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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Integrative filtration research and sustainable nanotechnology

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Particuology 2013年第1期11卷 5-13页

作者： Jing Wang Drew thompson David y.H.Pui Institute of Environmental Engineering ETH Zurich 8093Switzerland Analytical Chemistry Empa8600 DubendorfSwitzerland Particle Technology Laboratory University of Minnesota55455USA

With the wide applications of nanomaterials in an array of industries, more concerns are being raised about the occupational health and safety of nanoparticles in the workplace, and implications ofnanotech- nology on the environment and living systems. Studies on environmental, health and safety （EHS） issues of nanomaterials play a significant role in public acceptance, and eventual sustainability, of nanotechnol- ogy. We present research results on three aspects of the EHS studies： characterization and measurement of nanoparticles, nanoparticle emission and exposure at workplaces, and control and abatement of nanoparticle release using filtration technology. Measurement of nanoparticle agglomerates using a newly developed instrument, the Universal Nanoparticle Analyzer, is discussed. Nanoparticle emission and exposure measurement results for carbon nanotubes in the manufacture of nanocomposites and for silicon nanoparticles in their production at a pilot scale facility are presented. Filtration of nanoparticles and nanoparticle agglomerates are also studied.

关键词： Agglomerate Sustainability Exposure Filtration Nano-EHS Nanoparticle

Investigation of carbon dioxide photoreduction process in a laboratory-scale photoreactor by computational fluid dynamic and reaction kinetic modeling

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Frontiers of Chemical Science and Engineering 2022年第7期16卷 1149-1163页

作者： Xuesong Lu Xiaojiao Luo Warren A.thompson Jeannie Z.y.Tan MMercedes Maroto-Valer Research Centre for Carbon Solutions School of Engineering and Physical SciencesHeriot-Watt UniversityEdinburgh EH144ASUK

The production of solar fuels via the photoreduction of carbon dioxide to methane by titanium oxide is a promising process to control greenhouse gas emissions and provide alternative renewable fuels. Although several reaction mechanisms have been proposed, the detailed steps are still ambiguous, and the limiting factors are not well defined. To improve our understanding of the mechanisms of carbon dioxide photoreduction, a multiphysics model was developed using COMSOL. The novelty of this work is the computational fluid dynamic model combined with the novel carbon dioxide photoreduction intrinsic reaction kinetic model, which was built based on three-steps, namely gas adsorption, surface reactions and desorption, while the ultraviolet light intensity distribution was simulated by the Gaussian distribution model and Beer-Lambert model. The carbon dioxide photoreduction process conducted in a laboratory-scale reactor under different carbon dioxide and water moisture partial pressures was then modeled based on the intrinsic kinetic model. It was found that the simulation results for methane, carbon monoxide and hydrogen yield match the experiments in the concentration range of 10^(−4) mol·m^(–3) at the low carbon dioxide and water moisture partial pressure. Finally, the factors of adsorption site concentration, adsorption equilibrium constant, ultraviolet light intensity and temperature were evaluated.

关键词： carbon dioxide photoreduction computational fluid dynamic simulation kinetic model Langmuir adsorption

Plastic deformation behavior of Mg97Zn1y2 extruded alloys

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Transactions of Nonferrous Metals Society of China 2010年第7期20卷 1259-1268页

作者： K.HAGIHARA A.KINOSHITA y.SUGINO M.yAMASAKI y.KAWAMURA H.y.yASUDA y.UMAKOSHI Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1Yamada-okaSuitaOsaka 565-0871Japan Department of Materials Science Kumamoto University2-39-1KurokamiKumamoto 860-8555Japan National Institute for Materials Science 1-2-1SengenTsukubaIbaraki 305-0047Japan

