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LIM kinases in synaptic plasticity and their potential as therapeutic targets

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Neural Regeneration Research 2020年第8期15卷 1471-1472页

作者： Éva Halász Ellen Townes-anderson Weiwei Wang Department of Pharmacology Physiology and NeuroscienceGraduate School of Biomedical SciencesRutgersThe State University of New JerseyNewarkNJUSA Grousbeck Gene Therapy Center Schepens Eye Research Institute and Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA

LIM domain kinases(LIMKs),which modulate cytoskeletal dynamics,are found throughout the central nervous *** synaptic junctions between neurons show structural alteration or plasticity during neurodevelopment,learning and memory formation,or after injury and disease;in some cases completely new connections form,while others are *** remodeling is under the control of the actin cytoskeleton and therefore is influenced by the activity of LIMKs(Scott and Olson,2007).Recent reports discussed in this perspective shed light on the potential role of LIMK in hippocampal dendritic spines and photoreceptor presynaptic terminals and illustrate the importance of LIMK in nerve cell function.

关键词： function. plasticity potential

The Use of Triancinolone for the Treatment of Keloid Scars

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 270-275页

作者： José Humberto Cardoso Resende Luís Otávio Torres anderson Alves Brandão Delma dos Santos Assis Mercadante Jessyka Oliveira Barbosa Batista William Felix de Oliveira Pacheco Elisangelo Aparecido Costa Da Silva Douglas Henrique Farias de Oliveira Nébia Maria Almeida de Figueiredo UNIFAN-Centro Universitrio Alfredo Nasser Aparecida de Goinia Brazil UNIRIO Rio de Janeiro Brazil

Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.

关键词： Keloid Scar Hypertrophy Collagen Affection

Adding Value to Crop Production Systems by Integrating Forage Cover Crop Grazing

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American Journal of Plant Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchell Daren D. Redfearn Kenneth P. Vogel Terry J. Klopfenstein Galen Erickson P. Stephen Baenziger Bruce E. anderson Mary E. Drewnoski Jay Parsons Steven D. Masterson Marty R. Schmer Virginia L. Jin USDA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA Department of Animal Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricultural Economics University of Nebraska-Lincoln Lincoln NE USA USDA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. Replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near Ithaca, NE, USA. Each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. In 2005, average daily gain (ADG) for steers grazing triticale exceeded the ADG for wheat by 0.31 kghd-1d-1. In 2006, wheat ADG exceeded that for triticale by 0.12 kghd-1d-1. In 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghd-1d-1. Based on the 3-year average animal gains valued at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat

HLA class Ⅰ loss in colorectal cancer:implications for immune escape and immunotherapy

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Cellular & Molecular Immunology 2021年第3期18卷 556-565页

作者： Per anderson Natalia Aptsiauri Francisco Ruiz-Cabello Federico Garrido Instituto de Investigaci6n Biosanitaria(ibs.GRANADA) GranadaSpain Servicio de Analisis Clinicos e Inmunologia Hospital Universitario Virgen de las Nieves18014 GranadaSpain Departamento de Bioqufmica Bioiogta Molecular 3 e InmunologiaUniversidad de GranadaGranadaSpain

T cell-mediated immune therapies have emerged as a promising treatment modality in different malignancies including colorectal cancer(CRC).However,only a fraction of patients currently respond to *** the lack of responses and finding biomarkers with predictive value is of great *** is evidence that CRC is a heterogeneous disease and several classification systems have been proposed that are based on genomic instability,immune cell infiltration,stromal content and molecular subtypes of gene *** leukocyte antigen class Ⅰ(HLA-Ⅰ)plays a pivotal role in presenting processed antigens to T lymphocytes,including tumour *** molecules are frequently lost in different types of cancers,including CRC resulting in tumour immune escape from cytotoxic T lymphocytes during the natural history of cancer *** aim of this review is to(i)summarize the prevalence and molecular mechanisms behind HLA-Ⅰ loss in CRC,(ii)discuss HLA-Ⅰ expression/loss in the context of the newly identified CRC molecular subtypes,(iii)analyze the HLA-Ⅰ phenotypes of CRC metastases disseminated via blood or the lymphatic system,(iv)discuss strategies to recover/circumvent HLA-I expression/loss and finally(v)review the role of HLA class Ⅱ(HLA-Ⅱ)in CRC prognosis.

关键词： Colorectal cancer Immune escape HLA ClassⅠ

Yet Another Intelligent Code-Generating System： A Flexible and Low-Cost Solution

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Journal of Computer Science & Technology 2018年第5期33卷 940-965页

作者： Joao Fabricio Filho Luis Gustavo Araujo Rodriguez anderson Faustino da Silva Department of Informatics State University of Maringd Maringd-PR 87020-900 Brazil Federal University of Technology -- Parand Campo Mourao-PR 87301-899 Brazil

Modern compilers apply various code transformation algorithms to improve the quality of the target code. However, a complex problem is to determine which transformation algorithms must be utilized. This is difficult because of three reasons： a number of transformation algorithms, various combination possibilities, and several configuration possibil- ities. Over the last few years, various intelligent systems were presented in the literature. The goal of these systems is to search for transformation algorithms and thus apply them to a certain program. This paper proposes a flexible, low-cost and intelligent system capable of identifying transformation algorithms for an input program, considering the program＇s specific features. This system is flexible for parameterization selection and has a low-computational cost. In addition, it has the capability to maximize the exploration of available computational resources. The system was implemented under the Low Level Virtual Machine infrastructure and the results indicate that it is capable of exceeding, up to 21.36%, performance reached by other systems. In addition, it achieved an average improvement of up to 17.72% over the most aggressive compiler optimization level of the Low Level Virtual Machine infrastructure.

