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Detection of ARV-Resistant Mutants in HIV-1-Infected Individuals in a Context of Systematic Switching to an Association Based on Dolutegravir in Abidjan, Côte d’Ivoire

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American Journal of Molecular Biology 2024年第3期14卷 138-151页

作者： Odegue Kpadraux Danielle Kakou-Ngazoa Solange Dechi Jean-Jacques Renaud Diallo Zelica Sina Kouamé Mireille Sylla Aboubacar Tossea Koui Stéphane Kouakou Venance Adagba Marius Apia N’Chouo Kouamé Basile Touré Offianan andré Dosso Mireille Molecular Biology Platform Institut Pasteur Abidjan Cte dIvoire Laboratory of the Regional Blood Transfusion Center Yamoussoukro Cte dIvoire Department of Infectious and Tropical Diseases University Hospital Treichville Abidjan Cte dIvoire Laboratory of the Regional Blood Transfusion Center San-Pdro Cte dIvoire Department of Epidemic Virus Institut Pasteur Abidjan Cte dIvoire Department of Parasitology Mycology Institut Pasteur Abidjan Cte dIvoire Department of Bacteriology-Virology Institut Pasteur Abidjan Cte dIvoire

The emergence of antiretroviral resistance mutations represents a major threat to the achievement of national and global goals for the elimination of HIV-1 infection. The global strategy in 2019 in Cte d'Ivoire is a new national policy for the management of people living with HIV with the administration of dolutegravir (DTG)-based fixed-dose combination. The aim of our study was to evaluate HIV-1 resistance to antiretrovirals (ARVs) in infected adult subjects in Cte d’Ivoire in the context of a systematic switch to a DTG-based combination. Between February 2022 and October 2023, a cross-sectional survey with random sampling was conducted in 06 services caring for people living with HIV. A total of 139 participants were included in the study. Adults with a viral load ≥ 1000 copies/mL were tested for HIV-1 ARV resistance mutations. Molecular analyses were performed using protocol of ANRS-MIE (National Agency for Research on AIDS and emerging infectious diseases). The interpretation is performed by HIVGRAD (https://***/cms/grade/). The frequencies of HIV-1 resistance to non-nucleotide reverse transcriptase inhibitors (NNRTIs), nucleotide reverse transcriptase inhibitors (NRTIs), integrase inhibitors (IINTs) and protease inhibitors (PIs) were 82%, 73%, 19% and 11% respectively. The main mutations observed in the different classes were K103N (45%), M184V (64%), E157Q (19%) and L10V/M46I/A71V/I54V (6%) respectively. This study reveals the emergence of resistance to DTG-based fixed-dose combinations, favored by high rates of resistance to NRTIs and NNRTIs. This finding underlines the need for enhanced viral load monitoring and HIV-1 genotyping tests to guide the choice of NRTIs for combination therapy. In addition, monitoring for mutations to second-generation NRTIs is essential, given the scale-up of DTG-based regimens currently underway in Cte d’Ivoire.

关键词： Resistant Mutants Dolutegravir HIV-1 Antiretrovirals Côte d’Ivoire

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Personalized medicine:Clinical oncology on molecular view of treatment

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world Journal of Clinical Oncology 2024年第8期15卷 992-1001页

作者： Rafick Costa Dos Santos Da Silva Nathalia de andrade Simon andréAlves Dos Santos Gabriel De Melo Olegário Jayne Ferreira Da Silva Naide Oliveira Sousa Manuel Alvarez Troncoso Corbacho Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória Da Conquista 45029-094BahiaBrazil

Cancer,the second leading global cause of death,impacts both physically and *** treatments such as surgeries,chemotherapy,and radiotherapy have adverse effects,driving the need for more precise *** medicine enables more targeted *** mapping,alongside other molecular biology approaches,identifies specific genes,contributing to accurate *** review addresses,in clinical use,a molecular perspective on *** like alpha-fetoprotein,beta-human chorionic gonadotropin,5-hydroxyindoleacetic acid,programmed death-1,and cytotoxic T lymphocyte-associated protein 4 are explored,providing valuable ***,with an emphasis on artificial intelligence,revolutionizes the analysis of biological data,offering more accurate *** like liquid biopsy are emphasized for early *** medicine guides therapeutic strategies based on the molecular characteristics of the tumor,as evidenced in the molecular subtypes of breast *** allow personalized treatments,highlighting the role of trastuzumab and endocrine *** the benefits,challenges persist,including high costs,tumor heterogeneity,and ethical *** obstacles requires collaboration,ensuring that advances in molecular biology translate into accessible benefits for all.

