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饲养策略调控肉质的研究进展

国外畜牧学（猪与禽） 2006年第5期26卷 53-57页

作者：韩立明黄香文 Henrik j. anderson 丹麦农业学院食品科学系

前言从传统角度来看,'肉质'这个词涵盖了决定肉的适口性、深加工能力以及储存(包括零售展示)能力等性状的内在特性.人们主要关注肉的安全性、营养价值、风味、质地、系水力、色泽、脂肪含量及组成、氧化稳定性和质量均一性等.肉质被认... 详细信息

前言从传统角度来看,'肉质'这个词涵盖了决定肉的适口性、深加工能力以及储存(包括零售展示)能力等性状的内在特性.人们主要关注肉的安全性、营养价值、风味、质地、系水力、色泽、脂肪含量及组成、氧化稳定性和质量均一性等.肉质被认为是肉品的一个复杂而多元的特性,主要受管理系统、品种、基因型、饲养、宰前处理、击晕方式、屠宰方法、冷却方法及储藏条件等多种因素相互作用的影响.

关键词：饲养策略肉质调控加工能力氧化稳定性营养价值脂肪含量管理系统

维多利亚3个不同时期的极低出生体重儿童8岁时的感觉神经预后的改善

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世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 13-14页

作者： Doyle L.W. anderson P.j. 李开 Department of Obstetrics Royal Women's Hospital 132 Grattan St Carlton Vic. 3053 Australia

Aim: To determine neurosensory outcome at 8 years of age of extremely low birthweight (ELBW) children born in the 1990s, how it varies with birth weight, and how it compares with ELBW children born in the 1980s and 1970s. Methods: Subjects were born in the state of Victoria during 1991- 92 and comprised 224 of 241 consecutive survivors with a birth weight of 500- 999 g, and 223 of 262 normal birthweight (NBW) controls who had been randomly selected at birth. The comparison cohorts from earlier eras comprised 87 of 89 consecutive ELBW survivors born in 1979- 80, 206 of 212 consecutive ELBW survivors born in 1985- 87, and 51 of 60 randomly selected NBW survivors born in 1981- 82. Survivors were assessed for neurological impairments (cerebral palsy, blindness, deafness, intellectual impairment) and disabilities at 8 years of age by paediatricians and psychologists blinded to perinatal details. Results: For the 1991- 92 cohorts, the rate of neurosensory disability was substantially higher in ELBW children compared with NBW controls (P < 0.0001). Within the ELBW group, neurosensory disability was more prevalent in children with a birth weight of < 750 g compared with a birth weight of 750- 999 g (P=0.024). Disability rates were lower in the 1991- 92 ELBW cohort compared with the ELBW cohort born in 1979- 80 (p = 0.046). Conclusions: Neurosensory disability rates at school age were more common in ELBW children born in the 1990s compared with NBW controls, and were significantly more common in the 500- 749 g birthweight subgroup, but have improved compared with ELBW children born in earlier eras.

关键词：存活者学龄期脑性瘫痪神经功能障碍智力缺陷存活儿亚组儿科医师受试对象围生期

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反射式中继光学系统在激光偏转系统中的应用

计算机工程与应用 1978年第10期 76-80页

作者： R.j.anderson ,C.Larson ,朱广仁

光束偏转器的两个轴之间的光耦合,采用反射式中继系统很容易实现。这种系统与折射式比较损耗小,成本低,而且容易调整。主要的缺点是,中继系统必须偏轴工作,在按另一种形式的正交扫描轴之间产生了相互影响。然而这种相互影响可以用电的方... 详细信息

光束偏转器的两个轴之间的光耦合,采用反射式中继系统很容易实现。这种系统与折射式比较损耗小,成本低,而且容易调整。主要的缺点是,中继系统必须偏轴工作,在按另一种形式的正交扫描轴之间产生了相互影响。然而这种相互影响可以用电的方法,即在偏转放大器之间加上一个适当的耦合网络来得到消除。反射式中继系统的样机已经运用,而且达到了每轴大于1000个可分辨单元的分辨力(用2cm孔径),其精度大于0.5％。

关键词：光束偏转器孔径分辨单元分辨力反光镜球面焦面反射镜曲面通信传输系统中继系统反射式扫描角光学系统

Comparison of cognitive and UHDRS measures in monitoring disease progression in Huntington’s disease: a 12-month longitudinal study

