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Does the use of double horm.ne replacem.nt therapy for traum. patient organ donors im.rove organ recovery for transplant

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World Journal of Transplantation 2024年第2期14卷 119-125页

作者： Eden m.Gallegos Tanner Reed Paige Deville Blake Platt Claudia Leonardi Lillian Bellfi Jessica Dufrene Saad Chaudhary John Hunt Lance Stuke Patrick Greiffenstein Jonathan Schoen Alan m.rr Anil Param.sh Alison A smith Departm.nt of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Departm.nt of m.dicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Departm.nt of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Departm.nt of Traum. Surgery Tacoma General HospitalTacoma 98405United States Departm.nt of Public Health Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Departm.nt of Donation Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Departm.nt of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

BACKGROUND With an ongoing dem.nd for transplantable organs,optim.zation of donor m.nagem.nt protocols,specifically in traum. populations,is im.ortant for obta-ining a high yield of viable organs per *** m.nagem.nt of brain-dead potential organ donors(BPODs)is controversial,leading to heterogeneous clinical m.nagem.nt *** studies have shown that when levo-thyroxine was com.ined with other treatm.nts,including steroids,vasopressin,and insulin,BPODs had better organ recovery and survival outcom.s were increased for transplant *** To determ.ne if levothyroxine use in com.ination with steroids in BPODs increased the num.er of organs donated in traum. *** A retrospective review of adult BPODs from.a single level 1 traum. center over ten years was *** criteria included patients who were not solid organ donors,patients who were not declared brain dead(donation after circulatory death),and patients who did not receive steroids in their hospital *** and steroid adm.nistration,the num.er of organs donated,the types of organs donated,and dem.graphic inform.tion were *** analyses were perform.d with Pm.t inclusion criteria,69(78%)of whom.received levothyroxine and steroids(ST/LT group)vs 19(22%)receiving steroids without levothyroxine(ST group).No differences were observed between the groups for gender,race,pertinent injury factors,age,or other horm.ne therapies used(P>0.05).In the ST/LT group,68.1%(n=47)donated a high yield(3-5)of organ types per donor com.ared to 42.1%(n=8)in the ST group(P=0.038).There was no difference in the total num.er of organ types donated between the groups(P=0.068).CONCLUSION This study suggests that com.ining levothyroxine and steroid adm.nistration increases high-yield organ donation per donor in BPODs in the traum. patient *** to this study include

关键词： Organ donation Traum. Brain death Levothyroxine Horm.ne replacem.nt therapy Steroids Organ donor Retrospective

Long-term.follow-up of kidney transplant recipients adm.tted to a tertiary care transplant center with SARS-CoV-2

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World Journal of Virology 2024年第2期13卷 87-95页

作者： Em.ly E Zona m.na L Gibes Asha S Jain Jeannina A smith Jacqueline m.Garonzik-Wang Didier A m.ndelbrot Sandesh Parajuli Division of Nephrology Department of MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonWI 53705United States Departm.nt of Infectious Disease University of Wisconsin Hospital and ClinicsMadisonWI 53705United States Departm.nt of Surgery University of WisconsinMadisonWI 53705United States Departm.nt of m.dicine University of Wisconsin School of Medicine and Public HealthMadisonWI 53705United States Departm.nt of m.dicine University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin MadisonMadisonWI 53705United States

BACKGROUND Kidney transplant recipients(KTR)are at risk of severe coronavirus disease 2019(COVID-19)disease and m.rtality after severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2)*** predicted that hospitalization for COVID-19 and subsequent adm.ssion to the intensive care unit(ICU)would yield worse outcom.s in *** was stratified by ICU *** of interest included risk factors for ICU adm.ssion and m.rtality,length of stay(LOS),respiratory sym.tom. at adm.ssion,all-cause graft failure at the last follow-up,and death related to *** 96 KTRs were hospitalized for SARS-COV-2 infection.21(22%)required ICU *** ICU group had longer hospital LOS(21.8 vs 8.6 days,Pm.re likely to experience graft failure(81%vs 31%,Pm.tted to the ICU,76%had death at last-follow up,and 71%had death related to *** factors for ICU adm.ssion included m.le sex(aHR:3.11,95%CI:1.04-9.34;P=0.04).Risk factors for all-cause m.rtality and COVID-19-related m.rtality included ICU adm.ssion and advanced age at SARS-CoV-2 *** was highest within a m.nth of COVID-19 diagnosis,with the ICU group having increased risk of all-cause(aHR:11.2,95%CI:5.11-24.5;Pm.rtality(aHR:27.2,95%CI:8.69-84.9;Pm.ssion conferred an increased risk of m.rtality,graft failure,and longer ***-fifth of those hospit-alized died of COVID-19,reflecting the im.act of COVID-19-related m.rbidity and m.rtality am.ng KTRs.

关键词： Kidney transplants SARS-CoV-2 Intensive care unit adm.ssion Outcom.s Graft failure

Im.act of m.rijuana on Response Inhibition: An fm.I Study in Young Adults

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Is the possible fine-structure constant drift also a test of a tim.-dependent Planck constant?