The mechanical properties of the Mg97Znly2 extruded alloy containing the long-period stacking ordered phase, the so-called LPSO-phase, with a volume fraction of 24%-25%, were examined by compression tests and cyclic tension-compression deformation tests. The plastic behavior of the extruded alloys with compositions of Mg99.2Zn0.2y0.6 and Mg89Zn4y7 （molar fraction, %）, which were almost the same compositions of Mg matrix phase and LPSO phase in Mg97Zn1y2 Mg/LPSO two-phase alloy, respectively, were also prepared. By comparing their mechanical properties, the strengthening mechanisms operating in the Mg97Zn1 y2 extruded alloy were discussed. Existence of the LPSO-phase strongly enhanced the refinement of Mg matrix grain size during extrusion, which led to a large increment of the strength of alloy. In addition, the LPSO-phases, which were aligned along the extrusion direction in Mg97Zn1y2 extruded alloy, acted as hardening phases, just like reinforced fibers.

关键词： plastic deformation yield stress LPSO-phase dislocation twinning

楚地出土战国简册研究 . 1 :新出楚简研读

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Ultrasonic solidification mechanism and optimized application performances of ternary Mg_(71.5)Zn_(26.1)y_(2.4) alloy

2010年

作者：陈伟 20100519d2010 em y0chiy50 ea

本书收集了作者近几年来对新颁布的楚地出土战国简册的研究心得，其内容十分丰富，其研究有的是纠正他人的误读，更多的则是作者独到的学术见解，具有较高的学术价值和史料价值。

ISBN: (纸本)9787307079991

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来源：汇雅图书（南通市图书馆... 评论

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汇雅图书（南通市图书馆）

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Journal of Magnesium and Alloys 2023年第10期11卷 3829-3839页

作者： y.J.Hu J.y.Wang W.Zhai B.Wei School of Physical Science and Technology Northwestern Polytechnical UniversityXi’an 710072China

One dimensional(1D) and three dimensional(3D) ultrasound sources were applied to the solidification process of Mg_(71.5)Zn_(26.1)y_(2.4) *** acoustic spectra were in-situ measured, based on which the cavitation intensities and dynamic solidification mechanism were further investigated. With the increase of ultrasonic dimension and amplitude, the primary Mg_(3)Zn_(6)y phase was significantly refined from petals to nearly pentagonal shape. The sound field measurements showed that the transient cavitation played a decisive role in generating a high local undercooling, which facilitated the formation of icosahedral clusters and promoted the nucleation of primary Mg_(3)Zn_(6)y phase. The morphological transition of(α-Mg+Mg_(3)Zn_(6)y) eutectic from lamellar to anomalous structure occurred under 3D ultrasonic condition. The stable cavitation took the main responsibility because the high pressure excited by nonlinearly oscillating bubbles induced the preferential nucleation of α-Mg phase rather than Mg_(3)Zn_(6)y phase. As compared with its static values, the tensile strength and compression plasticity of this alloy were increased by the factors of 1.9 and 2.1, and its corrosion resistance was also improved with the corrosion current density decreased by one order of magnitude.

关键词： Three dimensional ultrasounds Quasicrystalline Mg_(3)Zn_(6)y phase Anomalous eutectic Mechanical performances Corrosion resistance

Nodal Solutions for a Nonlinear Fourth-Order Eigenvalue Problem

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Acta Mathematica Sinica,English Series 2008年第1期24卷 27-34页

作者： Ru yun MA Bevan thompson Department of Mathematics Northwest Normal University Lanzhou 730070 P. R. China Department of Mathematics the University of Queensland Brisbane Qld 4072 Australia

We are concerned with determining the values of λ, for which there exist nodal solutions of the fourth-order boundary value problem y″″=λa（x）f（y）,0〈x〈1,y（0）=y（1）=y″（0）=y″（1）=0where λ is a positive parameter, a ∈ C（[0, 1], （0, ∞）, f ∈C（R,R） satisfies f（u）u 〉 0 for all u ≠ 0. We give conditions on the ratio f（s）/s, at infinity and zero, that guarantee the existence of nodal *** proof of our main results is based upon bifurcation techniques.

关键词： multiplicity results eigenvalues bifurcation methods nodal zeros

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官箴的智慧 : 最新经典珍藏第2版