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An automated multiwell plate reading flim microscope for live cell autofluorescence lifetime assays

Journal of Innovative Optical Health Sciences 2014年第5期7卷 99-113页

作者： Douglas J.Kelly Sean C.Warren Sunil Kumar Joao L.Lagarto Benjamin T.Dyer anca margineanu Eric W.-F.Lam Chris Dunsby Paul M.W.French Photonics Group Department of PhysicsImperial College London South Kensington CampusLondonSW72AZUK Institute of Chemical Biology Department of Chemistry Imperial College LondonSouth Kensington Campus LondonSWT 2AZUK National Heart&Lung Institute Imperial Centre for Eaperimental&Translational Medicine Du Cane Road LondonW12 ONNUK Department of Surgery and Cancer Imperial Cllege London Du Cane RoadLondonW12 ONNUK Centre for Histopathology Imperial College London Du Cane RoadLondonW120NNUK

Fluorescence lifetime imaging(FLIM)is increasingly used to read out cellular autofluorescenceoriginating from the coenzyme NADH in the context of investigating cell metabolic *** here an automated multiwell plate reading FLIM microscope optimized for UV illumi-nation with the goal of extending high content fluorescence lifetime asays to readouts ofmetabolism,We demonstrate its application to automated cellular autofluorescence lifetime imaging and discuss the key practical issues associated with its *** particular,weillustrate its capability to read out the NADH-lifetime response of cells to metabolic modulators,thereby illustrating the potential of the instrument for cytotoxicity studies,assays for drugdiscovery and stratified medicine.

关键词： High content analysis FLIM NADH metabolism cisplatin.

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2-12 Fusion Cross Section of 13C + 12C at Sub-barrier Energies

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IMP & HIRFL Annual Report 2014年第1期 44-45页

作者： Zhang Ningtao D. Chesneanu Li Yunju M. Straticiuc Tang Xiaodong L. Trache D. G. Ghita I. Burducea R. margineanu A. Pantelica C. Gomoiu 不详 Horia Hulubei National Institute of Physics and Nuclear Engineering (IFIN-HH) Bucharest-Magurele 077125 Romania China Institute of Atomic Energy Beijing 102413 China

Heavy-ion fusion reactions between light nuclei such as carbon and oxygen isotopes have been studied becauseof their importance in a wide variety of stellar burning scenarios. However, due to extremely low cross sectionsand signal/background ratio, all the measurements could only be carried out at energies well above the regionof astrophysical interest. The reaction rates in stellar environment could be estimated only by extrapolating theexisted cross sections or the astrophysical S-factors at higher energies. The situation is even more complicated bythe strong, relatively narrow resonances in some reactions, such as 12C+12C, 12C+16O. Traditionally, optical modelor equivalent square-well optical model (ESW) were used to fit the average cross section and predict the reactioncross sections at the energies of astrophysical interest[1]. Recently, a new model, the hindrance model, was proposedto provide systematic fits to fusion reaction data at extreme sub-barrier energies[2]. Lacking of experimental datawithin this energy range, large discrepancies exist among different nuclear reaction models.

关键词： 13C 12C Cross

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