关键词： Oncology Neoplasia Molecular biology Personalized medicine Molecular Markers Cancer

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State-of-art modelling of inflammatory astrocyte-synapse interactions in injury and amyotrophic lateral sclerosis

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Neural Regeneration Research 2017年第1期12卷 75-76页

作者： andrás Lakatos John van Geest Centre for Brain Repair Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUnited Kingdom Department of Neurology Addenbrooke's HospitalCambridge University Hospitals NHS TrustCambridgeUnited Kingdom

Different outcomes of astrocyte inflammatory signalling in injury and neurodegeneration：It is emerging that astrocytes have a significant impact on the neuronal network by modulating synaptic connections and neuronal... 详细信息

关键词： astrocyte amyotrophic neuronal synaptic modulating insight viability glutamate inflammation NMDAR

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Cobalamin deficiency as an extra intestinal manifestation of Helicobacter pylori infection

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world Journal of Gastroenterology 2015年第11期21卷 3447-3448页

作者： Emmanuel andrès Department of Internal Medicine University Hospital of Strasbourg

we read with great interest the excellent review by wong et al on extra intestinal manifestations of Helicobacter pylori(***) infection published in the *** is a well-documented and structured ***,I believe that wong ... 详细信息

关键词： Cobalamin deficiency Helicobacter pylori Food-coba

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Symphyseal Disjunction after Dystocic Vaginal Delivery: About Two Cases at the SourôSanou University Hospital of Bobo-Dioulasso (CHUSS)

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 1-6页

作者： Millogo Jean De La Croix Sanou Jean de Dieu Gadigbé Akofa Méré Godé Sabi Tokobou william Ouédraogo andré Togbé Eric Serge Alihonou Yaméogo Rélwendé Barnabé Dembélé Adama Somé Der Adolphe Ouattara Souleymane Obstetrics-Gynecology and Reproductive Medecine Departement of Sourô Sanou Teaching Hospital Bobo-Dioulasso Burkina Faso Higher Institute of health Sciences (INSSA) Université nazi Boni Bobo-Dioulasso Burkina Faso

Diastasis of the symphysis pubis is a rare postpartum complication. we report two cases of symphysis diastasis after dystocic delivery, in two patients who presented in the postpartum period with functional impotence, pubalgia and acute urine retention. A frontal radiograph of the pelvis confirmed the diagnosis, showing a symphyseal separation of 12 mm and 18 mm. In our case, management was mainly medical, with a favorable clinical outcome.

关键词： Pelvis Symphyseal Disjunction/Diastasis Post-Partum Burkina Faso

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Genetic differentiation of grain, fodder and pod vegetable type cowpeas (Vigna unguiculata L.) identified through single nucleotide polymorphisms from genotyping-by-sequencing

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Molecular Horticulture 2022年第1期2卷 101-115页

作者： Xingbo wu andrés JCortés Matthew w.Blair Department of Agricultural and Environmental Sciences Tennessee State UniversityNashvilleTN 37209USA Tropical Research and Education Center Department of Environmental HorticulturalUniversity of Florida18905 SW 280th StHomesteadFL 33031USA Corporación Colombiana de Investigación Agropecuaria AGROSAVIA C.I.La SelvaKm 7 vía Rionegro–Las PalmasRionegroColombia Universidad Nacional de Colombia–Sede Medellín Facultad de Ciencias Agrarias–Departamento de Ciencias ForestalesMedellínColombia

The species Vigna unguiculata L.(walp),commonly known as cowpea,is a multi-purpose legume that has been selected into three subspecies that are divided into grain,fodder and pod(yardlong bean)***,genetic bases for distinctions are not well *** purpose of this study was to apply genotyping-by-sequencing(GBS)and current reference genome for *** to distinguish three subspecies and identify signatures of *** collection of 130 accessions included 128 cultivated from:1)***,fodder type;2)***,pod vegetable type;and 3)***,grain *** wilds genotypes from *** and ***,were used to anchor phylogeny.A total of 11,083 highly informative single nucleotide polymorphisms(SNPs)were *** accessions showed distinct genetic fingerprints and were separated from cultivated *** component analysis showed closer relationship between *** and *** compared to *** differentiation of cultivated subspecies(with Fixation Index,FST)indicated the existence of discrete signatures of *** work clarifies the population structure,phylogeny,and domestication of cultivated ***,significant genetic differences between grain and pod vegetable types can provide valuable information for future breeding in three cowpea groups.

关键词： Genomic landscape of divergence Relative differentiation FST GBS-derived SNP markers

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The exercise-cognition relationship:A virtuous circle

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Journal of Sport and Health Science 2019年第4期8卷 339-347页

作者： Michel Audiffren Nathalie andré Research Institute on Cognition and Learning (UMR CNRS 7295) University of PoitiersSport Sciences Faculty

Exercise and health psychology have generated 2 sets of empirical studies guided by separate theory-driven *** first axis focuses on the causal relationship between chronic exercise and cognition and,more particularly,high-level cognitive functions such as executive functions(EFs).The second axis examines factors influencing the adherence process to physical activity(PA).Research conducted during the past decade shows that these 2 topics are closely linked,with EFs and effortful control playing a pivotal role in the bidirectional relationship linking PA and mental/brain *** present article supports the idea that an individual engaged in the regular practice of effortful PA initiates a virtuous circle linking PA and effortful control in a bidirectional *** the one hand,chronic exercise leads to an improvement of EFs and effortful *** the other hand,gains in EFs and effortful control effectiveness lead to a reciprocal facilitation of the maintenance of PA over *** limitations and perspectives to this effort hypothesis are proposed in the last part of the article.