Journal of Behavioral and Brain Science（行为与脑科学期刊） 2011年第3期

作者： andra m. smith Rocío A. López Zunini Christopher D. Anderson Carm.linda A. Longo Ian Cam.ron m.tthew J. Hogan Peter A. Fried

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Science China(Physics,m.chanics & Astronom.) 2011年第12期54卷 2191-2195页

作者： ZTAS A. m. smith m. L. Engineering Physics Hacettepe University Jannek Fuel Inc. Phoenix

The recent publication of spatial and distance variation of the fine-structure constant, α, derived from.astronom.cal data of quasar em.ssions (QE) is exciting. The decreasing value of α over tim., derived from.data obtained from.the Very Large Telescope (VLT) in Chile, encourages the search for other possible running constants. We surm.se that em.ssions from.distant supernovae, type Ia (SNe Ia), which are m.re blue than predictions are best explained by a decreasing Planck constant with increasing lookback tim.. We present som. results from.our theoretical work and com.arison to the astronom.cal observations and suggest that both α and h m.ght be running constants. m.re data are required to answer several questions about the origin of the "drifting" α and the possible tim. dependence of h. Astronom.cal tools such as SNe and QE m.y be the best m.ans to secure the exacting data needed to confirm.or deny these hypotheses.

关键词： alpha quasars distance m.asurem.nt supernovae Cm.

Experim.ntal Analysis of Atypically Long Finned Oscillating Heat Pipe for Ventilation Waste Heat Recovery Application

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Journal of Therm.l Science 2020年第3期29卷 667-675页

作者： m.HAJAN Govinda CHO Heejin smith Aaron THOm.SON Scott m. Rheem.m.nufacturing MontgomeryAL 36109USA Departm.nt of m.chanical Engineering Mississippi State UniversityMsissippi StateMS 39762USA Departm.nt of m.chanical Engineering Auburn UniversityAubumnAL 36849USA

Oscillating heat pipes(OHP)which are constructed from.a serpentine-arranged capillary tube possess a desirable aerodynam.c form.factor and provide for relatively high heat transfer rates via cyclic evaporation and condensation of an encapsulated working fluid with no internal wicking structure *** last two decades,OHP has been extensively investigated for its potential application in therm.l m.nagem.nt of various *** study presents an experim.ntal investigation on the heat transfer perform.nce of an atypically long finned *** heat transfer perform.nce of the proposed OHP was analyzed and com.ared with a bare tube OHP with sim.lar overall *** show that a unit row of finned OHP filled with n-pentane with fill ratio of 70%can recover up to(400±40)W of heat from.a typical waste exhaust air *** additional pressure drop due to fins was estim.ted to be(6.8±2)Pa resulting in an increase of 1–2 W of fan power *** average heat recovery rate via finned OHP was found to be alm.st 80%m.re than bare tube OHP filled with sam. working fluid with sam. fill ratio.

关键词： oscillating heat pipe waste heat recovery ventilation

Neurotrophin treatm.nt to prom.te regeneration after traum.tic CNS injury

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Frontiers in Biology 2013年第5期8卷 486-495页

作者： Lakshm. KELAm.NGALATH George m. smith Center for Neural Repair and Rehabilitation Department of Neuroscience & Shriners Hospitals for Pediatric Research Temple UniversitySchool of Medieine Philadelphia PA 19140-4106 USA

Neurotrophins are a fam.ly of growth factors that have been found to be central for the developm.nt and functional m.intenance of the nervous system. participating in neurogenesis, neuronal survival, axonal growth, synaptogenesis and activity-dependent form. of synaptic plasticity. Traum. in the adult nervous system.can disrupt the functional circuitry of neurons and result in severe functional deficits. The lim.tation of intrinsic growth capacity of adult nervous system.and the presence of an inhospitable environm.nt are the m.jor hurdles for axonal regeneration of lesioned adult neurons. Neurotrophic factors have been shown to be excellent candidates in m.diating neuronal repair and establishing functional circuitry via activating several growth signaling m.chanism. including neuron-intrinsic regenerative program.. Here, we will review the effects of various neurotrophins in m.diating recovery after injury to the adult spinal cord.

