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Effects of neoadjuvant chemotherapy vs chemoradiotherapy in the treatment of esophageal adenocarcinoma:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第11期30卷 1621-1635页

作者： Armand Csontos Alíz Fazekas Lajos szakó Nelli Farkas Csenge papp szilárd Ferenczi szabolcs Bellyei Péter Hegyi andrás papp Department of surgery University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Institute of Bioanalysis University of PécsMedical SchoolPécs H-7624BaranyaHungary Institute for Translational Medicine University of PécsMedical SchoolPécs H-7624BaranyaHungary Department of Emergency Medicine Clinical CenterUniversity of PécsMedical SchoolPécs 7624BaranyaHungary Department of Oncotherapy University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Centre for Translational Medicine Semmelweis UniversityBudapest 1085Hungary Institute of Pancreatic Diseases Semmelweis UniversityBudapest H-1083Hungary

BACKGROUND Neoadjuvant therapy is an essential modality for reducing the clinical stage of esophageal cancer;however,the superiority of neoadjuvant chemotherapy(nCT)or neoadjuvant chemoradiotherapy(nCRT)is ***,a discussion of these two modalities is *** To investigate the benefits and complications of neoadjuvant *** To address this concern,predefined criteria were established using the PICO *** independent authors performed comprehensive searches using predetermined *** analyses were performed to identify significant differences between *** publication bias was visualized using funnel *** quality of the data was evaluated using the Risk of Bias Tool 2(RoB2)and the GRADE *** Ten articles,including 1928 patients,were included for the *** difference was detected in pathological complete response(pCR)[Ps ratio(OR):0.27;95%CI:0.16-0.46],30-d mortality(P=0.015;OR:0.4;95%CI:0.22-0.71)favoring the nCRT,and renal failure(P=0.039;OR:1.04;95%CI:0.66-1.64)favoring the *** significant differences were observed in terms of survival,local or distal recurrence,or other clinical or surgical *** result of RoB2 was moderate,and that of the GRADE approach was low or very low in almost all *** Although nCRT may have a higher pCR rate,it does not translate to greater long-term ***,nCRT is associated with higher 30-d mortality,although the specific cause for postoperative complications could not be *** the case of nCT,toxic side effects are suspected,which can reduce the quality of *** the quality of available studies,further randomized trials are required.

关键词： Neoadjuvant Chemotherapy Chemoradiotherapy Esophageal cancer Adenocarcinoma

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Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer:The superiority of minimally invasive surgery

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World Journal of Gastroenterology 2022年第30期28卷 4201-4210页

作者： Lajos szakó Dávid Németh Nelli Farkas szabolcs Kiss Réka Zsuzsa Domotor Marie Anne Engh Péter Hegyi Balint Eross andrás papp Institute of Translational Medicine University of PécsMedical SchoolPécs 7624Hungary János szentágothai Research Centre University of PécsMedical SchoolPécs 7624Hungary Institute for Translational Medicine University of PécsMedical SchoolPécs 7624Hungary of Bioanalysis University of PécsMedical SchoolPécs 7624Hungary Insittute of Translational Medicine University of PécsMedical SchoolPécs 7624Hungary Doctoral school of Clinical Medicine University of SzegedMedical SchoolSzeged 6720Hungary First Department of Medicine University of SzegedMedical SchoolSzeged 6725Hungary Institute of Translational Medicine University of PecsMedical SchoolPecs 7624Hungary Department of surgery Clinical CenterUniversity of PécsMedical SchoolPécs 7624Hungary

