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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 1-6页

作者： Millogo Jean De La Croix Sanou Jean de Dieu Gadigbé Akofa Méré Godé Sabi Tokobou William Ouédraogo andré Togbé Eric Serge Alihonou Yaméogo Rélwendé Barnabé Dembélé Adama Somé Der Adolphe Ouattara Souleymane Obstetrics-Gynecology and Reproductive Medecine Departement of Sourô Sanou Teaching Hospital Bobo-Dioulasso Burkina Faso Higher Institute of health Sciences (INSSA) Université nazi Boni Bobo-Dioulasso Burkina Faso

Diastasis of the symphysis pubis is a rare postpartum complication. We report two cases of symphysis diastasis after dystocic delivery, in two patients who presented in the postpartum period with functional impotence, pubalgia and acute urine retention. A frontal radiograph of the pelvis confirmed the diagnosis, showing a symphyseal separation of 12 mm and 18 mm. In our case, management was mainly medical, with a favorable clinical outcome.

关键词： Pelvis Symphyseal Disjunction/Diastasis Post-Partum Burkina Faso

Streamflow prediction in ungauged catchments by using the Grunsky method

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International Soil and Water Conservation Research 2023年第4期11卷 700-712页

作者： Bruno K.Marchezepe andréAlmagro andréS.Ballarin Paulo Tarso S.Oliveira Department of Hydraulics and Sanitary Engineering São Carlos School of EngineeringUniversity of São PauloSão CarlosSPBrazil Faculty of Engineering Architecture and Urbanism and GeographyFederal University of Mato Grosso do SulMS79070-900Brazil

Establish a reliable rainfall-runoff relation capable of predicting runoff in ungauged basins is a matter of interest across the world for a long time and has been taking importance during the past *** approaches,hydrological models and machine learning techniques have been used to estimate ***,returning some simplicity to the predictions might be necessary for practical *** this paper,we re-introduce *** approach,developed in the early 1900s to predict runoff from values of precipitation on a two-equations ***,we analyze the Grunsky generalized method applied for 716 Brazilian catchments,on an interannual and monthly ***,we established the best method to find the rainfall-runoff relation coefficient for each ***,we evaluate the performance of the method on a local scale,i.e.,catchment by ***,we analyze the method of regionalization,by grouping the catchments into six hydrologically similar *** local scale,the Kling-Gupta Efficiency(KGE)values range from 0.87 to 0.93 on the interannual scale and is greater than 0.50 on the monthly *** the regionalized approach,KGE varies from 0.60 to 0.84 on an interannual *** also found suitable KGE values on a monthly scale,with more than 22%of catchments with KGE greater than 0.50,being the best performances in the Non-seasonal and Extremely-wet groups,and the worst performance in the Dry *** findings indicate that Grunsky approach is suitable to predict streamflow for Brazilian catchments on interannual and monthly *** simple and easy-to-use equation presents a reliable alternative to more complex methods to compute runoff by only using rainfall data.

关键词： Regionalization Hydrological group Temporal scale Tropical basins

Novel electrocardiographic dyssynchrony criteria that may improve patient selection for cardiac resynchronization therapy

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Journal of Geriatric Cardiology 2022年第1期19卷 31-43页

作者： Gábor Katona andrás Vereckei Department of Medicine and Hematology Semmelweis UniversityBudapestHungary

