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Extensive adhesion formation in a total knee replacement in the setting of a gastrointestinal stromal tumor:A case report

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World j.urnal of Orthopedics 2022年第5期13卷 538-543页

作者： Steven Mitchell anderson Lee ryan Stenquist David YatsonskyⅡ Megan L Mooney Vithal B Shendge Department of Orthopaedic Surgery The University of Toledo Medical CenterToledoOH 43614United States

BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare primary neoplasms of the gastrointestinal tract,accounting for 1%to 2%of all gastrointestinal neoplasms *** are frequently discovered incidentally during workup for other diagnosis or intestinal obstruction,as they can present with few or no ***,GISTs confer a high degree of malignant transformation,with a progression in about 10%to 30%of *** SUMMARY A 63-year-old healthy female presented to our institution with complaints of right knee pain and limited passive and active motion in the setting of a previous right total knee arthroplasty(TKA).One year after TKA,the patient was incidentally diagnosed with a GIST,which was successfully *** removal,the patient continued to have limited range of motion of the right knee and subsequently underwent revision *** significant fibrotic adhesions were found encapsulating the femoral and tibial *** patient’s pain improved postoperatively,however,she continued to have decreased range of motion with difficulty *** We propose that this case may demonstrate a proinflammatory milieu arising from a GIST,which had a direct influence on the outcome of recent total knee *** proposed mechanism between neoplastic cytokinetic activity and adhesion formation could have implications on preoperative and postoperative orthopedic management of total knee arthroplasty.

关键词： Gastrointestinal stromal tumor Adhesion formation Total knee arthroplasty Inflammatory response Decreased range of motion Case report

Thrombospondin-1 Expression in RPE and Choroidal Neovascular Membranes

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眼科学报 2006年第4期22卷 265-274页

作者： Shikun He Francesca Incardona Manlin j. Stephen j. ryan David R. Hinton Departments of Patholog Keck School of Medicine of the University of Southern Cdifornia Ophthalmology Keck School of Medicine of the University of Southern Cdifornia Doheny Eye Institute Los A ngeles CA

Purpose: To investigate the expression of thrombospondin 1 (TSP-1) in retinal pigment epithelium (RPE) and choroidal neovascular membranes (CNVMs) from patients with age-related macular degeneration (AMD). Methods: Tissue sections from normal human fetal and adult eyes and surgically removed CNVMs were immunostained for TSP-1 localization. Polymerase chain reaction and Western blotting were used to analyze TSP-1 mRNA and protein from human RPE cells, respectively. TSP-1 in the supernatant of cultured RPE cells and eye explants were measured using enzyme-linked immunosorbent assay. MTT assay was used to evaluate the RPE survival after TSP-1 treatment. Results: The strongest immunostaining for TSP-1 was observed in the RPE monolayer around drusen in early AMD. The intensity of TSP-1 staining in normal eye sections was much weaker than that of early AMD and CNVM. TSP-1 mRNA was positive in cultured fetal and adult RPE cells. There was increasing secretion of TSP-1 into the supernatant of cultured RPE and eye explants. The specific band of TSP-1 was identified by Western blot. No significant inhibition of RPE survival was found with the exposure to TSP-1. Conclusions: TSP-1 expression in drusen and CNVM was upregulated and associated with RPE monolayer. TSP-1 may be a natural negative regulator for choroidal neovascularization.

关键词： thrombospondin 1 retinal pigment epithelium choroidal neovascular membrane

Role of ion channels in gastrointestinal cancer

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World j.urnal of Gastroenterology 2019年第38期25卷 5732-5772页

作者： Kyle j.anderson Robert T Cormier Patricia M Scott Department of Biomedical Sciences University of Minnesota Medical School

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer *** functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of *** this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and *** members of the TRP superfamily,including TRPM8,TRPM7,TRPM6 and TRPM2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon ***-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle *** VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC *** have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer ***2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all maj.r GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).More than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal *** distinct types of K+channels are found dysregulated in the GI *** are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CR

关键词： Ion channels Gastrointestinal cancer Colorectal cancer Gastric cancer Pancreatic cancer Esophageal cancer Hepatocellular carcinoma Prognostic biomarker Novel therapies Clinical targets

Practical Aspects for Designing Statistically Optimal Experiments

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j.urnal of Statistical Science and Application 2014年第3期2卷 85-92页

作者： Mark j. anderson Patrick j. Whitcomb Stat-Ease Inc. Minneapolis MN USA

Due to operational or physical considerations, standard factorial and response surface method （RSM） design of experiments （DOE） often prove to be unsuitable. In such cases a computer-generated statistically-optimal design fills the breech. This article explores vital mathematical properties for evaluating alternative designs with a focus on what is really important for industrial experimenters. To assess ＂goodness of design＂ such evaluations must consider the model choice, specific optimality criteria （in particular D and I）, precision of estimation based on the fraction of design space （FDS）, the number of runs to achieve required precision, lack-of-fit testing, and so forth. With a focus on RSM, all these issues are considered at a practical level, keeping engineers and scientists in mind. This brings to the forefront such considerations as subj.ct-matter knowledge from first principles and experience, factor choice and the feasibility of the experiment design.

关键词： design of experiments optimal design response surface methods fraction of design space.