BACKGROUND Previous meta-analyses,with many limitations,have described the beneficial nature of minimal invasive *** To compare all modalities of esophagectomies to each other from the results of randomized controlled trials(RCTs)in a network meta-analysis(NMA).METHODs We conducted a systematic search of the MEDLINE,EMBAsE,Reference Citation Analysis(https://***/)and CENTRAL databases to identify RCTs according to the following population,intervention,control,outcome(commonly known as PICO):P:Patients with resectable esophageal cancer;I/C:Transthoracic,transhiatal,minimally invasive(thoracolaparoscopic),hybrid,and robot-assisted esophagectomy;O:survival,total adverse events,adverse events in subgroups,length of hospital stay,and blood *** used the Bayesian approach and the random effects *** presented the geometry of the network,results with probabilistic statements,estimated intervention effects and their 95% confidence interval(CI),and the surface under the cumulative ranking curve to rank the *** We included 11 studies in our *** found a significant difference in postoperative pulmonary infection,which favored the minimally invasive intervention compared to transthoracic surgery(risk ratio 0.49;95%CI:0.23 to 0.99).The operation time was significantly shorter for the transhiatal approach compared to transthoracic surgery(mean difference-85 min;95%CI:-150 to-29),hybrid intervention(mean difference-98 min;95%CI:-190 to-9.4),minimally invasive technique(mean difference-130 min;95%CI:-210 to-50),and robot-assisted esophagectomy(mean difference-150 min;95%CI:-240 to-53).Other comparisons did not yield significant *** Based on our results,the implication of minimally invasive esophagectomy should be favored.

关键词： surgery Esophageal cancer Esophagectomy Network meta-analysis Minimally invasive Laparoscopy

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Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda

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World Journal of Gastroenterology 2024年第17期30卷 2308-2310页

作者： Veronika papp Pál Miheller Department of surgery Transplantation and GastroenterologySemmelweis UniversityBudapest 1082Hungary

Gastric cystica profunda(GCP)is an uncommon but underestimated gastric *** precancerous potential determines its *** addition to previous mucosa injury due to operations,biopsy or polypectomy,chronic active and atrophic gastritis may also lead to the development of *** carefully examining the stomach and taking biopsy samples from the susceptible regions,the stage of atrophy can be *** atrophic gastritis is a risk factor for cancer evolvement and it can also contribute to GCPs *** frequently occur close to early gastric cancers(EGCs)or EGC can arise from the cystic *** resection is an effective and minimally invasive treat-ment in GCP.

关键词： Gastric cystica profunda Chronic active gastritis Atrophic gastritis Operative Link for Gastritis Assessment staging Early gastric cancer Endoscopic resection

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Relationship between diabetes mellitus and cataract in Hungary

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 788-793页

作者： Anita Pék Dorottya szabó Gábor Lászlósándor Gábor Tóth andrás papp Zoltán Zsolt Nagy Hans Limburg János Németh Department of Ophthalmology Semmelweis UniversityMária u.39.Budapest 1085Hungary Department of Ophthalmology Petz Aladár HospitalVasvári Pál u.2-4.Győr 9023Hungary Health Information services Nijenburg 32LC1613 Grootebroekthe Netherlands

AIM:To examine the coexistence of diabetes mellitus(DM)and cataract in *** effects of DM on the cataract surgical results were also in the focus of ***:statistical data analysis of the results of the Rapid Assessment of Avoidable Blindness with Diabetic Retinopathy(RAAB+DR)module conducted in Hungary in *** cross-sectional,population-based,national survey included 3523 people aged 50 years and *** of the survey were examined *** acuity,main cause for visual impairment(using direct and indirect ophthalmoscopes),in case of best corrected visual acuity(BCVA)≤0.5 and blood glucose level(random test with glucometer)were ***:The prevalence of cataract was 23.4%,and DM was 20.0%.The occurrence of cataract steadily increased with *** the examined participants with DM,the prevalence of cataract was significantly(P=0.012)higher(+35%)than that in non-diabetic subjects(29.5%vs 21.8%).Following aging(OR=15.2%,Pst independent influencing risk factor(OR=49.9%,Psence of DM was neither an influencing factor for complications of cataract surgery,nor for postoperative visual ***:DM appears to be one of the main risk factors for developing *** risk factors,such as age,sex and environment also play an influencing *** does not seem to affect the occurrence of cataract surgical complications.

关键词： cataract diabetes mellitus Rapid Assessment of Avoidable Blindness

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Non-pancreatic hyperlipasemia:A puzzling clinical entity

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World Journal of Gastroenterology 2024年第19期30卷 2538-2552页

作者： Krisztina Eszter Feher David Tornai Zsuzsanna Vitalis Laszlo Davida Nora sipeki Maria papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary Kalman Laki Doctoral school of Biomedical and Clinical sciences Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary

