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Hepatocellular carcinoma in nonalcoholic fatty liver disease:A growing challenge

World Journal of Hepatology 2021年第9期13卷 1107-1121页

作者： Angelo Z Mattos Jose D Debes Renu Dhanasekaran Jihane N Benhammou Marco Arrese andre luiz v patricio Amanda C Zilio Angelo A Mattos Graduate Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericordia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Department of Medicine Division of Infectious Diseases and of GastroenterologyUniversity of MinnesotaMinneapolisMN 55455United States Department of Gastroenterology and Hepatology Erasmus Medical CenterRotterdam 3015 CNSouth HollandNetherlands Division of Gastroenterology and Hepatology Stanford UniversityStanfordCA 94305United States The vatche and Tamar Manoukian Division of Digestive Diseases University of CaliforniaLos AngelesCA 90095United States Department of Gastroenterology Pontificia Universidad Catolica de ChileSantiago 3580000Chile

Nonalcoholic fatty liver disease(NAFLD)is the most common cause of liver disease worldwide,and its prevalence increases *** it predisposes to hepatocellular carcinoma both in the presence and in the absence of cirrhosis,it is not surprising that the incidence of NAFLD-related hepatocellular carcinoma would also *** of the mechanisms involved in hepatocarcinogenesis are particular to individuals with fatty liver,and they help explain why liver cancer develops even in patients without *** and immune-mediated mechanisms seem to play an important role in the development of hepatocellular carcinoma in this ***,it is consensual that patients with NAFLD-related cirrhosis should be surveilled with ultrasonography every 6 mo(with or without alpha-fetoprotein),but it is known that they are less likely to follow this recommendation than individuals with other kinds of liver ***,the performance of the methods of surveillance are lower in NAFLD than they are in other liver ***,it is not clear which subgroups of patients without cirrhosis should undergo *** the mechanisms of hepatocarcinogenesis in NAFLD could hopefully lead to the identification of biomarkers to be used in the surveillance for liver cancer in these *** improving surveillance,tumors could be detected in earlier stages,amenable to curative treatments.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Hepatocellular carcinoma Hepatocarcinogenesis Surveillance

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Endocytic Trafficking towards the vacuole Plays a Key Role in the Auxin Receptor SCF^TIR-Independent Mechanism of Lateral Root Formation in A. thaliana

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Molecular Plant 2012年第6期5卷 1195-1209页

作者： patricio Perez-Henrique Natasha v. Raikhel Lorena Norambuena Plant Molecular Biology Laboratory Department of Biology Faculty of Sciences University of Chile Santiago Chile Millenium Nucleus in Plant Cell Biotechnology Chile Center for Plant Cell Biology and Department of Botany and Plant Sciences University of California Riverside CA 92521 USA

Plants＇ developmental plasticity plays a pivotal role in responding to environmental conditions. One of the most plastic plant organs is the root system. Different environmental stimuli such as nutrients and water deficiency may induce lateral root formation to compensate for a low level of water and/or nutrients. It has been shown that the hor- mone auxin tunes lateral root development and components for its signaling pathway have been identified. Using chemi- cal biology, we discovered an Arabidopsis thaliana lateral root formation mechanism that is independent of the auxin receptor SCFTM. The bioactive compound Sortin2 increased lateral root occurrence by acting upstream from the morpho- logical marker of lateral root primordium formation, the mitotic activity. The compound did not display auxin activity. At the cellular level, Sortin2 accelerated endosomal trafficking, resulting in increased trafficking of plasma membrane recy- cling proteins to the vacuole. Sortin2 affected Late endosome/PvC/MvB trafficking and morphology. Combining Sortin2 with well-known drugs showed that endocytic trafficking of Late E/PvC/MvB towards the vacuole is pivotal for Sortin2- induced SCFTm-independent lateral root initiation. Our results revealed a distinctive role for endosomal trafficking in the promotion of lateral root formation via a process that does not rely on the auxin receptor complex SCFTM.

关键词： lateral root development endocytic trafficking Sortin2 endosomes Arabidopsis.