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Translational Neurodegeneration 2014年第1期3卷 109-118页

作者： Eng A Toh Michael R MacAskill john C Dalrymple-Alford Daniel j Myall Leslie Livingston Sandy AD Macleod Tim j anderson Department of Medicine Christchurch School of Medicine&Health SciencesUniversity of OtagoChristchurchNew Zealand New Zealand Brain Research Institute ChristchurchNew Zealand Department of Psychology University of CanterburyChristchurchNew Zealand Brain Injury Rehabilitation Service Canterbury District Health BoardChristchurchNew Zealand Department of Neurology Canterbury District Health BoardChristchurchNew Zealand

Progressive cognitive decline is a feature of Huntington’s disease(HD),an inherited neurodegenerative movement *** neuropsychological testing is the‘gold standard’to establish cognitive status but is often impractical in time-constrained *** study evaluated the utility of brief cognitive tests(MMSE and MoCA),UHDRS measures and a comprehensive neuropsychological tests battery in monitoring short-term disease progression in ***-two manifest HD patients and 22 matched controls were assessed at baseline and 12-month.A linear mixed-effect model showed that although the HD group had minimal change in overall global cognition after 12 months,they did show a significant decline relative to the control *** controls exhibited a practice effect in most of the cognitive domain scores over *** decline at 12-month in HD was found in the executive function domain but the effect of this on global cognitive score was masked by the improvement in their language domain *** varying practice effects by cognitive domain with repeated testing indicates the importance of comparing HD patients to control group in research trials and that cognitive progression over 12 months in HD should not be judged by changes in global cognitive *** three brief cognitive tests effectively described cognition of HD patients on cross-sectional *** UHDRS cognitive component,which focuses on testing executive function and had low variance over time,is a more reliable brief substitute for comprehensive neuropsychological testing than MMSE and MoCA in monitoring cognitive changes in HD patients after 12 months.

关键词： Huntington’s disease Disease progression Cognition UHDRS Longitudinal

Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI)

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Translational Neurodegeneration 2017年第1期6卷 165-173页

作者： Ann j.jones Roeline G.Kuijer Leslie Livingston Daniel Myall Kyla Horne Michael MacAskill Toni Pitcher Paul T.Barrett Tim j.anderson john C.Dalrymple-Alford New Zealand Brain Research Institute 66 Stewart StreetChristchurch 8011New Zealand Department of Psychology University of CanterburyChristchurchNew Zealand Department of Medicine University of OtagoChristchurchNew Zealand Cognadev UK Ltd.SandtonSouth Africa Department of Neurology Christchurch HospitalChristchurchNew Zealand Brain Research New Zealand Centre of Research Excellence ChristchurchNew Zealand

Background:There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease(PD-MCI)and the coping strategies used by these ***:To investigate this relationship,we examined levels of burden,depression,anxiety,coping strategies and positive aspects of caregiving in the informal caregivers of 96 PD *** PD patients were classified using MDS-Task Force Level II criteria as showing either normal cognition(PD-N;n=51),PD-MCI(n=30)or with dementia(PDD;n=15).Results:Mean Zarit Burden Interview(ZBI)score increased significantly between carers of PD-N(M=13.39,SD=12.22)compared to those of PD-MCI patients(M=22.00,SD=10.8),and between carers of PD-MCI and PDD patients(M=29.33,SD=9.59).Moreover,the proportion of carers showing clinically significant levels of burden(ZBI score≥21)also increased as the patients’cognitive status declined(18% for PD-N;60% for PD-MCI;and 80%for PDD)and was mirrored by an increasing amount of time spent providing care by the *** ZBI score was independent of patient neuropsychiatric symptoms,motor function,disease duration and time that caregivers spent *** use of different coping strategies increased with worsening ***,we found only equivocal evidence that the use of problem-focused,emotion-focused and dysfunctional coping mediated the association between patient cognitive status and caregiver burden,because the inverse models that used caregiver burden as the mediator were also ***:The study highlights the impact of Parkinson’s disease on those providing care when the patient’s cognition is poor,including those with *** well-being has important implications for caregiver support,nursing home placement and disease course.