BACKGROUND Increased lipase level is a serological hallmark of the diagnosis of acute pancreatitis(AP)but can be detected in various other diseases associated with lipase leakage due to inflammation of organs surrounding the pancreas or reduced renal clearance and/or hepatic *** non-pancreatic hyperlipasemia(NPHL)is puzzling for attending physicians during the diagnostic procedure for *** would be clinically beneficial to identify the clinical and laboratory variables that hinder the accuracy of lipase diagnosis with the aim of improve it.A more precise description of the NPHL condition could potentially provide prognostic factors for adverse outcomes which is currently *** To perform a detailed clinical and laboratory characterization of NPHL in a large prospective patient cohort with an assessment of parameters determining disease *** A Hungarian patient cohort with serum lipase levels at least three times higher than the upper limit of normal(ULN)was prospectively evaluated over 31 *** were identified using daily electronic laboratory reports developed to support an ongoing observational,multicenter,prospective cohort study called the EAsY trial(IsRCTN10525246)to establish a simple,easy,and accurate clinical scoring system for early prognostication of *** of NPHL was established based on≥3×ULN serum lipase level in the absence of abdominal pain or abdominal imaging results characteristic of *** A total of 808 patients[male,n=420(52%);median age(IQR):65(51-75)years]were diagnosed with≥3×ULN serum lipase levels.A total of 392 patients had AP,whereas 401 had NPHL with more than 20 different *** and acute kidney injury(AKI)were the most prevalent etiologies of NPHL(27.7%and 33.2%,respectively).The best discriminative cut-off value for lipase was≥666 U/L(sensitivity,71.4%;specificity,88.8%).The presence of AKI or sepsis negatively affected the diagnostic performance of *** w

关键词： Non-pancreatic hyperlipasemia Acute pancreatitis Glycoprotein 2 Acute kidney injury sepsis Mortality

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Cataract blindness in Hungary

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 438-444页

作者： Gábor L.sándor Gábor Tóth Dorottya szabó Irén szalai Regina Lukács Anita Pék Georgina Z.Tóth andrás papp Zoltán Z.Nagy Hans Limburg János Németh Department of Ophthalmology Semmelweis UniversityBudapest 1085Hungary Department of Ophthalmology Flór Ferenc HospitalKistarcsa 2143Hungary Department of Ophthalmology Petz Aladár HospitalGyor 9024Hungary Faculty of Health sciences Semmelweis UniversityBudapest 1088Hungary Health Information services Grootebroek 1613The Netherlands

AIM:To estimate the prevalence of blindness and visual impairment resulting from cataract in the population aged≥50 y in Hungary,and to assess the cataract surgical ***:A rapid assessment of avoidable blindness(RAAB)was conducted.A total of 3523 eligible people were randomly selected and *** participant underwent surgery for cataract was interviewed with regard to the year,place,and costs of the *** with obvious cataract were asked why they had not yet undergone surgery(barriers to surgery).REsULTs:An estimated 12514 people were bilaterally blind;the visual acuity(VA)in 19293 people wassstimated 77933 eyes are blind;98067 eyes had a VA ofstimated 277493 eyes had a VA ofsurgeries were conducted in government *** age-and sexadjusted cataract surgical coverage with VAs was 90.0%.The rate of good visual outcome after surgery was 79.5%.Ocular comorbidity was the main cause of poor outcome(78.1%),followed by late complications(such as posterior capsule opacification)(17.2%),inadequate optical correction(3.1%),and surgical complications(1.6%).The main barrier to surgery in people with bilateral cataract and VA ofs‘need not felt’.CONCLUsION:The prevalence of visual impairment resulting from cataract is slightly higher than *** quality of the cataract surgical service seems adequate in ***,the number of cataract operations per year should continue to increase due to the increasing patient demands and the aging population.

关键词： cataract prevalence blindness visual impairment rapid assessment of avoidable blindness

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Tantalum pentoxide:a new material platform for high-performance dielectric metasurface optics in the ultraviolet and visible region

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Light(science & Applications) 2024年第1期13卷 142-152页

作者： Cheng Zhang Lu Chen Zhelin Lin Junyeob song Danyan Wang Moxin Li Okan Koksal Zi Wang Grisha spektor David Carlson Henri J.Lezec Wenqi Zhu scott papp Amit Agrawal school of Optical and Electronic Information&Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China National Institute of standards and Technology GaithersburgMD 20899USA University of Maryland College ParkMD 20742USA National Institute of standards and Technology BoulderCO 80305USA

