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聚乙交酯纤维膜体外降解结构与性能研究

合成纤维 2024年第1期53卷 20-25,30页

作者：林意华曾达张嵘蔡仁钦大博医疗科技股份有限公司福建厦门361026 常州大学材料科学与工程学院江苏常州213100

将熔喷法制备的聚乙交酯(PGA)纤维膜置于生理盐水中进行体外降解试验。采用pH计、傅里叶红外光谱仪、扫描电子显微镜、差示扫描量热仪、X射线衍射仪、万能材料试验机等研究PGA纤维膜降解前后的结构和性能。结果表明:在整个降解过程中,... 详细信息

将熔喷法制备的聚乙交酯(PGA)纤维膜置于生理盐水中进行体外降解试验。采用pH计、傅里叶红外光谱仪、扫描电子显微镜、差示扫描量热仪、X射线衍射仪、万能材料试验机等研究PGA纤维膜降解前后的结构和性能。结果表明:在整个降解过程中,降解液的pH值逐渐降低,纤维膜的质量损失率逐渐增大;纤维表面逐渐出现纵向裂纹直至断裂;熔点逐渐降低,晶体结构基本不变,但结晶度呈先升高后降低的趋势;纤维膜的平均拉伸强度呈现先缓后快的下降趋势,14 d平均拉伸强度保持率为21.3%,因此,该纤维膜在降解14 d后仍然保持一定的力学性能。

关键词：聚乙交酯纤维膜体外降解结晶度拉伸强度

Evolution of Viral Load in Patients Infected with HIV-1 at Point G University Hospital

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Open Journal of Medical Microbiology 2024年第1期14卷 66-76页

作者： A. Maiga D. Kone D. M. Coulibaly Ag M. Baraika A. Traore s. s. Diakite I. I. Maiga I. Konate A. I. Maiga Faculty of Medicine and Odontostomatology of Bamako (FMOs) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of Medical Biology and Hospital Hygiene of Point-G University Hospital Bamako Mali Faculty of Pharmacy of Bamako (FaPh) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of the Luxembourg Mother-Child Hospital Bamako Mali National Institute of Public Health Bamako Mali National Institute for Training in Health sciences Bamako Mali Laboratory of the Kati University Hospital Center Bamako Mali Infectious and Tropical Diseases Department of Point-G University Hospital Bamako Mali Laboratory of CHU Gabriel Touré Bamako Mali

Introduction: HIV, the human immunodeficiency virus, is the etiological agent of acquired immunodeficiency syndrome (AIDs). The aim of this study was to assess the evolution of the viral load in patients under treatment. Methodology: This was a study carried out from July 2017 to June 2022 at the Point G University Hospital laboratory. The determination of the viral load of patients was carried out by PCR on the ABOTT M2000sp/rt platform. Results: A total of 129 patients infected with HIV-1, aged 19 to 72 years with a mean age of 40.05 years ± 10.71;all on antiretroviral chemotherapy. The female gender predominated among our patients. The most common treatment regimen was 2INTI + 1INNTI with 72.9% followed by 2INTI + 1INI with 13.2%. As for the combinations of molecules, the combination TDF + 3TC + EFV and TDF + 3TC + DTG predominated, respectively 65.1% and 13.2%. 89.9% of our patients had undetectable viremia after 12 months of treatment (p s/ml ± 1616908.484 to M0 at 5742.36 copies /ml ± 35756.883 at M12 (p Conclusion: Generally speaking, antiretroviral treatment had contributed to controlling viral loads, however the therapeutic combination TDF + 3TC + DTG had made it possible to obtain more patients with undetectable viremia instead.

关键词： HIV-1 Treatment Viral Load Point G University Hospital

PBL结合seminar教学模式在妇产科见习中的应用方法研究

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教育教学论坛 2024年第18期 129-132页

作者：曹羽陈怡钱相容宋广大苏州大学附属常熟医院产科江苏常熟215500

探讨了seminar形态结合以问题为基础的课堂教学(PBL)教学法,以及在临床驻点班妇产科见习教育中的效果。在临床驻点班妇产科见习教育中,展开了seminar形态的与临床应用个案探讨、床边教育等结合的PBL教学模式。seminar紧密结合PBL课堂教... 详细信息

