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Gene Expression Analysis of Extracellular Matrix and Cytokines after Uterine Artery Embolization

Open Journal of Obstetrics and Gynecology 2014年第15期4卷 935-943页

作者： andré bernardo Tatiana Carvalho de Souza Bonetti Ismael Dale Cotrim Guerreiro da Silva Mariano Tamura Vieira Gomes Rodrigo Aquino Castro Manoel Joao Batista Castello Girao Claudio Emilio Bonduki Gynecology Department Paulista School of MedicineFederal University of Sao Paulo(EPM-UNIFESP)Sao PauloBrazil

Arterial embolization of myomas (AEM) is an established option for the conservative treatment of uterine leio-myomas;it treats all present uterine nodules at once, is less invasive than other procedures and effective in controlling symptoms, and does not require long term hospitalizations. Nevertheless, the potential impact on endometrial morphological and functional outcomes after the procedure is still controversial based on reports of endometritis or eventual transient ischemia. This study evaluated endometrial reorganization in uterine leiomyoma patients, before and after AEM, through gene expression analyses of extracellular matrix and cytokines genes in theendometrial tissue. Eight patients with leiomyomas were evaluated before AEM and 6 months after. The examinations included transvaginal pelvic ultrasonography, dosing of the follicle-stimulating hormone, and endometrial biopsy during the second phase of the menstrual cycle. RNA was extracted from endometrial samples, cDNA was synthesized, and applied on PCR arrayTM plates to evaluate the expression of extracellular matrix (ECM) genes and cytokines and their receptors’ genes (CYT). The ECM overexpressed genes were MMP (1, 3, 10, 11, and 14), CTGF1, ICAM1, TBHS1, ITGA2, ITGA3, ITGB3, COL7A1, COL12A, SPP1, and TNC;ADAMTS8 was underexpressed. The CYT overexpressed genes were SPP1, BCL6, CXCL12, IL-8, and CEBPB;CXCL13 and CCL21 were underexpressed. The ECM results showed overexpression of proteases that are responsible for dysfunctions in the ECM, and of genes responsible for adhesion and membrane components. The CYT results showed overexpression of chemokines responsible for endometrial repair, and underexpression of cytokines involved in inflammatory processes in the endometrial tissue. AEM treatment did not negatively affect the endometrial function at 6 months after embolization. This study broadens the knowledge about using a procedure that is relevant to the treatment of leiomyomas and contributes to the es

关键词： Component Myoma Arterial Embolization of Myomas Extracellular Matrix Cytokines

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Gene Expression Analysis of Extracellular Matrix and Cytokines after Uterine Artery Embolization

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2014年第15期

作者： andré bernardo Tatiana Carvalho de Souza Bonetti Ismael Dale Cotrim Guerreiro da Silva Mariano Tamura Vieira Gomes Rodrigo Aquino Castro Manoel João Batista Castello Girão Claudio Emilio Bonduki

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Endoscopy vs surgery in the treatment of early gastric cancer:Systematic review

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World Journal of Gastroenterology 2015年第46期21卷 13177-13187页

作者： andré Kondo Eduardo Guimaraes Hourneaux de Moura Wanderley Marques bernardo Osmar Kenji Yagi Diogo Turiani Hourneaux de Moura Eduardo Turiani Hourneaux de Moura José Gon?alves Pereira Bravo Kendi Yamazaki Paulo Sakai Gastrointestinal Endoscopy Division Department of GastroenterologyHospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo Guidelines Program Coordinator Brazilian Medical Association (AMB) Gastrointestinal Surgery Division Sao Paulo State Cancer Institute (ICESP)Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo

AIM: To report a systematic review,establishing the available data to an unpublished 2a strength of evidence,better handling clinical ***: A systematic review was performed using MEDLINE,EMBASE,Cochrane,LILACS,Scopus and CINAHL databases. Information of the selected studies was extracted on characteristics of trial participants,inclusion and exclusion criteria,interventions(mainly,mucosal resection and submucosal dissection vs surgical approach) and outcomes(adverse events,different survival rates,mortality,recurrence and complete resection rates). To ascertain the validity of eligible studies,the risk of bias was measured using the Newcastle-Ottawa Quality Assessment Scale. The analysis of the absolute risk of the outcomes was performed using the software Rev Man,by computingrisk differences(RD) of dichotomous variables. Data on RD and 95%CIs for each outcome were calculated using the Mantel-Haenszel test and inconsistency was qualified and reported in χ2 and the Higgins method(I2). Sensitivity analysis was performed when heterogeneity was higher than 50%,a subsequent assay was done and other findings were ***: Eleven retrospective cohort studies were selected. The included records involved 2654 patients with early gastric cancer that filled the absolute or expanded indications for endoscopic resection. Threeyear survival data were available for six studies(n = 1197). There were no risk differences(RD) after endoscopic and surgical treatment(RD = 0.01,95%CI:-0.02-0.05,P = 0.51). Five-year survival data(n = 2310) showed no difference between the two groups(RD = 0.01,95%CI:-0.01-0.03,P = 0.46). Recurrence data were analized in five studies(1331 patients) and there was no difference between the approaches(RD = 0.01,95%CI:-0.00-0.02,P = 0.09). Adverse event data were identified in eight studies(n = 2439). A significant difference was detected(RD =-0.08,95%CI:-0.10--0.05,P < 0.05),demonstrating better results with endoscopy. Mortality data were

关键词： Gastric cancer Endoscopy Gastroscopy Gastrectomy Surgery Systematic review

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Quality of life, elderly and physical activity

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Health 2012年第2期4卷 88-93页

作者： Carlos Soares Pernambuco bernardo Minelli Rodrigues Jani Cleria Pereira Bezerra Alessandro Carrielo andré Dias de Oliveira Fernandes Rodrigo Gomes de Souza Vale Estelio Henrique Martin Dantas Biosciences of Human Motricity Laboratory Labimh/Unirio Rio de Janeiro Brazil Universidade Trás os Montes e Alto Douro Vila Real Portugal

The concept of quality of life is multiple concerns as a cultural, social and environmental individuality. The aim of this study was to verify the levels of quality of life in elderly practitioners of physical activity comparing a active group with a control group The sample consisted of 159 physically independent and apparently healthy individuals of either sex, with mean age of 66.61 ± 4.73 years. Active group obtained mean 14.32 ± 0.763 in whoqol’s scores for levels of quality of life, the Control group (CG) obtained mean 13.31 ± 0.94 and p-value 0.05. The ANOVA with repeated samples showed higher values for active group when compared with control group after intervention, the significant level was p < 0.05. It must be recognized that not every aspect of human life is reduced to the practice of physical activity;however, it is an important instrument that generates well-being in this age group.

关键词： Quality of Life Aged Motor Activity Exercise

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Endoscopic stenting for inoperable malignant biliary obstruction: A systematic review and meta-analysis

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World Journal of Gastroenterology 2015年第47期21卷 13374-13385页

作者： Leonardo Zorrón Pu Eduardo Guimaraes Hourneaux de Moura Wanderley Marques bernardo Felipe Iankelevich Baracat Ernesto Quaresma Mendonca andréKondo Gustavo Oliveira Luz Carlos Kiyoshi Furuya Júnior Everson Luiz de Almeida Artifon Gastrointestinal Endoscopy Division Department of GastroenterologyHospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo Guidelines Program Coordinator Brazilian Medical Association