Dielectric metasurfaces,composed of planar arrays of subwavelength dielectric structures that collectively mimic the operation of conventional bulk optical elements,have revolutionized the field of optics by their potential in constructing high-efficiency and multi-functional optoelectronic systems on *** performance of a dielectric metasurface is largely determined by its constituent material,which is highly desired to have a high refractive index,low optical loss and wide bandgap,and at the same time,be fabrication ***,we present a new material platform based on tantalum pentoxide(Ta2O5)for implementing high-performance dielectric metasurface optics over the ultraviolet and visible spectral *** wide-bandgap dielectric,exhibiting a high refractive index exceeding 2.1 and negligible extinction coefficient across a broad spectrum,can be easily deposited over large areas with good quality using straightforward physical vapor deposition,and patterned into high-aspect-ratio subwavelength nanostructures through commonly-available fluorine-gas-based reactive ion *** implement a series of highefficiency ultraviolet and visible metasurfaces with representative light-field modulation functionalities including polarization-independent high-numerical-aperture lensing,spin-selective hologram projection,and vivid structural color generation,and the devices exhibit operational efficiencies up to 80%.Our work overcomes limitations faced by scalability of commonly-employed metasurface dielectrics and their operation into the visible and ultraviolet spectral range,and provides a novel route towards realization of high-performance,robust and foundry-manufacturable metasurface optics.

关键词： dielectric optics ultraviolet

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serological biomarkers for management of primary sclerosing cholangitis

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World Journal of Gastroenterology 2022年第21期28卷 2291-2301页

作者： David Tornai Peter Laszlo Ven Peter Laszlo Lakatos Maria papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary European Reference Network on Hepatological Diseases ERN RARE-LIVERDebrecen H-4032Hajdu-BiharHungary The First Department of Medicine Division of GastroenterologyUniversity of PécsPécs H-7624BaranyaHungary Kálmán Laki Doctoral school of Biomedical and Clinical sciences Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary Division of Gastroenterology McGill University Health CentreMontreal QC H4A 3J1QuebecCanada The First Department of Medicine Semmelweis UniversityBudapest H-1083PestHungary

Clinical manifestations and progression of primary sclerosing cholangitis(PsC)are heterogeneous,and its pathogenesis is poorly *** importance of gut-liver interactions in the pathogenesis has been clinically confirmed and highlighted in different *** advances regarding biomarkers of biliarygut crosstalk may help to identify clinically relevant PsC subgroups assisting everyday clinical work-up(e.g.,diagnosis,disease stratification,or surveillance)and the exploration of potential therapeutic *** phosphatase produced by the biliary epithelium is consistently associated with ***,its level shows natural fluctuation limiting its use in individual ***,cell activation,and tissue remodeling markers have been reported to predict clinical *** immunoglobulin(Ig)G4 level is associated with a shorter transplantation-free *** type atypical perinuclear anti-neutrophil cytoplasmic antibodies(P-ANCAs)are non-specific markers of various autoimmune liver diseases and may reflect an abnormal B-cell response to gut microbial *** type atypical P-ANCA identifies PsC patients with particular clinical and genetic(for human leukocyte antigens)*** presence of IgA type anti-F-actin antibody(AAA)may predict a progressive disease course,and it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte *** type anti-glycoprotein 2(GP2)antibodies identify patients with a severe disease phenotype and poor survival due to enhanced fibrogenesis or development of *** soluble vascular adhesion protein-1(sVAP-1)level is associated with adverse disease outcomes in *** sVAP-1 levels correlate with mucosal addressin cell adhesion molecule-1(MAdCAM-1)expression in the liver that contributes to gut activated T-cell homing to the hepatobiliary *** the present paper,we review the evidence on these possible serological ma

关键词： Primary sclerosing cholangitis Hepatobiliary serological biomarker Immunoglobulin Inflammatory Tissue remodeling

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Location-based prediction model for Crohn’s disease regarding a novel serological marker,anti-chitinase 3-like 1 autoantibodies

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World Journal of Gastroenterology 2023年第42期29卷 5728-5750页