关键词： Adherence Effort Executive functions Physical activity Salience network

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wide QRS complex tachycardia in a patient with wide QRS complex sinus rhythm due to left bundle branch block pattern

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Journal of Geriatric Cardiology 2020年第8期17卷 530-532页

作者： andrás Vereckei Katalin Vadász andrás Zsáry 3^rd Department of Medicine Semmelweis UniversityBudapestHungary 2^nd Department of Medicine Semmelweis UniversityBudapestHungary

A 58-year-old man with hypertension and half a year ago documented left bundle branch block(LBBB)in his past history presented with progressive dyspnea.A pre-admission echocardiography showed severely depressed systolic left ventricular function[ejection fraction(EF)=27%],diffuse hypokinesis and dilated heart chambers consistent with dilated cardiomyopathy(DCM).

关键词： Dilated cardiomyopathy Electrocardiogram Supraventricular tachycardia Ventricular tachycardia wide QRS complex tachycardia

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Streamflow prediction in ungauged catchments by using the Grunsky method

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International Soil and water Conservation Research 2023年第4期11卷 700-712页

作者： Bruno K.Marchezepe andréAlmagro andréS.Ballarin Paulo Tarso S.Oliveira Department of Hydraulics and Sanitary Engineering São Carlos School of EngineeringUniversity of São PauloSão CarlosSPBrazil Faculty of Engineering Architecture and Urbanism and GeographyFederal University of Mato Grosso do SulMS79070-900Brazil

Establish a reliable rainfall-runoff relation capable of predicting runoff in ungauged basins is a matter of interest across the world for a long time and has been taking importance during the past *** approaches,hydrological models and machine learning techniques have been used to estimate ***,returning some simplicity to the predictions might be necessary for practical *** this paper,we re-introduce *** approach,developed in the early 1900s to predict runoff from values of precipitation on a two-equations ***,we analyze the Grunsky generalized method applied for 716 Brazilian catchments,on an interannual and monthly ***,we established the best method to find the rainfall-runoff relation coefficient for each ***,we evaluate the performance of the method on a local scale,i.e.,catchment by ***,we analyze the method of regionalization,by grouping the catchments into six hydrologically similar *** local scale,the Kling-Gupta Efficiency(KGE)values range from 0.87 to 0.93 on the interannual scale and is greater than 0.50 on the monthly *** the regionalized approach,KGE varies from 0.60 to 0.84 on an interannual *** also found suitable KGE values on a monthly scale,with more than 22%of catchments with KGE greater than 0.50,being the best performances in the Non-seasonal and Extremely-wet groups,and the worst performance in the Dry *** findings indicate that Grunsky approach is suitable to predict streamflow for Brazilian catchments on interannual and monthly *** simple and easy-to-use equation presents a reliable alternative to more complex methods to compute runoff by only using rainfall data.

关键词： Regionalization Hydrological group Temporal scale Tropical basins

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Nanotribological studies using nanoparticle manipulation: Principles and application to structural lubricity

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Friction 2014年第2期2卷 114-139页

作者： Dirk DIETZEL Udo DSCHwARZ andréSCHIRMEISEN Institute of Applied Physics(IAP) Justus-Liebig-Universität GiessenGermany Departments of Mechanical Engineering&Materials Science and Chemical&Environmental Engineering and Center for Research on Structures and Phenomena(CRISP) Yale UniversityNew HavenCTUSA

The term“structural lubricity”denotes a fundamental concept where the friction between two atomically flat surfaces is reduced due to lattice mismatch at the *** favorable circumstances,its effect may cause a contact to experience ultra-low friction,which is why it is also referred to as“superlubricity”.while the basic principle is intriguingly simple,the experimental analysis of structural lubricity has been *** of the main reasons for this predicament is that the tool most frequently used in nanotribology,the friction force microscope,is not well suited to analyse the friction of extended *** overcome this deficiency,substantial efforts have been directed in recent years towards establishing nanoparticle manipulation techniques,where the friction of nanoparticles sliding on a substrate is measured,as an alternative approach to nanotribological *** choosing appropriate nanoparticles and substrates,interfaces exhibiting the characteristics needed for the occurrence of structural lubricity can be *** a consequence,nanoparticle manipulation experiments such as in this review represent a unique opportunity to study the physical conditions and processes necessary to establish structural lubricity,thereby opening a path to exploit this effect in technological applications.

关键词： Nanotribology nanoparticle manipulation friction force microscopy structural lubricity superlubricity HOPG

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