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Correction to:Proposed nomenclature for Pseudallescheria,Scedosporium and related genera

Fungal Diversity 2022年第2期113卷 193-194页

作者： Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro Ferreira Moreno Sarah A.Ahmed Fritz Andreas Josef Kaltseis Markus Nagl Cornelia Lass-Florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gene Fabiola Fernandez Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea garcia-Hermoso Jacques F.Meis Ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zoderer Wieland Meyer Felix Gilgado Vania A.Vicente Elena Pieckova Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar Françoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina Kinga Rigler-Hohenwarter Fernando L.Hernando andoni ramirez-garcia Aize Pellon Jashanpreet Kaur Eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquierdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes Division of Hygiene and Medical Microbiology Innsbruck Medical UniversityInnsbruckAustria CBS Fungal Biodiversity Centre UtrechtThe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Medical University of Graz GrazAustria Centre for Infectious Diseases and Microbiology Westmead HospitalWestmeadAustralia Laboratoire de Parasitologie-Mycologie Centre Hospitalier UniversitaireAngersFrance Unitats de Microbiologia i d’Anatomia Patologica Facultat de Medicina i Ciencies de la Salut IISPVUniversitat Rovira i VirgiliReusSpain Universidade Federal do Estado do Rio de Janeiro Rio de JaneiroBrazil Institute of Medical Microbiology University Hospital RWTHAachenGermany Institute of Microbiology Academy of SciencesPragueCzech Republic Institut Pasteur Unite de Mycologie MoleculaireCentre National de Reference Mycoses Invasives et AntifongiquesParisFrance Department of Medical Microbiology and Infectious Diseases Canisius-Wilhelmina HospitalNijmegenThe Netherlands Department of Medical Microbiology RadboudumcNijmegenThe Netherlands Institute of Microbiology eopold-Franzens-University InnsbruckInnsbruckAustria Molecular Mycology Research Laboratory Centre for Infectious Diseases and MicrobiologySydneyMedical School—Westmead HospitalMarie Bashir Institute for Infectious Diseases and BiosecurityThe University of SydneyWestmead Millennium InstituteWestmeadNSWAustralia Basic Pathology Department Federal University of Parana StateCuritibaParanaBrazil Fellowship from Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq) BrasiliaBrazil Institute of Preventive and Clinical Medicine BratislavaSlovakia Institut für Hygiene und Mikrobiologie Landesklinikum St.Pölten St.PoltenAustria Institute of Medical Microbiology University Hospital EssenEssenGermany Nursing School of Unigranrio Rio de JaneiroBrazil Scientific Institute of Public Health Culture Collect

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Proposed nomenclature for Pseudallescheria,Scedosporium and related genera

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Fungal Diversity 2014年第4期67卷 1-10页

作者： Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro Ferreira Moreno Sarah A.Ahmed Fritz Andreas Josef Kaltseis Markus Nagl Cornelia Lass-Florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gené Fabiola Fernández Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea garcia-Hermoso Jacques F.Meis Ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zoderer Wieland Meyer Felix Gilgado Vania A.Vicente Elena Piecková Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar Francoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina Kinga Rigler-Hohenwarter Fernando L.Hernando andoni ramirez-garcia Aize Pellon Jashanpreet Kaur Eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquerdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes Division of Hygiene and Medical Microbiology Innsbruck Medical UniversityInnsbruckAustria CBS Fungal Biodiversity Centre UtrechtThe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Medical University of Graz GrazAustria Centre for Infectious Diseases and Microbiology Westmead HospitalWestmeadAustralia Laboratoire de Parasitologie-Mycologie Centre Hospitalier UniversitaireAngersFrance Unitats de Microbiologia i d’Anatomia Patològica Facultat de Medicina i Ciències de la Salut IISPVUniversitat Rovira i VirgiliReusSpain Universidade Federal do Estado do Rio de Janeiro Rio de JaneiroBrazil Institute of Medical Microbiology University Hospital RWTHAachenGermany Institute of Microbiology Academy of SciencesPragueCzech Republic Institut Pasteur Unitéde Mycologie MoléculaireCentre National de Référence Mycoses Invasives et AntifongiquesParisFrance Department of Medical Microbiology and Infectious Diseases Canisius-Wilhelmina HospitalNijmegenThe Netherlands Department of Medical Microbiology RadboudumcNijmegenThe Netherlands Institute of Microbiology eopold-Franzens-University InnsbruckInnsbruckAustria Molecular Mycology Research Laboratory Centre for Infectious Diseases and MicrobiologySydneyMedical School—Westmead HospitalMarie Bashir Institute for Infectious Diseases and BiosecurityThe University of SydneyWestmead Millennium InstituteWestmeadNSWAustralia Basic Pathology Department Federal University of ParanáStateCuritibaParanáBrazil Fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) BrasíliaBrazil Institute of Preventive and Clinical Medicine BratislavaSlovakia Institut für Hygiene und Mikrobiologie Landesklinikum St.Pölten St.PöltenAustria Institute of Medical Microbiology University Hospital EssenEssenGermany Nursing School of Unigranrio Rio de JaneiroBrazil Scientific Institute of Public Health Culture Collectio