探讨了seminar形态结合以问题为基础的课堂教学(PBL)教学法,以及在临床驻点班妇产科见习教育中的效果。在临床驻点班妇产科见习教育中,展开了seminar形态的与临床应用个案探讨、床边教育等结合的PBL教学模式。seminar紧密结合PBL课堂教学,充分调动了学生的学习积极性,培养了学生的语言交流技能,也训练了学生应用与反思的能力。seminar紧密结合PBL课堂教学可以改善临床见习教学效果,但还应进行深入研究与应用。

关键词： PBL seminar 教学模式妇产科临床见习

老年急性胰腺炎患者严重程度的评估:一种新的临床预测模型

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肝胆外科杂志 2024年第3期32卷 172-177页

作者：芮晨辉周大臣孙昀耿小平侯辉安徽医科大学第二附属医院合肥230601

目的本研究旨在筛选导致老年急性胰腺炎(AP)患者发展为重症急性胰腺炎的关键风险因素,并建立一个预测模型,精确评估老年AP患者的严重程度。方法回顾性分析2018年6月至2023年6月安徽医科大学第二附属医院收治的374名老年急性胰腺炎患者(... 详细信息

目的本研究旨在筛选导致老年急性胰腺炎(AP)患者发展为重症急性胰腺炎的关键风险因素,并建立一个预测模型,精确评估老年AP患者的严重程度。方法回顾性分析2018年6月至2023年6月安徽医科大学第二附属医院收治的374名老年急性胰腺炎患者(年龄>65岁),按照严重程度将患者分为重症急性胰腺炎组和非重症急性胰腺炎组,比较两组患者人院24 h内收集的临床指标的差异,利用多因素Logistic回归识别独立危险因素并构建Nomogram临床预测模型。结果重症急性胰腺炎组患者BIsAP评分、合并高血压的比例显著高于非重症急性胰腺炎组患者。在实验室指标上,重症急性胰腺炎组白细胞、中性粒细胞百分比、血红蛋白、血细胞比容、血浆凝血酶原时间、纤维蛋白原、D-二聚体、尿素氮、肌酐、血钾显著高于非重症急性胰腺炎组,抗凝血酶-III活性、白蛋白显著低于非重症急性胰腺炎组。多因素Logistic回归分析结果显示,合并高血压(0R=1.88,95%CI:1.02~3.46,P=0.042)、BIsAP评分高(0R=3.62,95%CI:2.28~5.75,PsAP评分、高血细胞比容和低白蛋白是老年AP患者发展为sAP的显著危险因素。所建立的预测模型具备高度的预测价值和临床应用潜力,为医生在早期阶段制定治疗策略提供了重要依据。

关键词：重症急性胰腺炎老年预测模型

Analytical　and　Numerical　study　on　the　Uniformity　of　Temperature　Difference　Field　in　Heat　Exchangers

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Journal of Thermal science 1995年第2期4卷 104-108页

作者： Zhi－XinLi da－XiXiong 等 DepartmentofEngineeringMechanics TsinghuaUniversity DepartmentofEngineeringMechanics TsinghuaUniversi

The relations of the uniformity factor of temperature difference field with the effectiveness of heat exchangers were studied analytically and numerically. The results for eleven kinds of heat exchangers show that the more uniform the temperature difference field, the higher the effectiveness of heat exchanger for a given Ntu and Cr.

关键词： heat exchanger uniformity of TDF effectiveness.

Improvement of sporulation Conditions of a New strain of Bacillus amyloliquefaciens in Liquid Fermentation

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Advances in Bioscience and Biotechnology 2015年第4期6卷 302-310页

作者： andrés Díaz-García Jennifer García-Riano Jimmy Zapata-Narvaez Biological Control Laboratory Tibaitata Research CenterColombian Corporation for Agricultural Research(Corpoica)BogotáColombia

The desirable active ingredients for the development of bioproducts based in Bacillus sp. for the control of soil pathogens are the spores because these structures exhibit more resistance and stability to conditions present during the fermentation, formulation, and storage processes. To improve the sporulation of a native strain of Bacillus amyloliquefaciens (Bs006) using liquid fermentation, some modifications in the concentrations of the components in a previously standardized culture media were made. subsequently, five sporulation inducers (iron nitrate, mixture of salts, peroxide hydrogen, temperature, and initial cell concentration) were evaluated. The treatment with a mixture of salts in combination with an initial cell concentration of 1 × 108 cells/ml was selected because a final spore concentration of 1.05 × 1010 spores/ml after 66 hours with a fully substrate consumption and sporulation efficiency of 88.7% was obtained. To demonstrate the biological activity of B. amyloliquefaciens Bs006 in Cape gooseberry seedlings, a greenhouse bioassay was conducted, and statistical differences in plant growth-promoting parameters compared with previous media were not found. Additionally, the proposed modified media (coded as JM) presented a benefit-cost ratio 2.65 times higher compared with the baseline media.