关键词： Parkinson’s disease Mild cognitive impairment Zarit caregiver burden interview Coping Depression Anxiety Positive aspects of caregiving

新致病基因在颅缝早闭Crouzon综合征中的初步机制研究

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组织工程与重建外科杂志 2012年第5期8卷 256-263页

作者：杨娴娴 jodie T Hatfield Susan j Hinze 穆雄铮 Peter j anderson Barry C Powell 上海交通大学医学院附属第九人民医院整复外科上海市200011 澳大利亚颅颌面外科中心阿德莱德妇女儿童健康研究中心复旦大学医学院附属华山医院整形外科上海市200040

目的研究Rbp4(Retinol binding protein 4)、Gpc3(Glypican family of growth factor binding protein 3)、C1qtnf3(Collagenous repeat-containing sequence of 26 KDa protein)等新致病基因在颅缝早闭症中的发病机制,为疾病非手术治疗奠定理论基础。方法以Crouzon综合征Fgfr2cC342Y/+小鼠为实验模型,应用MicroCT和组织学染色,研究小鼠颅缝闭合模式;以Fgfr2cC342Y/+模型,RT-qPCR研究Rbp4、Gpc3、C1qtnf3等新致病基因的表达差异,初步探讨其在颅缝闭合过程中的调控作用;以体外培养的Fgfr2cC342Y/+小鼠颅缝细胞为模型,研究基因突变动物细胞增殖与代谢改变。结果获得Fgfr2cC342Y/+小鼠后额缝、冠状缝、人字缝、矢状缝等颅缝闭合模式,随颅骨发育、颅缝闭合,OC(Osteocalcin)、ALP(Alkalinephosphatase)表达增加,目的基因Rbp4、Gpc3、C1qtnf3表达下降,Msx2(Muscle segment homeobox gene 2)表达增加,杂合子与野生型小鼠之间均存在显著统计学差异,与前期人颅缝组织Microarray研究结果一致。Gpc1(Glypican family ofgrowth factor binding protein 1)、FliI(Flightless I)在颅缝闭合中的表达较恒定,野生型与杂合子之间未见明显统计学差异。体外培养Fgfr2cC342Y/+小鼠颅缝细胞,CellTiter96 MTS和Quant-iT Picogreen dsDNA细胞增殖与代谢分析结果显示,Fgfr2功能获得性突变可促进冠状缝细胞的增殖,从而导致成骨增加,颅缝早闭。结论 Fgfr2cC342Y/+模型新致病基因表达趋势与前期人颅缝组织Microarray研究结果一致,Rbp4、Gpc3、C1qtnf3可能在颅缝早闭中具重要调控作用。

关键词：颅缝早闭症 Fgfr2cC342Y/+小鼠 Crouzon综合征 RT-qPCR 微量CT Rbp4 Gpc3 Clqtnf3

颅缝早闭症相关实验荧光定量PCR内参基因的选择研究

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组织工程与重建外科杂志 2012年第3期8卷 140-145页

目的探讨用于颅缝早闭症相关实验的荧光定量PCR的最佳内参基因。方法应用与颅骨成骨、颅缝闭合相关的3组实验标本,分别为:Fgfr2cC342Y/+Crouzon综合征小鼠颅缝组织、颅缝早闭患者体外培养颅缝原代细胞和体外培养的小鼠Kusa 4b 10成骨细... 详细信息

目的探讨用于颅缝早闭症相关实验的荧光定量PCR的最佳内参基因。方法应用与颅骨成骨、颅缝闭合相关的3组实验标本,分别为:Fgfr2cC342Y/+Crouzon综合征小鼠颅缝组织、颅缝早闭患者体外培养颅缝原代细胞和体外培养的小鼠Kusa 4b 10成骨细胞株。以常用的候选管家基因作为研究对象,利用geNorm软件对RT-qPCR结果进行比较分析,以筛选出在不同组织细胞中表达最为稳定的管家基因作为内参。结果Fgfr2cC342Y/+小鼠颅缝组织,Cyc1-Gapdh-Canx为最佳组合;颅缝早闭症患者体外培养颅缝原代细胞,18S rRNA和ATP5B为最佳组合;体外培养的小鼠Kusa 4b10成骨细胞株,18S rRNA和Canx为最佳组合。选择不同内参基因对目的基因RT-qPCR的结果影响显著。结论在设计RT-qPCR实验之前,应针对所选择的标本类型与种类进行管家基因稳定性分析,以增加结果的可信度。