As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be *** of the ECMM/ISHAM working group on Pseudallescheria/Scedosporium infections herein advocate a novel nomenclature for genera and species in Pseudallescheria,Scedosporium and allied *** generic names Parascedosporium,Lomentospora,Petriella,Petriellopsis,and Scedosporium are proposed for a lineage within Microascaceae with mostly Scedosporium anamorphs producing slimy,annellidic *** that Scedosporium has priority over Pseudallescheria and that Scedosporium prolificans is phylogenetically distinct from the other Scedosporium species,some name changes are *** minutispora and Petriellidium desertorum are renamed as Scedosporium minutisporum and ***,*** prolificans is renamed as Lomentospora prolificans.

关键词： Graphium Lomentospora Petriella Scedosporium apiospermum complex Microascaceae Nomenclature

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Landscape genetics reveals inbreeding and genetic bottlenecks in the extremely rare short-globose cacti Mammillaria pectinifera (Cactaceae) as a result of habitat fragmentation

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Plant Diversity 2017年第1期39卷 13-19页

作者： Reyna Maya-garcia Santiago Arizaga Pablo Cuevas-Reyes Juan Manuel Penaloza-ramirez Victor Rocha ramirez Ken Oyama Facultad de Biologia Universidad Michoacana de San Nicolas de Hidalgo Mexico Escuela Nacional-de Estudios Superiores Unidad Morelia UNAM Antigua Carretera a Pdtzcuaro 8701 Colonia Ex-Hacienda de SanJose de la Huerta58190 Morelia Michoacan Mexico

Mammillaria pectinifera is an endemic, short-globose cactus species, included in the IUCN list as a threatened species with only 18 remaining populations in the Tehuacán-Cuicatlán Valley in central Mexico. We evaluated the population genetic diversity and structure, connectivity, recent bottlenecks and population size, using nuclear microsatellites. M. pectinifera showed high genetic diversity but some evidence of heterozygote deficiency(F_(IS)), recent bottlenecks in some populations and reductions in population size. Also, we found low population genetic differentiation and high values of connectivity for M. pectinifera, as the result of historical events of gene flow through pollen and seed dispersal.M. pectinifera occurs in sites with some degree of disturbance leading to the isolation of its populations and decreasing the levels of gene flow among them. Excessive deforestation also changes the original vegetation damaging the natural habitats. This species will become extinct if it is not properly ***, this species has some ecological features that make them more vulnerable to disturbance such as a very low growth rates and long life cycles. We suggest in situ conservation to prevent the decrease of population sizes and loss of genetic diversity in the natural protected areas such as the Tehuacán-Cuicatlán Biosphere Reserve. In addition, a long-term ex situ conservation program is need to construct seed banks, and optimize seed germination and plant establishment protocols that restore disturbed habitats. Furthermore, creating a supply of living plants for trade is critical to avoid further extraction of plants from nature.

关键词： Mammillaria pectinifera Nuclear SSR Genetic diversity Recent bottlenecks Effective population size

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Uncovering the genetic diversity of Giardia intestinalis in isolates from outbreaks in New Zealand

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Infectious Diseases of Poverty 2022年第3期11卷 27-36页

作者： Paul Ogbuigwe Patrick J.Biggs Juan Carlos garcia-ramirez Matthew A.Knox Anthony Pita Niluka Velathanthiri Nigel P.French David T.S.Hayman School of Veterinary Science Massey UniversityPalmerston NorthManawatu-WanganuiNew Zealand School of Natural Sciences Massey UniversityPalmerston NorthManawatu-WanganuiNew Zealand