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Biceps femoris long head sarcomere and fascicle length adaptations after 3 weeks of eccentric exercise training

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Journal of Sport and Health Science 2022年第1期11卷 43-49页

作者： patricio A.Pincheira Melissa A.Boswell Martino v.Franchi Scott L.Delp Glen A.Lichtwark School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Bioengineering and Mechanical Engineering Stanford UniversityStanfordCA 94305USA Department of Biomedical Sciences University of PadovaPadova 35122Italy

Background:Eccentric exercise increases muscle fascicle lengths;however,the mechanisms behind this adaptation are still *** study aimed to determine whether biceps femoris long head(BFlh)fascicle length increases in response to 3 weeks of eccentric exercise training are the result of an in-series addition of sarcomeres within the muscle ***:Ten recreationally active participants(age=27±3 years;mass=70±14 kg;height=174±9 cm;mean±SD)completed 3 weeks of Nordic hamstring exercise(NHE)training on a custom exercise device that was instrumented with load *** collected in vivo sarcomere and muscle fascicle images of the BFlh in 2 regions(central and distal)by using microendoscopy and 3 dimension *** then estimated sarcomere length,sarcomere number,and fascicle length before and after the training ***:Eccentric knee flexion strength increased after the training(15%;pving regional increases in fascicle and sarcomere length remains unknown,but we speculate that it may be driven by regional changes in the pas sive tension of muscle or connective tis sue adaptations.

关键词： Hamstrings Nordic hamstring exercise Sarcomerogenesis

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On the Possibilities of Leisure Studies in Mozambique： Historical and Sociological Considerations

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Sociology Study 2014年第2期4卷 157-169页

作者： patricio v. Langa Eduardo Mondlane University Mozambique

In this paper, the author examines the possibilities of leisure （studies） in Mozambique. First, the author suggests that leisure can he looked at as a social construct which resulted from the colonial regulation of native labour, particularly between 1890s and 1974. Secondly, the author proposes that people look at the conditions of possibility of leisure in a context dominated by the new moral code of conduct, a cathartic purification of the colonial mentality, introduced through the ideology of the ＂New Man＂ created by the ruling party, Frelimo. Thirdly, the author examines the possibility of leisure in the context of Mozambique＇s adherence to neo-liberalism and market-driven economy after the collapse of socialism. The author concludes by providing the ground to establish lines of inquiry for an eventual field of leisure studies.

关键词： Leisure leisure studies forced labour native labour regulation Mozambique

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Critical Success Factors to Improve the Game Development Process from a Developer＇s Perspective

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Journal of Computer Science & Technology 2016年第5期31卷 925-950页

作者： Saiqa Aleem luiz Fernando Capretz Faheem Ahmed College of Technological Innovation Zayed University Abu Dhabi 144534 United Arab Emirates Department of Electrical and Computer Engineering Western University Ontario N6A 5B9 Canada Department of Computing Science Thompson Rivers University Kamloops BC V2C OC8 Canada

The growth of the software game development industry is enormous and is gaining importance day by day. This growth imposes severe pressure and a number of issues and challenges on the game development community. Game development is a complex process, and one important game development choice is to consider the developer＇s perspective to produce good-quality software games by improving the game development process. The objective of this study is to provide a better understanding of the developer＇s dimension as a factor in software game success. It focuses mainly on an empirical investigation of the effect of key developer＇s factors on the software game development process and eventually on the quality of the resulting game. A quantitative survey was developed and conducted to identify key developer＇s factors for an enhanced game development process. For this study, the developed survey was used to test the research model and hypotheses. The results provide evidence that game development organizations must deal with multiple key factors to remain competitive and to handle high pressure in the software game industry. The main contribution of this paper is to investigate empirically the influence of key developer＇s factors on the game development process.

关键词： developer's perspective software game empirical investigation good-quality game game development process,game developer's factor

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Pericyte Plasticity in the Brain

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Neuroscience Bulletin 2019年第3期35卷 551-560页

作者： Gabryella S.P.Santos luiz A.v.Magno Marco A.Romano-Silva Akiva Mintz Alexander Birbrair Departamento de Patologia Universidade Federal de Minas GeraisBelo HorizonteMG 31270-901Brazil Department of Mental Health Federal University of Minas GeraisBelo HorizonteMG 30130-100Brazil Department of Radiology Columbia University Medical CenterNew YorkNY 10032USA

Cerebral pericytes are perivascular cells that stabilize blood vessels. Little is known about the plasticity of pericytes in the adult brain in vivo. Recently, using stateof-the-art technologies, including two-photon microscopy in combination with sophisticated Cre/loxP in vivo tracing techniques, a novel role of pericytes was revealed in vascular remodeling in the adult brain. Strikingly, after pericyte ablation, neighboring pericytes expand their processes and prevent vascular dilatation. This new knowledge provides insights into pericyte plasticity in the adult brain.

