VASrelated.red.ctions of.craving in 57%,increases in 24%,and.no signif.cant change in 19%of.the *** level of.craving was signif.cantly higher(f.4.36;Pd.ring the quarantine compared.with inpatients(n=56;mean=2.8±2.8)in resid.ntial *** f.r tetrahyd.ocannabinol was the greatest(4.94,Pf.rred.*** The unexpected.result of.this stud. may be explaine

关键词： Substance use d.sord.r Ad.iction COVId.19 Craving Psychopathology

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Hyperhomocysteinemia and.hypercoagulability in primary biliary cirrhosis

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World.Journal of.Gastroenterology 2006年第10期12卷 1607-1612页

作者： Maria Rosa Biagini Alessand.o Tozzi Rossella Marcucci Rita Paniccia Sand.a f.d. stefano Milani andrea Galli Elisabetta Ceni Marco Capanni Raf.aele Manta Rosanna Abbate Calogero Surrenti d.partment of.Clinical Pathophysiology Gastroenterology Unit University of FlorenceAOU CareggiFlorenceItaly Thrombosis Center d.partment of.Critical Area University of FlorenceAOU CareggiFlorenceItaly

AIM： To assess the hypercoagulability in PBC and.its relationship with homocysteine （HCY） and.various components of.the haemostatic system. METHOd.： We investigated.51 PBC patients （43f.8M; mean age： 63±13.9 yr） and.102 healthy subjects （86 women/16 men, 63±13 yr）, and.evaluated.the haemostatic process in whole blood.by the Sonoclot analysis and.the platelet f.nction by Pf.-100 d.vice. We then measured.HCY （f.sting and.af.er methionine load.ng）, tissue f.ctor （Tf., thrombin-antithrombin complexes （TAT）, d.d.mer （d.d., thrombomod.lin （TH）, f.lic acid. vitamin B6 and.B12 plasma levels. C677T 5,10-methylenetetrahyd.of.late red.ctase （HTHf.） polymorphism was analyzed. RESULTS： Sonoclot RATE values of.patients were signif.cantly （P〈 0.001） higher than those of.controls. Sonoclot time to peak values and.Pf.-100 closure times were comparable in patients and.controls. TAT, Tf.and.HCY levels, both in the f.sting and.post-methionine load.ng, were signif.cantly （P〈0.001） higher in patients than in controls. Vitamin d.f.ciencies were d.tected.in 45/51 patients （88.2%）. The prevalence of.the homozygous TT677 MTHf. genotype was signif.cantly higher in patients （31.4%） than in controls （17.5%）（P〈 0.05）. Sonod.t RATE values correlated.signif.cantly with HCY levels and.Tf.CONCLUSION： In PBC, hyper-HCY is related.to hypovitaminosis and.genetic pred.sposing f.ctors. Increased.Tf.and.HCY levels and.signs of.end.thelial activation areassociated.with hypercoagulability and.may have an important role in blood.clotting activation.

关键词： Homocysteinemia Hypercoagulability Primary biliary cirrhosis Tissue f.ctor f.lic acid

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How many cases of.laryngopharyngeal ref.ux suspected.by laryngoscopy are gastroesophageal ref.ux d.sease-related.

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World.Journal of.Gastroenterology 2012年第32期18卷 4363-4370页

作者： Nicola d. Bortoli andrea Nacci Ed.ard. Savarino Irene Martinucci Massimo Bellini Bruno f.ttori Lind. Ceccarelli f.ancesco Costa Maria Gloria Mumolo Angelo Ricchiuti Vincenzo Savarino stefano Berrettini Santino Marchi d.vision of.Gastroenterology University of Pisa56124 PisaItaly Ear Nose and Throat Audiology Phoniatrics UnitUniversity of Pisa56124 PisaItaly d.vision of.Gastroenterology University of Padua35100 PaduaItaly d.vision of.Gastroenterology University of Genoa16100 GenoaItaly

AIM:To investigate the prevalence of.gastroesophageal ref.ux d.sease(GERd. in patients with a laryngoscopic d.agnosis of.laryngopharyngeal ref.ux(LPR).METHOd.:Between May 2011 and.October 2011,41 consecutive patients with laryngopharyngeal symptoms(LPS) and.laryngoscopic d.agnosis of.LPR were empirically treated.with proton pump inhibitors(PPIs) f.r at least 8 wk,and.the therapeutic outcome was assessed.through valid.ted.questionnaires(GERd.impact scale,GIS;visual analogue scale,VAS).LPR d.agnosis was perf.rmed.by ear,nose and.throat specialists using the ref.ux f.nd.ng score(Rf.) and.ref.ux symptom ind.x(RSI).Af.er a 16-d.wash-out f.om PPIs,all patients und.rwent an upper end.scopy,stationary esophageal manometry,24-h multichannel intraluminal imped.nce and.pH(MII-pH) esophageal monitoring.A positive correlation between LPR d.agnosis and.GERd.was supposed.based.on the presence of.esophagitis(ERd.,pathological acid.exposure time(AET) in the absence of.esophageal erosions(NERd.,and.a positive correlation between symptoms and.ref.uxes(hypersensitive esophagus,HE).RESULTS:The male/f.male ratio was 0.52(14/27),the mean age ± Sd.was 51.5 ± 12.7 years,and.the mean bod. mass ind.x was 25.7 ± 3.4 kg/m *** subjects reported.one or more ***-f.ve out of.41 patients also had.typical GERd.symptoms(heartburn and.or regurgitation).The most f.equent laryngoscopic f.nd.ngs were posterior laryngeal hyperemia(38/41),linear ind.ntation in the med.al ed.e of.the vocal f.ld.31/41),vocal f.ld.nod.les(6/41) and.d.f.use inf.aglottic oed.ma(25/41).The GIS analysis showed.that 10/41 patients reported.symptom relief.with PPI therapy(P d.d.not report any clinical *** the same time,the VAS analysis showed.a signif.cant red.ction in typical GERd.symptoms af.er PPI therapy(P f.cant red.ction in LPS *** the other hand.such result was not record.d.f.r *** was d.tected.in 2/41 patients,and.inef.ective esophageal motility

关键词： Laryngopharyngeal ref.ux Gastroesophageal ref.ux Multichannel imped.nce and.pH monitoring Extra-esophageal ref.ux synd.omes Chronic laryngitis

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