AIM: To analyze through meta-analyses the benefits of two types of stents in the inoperable malignant biliary ***: A systematic review of randomized clinical trials(RCT) was conducted, with the last update on March 2015, using EMBASE, CINAHL(EBSCO), MEDLINE, LILACS/CENTRAL(BVS), SCOPUS, CAPES(Brazil), and gray literature. Information of the selected studies was extracted in sight of six outcomes: primarily regarding dysfunction, complication and reintervention rates; and secondarily costs, survival, and patency time. The data about characteristics of trial participants, inclusion and exclusion criteria and types of stents were also extracted. The bias was mainly assessed through the JADAD scale. This meta-analysis was registered in the PROSPERO database by the number CRD42014015078. The analysis of the absolute risk of the outcomes was performed using the software Rev Man, by computing risk differences(RD) of dichotomous variables and mean differences(MD) of continuous variables. Data on RD and MD for each primary outcome were calculated using the MantelHaenszel test and inconsistency was qualified and reported in χ2 and the Higgins method(I2). Sensitivity analysis was performed when heterogeneity was higher than 50%, a subsequent assay was done and other findings were compiled. Student's t-test was used for the comparison of weighted arithmetic means regarding secondary ***: Initial searching identified 3660 studies; 3539 were excluded through title, repetition, and/or abstract, while 121 studies were fully assessed and were excluded mainly because they did not compare self-expanding metal stents(SEMS) and plastic stents(PS), leading to thirteen RCT selected, with 13 articles and 1133 subjects meta-analyzed. The mean age was 69.5 years old, that were affected mostly by bile duct(proximal) and pancreatic tumors(distal). The preferred SEMS diameter used was the 10 mm(30 Fr) and the preferred PS diameter used was 10 Fr. In the metaanalysis

关键词： Biliary tract neoplasms Malignant biliaryobstruction Jaundice Palliative care Endoscopicretrograde cholangiopancreatography Stent Systematicreview Meta-analysis

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Maintenance of demographic and hematological profiles in a long-lasting dengue fever outbreak: implications for management

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Infectious Diseases of Poverty 2016年第1期5卷 776-786页

作者： andréia Moreira dos Santos Carmo Rodrigo Buzinaro Suzuki Michele Marcondes Riquena andré Eterovic árcia Aparecida Sperança Center for Natural and Human Sciences Universidade Federal do ABCCampus São Bernardo do Campo09606-070 São Bernardo Do CampoSão PauloBrasil Secretaria do Estado da Saúde do Estado de São Paulo Instituto Adolfo LutzCentro de Laboratório Regional VIIISanto André09040-160São PauloBrazil Discipline of Parasitology Marilia Medical SchoolMarilia 17519-030São PauloBrazil Center for Natural and Human Sciences Universidade Federal do ABCCampus Santo AndréSanto André09210-170São PauloBrazil

Background:Dengue fever(DF)outbreaks present regionally specific epidemiological and clinical *** certain medium-sized cities(100000–250000 inhabitants)of São Paulo State,Brazil,and after reaching an incidence of 150 cases/100000 inhabitants(“epidemiological threshold”),clinical diagnosis indicated dengue virus(DENV)*** this period,other seasonally infectious diseases with symptoms and physical signs mimicking DF can simultaneously occur,with the consequential overcrowding of health care facilities as the principal *** of clinical diagnosis of DF with serological tests may help in avoiding faulty diagnosis in patients,who might later undergo dengue hemorrhagic fever(DHF)and the dengue-shock syndrome(DSS).Furthermore,demographic and hematological profiles of patients are useful in detecting specific early characteristics associated to DF,DHF and ***:From March to June,2007,456 patients from Marilia in northwest São Paulo State who had only been diagnosed for DF by clinical criteria,underwent serologic testing for non-structural 1(NS1)DENV *** results were used in comparative analysis according to demographic(gender,age)and hematological(leukocyte and platelet counts,percentage of atypical lymphocytes)*** patterns were evaluated by subdividing data according to time of initial attendance,using recorded variables as predictors of DENV infection in logistic regression models and ROC ***:Serologic DENV detection was positive in 70.6%of the *** leukocyte and platelet counts were the most important factors in predicting DENV infection(respective medians DENV+=3715 cells/ml and DENV-=6760 cells/ml,and DENV+=134896 cells/ml and DENV-=223872 cells/ml).Furthermore,all demographic and hematological profiles presented a conservative temporal pattern throughout this long-lasting ***:As consistency throughout the epidemic facilitated defining the conservation

关键词： Clinical diagnosis Demographic profile Dengue fever Dengue-outbreak pattern Epidemiological threshold Hematological profile

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Relationship between maturity levels and neuromuscular capacity among youth soccer players and individuals not practicing soccer