Cardiac resynchronization therapy(CRT)is an evidence-based effective therapy of symptomatic heart failure with reduced ejection fraction refractory to optimal medical treatment associated with intraventricular conduction disturbance,that results in electrical dyssynchrony and further deterioration of systolic ventricular ***,the non-response rate to CRT is still 20%−40%,which can be decreased by better patient *** main determinant of CRT outcome is the presence or absence of significant ventricular dyssynchrony and the ability of the applied CRT technique to eliminate *** current guidelines recommend the determination of QRS morphology and QRS duration and the measurement of left ventricular ejection fraction for patient selection for ***,QRS morphology and QRS duration are not perfect indicators of electrical dyssynchrony,which is the cause of the not negligible non-response rate to CRT and the missed CRT implantation in a significant number of patients who have the appropriate substrate for *** imaging modalities,many ventricular dyssynchrony criteria were devised for the detection of mechanical dyssynchrony,but their utility in patient selection for CRT is not yet proven,therefore their use is not recommended for this ***,CRT can eliminate only mechanical dyssynchrony due to underlying electrical dyssynchrony,for this reason ECG has a greater role in the detection of ventricular dyssynchrony than imaging *** improve assessment of electrical dyssynchrony,we devised two novel ECG dyssynchrony criteria,which can estimate interventricular and left ventricular intraventricular dyssynchrony in order to improve patient selection for *** we discuss the results achieved by the application of these new ECG dyssynchrony criteria,which proved to be useful in predicting the CRT response in patients with nonspecific intraventricular conduction disturbance pattern(the second greatest group of CRT candidates),an

关键词： patient synchronization eliminate

Hybrid Cellular Automaton-Parabolic Thick Needle model for equiaxed dendritic solidification

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Journal of Materials Science & Technology 2022年第29期124卷 26-40页

作者： Romain Fleurisson Oriane Senninger Gildas Guillemot Charles-andré Gandin MINES ParisTech PSL Research UniversityCEMEF UMR CNRS 7635CS1020706904 Sophia AntipolisFrance

A hybrid Cellular Automaton(CA)-Parabolic Thick Needle(PTN)model is developed for the simulation of an equiaxed dendritic *** is implemented by solving conservation equations with the Finite Element(FE)method at two *** the scale of the microstructure,dendritic branches are approximated by a network of *** solute field is computed in the liquid using a FE mesh with minimum size smaller than the diffusion length ahead of the dendrite tips,giving access to a detailed description of each dendrite tip growth velocity as well as solutal interactions between *** the simulation domain scale,volume averaged heat and solute transfers are solved on a coarser FE *** average volumetric fraction of phases is deduced from a field giving the fraction of dendritic microstructure together with a microsegregation *** the PTN themselves grow on CA cells,the dendrite tip growth velocity is transferred to the vertices of the polygon associated to the CA growth ***,the field giving the fraction of dendritic microstructure is deduced from the fraction of CA cells part of the mushy zone,which include cells containing PTN *** of the new multiple scale CAPTN model include solutal interaction between dendrite branches together with long range transfer of heat and solute mass,together with the role of latent heat release on equiaxed solidification.

关键词： Solidification Dendrite growth law Multiscale Finite element method

Lipid scrambling in immunology:why it is important

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Cellular & Molecular Immunology 2023年第9期20卷 1081-1083页

作者： Ning Wu andréVeillette The First Affiliated Hospital of Anhui Medical University Clinical Immunology InstituteAnhui Medical UniversityHefeiAnhuiChina Laboratory of Molecular Oncology Institut de recherches cliniques de Montréal(IRCM)MontréalQC H2W1R7Canada Department of Medicine University of MontréalMontréalQC H3T 1J4Canada Department of Medicine McGill UniversityMontréalQC H3G 1Y6Canada

Asymmetric lipid distribution in the plasma membrane(PM)is one of the fundamental features of living *** not only serve as structural components of the biophysical structure of the PM that preserves cell integrity but also participate directly in *** phospholipids(PLs),such as phosphatidylserine(PS),phosphatidylethanolamine(PE),and phosphoinositol(PI),are preferentially located in the inner layer of the PM,creating electrostatic charges for the docking of membrane-associated and cytoplasmic proteins carrying polybasic stretches of amino ***,there is emerging evidence that reversible changes in the distribution of these lipids take place in the PM and that these changes are critical for normal cell signaling,functions and homeostasis[1–3].They can also be implicated in the genesis of pathologies.

