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Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease

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Translational Neurodegeneration 2023年第1期12卷 801-823页

作者： Luis Enrique Arroyo-García Sara Bachiller Rocío Ruiz Antonio Boza-Serrano Antonio Rodríguez-Moreno Tomas Deierborg Yuniesky andrade-Talavera andréfisahn Neuronal Oscillations Laboratory Division of NeurogeriatricsCenter for Alzheimer ResearchDepartment of NeurobiologyCare Sciences and SocietyKarolinska Institutet17164 SolnaSweden Experimental Neuroinflammation Laboratory Department of Experimental Medical ScienceLund UniversityBMC B1122184 LundSweden Clinical Unit of Infectious Diseases Microbiology and ParasitologyInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Biochemistry and Molecular Biology University of SevilleCalle Profesor García González Nº241012 SevilleSpain Laboratory of Cellular Neuroscience and Plasticity Department of PhysiologyAnatomy and Cellular BiologyUniversidad Pablo de OlavideCarretera de Utrera Km-141013 SevilleSpain Department of Biosciences and Nutrition NeoKarolinska Institutet14183 HuddingeSweden

Background Alzheimer’s disease(AD)is a progressive multifaceted neurodegenerative disorder for which no disease-modifying treatment *** is central to the pathology progression,with evidence suggesting that microglia-released galectin-3(gal3)plays a pivotal role by amplifying neuroinflammation in ***,the possible involvement of gal3 in the disruption of neuronal network oscillations typical of AD remains *** Here,we investigated the functional implications of gal3 signaling on experimentally induced gamma oscillations ex vivo(20-80 Hz)by performing electrophysiological recordings in the hippocampal CA3 area of wild-type(WT)mice and of the 5×FAD mouse model of *** addition,the recorded slices from WT mice under acute gal3 application were analyzed with RT-qPCR to detect expression of some neuroinflammation-related genes,and amyloid-β(Aβ)plaque load was quantified by immunostaining in the CA3 area of 6-month-old 5×FAD mice with or without Gal3 knockout(KO).Results Gal3 application decreased gamma oscillation power and rhythmicity in an activity-dependent manner,which was accompanied by impairment of cellular dynamics in fast-spiking interneurons(FSNs)and pyramidal *** found that the gal3-induced disruption was mediated by the gal3 carbohydrate-recognition domain and prevented by the gal3 inhibitor TD139,which also prevented Aβ42-induced degradation of gamma ***-more,the 5×FAD mice lacking gal3(5×FAD-Gal3KO)exhibited WT-like gamma network dynamics and decreased Aβplaque *** We report for the first time that gal3 impairs neuronal network dynamics by spike-phase uncoupling of FSNs,inducing a network performance ***,our findings suggest gal3 inhibition as a potential therapeutic strategy to counteract the neuronal network instability typical of AD and other neurological disorders encompassing neuroinflammation and cognitive decline.

关键词： Galectin-3 Gamma oscillations Neuronal network dynamics Fast-spiking interneurons Alzheimer’s disease models Neuroinflammation TD139 Hippocampus

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Touristic urbanization and greening of coastal dune fields:A long-term assessment of a temperate sandy barrier of Argentina

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Journal of Geographical Sciences 2025年第1期35卷 206-230页

作者： GARZO Pedro andrés DADON José Roberto ISLA Federico Ignacio Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICET/UNMDP) Instituto de Geología de Costas y del Cuaternario Dr.Enrique J.Schnack (IGCC-CIC/UNMDP) Universidad de Buenos Aires Facultad de Arquitectura Dise?o y Urbanismo Centro de Investigaciones Gestión de Espacios Costeros (GEC-FADU/UBA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world. However, a century ago, they were considered hazardous environments due to their great dynamic nature. As a result, stabilization practices were considered necessary. The systematic introduction of fast-growing exotic trees helped stabilize the sand, making it easier for tourism urbanization to take place, but also leading to erosion processes. This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina. This complex region includes urban resorts, afforestation zones, and protected areas. A GIS-based geospatial analysis was conducted using a large satellite database(> 350 images), and the future evolution of the vegetation was modeled. The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover, accompanied by a concurrent reduction in sandy areas. In 1986, the dune area comprised 75% more surface than vegetation, whereas in 2021, it represented 60% less than vegetation. Furthermore, the 2050 scenario suggests a potential 40% reduction of dunes in certain areas. It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance. Long-term management strategies must focus on restoring native plant communities and controlling invasive species, and avoiding new dune fixation initiatives based on the introduction of exotic species.

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Evaluation of a cost effective technique for treating aquaculture water discharge using Lolium perenne Lam as a biofilter

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Journal of Environmental Sciences 2007年第9期19卷 1079-1085页

作者： NDUWIMANA andré College of Biosystems Engineering and Food Sciences Zhejiang UniversityHangzhou 310029China.