关键词： Pericytes Brain Blood vessel Plasticity

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Dendritic Growth, Eutectic Features and Their Effects on Hardness of a Ternary Sn–Zn–Cu Solder Alloy

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Acta Metallurgica Sinica(English Letters) 2017年第6期30卷 528-540页

作者： Bismarck luiz Silva Rodrigo valenzuela Reyes Amauri Garcia JoséEduardo Spinelli Department of Materials Engineering Federal University of Rio Grande do Norte-UFRNNatalRN 59078-970Brazil Department of Materials Engineering Federal University of Sao Carlos-UFSCarSao CarlosSP 13565-905Brazil Department of Manufacturing and Materials Engineering University of CampinasUNICAMPCampinasSP 13083-860Brazil

The present investigation is based on the results of a directionally solidified （DS） Sn-9 wt%Zn-2 wt%Cu alloy, including primary/secondary/tertiary dendrite arm spacings of the Sn-rich matrix, the morphologies of the eutectic mixture and the corresponding interphase spacing, the nature and proportion of the Cu-Zn intermetallic compound （IMC）. The main purpose is to establish interrelations of these microstructure features with experimental solidification thermal parameters, such as cooling rates and growth rates （v）, macrosegregation and hardness. Such interrelations are interesting for both industry and academy since they represent a tool permitting the preprogramming of final properties based on the design of the microstructure. In the case of Sn-Zn-Cu alloys, hardly anything is known about the combined effects of the length scale of the microstructure and fraction and distribution of the primary IMC on hardness. The alloy microstructure is composed of a β-Sn dendritic region, surrounded by a eutectic mixture of α-Zn and β-Sn phases and the γ-Cu5Zn8 IMC. The eutectic interphase spacing varies in the range 1.2-3.6 μm, with the α-Zn phase having a globular morphology for ν 〉 0.5 mm/s and a needle-like morphology for ν 〈 0.3 mm/s. A modified Hall-Petch-type experimental expression relating hardness to the interphase spacing is proposed.

关键词： Sn-Zn-Cu solder alloy Solidification Microstructure Eutectic morphology Hardness

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Changes in rainfall partitioning caused by the replacement of native dry forests of Lithraea molleoides by exotic plantations of Pinus elliottii in the dry Chaco mountain forests, central Argentina

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Journal of Arid Land 2020年第5期12卷 717-729页

作者： Samia S CORTÉS Juan I WHITWORTH-HULSE Eduardo L PIOvANO Diego E GURvICH patricio N MAGLIANO Land Science Research Center(CICTERRA-CONICET)and National University of Córdoba Av.Vélez Sarsfield 1611X5016GCA CórdobaArgentina Multidisciplinary Institute of Plant Biology National University of Córdoba and CONICETCC 495X5000JJC CórdobaArgentina Environmental Study Group Institute of Applied Maths of San LuisNational University of San Luis and CONICETEjército de los Andes 950D5700HHW San LuisArgentina Department of Biology Faculty of ChemistryBiochemistry and PharmacyNational University of San LuisEjército de los Andes 950D5700HHW San LuisArgentina

The replacement of native dry forests by commercial(exotic)tree plantations could generate changes in rainfall partitioning,which further affects the water *** this study,we determined(i)the rainfall partitioning into interception,throughfall and stemflow,(ii)the role of rainfall event size on rainfall partitioning,(iii)the pH of water channelized as throughfall and stemflow,and(iv)the runoff in Lithraea molleoides(a native species)and Pinus elliottii(an exotic species)stands in the dry Chaco mountain forests,central *** average,interception,throughfall and stemflow accounted for 19.3%,79.5%and 1.2%of the gross rainfall in *** stand,and 32.6%,66.7%and 0.7%of the gross rainfall in *** stand,*** of interception,throughfall and stemflow presented positive linear relationships with the increment of rainfall event size for both tree species(Pvent size,showing different *** increasing rainfall event size,interception exponentially decreased,throughfall asymptotically increased and stemflow linearly *** *** and *** stands presented significant differences in the pH values of water channelized as throughfall(6.3 vs.6.7,respectively;Pvs.5.8,respectively;Pve species *** presented 13.6%more water reaching the topsoil(i.e.,net rainfall;net rainfall=gross rainfall-interception-runoff)than the exotic species *** study improves our understanding of the effects of native vegetation replacement on the local water balance in the dry forest ecosystems.