作者： Nora sipeki Patricia Julianna Kovats Claudia Deutschmann Peter schierack Dirk Roggenbuck Maria papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary Kálmán Laki Doctoral school Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary Institute of Biotechnology Faculty Environment and Natural SciencesBrandenburg University of Technology Cottbus-SenftenbergSenftenberg 01968Germany Faculty of Health sciences Brandenburg Brandenburg University of Technology Cottbus-SenftenbergSenftenberg 01968Germany Medipan GmbH&GA Generic Assays GmbH Dahlewitz-Berlin 15827Germany

BACKGROUND Defective neutrophil regulation in inflammatory bowel disease(IBD)is thought to play an important role in the onset or manifestation of IBD,as it could lead to damage of the intestinal mucosal barrier by the infiltration of neutrophils in the inflamed mucosa and the accumulation of *** neutrophils in the context of innate immune responses,immunoglobulin A(IgA)as an acquired immune response partakes in the defense of the intestinal *** normal conditions,IgA contributes to the elimination of microbes,but in connection with the loss of tolerance to chitinase 3-like 1(CHI3L1)in IBD,IgA could participate in CHI3L1-mediated improved adhesion and invasion of potentially pathogenic *** tolerance brake to CHI3L1 and the occurrence of IgA autoantibodies to this particular target,the exact role and underlying mechanisms of CHI3L1 in the pathogenesis of IBD are still *** To determine the predictive potential of Ig subtypes of a novel serological marker,anti-CHI3L1 autoantibodies(aCHI3L1)in determining the disease phenotype,therapeutic strategy and long-term disease course in a prospective referral cohort of adult IBD *** sera of 257 Crohn’s disease(CD)and 180 ulcerative colitis(UC)patients from a tertiary IBD referral center of Hungary(Division of Gastroenterology,Department of Internal Medicine,Faculty of Medicine,University of Debrecen)were assayed for IgG,IgA,and secretory IgA(sIgA)type aCHI3L1 by enzyme-linked immunosorbent assay using recombinant CHI3L1,along with 86 healthy controls(HCONT).REsULTs The IgA type was more prevalent in CD than in UC(29.2%vs 11.1%)or HCONT(2.83%;PsIgA subtype aCHI3L1 positivity was higher in both CD and UC patients than in HCONT(39.3%and 32.8%vs 4.65%,respectively;Psence of both IgA and sIgA aCHI3L1 antibodies was associated with colonic involvement(Pspectively)in patients with *** disease behavior a

关键词： Chitinase 3-like 1 autoantibodies Crohn’s disease Ulcerative colitis Disease progression Immunoglobulin subtypes Enzyme-linked immunosorbent assay

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Effect of herpesvirus infection on pancreatic duct cell secretion

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World Journal of Gastroenterology 2005年第38期11卷 5997-6002页

作者： Péter Hegyi Balázs rdg Zoltán Rakonczai Jr Tamás Takács János Lonovics Annamária szabolcs Réka sári andrás Tóth Julius G papp andrás Varró Mária K Kovács Mike A Gray Barry E Argent Zsolt Boldogki First Department of Medicine Department of Biology Division of Cardiovascular Pharmacology school of Cell and Molecular Biosciences

AIM: To examine the effect of acute infection caused by herpesvirus (pseudorabies virus, PRV) on pancreatic ductal ***: The virulent Ba-DupGreen (BDG) and nonvirulent Ka-RREpOlacgfp (KEG) genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein (GFP). small intra/interlobular ducts were infected with BDG virus (107 PFU/mL for 6 h) or with KEG virus (1010 PFU/mL for 6 h), while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 *** rate of HCO3- secretion [base efflux -J(B-)] was determined from the buffering capacity of the cells and the initial rate of intracellular acidification (1) after sudden blockage of basolateral base loaders with dihydro-4,4,-diisothiocyanatostilbene-2,2,-disulfonic acid (500 μmol/L)and amiloride (200 μmol/L), and (2) after alkali loading the ducts by exposure to NH4Cl. All the experiments were performed in HCO3--buffered Ringer solution at 37 ℃ (n = 5ducts for each experimental condition). Viral structural proteins were visualized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning ***: The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral antigens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -J(B-) 24 h after the infection, compared to the non-infected group. However, KEG infection did not modify -J(B-). After alkali loading the ducts, -J(B-) was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected ***: Incubation with the BDG or KEG strains of PRV results in an effective infection o

关键词：疱疹病毒胰腺细胞胰管分泌病毒感染

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