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Health 2013年第1期5卷 30-34页

作者： Dihogo Gama de Matos Estélio Henrique Martin Dantas Felipe José Aidar Aldo Coelho Silva bernardo Minelli Rodrigues Ingi Klain Robert C. Hickner andré Luiz Carneiro Mauro Lucio Mazini Filho Department of Sports Science Exercise and Health of the Trás-os-Montes e Alto Douro University Vila Real Portugal Departments of Kinesiology and Physiology Center for Health Disparities Research East Carolina University Greenville USA Doctoral Program in Nursing and Biosciences—PpgEnfBio Federal University of State of Rio de Janeiro—UNIRIO Rio de Janeiro Brazil Physical Education Department Federal University of Paraná Curitiba Brazil State University at Montes Claros (UNIMONTES) Montes Claros Brazil University Center of the Triangulo UNITRI Uberlandia Brazil

The aim of this study was to compare maturational stage and neuromuscular skills among soccer players and non-athletes, as well as to investigate the relationship between maturation and neuromuscular performance. Twenty five adolescent males (14.3 ± 0.45 years) participated in the study and were divided into two groups: soccer players (SP – n = 13, 14.1 ± 0.3 years, 58.9 ± 6.90 kg, 1.72 ± 0.04 m, 19.9 ± 1.7 kg·m2, 13.3% ± 4.3% fat) and non-athletes (NA – n = 12, 14.5 ± 0.5 years, 57.3 ± 6.9 kg, 1,67 ± 0.06 m, 20.6 ± 3.9 kg·m2, 14.0% ± 5.7% fat). The square test and 20 m speed test were used to assess agility and speed, respectively. The Tanner self-assessment of pubic hair and genitalia development test was used to estimate maturational development. The Shapiro Wilk test was used to verify the normality of samples. For any data not normally distributed, the non-parametric Mann Whitney test, as well as Kendall’s Tau correlation test, were used. The p-values determined for agility (p = 0.017) and speed (p = 0.054) indicated that agility was the only variable significantly different between SP and NA. The SP and NA groups showed no difference in the levels of maturation (p = 0.41), and maturational status was not significantly correlated with agility (r = 0.013) or speed (r = ?0.003). Conclusion: Individuals who practiced football had better results for the agility test than non-athletes, even with no difference between the degree of maturation and speed. There is a low correlation between level of maturity and agility or speed.

关键词： Training Maturity Physical Capabilities

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Transcranial direct current stimulation in psychiatric disorders

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World Journal of Psychiatry 2015年第1期5卷 88-102页

作者： Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione andré R Brunoni Service of Interdisciplinary Neuromodulation Laboratory of Neurosciences (LIM-27)Department and Institute of PsychiatryUniversity of Sao Paulo Interdisciplinary Center for Applied Neuromodulation University HospitalUniversity of Sao Paulo Psychology Department Advanced School in NeuropsychologyUniversità degli Studi Milano Bicocca Department of Physiology Pharmacology and Neuroscience Sophie Davis School of Biomedical Education City University of New York (CUNY) Obsessive Compulsive Disorder Project (PROTOC) Department and Institute of PsychiatryUniversity of Sao Paulo Unit of Psychiatry Department of Neurosciences Reproductive and Odontostomatological Sciences University of Naples Federico II Université de Lyon Université Claude Bernard Lyon I Centre Hospitalier le Vinatier National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq) Department of Psychiatry Department and Institute of PsychiatryUniversity of Sao Paulo Santa Casa de Sao Paulo Medical School Institute of Physical Medicine and Rehabilitation Clinics Hospital of the University of Sao Paulo Medical School

The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry.