Lipid droplet dynamics in alcoholic fatty liver disease

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Liver Research 2019年第3期3卷 185-190页

作者： ryan j.Schulze Wen-Xing Ding Department of Biochemistry and Molecular Biology and the Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA Department of Pharmacology Toxicologyand TherapeuticsThe University of Kansas Medical CenterKansas CityKSUSA

The rising incidence of alcohol-related liver disease(ALD)demands making urgent progress in understanding the fundamental molecular basis of alcohol-related hepatocellular *** of the key early events accompanying chronic alcohol usage is the accumulation of lipid droplets(LDs)in the hepatocellular *** are far from inert sites of neutral lipid storage;rather,they represent key organelles that play vital roles in the metabolic state of the *** this review,we will examine the biology of these structures and outline recent efforts being made to understand the effects of alcohol exposure on the biogenesis,catabolism,and motility of LDs and how their dynamic nature is perturbed in the context of ALD.

关键词： Lipid droplet(LD) Alcohol Autophagy Lipolysis Hepatocyte Steatosis

Should we have a guard against therapeutic nihilism for patients with severe traumatic brain inj.ry?

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Neural Regeneration Research 2017年第11期12卷 1801-1803页

作者： ryan Hirschi Casey Rommel Gregory W.j.Hawryluk School of Medicine University of UtahSalt Lake CityUTUSA Department of Biomedical Informatics School of MedicineUniversity of UtahSalt Lake CityUTUSA Department of Neurological Surgery University of UtahClinical Neurosciences CenterSalt Lake CityUTUSA

Many clinicians would agree that a vegetative outcome is a fate worse than death after a severe traumatic brain inj.ry （TBI）. In an effort to avoid poor outcomes of this nature, neurotrauma practitioners draw from their training and experience to make the monumental decision of when to recommend against aggressive care in severe TBI patients. Such j.dgements are,

关键词： guard against therapeutic evere traumatic

Does sexual dimorphism vary by population? Laryngeal and ear anatomy in cricket frogs

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Current Zoology 2019年第3期65卷 343-352页

作者： Blinda E.MCCLELLAND Michael j.ryan Walter WILCZYNSKI Department of Integrative Biology University of Texas at Austin Austin TX 78712 USA Neuroscience Institute and Center for Behavioral Neuroscience Georgia State University Atlanta GA 30303 USA

Acoustic communication in many anuran species can show the effects of both natural and sexual selection. This is reflected in the sexually dimorphic an atomy of the lary nx and ear structures, as well as the allometric relationship of these morphological traits to head or body size. In this study, we examined laryngeal and ear structures of cricket frogs Acris crepitans not only as sexually dimorphic characteristics, but also as they differ across populations in environmentally different habitats. We used 2-way ANOVA to determine whether the volumetric or linear measurements of these structures differed by sex and population. Females have significantly larger body, head, and ear sizes, but significantly smaller larynges than males. Furthermore, females as well as males show larger body and head sizes, ears, and larynges in a dryer open habitat. An ANCOVA analysis shows that males, but not females, differ in laryngeal size across populations beyond the allometric changes attributable to head size alone indicating that males have a greater degree of laryngeal population variation. In contrast, our covariate analysis found that in both sexes many of the ear differences are non-sigrdficant once head size is accounted for, suggesting that most of the population-level ear variation is due to allometric effects of body size. We conclude that although both sexes show size differences in the larynx related to selection for larger body size in dry, open habitats, selection on males for larger larynx size related to the production of lower frequency calls in those habitats does not result in correlated changes in the female larynx. The results suggest that in anurans, selection for changes in body and head size affects both sexes equally, male calls and the vocal structures responsible for them can further diversify without concordant changes in females.

关键词： acoustic communication allometry amphibians population variation sex differences

Simulation of an Antimatter Beam Core Engine for Space Travel

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j.urnal of Modern Physics 2019年第11期10卷 1353-1363页

作者： Matthew Dubiel ryan j. Hooper Department of Physics Lewis University Romeoville Illinois USA

An exciting prospect is the use of antimatter as a fuel source due to its ability to convert mass energy to kinetic energy. Upon annihilation of antimatter with matter, tremendous amounts of energy are carried away by charged and neutral particles. By redirecting the charged particles through an exhaust using a non-uniform magnetic field, an impulse can be generated capable of supplying thrust to an engine. Using the Geant 4 simulation toolkit developed by CERN, we simulate this process using a beam core engine design. By analyzing charged pions that result from antiproton-proton annihilation, we optimize the engine parameters and derive a specific impulse for antiproton fuel as used in the beam core configuration. A specific impulse of (2.49 ± 0.08) × 106 s was determined. This value is significantly higher than specific impulses of current chemical rocket fuels which range from 240 - 400 s.

关键词： Antimatter Antiproton Annihilation Space Travel Geant4

Physical activity,exercise,and chronic diseases:A brief review

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Sports Medicine and Health Science 2019年第1期1卷 3-10页

作者： Elizabeth anderson j.Larry Durstine Department of Exercise Science University of South CarolinaColumbiaSCUSA

Chronic diseases are the leading cause of death worldwide with increasing prevalence in all age groups,genders,and *** chronic disease deaths occur in middle-to low-income countries but are also a significant health problem in developed *** chronic diseases now affect children and adolescents as well as *** physically inactive is associated with increased chronic disease *** societies are being negatively impacted by the increasing prevalence of chronic disease which is directly related to rising healthcare expenditures,workforce complications regarding attendance and productivity,military personnel recruitment,and academic ***,increased physical activity(PA)and exercise are associated with reduced chronic disease *** physiologic systems in the body benefit positively from PA and exercise by primary disease prevention and secondary disease prevention/*** purpose of this brief review is to describe the significant global problem of chronic diseases for adults and children,and how PA and exercise can provide a noninvasive means for added prevention and treatment.

关键词： Chronic disease Noncommunicable diseases Obesity Diabetes Cardiovascular disease Cancer Physical activity Exercise