关键词： Bacillus amyloliquefaciens sporulation Induction Liquid Media Design Cape Gooseberry Plant Growth Promotion

Adaptive synchronization of Fractional Order Complex-Variable Dynamical Networks via Pinning Control

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Communications in Theoretical Physics 2017年第9期67卷 366-374页

作者： da-Wei Ding Jie Yah Nian Wang Dong Liang school of Electronics and Information Engineering Anhui University Hefei 230039 China

In this paper, the synchronization of fractional order complex-variable dynamical networks is studied using an adaptive pinning control strategy based on close center degree. some effective criteria for global synchronization of fractional order complex-variable dynamical networks are derived based on the Lyapunov stability theory. From the theoretical analysis, one concludes that under appropriate conditions, the complex-variable dynamical networks can realize the global synchronization by using the proper adaptive pinning control method. Meanwhile, we succeed in solving the problem about how much coupling strength should be applied to ensure the synchronization of the fraetionla order complex networks. Therefore, compared with the existing results, the synchronization method in this paper is more general and convenient. This result extends the synchronization condition of the real-variable dynamical networks to the complex-valued field, which makes our research more praetical. Finally, two simulation examples show that the derived theoretical results are valid and the proposed adaptive pinning method is effective.

关键词： complex-variable fractional order complex networks synchronization adaptive pinning control

基于中药监管科学创新技术体系破解国家中药类产品集中带量采购难点

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中国食品药品监管 2024年第1期 108-117页

作者：魏胜利李大宁徐安龙北京中医药大学国家药品监督管理局中药监管科学研究院中药材规范化生产教育部工程研究中心三明采购联盟省际中药(材)采购联盟专家组委员会

在国家推动药品集中带量采购(以下简称集采)工作常态化背景下,中成药大品种在全国范围内的集采已经落地开展,中药饮片的省际联合采购也正在进行,而未来中药配方颗粒纳入集采也是大势所趋。然而,中药不同于化学药品,其原料来源于天然资源... 详细信息

在国家推动药品集中带量采购(以下简称集采)工作常态化背景下,中成药大品种在全国范围内的集采已经落地开展,中药饮片的省际联合采购也正在进行,而未来中药配方颗粒纳入集采也是大势所趋。然而,中药不同于化学药品,其原料来源于天然资源,组成成分复杂、功效主治多样,是一个多功效、多组分的复杂体系,加之中药类产品生产过程复杂,产品质量良莠不齐,生产成本相差悬殊,如何在中药类产品集采中科学评价产品质量,体现优质优价,以及如何科学评估中药类产品的生产成本,制定合理的最高限价,都是中药集采工作执行中亟待解决的难点问题。针对上述难点,笔者提出基于中药监管科学体系,创新制定中药类产品质量等级标准以及构建全产业链溯源与供应保障平台,从而确保中药类产品集采保质、提级、稳供、高质量发展的新思路。

关键词：中药集采中成药中药饮片精准药材精准饮片

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高管团队特征对企业绩效影响研究综述

生产力研究 2024年第4期 144-148页

作者：彭英王星然孙大媛南京邮电大学管理学院江苏南京210003 南京邮电大学国际电联经济和政策问题研究中心江苏南京210003

高管团队是一群对公司运作具有决策权和控制力的高级管理人员。高管团队的背景特征和技能水平是企业战略决策的重要组成部分,是构建企业核心竞争力和实现企业可持续发展的重要因素,因此高管团队特征对企业绩效的影响成为企业人力资本领... 详细信息

高管团队是一群对公司运作具有决策权和控制力的高级管理人员。高管团队的背景特征和技能水平是企业战略决策的重要组成部分,是构建企业核心竞争力和实现企业可持续发展的重要因素,因此高管团队特征对企业绩效的影响成为企业人力资本领域的核心议题。文章以高管团队的同质性和异质性特征为中心,构建逻辑框架,从现有理论和实证结果出发,分别梳理同质性特征与异质性特征对企业绩效的影响,以期进一步为我国上市公司高管团队的构建提供理论借鉴。

关键词：高管团队特征企业绩效公司治理