Wastewater stabilization ponds generate low cost by-products that are useful for agriculture. The utilization of these by-products for soil amendment and as a source of nutrients for plants requires a high level of sanitation and stabilization of the organic matter, to maintain acceptable levels of soil, water and air quality. In this study, two aquaculture wastewater treatment systems; recirculating system and a floating plant bed system were designed to improve the quality of irrigation water in local communities with low income. In both systems the grass species Lolium perenne Lam was used as a plant biofilter while vegetable specie Amaranthus viridis was used to evaluate the performance of the system and the suitability of the phyto-treated water for irrigation. It was found that the harmful material removal rate for recirculating system was 88.9% for TAN （total ammonia nitrogen）, 90% for NO2--N, 64.8% for NO3--N while for floating plant bed system 82.7% for TAN, 82% for NO2--N and 60.5% for NO3--N. Comparative analysis of the efficiency of waste element removal between the two systems revealed that both systems performed well, however, plant growth was not robust for floating plant bed system while recirculating system is energy consuming. Although both systems did not attain sufficient levels of TN （total nitrogen） and TP （total phosphorus） load reduction, the treatment with L. perenne remarkably improved the irrigation water quality. A. viridis plants irrigated with the phyto-treated discharge water had lesser concentrations of heavy metals in their tissues compared to those irrigated with untreated discharge. The control plants irrigated with untreated discharge were also found to be highly lignified with few stems and small leaves.

关键词： recirculating system float system plant filter Lolium perenne Lam Amaranthus viridis Burundi

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Setpoint Feasibility and Stability of Wind Park Control Interactions at Weak Grids

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1790-1796页

作者： Argüello andrés IEEE the School of Electrical Engi‐neering and Computation University of CampinasCampinasBrazil

The controllers of wind parks that are connected to weak grids can induce unstable oscillations near the fundamental *** phenomenon can be studied with equivalent impedances of the wind generators,which depend on their operational setpoints at the fundamental *** feasibility of such setpoint,i.e.,solution to the power flow,does not depend on the control ***,oscillations from unfeasible setpoints and control instabilities both occur at weak grids and near the fundamental *** letter presents an exploratory study to map the conditions where both phenomena occur,using sensitivity studies comprising multiple setpoints and control parameter *** results are visually presented as the regions which inform the configurations leading to unfeasible setpoints,and unstable control interaction *** the results,it can be observed that the trajectory of the eigenvalues in the Nyquist plots towards an unfeasible setpoint approaches a fundamental frequency instability.

关键词： Control interaction impedance power quality resonance stability wind generator

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Aquaculture Solids Management Using A Combination of Sand/Gravel or Unwoven Fabric Bed With Lolium perenne Lam as A Plant Biofilter

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Biomedical and Environmental Sciences 2007年第6期20卷 439-444页

作者： andr NDUWIMANA Institute of Agricultural and Bio-Environmental Engineering College of Biosystems Engineering and Food Sciences Zhejiang University

Objective This work is an evaluation of the efficiency of a sand-gravel or unwoven fabric bed system and Lolium perenne Lam as plant biofilter in the reduction of solids and nutrients removal from aquaculture discharge water. Methods The fzrst step consisted of the collection of wastewater in the tank and the distribution at three different hydraulic loading regimes （0.5, 1, 1.5 L/hour） to the different experimental systems. The second step was to evaluate the performance of the different systems. The fzrst system consisted of a bucket filled with a substrate of sand/gravel （20 cm in depth）, on the bottom of which was a 80 mesh/inch2 of nylon （S1）; the second was similar, but was planted with Lolium perenne lam （S2）; the third was planted with a grass plate consisting of 7 layers of unwoven fabric planted with L. perenne （S3）. Results The second system showed the best performance in reducing solids as well as in nutrients （TN, TP, and COD） reduction. The removal rates for TS, TN, and TP were negatively correlated with the loading regimes, with 0.5 L/hour being the most efficient and thus taken as the reference. Conclusions Solids management using a sand/gravel substrate as bed culture and Lolium perenne L. as plant biofilter has proved to be an efficient technique for solids reduction with low operating cost. This grass plays an important role in wastewater eco-treatment by absorbing dissolved pollutants （TAN） as nutrients for its growth.

关键词： Lolium perenne lam Hydraulic loading regimes Microcosm

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Litterfall production modeling based on climatic variables and nutrient return from stands of Eucalyptus grandis Hill ex Maiden and Pinus taeda L.