关键词： drylands ecohydrology land use changes spatial heterogeneity water-limited environments

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Does bilioenteric anastomosis impair results of liver resection in primary intrahepatic lithiasis?

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World Journal of Gastroenterology 2010年第27期16卷 3423-3426页

作者： Paulo Herman Marcos v Perini vincenzo Pugliese Julio Cesar Pereira Marcel Autran C Machado William A Saad luiz AC D'Albuquerque Ivan Cecconello Department of Gastroenterology Hospital Das Clínicas-University of So Paulo Medical SchoolSo Paulo-SP-CEP 05403-000BrazilPaulo HermanPraa Santos Coimbra10So Paulo-SP-CEP 05614-050Brazil

AIM:To evaluate the long-term results of liver resection for the treatment of primary intrahepatic *** factors,especially the impact of bilioenteric anastomosis on recurrence of symptoms were ***:Forty one patients with intrahepatic stones and parenchyma fibrosis/atrophy and/or biliary stenosis were submitted to liver *** was associated with a Roux-en-Y hepaticojejunostomy in all patients with bilateral stones and in those with unilateral disease and dilation of the extrahepatic biliary duct(>2 cm).Late results and risk factors for recurrence of symptoms or stones were ***:There was no operative *** a mean follow-up of 50.3 mo,good late results were observed in 82.9% of patients;all patients submitted to liver resection alone and 58.8% of those submitted to liver resection and hepaticojejunostomy were free of symptoms(P=0.0006).Patients with unilateral and bilateral disease showed good late results in 94.1% and 28.6%,respectively(P<0.001).CONCLUSION:Recurrence of symptoms in patients with hepaticojejunostomy showed that this may not be the ideal *** studies are needed to establish the best treatment for patients with bilateral stones or unilateral disease and a dilated extrahepatic duct.

关键词： Biliary lithiasis Bilioenteric anastomosis Cholangitis Intrahepatic lithiasis Liver resection

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The burden of prolonged sedentary behavior imposed by uberization

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Sports Medicine and Health Science 2023年第2期5卷 159-163页

作者： Thalles Guilarducci Costa vinnycius Nunes de Oliveira Douglas Assis Teles Santos Ricardo Borges viana Marilia Santos Andrade Rodrigo luiz vancini Katja Weiss Beat Knechtle Claudio andre Barbosa de Lira Laboratório de Avaliação do Movimento Humano Faculdade de Educação Física e DançaUniversidade Federal de GoiásGoiâniaBrazil Colegiado de Educação Física Universidade do Estado da BahiaCampus XTeixeira de FreitasBahiaBrazil Instituto de Educação Física e Esportes Universidade Federal do CearáFortalezaBrazil Departamento de Fisiologia Universidade Federal de São PauloSão PauloBrazil Centro de Educação Física e Desportos Universidade Federal do Espírito SantoVitóriaBrazil Institute of Primary Care University of Zurich8006ZurichSwitzerland Medbase St.Gallen Am vadianplatz 9000St.GallenSwitzerland

Mobility applications are rapidly growing in cities worldwide due to their convenience and low *** applications drivers experience vast flexibility in work hours,often work longer than in fixed-hours jobs,and can constantly transport passengers in their vehicles for up to 12 h;after this,they must go offline for eight consecutive hours before driving ***,drivers have found an easy way around this limitation by switching to other apps and continuing *** burden of prolonged work can increase sedentary behavior among mobility applications *** behavior is any waking activity in which the individual expends 1.5 metabolic equivalents(METs)or less while sitting or *** behavior can increase the risk of detrimental effects on *** this opinion article,we aim to discuss the possible effects of the burden of prolonged work on the sedentary behavior of mobility applications drivers and propose possible strategies to face this concerning situation.

关键词： Mobility application Drivers Health outcomes Sedentary lifestyle Quality of life

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