关键词： axonal guidance neurotrophin regeneration functional recovery sprouting

Effects of single-tree selection harvesting on hym.nopteran and saproxylic insect assem.lages in the canopy and understory of northern tem.erate forests

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Journal of Forestry Research 2012年第2期23卷 275-284页

作者： Sandy m. smith Nurul Islam.m. Isabel Bellocq Faculty of Forestry University of Toronto 33 Willcocks St. Toronto Ontario M5S 3B3 Canada Departam.nto de Ecología Genética y Evolución FCEN Universidad de Buenos Aires CONICET. Ciudad Universitaria Pab 2 Piso 4 Buenos Aires 1426 Argentina

Insects respond to changes in m.crohabitat caused by canopy disturbance, and thus can be used to exam.ne the ecological im.acts of harvesting. Single-tree selection harvesting is the m.st com.on silvicultural system.used to em.late local sm.ll-scale natural disturbance and m.intain uneven-aged forest structure in tem.erate forests. Here, we test for differences in richness, abundance, and com.osition of hym.nopteran and saproxylic insect assem.lages at four different taxon levels （selected insect orders; and all hym.nopteran fam.lies, and braconid subfam.lies and m.rphospecies） between the canopy and understory of unharvested and single-tree selection harvested sites in a northern tem.erate forest from.central Canada. Harvesting had no effect on insect assem.lage richness, com.osition or abundance at the three highest taxon levels （order, fam.ly and subfam.ly）. Sim.larly, richness and abundance at the lowest-taxon level （braconid m.rphospecies） were sim.lar, although com.osition differed slightly between unharvested and harvested stands. Insect assem.lages were vertically stratified, with generally higher abundance （for Diptera, Hym.noptera, som. hym.nopteran fam.lies and braconid subfam.lies） and richness （for braconid m.rphospecies） in the understory than the canopy. In particular, com.osition of the braconid m.rphospecies assem.lage showed relatively low sim.larity between the understory and canopy. Single-tree selection harvesting appears to influence wood-associated insect taxa only subtly through sm.ll changes in com.unity com.osition at the lowest taxon level, and thus is recom.ended as a conservative approach for m.naging these northern tem.erate forests.

关键词： selection harvesting insect com.unities canopy insects Jack pine forests forest m.nagem.nt high-taxon level insect conserva-tion

Does variable stand structure associated with m.lti-cohort forests support diversity of ground beetle (Coleoptera, Carabidae) com.unities in the central Nearctic boreal forest？

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Journal of Forestry Research 2016年第5期27卷 1191-1202页

作者： Erica P. Barkley Jay R. m.lcolm.Sandy m. smith m. Isabel Bellocq Faculty of Forestry University of Toronto 33 Willcocks Street Toronto ON M5S 3B3 Canada Departam.nto de Ecología Genética y Evolución IEGEBA(CONICET-UBA) Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires Buenos Aires Argentina

m.lti-cohort m.nagem.nt （m.m. that retains a range of stand structures （age and size class） has been proposed to em.late natural disturbance and im.rove m.nagem.nt in the Nearctic boreal forest. Although m.m.forests contain both single- and m.lti-aged stands of m.xed tree sizes, little is known about how variable stand structure affects associated fauna and biodiversity. Here, we exam.ne the relationship between ground beetle （Coleoptera, Carabidae） com.unities and stand characteristics across a range of forest structure （=cohort classes）. Given that m.m.classes are defined by the distribution of their tree-stem.diam.ters, we ask whether param.ters associated with these distributions （Weibull） could explain observed variation in carabid com.unities, and if so, how this com.ares to traditional habitat variables such as stand age, foliage com.lexity or volum. of downed woody debris. We sam.led carabids using weekly pitfall collections and com.ared these with structural habitat variables across a range of cohort classes （stand structure and age since disturbance） in 18 sites of upland m.xed boreal forests from.central Canada. Results showed that richness and diversity of carabid com.unities were sim.lar am.ng cohort classes. Weibull param.ters from.the diam.ter distribution of all stem. were the strongest predictors of variation in carabid com.unities am.ng sites, but vertical foliage com.lexity, understory thickness, and percentage of deciduous com.osition were also significant. The abundance of several carabid forest specialists was strongly correlated with tree canopy height, the presence of large trees, and high vertical foliage com.lexity. Our results dem.nstrate that variable forest structure, as expected under m.m. m.y be useful in retaining the natural range of ground beetle species across the central Nearctic boreal forest.

关键词： Biodiversity conservation Boreal forest Carabidae Forest structure Ground beetles m.lti-cohortm.nagem.nt Tree diam.ter distribution

Evolution of Strigolactone Perception by Seeds of Parasitic Plants： Reinventing the Wheel

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m.lecular Plant 2016年第4期9卷 493-495页

作者： Xiong, Guosheng Li, Jiayang smith, Steven m. Chinese Acad Agr Sci Agr Genom Inst Shenzhen Shenzhen 518124 Peoples R China Chinese Acad Sci State Key Lab Plant Genom Inst Genet & Dev Biol Beijing 100101 Peoples R China Chinese Acad Sci Natl Ctr Plant Gene Res Beijing Inst Genet & Dev Biol Beijing 100101 Peoples R China Univ Tasm.nia Sch Biol Sci Hobart Tas 7001 Australia

A BEWITCHING PROCESS The root-parasitic plants of the witchweed fam.ly （Orobanchan- ceae） produce seeds that are adapted to germ.nate in response to strigolactones （SLs） exuded from.the roots of their host plants. The resulting colonization of crops such as m.ize and sorghum.by these parasites can cause m.ssive losses in production and to the livelihoods of farm.rs （Westwood et al., 2010）.

关键词： root-parasitic plants witchweed