Background:Giardia intestinalis is one of the most common causes of diarrhoea worldwide. Molecular techniques have greatly improved our understanding of the taxonomy and epidemiology of this parasite. Co-infection with mixed (sub-) assemblages has been reported, however, Sanger sequencing is sometimes unable to identify shared subtypes between samples involved in the same epidemiologically linked event, due to samples showing multiple dominant subtypes within the same outbreak. Here, we aimed to use a metabarcoding approach to uncover the genetic diversity within samples from sporadic and outbreak cases of giardiasis to characterise the subtype diversity, and determine if there are common sequences shared by epidemiologically linked cases that are missed by Sanger ***:We built a database with 1109 unique glutamate dehydrogenase (gdh) locus sequences covering most of the assemblages of G. intestinalis and used gdh metabarcoding to analyse 16 samples from sporadic and outbreak cases of giardiasis that occurred in New Zealand between 2010 and ***:There is considerable diversity of subtypes of G. intestinalis present in each sample. The utilisation of metabarcoding enabled the identification of shared subtypes between samples from the same outbreak. Multiple variants were identified in 13 of 16 samples, with Assemblage B variants most common, and Assemblages E and A present in mixed ***:This study showed that G. intestinalis infections in humans are frequently mixed, with multiple subtypes present in each host. Shared sequences among epidemiologically linked cases not identified through Sanger sequencing were detected. Considering the variation in symptoms observed in cases of giardiasis, and the potential link between symptoms and (sub-) assemblages, the frequency of mixed infections could have implications for our understanding of host–pathogen interactions.

关键词： DNA sequencing Epidemiology Genetic diversity Giardiasis Metabarcoding

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Intercropping effect on root growth and nitrogen uptake at different nitrogen levels

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Journal of Plant Ecology 2015年第4期8卷 380-389页

作者： Javier ramirez-garcia Helle J.Martens Miguel Quemada Kristian Thorup-Kristensen Dpto.Producción Vegetal:Fitotecnia ETSI AgrónomosAvd.Complutense s/nUniversidad Politécnica de Madrid28040 MadridSpain Department of Plant and Environmental Sciences University of CopenhagenHøjbakkegaards Alle 13DK-2630TaastrupDenmark

Aims Intercropping legumes and non-legumes may affect the root growth of both components in the mixture,and the non-legume is known to be strongly favored by increasing nitrogen(N)*** knowledge of how root systems affect the growth of the individual species is useful for understanding the interactions in intercrops as well as for planning cover cropping *** aim of this work was(i)to determine if different levels of N in the topsoil influence root depth(rD)and intensity of barley and vetch as sole crops or as an inter-cropped mixture and(ii)to test if the choice of a mixture or the N availability in the topsoil will influence the N uptake by deep *** In this study,we combined rhizotron studies with root extraction and species identification by microscopy with studies of growth,N uptake and 15N uptake from deeper soil layers,for studying the root interactions of root growth and N foraging for barley(Hordeum vul-gare l.)and vetch(Vicia sativa l.),frequently grown in mixtures as cover crops.N was added at 0(N0),50(N1)and 150(N2)kg N ha−*** roots discrimination relying on the anatomical and morphologi-cal differences observed between dicots and monocots proved to be a reliable method providing valuable data for the *** Findingsthe intercrop and the barley attained slightly higher root intensity(rI)and rD than the vetch,with values around 150 crosses m−1 and 1.4 m,respectively,compared to 50 crosses m−1 and 0.9 m for the *** deep soil layers,intercropping showed slightly larger rI values compared to the sole-cropped *** barley and the intercropping had larger root length density(r D)values(200-600 m m−3)than the vetch(25-130)at 0.8-1.2 m *** topsoil N supply did not show a clear effect on the rI,rD or r D;however,increasing topsoil N favored the proliferation of vetch roots in the intercropping at deep soil layers,with the barley:vetch root ratio ranging from 25 at N0 to 5 at *** N uptake of the barley was

关键词： grasses legumes cover crops crop mixture root discrimination labeled N

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Submegahertz spectral width photon pair source based on fused silica microspheres

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Photonics Research 2021年第11期9卷 2237-2252页

作者： ERASTO ORTIZ-RICARDO CESAR BERTONI-OCAMPO MONICA MALDONADO-TERRON ARTURO garcia ZURITA ROBERTO ramirez-ALARCON HECTOR CRUZ ramirez R.CASTRO-BELTRAN ALFRED B.U’REN Instituto de Ciencias Nucleares Universidad Nacional Autonoma de MexicoApartado Postal 70-54304510 MexicoD.F.Mexico Centro de Investigaciones en Optica A.C. Loma del Bosque 115Colonia Lomas del Campestre37150 LeonGuanajuatoMexico Departamento de Ingenieria Fisica Cuerpo Academico de Mecanica EstadisticaDivison de Ciencias e IngenieriasUniversidad de Guanajuato37150 LeonGuanajuatoMexico