关键词： compiler code transformation iterative compilation knowledge representation machine learning

On the development of optical peripheral nerve interfaces

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Neural Regeneration Research 2019年第3期14卷 425-436页

作者： Hans E.anderson Richard F.ff.Weir Department of Bioengineering University of Colorado Denver|Anschutz Medical Campus

Limb loss and spinal cord injury are two debilitating conditions that continue to grow in prevalence. Prosthetic limbs and limb reanimation present two ways of providing affected individuals with means to interact in the world. These techniques are both dependent on a robust interface with the peripheral nerve. Current methods for interfacing with the peripheral nerve tend to suffer from low specificity, high latency and insufficient robustness for a chronic implant. An optical peripheral nerve interface may solve some of these problems by decreasing invasiveness and providing single axon specificity. In order to implement such an interface three elements are required:(1) a transducer capable of translating light into a neural stimulus or translating neural activity into changes in fluorescence,(2) a means for delivering said transducer and(3) a microscope for providing the stimulus light and detecting the fluorescence change. There are continued improvements in both genetically encoded calcium and voltage indicators as well as new optogenetic actuators for stimulation. Similarly, improvements in specificity of viral vectors continue to improve expression in the axons of the peripheral nerve. Our work has recently shown that it is possible to virally transduce axons of the peripheral nerve for recording from small fibers. The improvements of these components make an optical peripheral nerve interface a rapidly approaching alternative to current methods.

关键词： peripheral nerve interfaces optogenetics optical neural interface optical peripheral nerve interface GCaMP ArcLight adenoassociated viral vector lentiviral vectors viral vectors implantable microscopy

Sexual selection affects the sizes of the mammalian prostate gland and seminal vesicles

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Current Zoology 2009年第1期55卷 1-8页

作者： Matthew J. anderson Alan F. DIXSON Conservation and Research for Endangered Species Zoological Society of San Diego School of Biological Sciences Victoria University of Wellington

The accessory reproductive glands of male mammals contribute the bulk of the secretions in which spermatozoa are transported to the female tract during copulation. Despite their morphological diversity, and the chemical complexity of their products, little is known about the possible effects of sexual selection upon these glands in mammals. Here we consider the seminal vesicles and prostate glands in a sample of 89 species and 60 genera representing 8 Orders of mammals. The sizes of the accessory glands are analysed in relation to body weight and testes weight. Both the seminal vesicles size and prostate size （corrected for body weight） correlate positively with relative testes size in this sample; this finding remains highly significant after application of procedures to correct for possible phylogenetic biases in the data set. The accessory reproductive glands are also significantly larger in those mammals which have large relative testes sizes, and in which the likelihood of sperm competition is greatest. These results support the hypothesis that sexual selection has played an important role in the evolution of the mammalian prostate gland and seminal vesicles.

关键词： Mammals Prostrate gland Seminal vesicles Sexual selection Sperm competition

From Lung to Brain:Respiration Modulates Neural and Mental Activity

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Neuroscience Bulletin 2023年第10期39卷 1577-1590页

作者： Josh Goheen John A.E.anderson Jianfeng Zhang Georg Northof The Royal Ottawa Mental Health Centre The University of OttawaOttawa K1Z 7K4Canada Department of Cognitive Science Carleton UniversityOttawa K1S 5B6Canada Center for Brain Disorders and Cognitive Sciences Shenzhen UniversityShenzhen 518060China School of Psychology Shenzhen UniversityShenzhen 518060China

Respiration protocols have been developed to manipulate mental states,including their use for therapeutic *** this systematic review,we discuss evidence that respiration may play a fundamental role in coordinating neural activity,behavior,and *** main findings are:(1)respiration affects the neural activity of a wide variety of regions in the brain;(2)respiration modulates different frequency ranges in the brain’s dynamics;(3)different respiration protocols(spontaneous,hyperventilation,slow or resonance respiration)yield different neural and mental effects;and(4)the effects of respiration on the brain are related to concurrent modulation of biochemical(oxygen delivery,pH)and physiological(cerebral blood flow,heart rate variability)*** conclude that respiration may be an integral rhythm of the brain’s neural *** provides an intimate connection of respiration with neuro-mental features like emotion.A respiratory-neuro-mental connection holds the promise for a brain-based therapeutic usage of respiration in mental disorders.

关键词： Respiration Cognition Emotion Heart rate variability Carbon dioxide

Mapping Between Charge-Dyon and Position-Dependent Mass Systems

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Communications in Theoretical Physics 2019年第10期71卷 1261-1266页

作者： anderson L.de Jesus Alexandre G.M.Schmidt Departamento de Fisica de Volta Redonda Instituto de Ciencias Exatas—Universidade Federal Fluminense

The primary purpose of this work is to reproduce the scenario composed of a charge-dyon system utilizing position-dependent effective mass(PDM) background in the non-relativistic and in the relativistic regimes. In the nonrelativistic case we substitute the exact charge-dyon eigenfunction into PDM Schr?dinger equation, in the Zhu-Kroemer parametrization, and then solve it for the mass distribution considering M = M(r). Analogously, in the relativistic case we study the Klein-Gordon equation for a position-dependent mass, and in this case, we are able to analytically solve the equation for M = M(r, θ).

关键词： position-dependent mass Schrodinger equation Klein-Gordon equation dyon