关键词： electrostatic reversible distribution

Initial medication adherence in newly diagnosed glaucoma patients:three adherence measures

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 630-637页

作者： Joana Menino Pedro Camacho andréCoelho Escola Superior de Tecnologia da Saúde Instituto Politécnico de LisboaLisbon 1990-096Portugal H&TRC-Health&Technology Research Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal iNOVA4Health NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Oftalmologia Dr.Gama Pinto Lisbon 1150-255Portugal

AIM:To determine initial medication adherence in newly diagnosed glaucoma patients treated with anti-glaucoma ***:This retrospective and observational study included all patients diagnosed with glaucoma in the Primary Health Care units in Portugal during the years 2012 and 2013,which in consequence received a first prescription for anti-glaucoma *** was collected from electronic prescribing records of the primary care units and from pharmacy claims *** of glaucoma treatment and early discontinuation were measured,and the combination of(non)-initiation and early discontinuation accounted for initial medication(non)-***:A total of 3548 new glaucoma patients(40.1%male;59.9%female)were *** 1133(31.9%)patients were initially classified as non-users,since there was no pharmacy claim found for their first prescription for glaucoma ***,277(11.5%)patients early discontinued their treatment,acquiring only their first ***,the initial medication non-adherence rate was 39.7%since 1410 patients either didn’t initiate treatment or discontinued it ***:This study,reveals a major opportunity to improve glaucoma treatment and its control,since a large proportion of patients fail to engage with their prescribed therapy,which implies that implementation of individual or group strategies that enable patients with glaucoma to correctly perform their treatment is still needed.

关键词： glaucoma glaucoma treatment initiation early discontinuation initial medication adherence

Clinical application and management of temporary mechanical circulatory support:A clinical consensus

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Chinese Medical Journal 2024年第10期137卷 1135-1139页

作者： Nianguo Dong Liangwan Chen Xin Chen Huishan Wang Yingbin Xiao Xianqiang Wang Jinsong Huang Yang Yan Pramod Bonde Neel Sodha Pavan Atluri Juan Pablo Maureira andréVincentelli Masanobu Yanase Yixuan Wang Haitao Zhang Xiaotong Hou Yoshijuki Takami Pascal Leprince Thierry Folliguet Frank W Sellke Chinese Society for Thoracic and Cardiovascular Surgery Chinese Association of Cardiovascular Surgeons Cardiac Critical Care Professional Committee of Chinese Medical Association Chinese Society of Extracorporeal Life Support European Society of Cardiovascular and Endovascular Surgery French Society of Thoracic and Cardiovascular Surgery Japanese Society for Cardiovascular Surgery Japanese Society of Artificial Organs Department of Cardiovascular Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovascular Surgery Fujian Medical University Union HospitalFuzhouFujian 350000China Department of Thoracic and Cardiovascular Surgery Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210000China Department of Cardiovascular Surgery General Hospital of Northern Theater CommandShenyangLiaoning 110000China Department of Cardiovascular Surgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037 China Department of Cardiovascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000 China Department of Cardiovascular Surgery Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510000 China Department of Cardiovascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Cardiac Surgery Yale School of Medicine330 Cedar St204 BoardmanNew HavenCT 06510USA Department of Cardiothoracic Surgery Alpert Medical SchoolBrown University Rhode Island HospitalProvidenceRI 02912USA Department of Cardiovascular Surgery Department of SurgeryUniversity of PennsylvaniaPhiladelphiaPA 19113USA Department of Cardiovascular Surgery and Transplantation University Hospital of NancyUniversity of LorraineVandoeuvre-lès-Nancy 54500France Department of Cardiovascular Surgery University Hospital of LilleUniversity of LilleLille 59037France Department of Cardiology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan Department of Adult Surgical Intensive Care Unit Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000China Department of Cardiac Intensive Care Beijing Institute of HeartLung and B

Temporary mechanical circulatory support(tMCS)plays a pivotal role in managing severe or refractory cardiogenic shock(CS),furnishing essential hemodynamic support,and sustaining organ perfusion from hours to weeks,or to even *** the past decade,the utilization of tMCS has witnessed a signicant increase in American and European *** in Asia,the newly developed concepts and devices constituting tMCS have also made rapid ***,the absence of a consensus or standardized guidelines,especially for the Asian population considering inherited polymorphism,is *** address this knowledge gap,eight associations/societies and experts in thiseld came up with the present consensus after repeated discussions,more specically for the Asian *** comprehensively elucidates the commonly employed tMCS devices,criteria for patient selection,indications and contraindications,clinical management,and the optimal timing for implantation and *** goal of this statement is to promote the standardized application of tMCS and make reasonable decisions in clinical ***-length version of the consensus can be seen in Supplementary File,http://***/CM9/B883.