High-efficiency submegahertz bandwidth photon pair generators will enable the field of quantum technology to transition from laboratory demonstrations to transformational applications involving information transfer from photons to *** spontaneous parametric processes are able to achieve high-efficiency photon pair generation,the spectral bandwidth tends to be relatively large,as defined by phase-matching *** solve this fundamental limitation,we use an ultrahigh quality factor(Q)fused silica microsphere resonant cavity to form a photon pair *** present the full theory for the spontaneous four-wave mixing(SFWM)process in these devices,fully taking into account all relevant source characteristics in our *** exceptionally narrow(down to kilohertz-scale)linewidths of these devices result in a reduction in the bandwidth of the photon pair generation,allowing submegahertz spectral bandwidth to be ***,using a pump source centered around 1550 nm,photon pairs with the signal and idler modes at wavelengths close to 1540 and 1560 nm,respectively,are *** herald a single idler-mode photon by detecting the corresponding signal photon,filtered via transmission through a wavelength division multiplexing channel of *** demonstrate the extraction of the spectral profile of a single peak in the single-photon frequency comb from a measurement of the signal–idler time of emission *** improvements in device design and experimental methods enabled the narrowest spectral width(Δν=366 k Hz)to date in a heralded single-photon source based on SFWM.

关键词： fused silica spectral

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Is device-measured vigorous physical activity associated with health-related outcomes in children and adolescents? A systematic review and meta-analysis

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Journal of Sport and Health Science 2021年第3期10卷 296-307页

作者： Antonio garcia-Hermoso Yasmin Ezzatvar Robinson ramirez-Velez Jordi Olloquequi Mikel Izquierdo Navarrabiomed Navarra Hospital Complex(CHN)Public University of Navarra(UPNA)IdiSNAPamplona 31008Spain University of Santiago of Chile(USACH) Sciences of Physical ActivitySports and Health SchoolSantiago 71783-5Chile Exercise Intervention for Health Research Group(EXINH-RG) Department of PhysiotherapyUniversitat de ValenciaValencia 46010Spain Institute of Biomedical Sciences Faculthy of Health SciencesUniversidad Autonoma de ChileTalca 3460000Chile

Objective:This study sought to analyze the prospective association between vigorous-intensity physical activity(VPA)and health-related outcomes in children and ***:Studies reporting associations between device-measured VPA and health-related factors in children and adolescents aged 318 years were identified through database searches(MEDLINE,EMBASE,and SPORTDiscus).Correlation coefficients were pooled if outcomes were reported by at least 3 studies,using DerSimonian-Laird random effects ***:Data from 23 studies including 13,674 participants were pooled using random effects *** associations were found between VPA at baseline and overall adiposity(r=0.09,95%confidence interval(95%CI):0.15 to0.03;p=0.002;I^(2)=89.8%),cardiometabolic risk score(r=0.13,95%CI:0.24 to0.02,p=0.020;I^(2)=69.6%),cardiorespiratory fitness(r=0.25,95%CI:0.150.35;p<0.001;I^(2)=57.2%),and total body bone mineral density(r=0.16,95%CI:0.06 to 0.25;p=0.001;I^(2)=0%).Conclusion:VPA seems to be negatively related to adiposity and cardiometabolic risk score and positively related to cardiorespiratory fitness and total body bone mineral density among children and adolescents at ***,our findings support the need to strengthen physical activity recommendations regarding VPA due to its health benefits in children and adolescents.

关键词： Accelerometry Adiposity Fitness Physical activity

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Tentative Identification of Phytochemicals and Antioxidant Activities during Fruit-Ripening on Chamaedorea radicalis Mart.

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Phyton-International Journal of Experimental Botany 2020年第2期89卷 361-373页

作者： Gerardo Montelongo-Ruiz Yolanda del Rocio Moreno-ramirez Maria Cruz Juarez-Aragon NohemiNino-garcia Reyna Ivonne Torres-Acosta Torres-Castillo Jorge Ariel Universidad Autonoma de Tamaulipas Instituto de Ecologia AplicadaCiudad Victoria87019Mexico Universidad Autonoma de Tamaulipas Unidad Academica Multidisciplinaria ManteCiudad Mante89840Mexico