关键词： Non-invasive brain stimulation Transcranial direct current stimulation Psychiatry disorders Review

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Are There Schizophrenia Genetic Markers and Mutations? A Systematic Review and Meta-Analyses

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Health 2017年第5期9卷 811-838页

作者： Maria Auxiliadora Brasil Sampaio Cardoso Tárcia Januário do Nascimento Gabriel Pereira bernardo Lorena Pereira bernardo Maria Mirelle Ferreira Leite Barbosa Pedro Januário Nascimento Neto Danilo Ferreira de Sousa Antonio Gilvan Teixeira Júnior Marcos Antonio Pereira de Lima Marcial Moreno Moreira David de Sousa Gregório Lídia Coelho do Nascimento Santos Modesto Leite Rolim Neto Postgraduate Program in Health Science FMABC Santo André Brazil Faculty of Medicine Estacio (FMJ) Juazeiro do Norte Brazil Federal University of Cariri (UFCA) Faculty of Medicine Barbalha Brazil Science without Borders fellow at University of Liverpool Liverpool UK

Background: Schizophrenia is a severe psychiatric disorder with a complex genetic factor determining its disease onset. Nevertheless, it is not clear in this mental disorder. Objective: To conduct a systematic review of articles regarding the genetic markers and mutations in schizophrenia. Methods: A systematic review of articles on genetic markers and mutations in schizophrenia, published from January 1, 2011, to September 7, 2015, on SCOPUS database was carried out. Search terms were “Genetic markers”, “Mutation”, and “Schizophrenia”. Results: Of the 527 retrieved studies, 31 met the eligibility criteria. Genetic polymorphism, Immune-associated genes, TCF4 and ZNF804A association with microRNA, Neuregulin gene, Chromosome 13q32 and 11p15.4, genes involved in glutamatergic via schizophrenia and brain structure, appeared to be associated with the origin of schizophrenia. Conclusion: Some studies show genes involved in several pathways leading to the disease pathogenesis such as that one related with the dopaminergic and immune system, or rare alleles. Some genes present no involvement in the etiology of this mental disorder. These findings clarify the genetic complexity of schizophrenia and affirm that together, the genes have an overall effect greater than the sum of the individual effect of each gene.

关键词： Schizophrenia Genetic Markers Mutations Systematic Review

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Primary Effusion Lymphoma in a HIV-1/2-Infected Patient

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World Journal of AIDS 2023年第3期13卷 116-124页

作者： Maria Caixas Lima Pedro Vasques andreia Paulos andré Valente Joana Santos Carla Antunes Matilde Gonçalves Maria Isabel Casella Nuno Luis José Poças Department of Infectious Diseases Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of General Surgery Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of Hematology Hospital de Santo António dos Capuchos Centro Hospitalar Lisboa Central Lisboa Portugal Department of Anatomical Pathology Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal

Background: Primary effusion lymphoma (PEL) is a lymphoid proliferation related to Kaposi sarcoma herpesvirus 8/human herpesvirus 8 (KSHV/HHV8) that affects mainly human immunodeficiency virus (HIV) infected individuals but can also occur in other immunodeficiency settings. It is characterized by lymphomatous effusions in different serous body cavities without the presence of a detectable tumor mass. The diagnosis is challenging and the clinical outcomes are poor. Aim: The aim of this paper is to report a rare case of PEL in a man who have sex with women (MSW) with HIV-1/2 infection, history of visceral Kaposi sarcoma (KS) and the development of a seronegative arthritis previous to the lymphoproliferative disease diagnosis. PEL presented with ascites, was treated with high-dose chemotherapy and autologous stem cell transplantation, with a good clinical outcome. Case Presentation: We describe a case of a 48-year-old HIV-1/2-infected patient from a high HHV8 seroprevalent country, hospitalized following a three-month history of increased abdominal volume and general constitutional symptoms. Laboratory data revealed normocytic normochromic anemia and a high level of lactate dehydrogenase. A diagnostic paracentesis was performed with cytology compatible with high-grade B-cell lymphoma. Peritoneal fluid cytology showed large lymphoid cells expressing leucocyte-common antigen CD45 without expression of the CD20 antigen (B-lymphocytes) and positivity for HHV8 by immunocytochemical staining, compatible with the diagnosis of PEL.

关键词： Primary Effusion Lymphoma Acquired Immunodeficiency Syndrome HIV-1 HIV-2 Kaposi Sarcoma Herpesvirus 8/Human Herpesvirus 8 People Living with HIV

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