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Journal of Forestry Research 2024年第5期35卷 26-36页

作者： andrés Baietto andrés Hirigoyen Jorge Hernández Amabelia del Pino Forest Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay National Research Program of Forest Production National Agriculture Research InstituteINIA97000 TacuarembóUruguay Soil and Water Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay

Native grasslands in the Pampas of South America are increasingly being replaced by Eucalyptus and Pinus *** short rotation regimes used for the stands require high nutrient levels,with litterfall being a major source of nutrient *** model the litterfall production using climatic variables and assess the nutrient return in 14-year-old Eucalyptus grandis and Pinus taeda stands,we measured litter production over 2 years,using conical litter traps,and monitored climatic *** temperature,accumulated precipitation,and mean maximum vapor pres-sure deficit at the seasonal level influenced litterfall produc-tion by ***;seasonal accumulated precipitation and mean maximum temperature affected litterfall by *** regression tree modeling based on these climatic vari-ables had great accuracy and predictive power for ***(N=33;MAE(mean absolute error)=0.65;RMSE(root mean square error)=0.91;R^(2)=0.71)and ***(N=108;MAE=1.50;RMSE=1.59;R^(2)=0.72).The nutrient return followed a similar pattern to litterfall deposition,as well as the order of importance of macronutrients(***:Ca>N>K>Mg>P;***:N>Ca>K>Mg>P)and micronutrients(*** and ***:Mn>Fe>Zn>Cu)in both *** study constitutes a first approximation of factors that affect litterfall and nutrient return in these systems.

关键词： Afforestation Litterfall Nutrient recycling Climate modeling Myrtaceae Pinaceae

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Surface movement above old coal longwalls after mine closure

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International Journal of Mining Science and Technology 2017年第3期27卷 481-490页

作者： andré Vervoort Pierre-Yves Declercq Department of Civil Engineering KU Leuven Leuven 3001 Belgium Geological Survey of Belgium Royal Belgian Institute of Natural Sciences Brussels 1000 Belgium

Although most subsidence occurs in the months and years after mining by the longwall method, surface movement is still occurring many decades after the mining. The aim of the study is to quantify the long term behavior. Satellite data(radar-interferometry) were analyzed to study an area of about 2 km^2 during the 18 years following the closure of the underground infrastructure and the flooding of the underground workings and rock mass. It was observed that, on average, a residual downward movement took place till 7–12 years after the closure, followed by a clear uplift. However, the first signs of an uplift occurred in certain sub-areas 3–4 years after the closure. Zones within the area studied were identified with either larger or smaller movements. However, the spatial variation of the surface subsidence or uplift could not be directly explained by the characteristics of mining.

关键词： Coal mining Surface movement Subsidence Uplift Radar-interferometry

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Electrocardiographic and echocardiographic dyssynchrony parameters that might better predict the response to cardiac resynchronization therapy than QRS morphology and duration

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Journal of Geriatric Cardiology 2022年第2期19卷 98-100页

作者： andrás Vereckei Department of Medicine and Hematology Semmelweis UniversityBudapestHungary

Cardiac resynchronization therapy(CRT)is an evidence-based effective therapy of symptomatic heart failure with reduced ejection fraction refractory to optimal medical ther-apy and associated with intraventricular conduction disturbance,that results in a significant electrical ventricular ***,the non-response rate to CRT is still 20%−40%.[1]The potential underlying causes of CRT nonresponse are:(1)suboptimal localization of the left ventricular(LV)electrode,far away from the latest activated LV region.

关键词： ventricular synchronization echocardiographic

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Upward surface movement above deep coal mines after closure and flooding of underground workings

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International Journal of Mining Science and Technology 2018年第1期28卷 53-59页

作者： andré Vervoort Pierre-Yves Declercq Department of Civil Engineering KU Leuven Geological Survey of Belgium Royal Belgian Institute of Natural Sciences

After the mass closures of entire coal mine districts in Europe at the end of the last century, a new phenomenon of surface movement was observed—an upward *** most surface movement(i.e., subsidence) occurs in the months and years after mining by the longwall method, surface movement still occurs many decades after mining is *** the closure and flooding of underground excavations and surrounding rock, this movement was *** paper focuses on quantifying the upward movement in two neighboring coal mines(Winterslag and Zwartberg, Belgium).The study is based on data from a remote sensing technique: interferometry with synthetic aperture radar(INSAR).The results of the study show that the rate of upward movement in the decade after closure is about 10 mm/year on *** upward movements are not linked directly to the past exploitation directly underneath a *** amounts of subsidence at specific locations are linked mainly to their positions relative to an inverse trough shape situated over the entire mined-out areas and their immediate *** features, such as geological faults, can have a secondary effect on the local variation of the *** processes of subsidence and uplift are based on completely different *** is initiated by a caving process, while the process of uplift is clearly linked to flooding.

关键词： Coal mining Surface movement Subsidence Uplift Radar-interferometry

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State-of-art modelling of inflammatory astrocyte-synapse interactions in injury and amyotrophic lateral sclerosis

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Neural Regeneration Research 2017年第1期12卷 75-76页

作者： andrás Lakatos John van Geest Centre for Brain Repair Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUnited Kingdom Department of Neurology Addenbrooke's HospitalCambridge University Hospitals NHS TrustCambridgeUnited Kingdom

Different outcomes of astrocyte inflammatory signalling in injury and neurodegeneration：It is emerging that astrocytes have a significant impact on the neuronal network by modulating synaptic connections and neuronal... 详细信息

关键词： astrocyte amyotrophic neuronal synaptic modulating insight viability glutamate inflammation NMDAR

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