This work aims to determine the phytochemical characterization of the pericarp of Chamaedorea radicalis *** as a non-timber product with potential to obtain phytochemicals with potential applications in the *** from *** were grouped in four ripening stages named as S1,S2,S3 and S4,according to maturity;S1 the most unripe stage and S4 the completely ripe *** of total phenolic compounds,free radical scavenging activities and total flavonoid contents using spectrophotometric methods were ***,the tentative identification of phytochemicals during fruit ripening was done using *** phenolic compound(TPC)content ranged from 7.24 to 12.53 mg gallic acid equivalents per gram of fresh weight(mg GAE/g FW).Total flavonoids(TF)contents ranged from 0.163 to 0.23 mg of quercetin equivalents per g FW(mg QE/g FW).Free radical scavenging activity against DPPH and ABTS radicals varied from 40.80 to 53.68 and from 22.29 to 37.76 mmol Trolox equivalents g FW(mmol TE/g FW),*** assay in vitro by FRAP(ferric reducing antioxidant power)method showed that S3 was the highest level with antioxidant power while S4 was the lowest with Red ripeness stage showed the lowest contents for all *** spectrometry allowed detection of 26 compounds,including phenolics,alkaloids and ***,Kaempferol 3-neohesperidoside and the four saponins identified were present in all ripeness *** phytochemical identification and the spectrophotometric determinations showed that the pericarp of *** presented antioxidants and compounds related to alkaloids,phenolics and *** presence and abundance of each phytochemical regarding each ripeness stage should be considered.

关键词： Metabolite identification palm free radical scavenging phenolic compounds saponins

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Strong emissions of blue-yellow-red regions of La and Ti modified KNaNbO_(3) ferroelectric ceramics

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Journal of Advanced Ceramics 2015年第3期4卷 183-189页

作者： M.D.DURRUTHY-RODRIGUEZ M.HERNANDEZ-garcia J.PORTELLES J.FUENTES M.A.HERNANDEZ-LANDAVERDE M.ramirez CARDONA J.M.YANEZ-LIMON Departamento de Fisica Aplicada Instituto de CiberneticaMatematica y FisicaCITMA15#551VedadoLa HabanaCP 10400Cuba Facultad de Fisica Universidad de La HabanaSan Lazaro y LVedadoLa HabanaCP 10400Cuba CINVESTAV-Unidad Queretaro IPNLibramiento Norponiente 2000Fracc.Real de JuriquillaCP 76230QueretaroMexico Centro de Investigaciones en Ciencias de la Tierra y Materiales Universidad Autonoma del Estado de HidalgoMexico

In this work,the results of the study on the optical properties of the perovskite structure ABO3 with La^(3+) substitution for ions K^(+) and Na^(+) in the A site and Ti^(4+) substitution for ion Nb^(5+) in the B site are *** ceramics were sintered at 1100℃ and 1190℃ and formed at 10 MPa and 80 *** ceramics were obtained with 94% of the theoretical *** piezoresponse force microscopy(PFM)showed needle-shaped grains with a size of 30 nm for the samples formed at 10 MPa at both sintering ***,the high temperature and high pressure used in formation reduced the energy of the band gap(Eg)from 3.36 to 3.09 *** emissions to 2.19,1.86,2.5,and 2.31 eV were obtained by exciting the samples at 325,373,457,and 500 nm,respectively;these emissions corresponded to blue-yellow-red regions of the visible spectrum.

关键词： emission spectra condense matter ferroelectric materials band structure X-ray diffraction(XRD)

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Beneficial effects of saffron(Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases

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Neural Regeneration Research 2020年第8期15卷 1408-1416页

作者： Jose A.Fernandez-Albarral Rosa de Hoz Ana I.ramirez Ines Lopez-Cuenca Elena Salobrar-garcia Maria D.Pinazo-Duran Jose M.ramirez Juan J.Salazar Instituto de Investigaciones Oftalmologicas Ramon Castroviejo MadridSpain Departamento de Inmunologia Oftalmologia y ORLFacultad de Optica y OptometriaMadridSpain Departamento de Inmunologia Oftalmologia y ORLFacultad de MedicinaMadridSpain Unidad de Investigacion Oftalmologica Santiago Grisolia Universidad de ValenciaValenciaSpain

Saffron(Crocus sativus L.)has been traditionally used in food preparation and as a medicinal *** currently has numerous therapeutic properties attributed to it,such as protection against ischemia,as well as anticonvulsant,antidepressant,anxiolytic,hypolipidemic,anti-atherogenic,anti-hypertensive,antidiabetic,and anti-cancer *** addition,saffron has remarkable beneficial properties,such as anti-apoptotic,anti-inflammatory and antioxidant activities,due to its main metabolites,among which crocin and crocetin stand ***,increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases,such as Parkinson’s and Alzheimer’s diseases,both in experimental models and in clinical studies in ***,saffron supplementation is being tested for ocular neurodegenerative pathologies,such as diabetic retinopathy,retinitis pigmentosa,age-related macular degeneration and glaucoma,among others,and shows beneficial *** present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular *** review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases.

关键词： AMD crocetin crocin Crocus sativus L. diabetic retinopathy glaucoma neuroprotection ocular diseases retinitis pigmentosa saffron safranal

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