关键词：颅缝早闭症荧光定量聚合酶链反应geNorm分析

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新生儿MRI可预测早产儿的神经发育预后

世界核心医学期刊文摘(神经病学分册) 2006年第12期 3-4页

作者： Woodward L.j. anderson P.j. Austin N.C. 郭俊 Dr.Canterbury Child Development Research Group Department of PsychologyUniversity of CanterburyPrivate Bag 4800ChristchurchNew Zealand

BACKGROUND:Very preterm infants are at high risk for adverse neurodevelopmental *** resonance imaging(MRI)has been proposed as a means of predicting neurodevelopmental outcomes in this ***:We studied 167 very preterm infants(gestational age at birth,30 weeks or less)to assess the associations between qualitatively defined white-matter and gray-matter abnormalities on MRI at term equivalent(gestational age of 40 weeks)and the risks of severe cognitive delay,severe psychomotor delay,cerebral palsy,and neurosensory(hearing or visual)impairment at 2 years of age(corrected for prematurity).RESULTS:At two years of age,17 percent of infants had severe cognitive delay,10 percent had severe psychomotor delay,10 percent had cerebral palsy,and 11 percent had neurosensory ***-to-severe cerebral white-matter abnormalities present in 21 percent of infants at term equivalent were predictive of the following adverse outcomes at two years of age:cognitive delay(odds ratio,3.6;95 percent confidence interval,1.5 to 8.7),motor delay(odds ratio,10.3;95 percent confidence interval,3.5 to 30.8),cerebral palsy(odds ratio,9.6;95 percent confidence interval,3.2 to 28.3),and neurosensory impairment(odds ratio,4.2;95 percent confidence interval,1.6 to 11.3).Gray-matter abnormalities(present in 49 percent of infants)were also associated,but less strongly,with cognitive delay,motor delay,and cerebral ***-to-severe white-matter abnormalities on MRI were significant predictors of severe motor delay and cerebral palsy after adjustment for other measures during the neonatal period,including findings on cranial ***:Abnormal findings on MRI at term equivalent in very preterm infants strongly predict adverse neurodevelopmental outcomes at two years of *** findings suggest a role for MRI at term equivalent in risk stratification for these infants.

关键词：神经发育新生儿早产儿预后

Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as Drug Delivery System

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journal of Biomaterials and Nanobiotechnology 2015年第1期6卷 53-63页

作者： Camila Rufino Souza Henrique R. Oliveira Wagner M. Pinheiro Lubhandwa S. Biswaro Ricardo B. Azevedo anderson j. Gomes Claure N. Lunardi Laboratory of Nanobiotechnology Faculty of Ceilandia University of Brasilia Brasilia Brazil Institute of Biological Sciences University of Brasilia Brasilia Brazil

In this study the novel hydrogel loaded with gold nanoparticle (AuNP) enhanced the berberine (BS) release when compared with other formulations of hydrogel. Hydrogels are hydrophilic polymer networks having the capacity to absorb water, ranging from about twenty to thousand times their dry weight. BS is a natural product, a quaternary ammonium salt from the group of isoquinoline alkaloids found in medicinal plants as Berberis Vulgaris. BS has some activity against dysentery, hypertension, inflammation, and liver disease in China and japan. In this work, BS was used as a model drug to study its association with different types of hydrogel composites of polyvinyl alcohol (BS-PVA 10%);gellan gum (BS-GG 2%), gellan gum-PVA crosslinked with cysteine (cys) (BSGG2%PVA2%cys) and gellan gum-PVA cosslinked with cysteine associated with gold nanoparticles (AuNP-BSGG2%PVA2%cys). Several parameters such as fraction of retained water (Wf), hydration percentage (%H), Swelling (DSw) and time course profile (t = 100%) (TC) were evaluated for all preparations. The results showed that the AuNP-BS-GG2%PVA2%cys was able to retain more water and swelling than the other preparations. The time course of release of the BS to the medium was greater for AuNP-BS-GG2%PVA2%cys making it a candidate to drug delivery studies in biological assays. Also Scanning Electron Microscopy (SEM) images of the surface of these hydrogel were performed. Furthermore, crosslink of the resulting hydrogels were investigated by Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Thus, briefly, the aim of this work was to study three composition of hydrogel loaded with BS and its composition in relation to addition to AuNP and evaluate its profile for further drug delivery application using the Surface Plasmonic Resonance (SPR) as a tool improving the drug release in the new hydrogel.

关键词： Hydrogel Berberine Drug Delivery AuNPs