关键词： application statement discussions

Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity

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Bioactive Materials 2023年第6期24卷 174-184页

作者： andrés García-García Sébastien Pigeot Ivan Martin Department of Biomedicine University Hospital BaselUniversity of Basel4031BaselSwitzerland Department of Biomedical Engineering University of Basel4123AllschwillSwitzerland

The increasing recognition of the contribution of the immune system to activate and prime regeneration implies that tissue engineering strategies and biomaterials design should target regulation of early immunological *** previously proposed the cell-based engineering and devitalization of extracellular matrices(ECMs)as a strategy to generate implant materials delivering custom-defined ***,in the context of bone regeneration,we aimed at enhancing the osteoinductivity of such ECMs by enriching their immunomodulatory factors *** with IL1βa cell line overexpressing BMP-2 enabled engineering of ECMs preserving osteoinductive signals and containing larger amounts of angiogenic(VEGF)and pro-inflammatory molecules(IL6,IL8 and MCP1).Upon implantation,these IL1β-induced materials enhanced processes typical of the inflammatory phase(e.g.,vascular invasion,osteoclast recruitment and differentiation),leading to‘regenerative’events(e.g.,M2 macrophage polarization)and ultimately resulting in faster and more efficient bone *** results bear relevance towards the manufacturing of potent off-the-shelf osteoinductive materials and outline the broader paradigm of engineering immunoinstructive implants to enhance tissue regeneration.

关键词： Immunomodulation Bone tissue engineering Inflammation Hypertrophic cartilage matrices Osteoinduction

Trends in lactose-derived bioactives:synthesis and purification

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Systems Microbiology and Biomanufacturing 2022年第3期2卷 393-412页

作者： Carlos Vera Cecilia Guerrero andrés Illanes Department of Biology Faculty of Chemistry and BiologyUniversidad de Santiago de Chile(USACH)SantiagoChile School of Biochemical Engineering Pontificia Universidad Católica de Valparaíso(PUCV)ValparaisoChile

Lactose obtained from cheese whey is a low value commodity despite its great potential as raw material for the production of bioactive *** them,prebiotics stand out as valuable ingredients to be added to food matrices to build up functional foods,which currently represent the most active sector within the food *** foods market has been growing steadily in the recent decades along with the increasing awareness of the World population about healthy nutrition,and this is having a strong impact on lactose-derived *** of them are produced by enzyme biocatalysis because of molecular precision and environmental sustainability *** current status and outlook of the production of lactose-derived bioactive compounds is presented with special emphasis on downstream operations which are critical because of the rather modest lactose conversion and product yields that are *** though some of these products have already an established market,there are still several challenges referring to the need of developing better catalysts and more cost-effective downstream operations for delivering high quality products at affordable *** technological push is expected to broaden the spectrum of lactose-derived bioactive compounds to be produced at industrial scale in the near future.

关键词： Prebiotic Lactose β-Galactosidase Oligosaccharide purification

On the role of RNA binding proteins in polyglutamine diseases:from pathogenesis to therapeutics

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Neural Regeneration Research 2023年第12期18卷 2695-2696页

作者： andréConceição Rebekah Koppenol Clévio Nóbrega Algarve Biomedical Center Research Institute(ABC-RI) FaroPortugalFaculdade de Medicina e Ciências BiomédicasUniversidade do AlgarveFaroPortugal PhD Program in Biomedical Sciences Faculdade de Medicina e Ciências BiomédicasUniversidade do AlgarveFaroPortugalCenter for Neuroscience and Cell BiologyUniversity of CoimbraPortugal

Polyglutamine(polyQ) diseases are a group of different neurodegenerative disorders characterized by an abnormal expansion of the trinucleotide cytosine-adenine-guanine(CAG)within coding regions of each disease-associa... 详细信息

关键词： diseases pathogenesis translate