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Immuno-contraceptive potential of sperm specific LDHC<sub>4</sub>and SPAM-1 (PH-20) sub units in dog

Open Journal of Animal Sciences 2012年第4期2卷 265-280页

作者： Ranjna S. Cheema Nisha Vashishat Amrit K. Bansal gaurav Bakhri Vinod Kumar Gandotra Department of Veterinary Gynaecology and Obstetrics Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India Department of Veterinary Gynaecology and Obstetrics Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India Department of Zoology Punjab Agricultural University Ludhiana India Division of Biochemistry National Dairy Research Institute Karnal India

PH-20 (Spam-1) antigen appears to be a bi-functional sperm plasma membrane protein with hyaluronidase activity and its role is related to cumulus penetration as well as zona binding. (LDH-C4) is a key enzyme, distributed specifically in testis and is highly immunogenic, function of which relates to energy metabolism and capacitation of the sperm. Therefore, in this study, we observed the effect of purified native PH-20 and LDH-C4 antigens on sperm function and morphology in dog. Native PH-20 (46, 32 kDa) and LDH-C4 (36, 30, 28) sub units, purified from dog sperm SDS- extracts were used to test as immunocontraceptive candidates in stray dog. Dogs 1, 2, 3, 4, 5/6 and 7/8 were immunized with 46, 32, 36, 30/28, 46/32, 36/30/28 kDa sub units respectively by i/m route and semen was analysed at weekly intervals. High titre of 3200 - 6400 was achieved in all dogs after three boosters. Immune response in treated dogs was confirmed by increase in Ig level in blood serum and reaction of partially purified serum Ig of immunized dogs with respective antigens in double immune diffusion and immunoblots. Immunization of dogs either with individual PH-20/ LDHC sub units or pooled PH-20/LDHC4 sub units showed a significant effect on sperm count, percent motility, viability, HOST and sperm morphology. All the sperm parameters declined to a significant level (p < 0.05) between 45 - 115 DPI and remained low than that of the recommended values for fertile dog semen till 175 DPI. The incubation of spermatozoa in HOS solution in the presence of anti-PH-20 and anti-LDHC Ig significantly reduced the percent HOS positive spermatozoa. A significant decline (p ≤ 0.05) in acrylamide penetration assay was also observed in the presence of anti 46 and 30/28 kDa Ig. Since percent motility, sperm count, HOST and percent normal spermatozoa in immunized dogs were significantly less than that of recommended fertile dog semen, it can be concluded that PH-20 (46/32 kDa) and LDHC4 (36/30/28 kDa) sub units

关键词： Immunocontraception Dog Sperm LDHC4 PH-20

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Estimation of Sex by Applying Discriminant Function Analysis on Osteo-metric Parameters of Clavicle in Population of Haryana

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Journal of Forensic Science and Medicine 2023年第2期9卷 106-111页

作者： Arun Kumar Luv Sharma Archana gaurav Kaushik Naresh Saini Ravi Kanth Soni Mohan Singh Meena Department of Forensic Medicine National Institute of Medical Sciences and ResearchNIMS UniversityJaipurRajasthanIndia Department of Forensic Medicine PGIMSRohtakHaryanaIndia Department of Organaon of Medicine Sri Ganganagar Homeopathic Medical CollegeSri GanganagarRajasthanIndia

It is important to pinpoint the identity of the deceased in scenarios such as decomposed bodies,skeletonized remains,mutilated remains,exhumed dead bodies,and in mass *** are many important parameters to establish the identity of a *** estimation of sex is one of *** of sex from bones is easy when the whole skeleton is available,but it becomes difficult when the body is mutilated and only parts of the body or bones are *** present study is undertaken to estimate the sex by applying discriminant function analysis(DFA)on various osteo-metric parameters of the clavicle in the population of *** hundred pairs of clavicles were collected from the bodies brought for *** were macerated and air dried for the removal of soft *** variables of clavicle of both sexes were measured and analyzed using the analysis of variance test which provided descriptive *** of the values helped in sexing of the *** of sex from different parameters of the clavicle was possible with overall accuracy of 93%in original and 92.5%in crossvalidated cases among total *** was 96%and 90%in original and 96%and 89%in cross validated cases among males and females respectively,indicating a strong correlation in estimation of sex of a person from the *** most important parameters to determine the sex from the clavicle are length of clavicle,mid clavicular circumference of clavicle,weight of clavicle,transverse diameter of lateral end of right clavicle,and longitudinal diameter of medial end of the left clavicle.

关键词： Clavicle estimation of sex identification

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Comparative Evaluation of Nanoemulsion based Transdermal system with Marketed Patch

Comparative Evaluation of Nanoemulsion based Transdermal sys...

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5th East-Asian Polymer Conference

作者： Leema Joseph gaurav Goyal Mahanwar P.A Vavia P.R Polymer Engineering and Technology University Institute of Chemical Technology (UICT) Matunga Mumbai -400019India

The present work covers the comparative evaluation of nanoemulsion based transdermal patches of Diclofenac Diethylamine （DDEA） with marketed patch. The comparative evaluation was done for the physical parameters like thickness, tackiness, and peel adhesion test and in-vitro release. The in-vitro release characteristics was compared using USP Dissolution apparatus 6 （Cylinder Type） and Keshary-Chein cells using cellulose mixed ester membrane. Dissolution studies were carried out in pH 6.5 phosphate buffer solution at stirring rate of 50rpm at 32 ± *** sampling points selected for the studies were 0, 2, 4, 12 and 24 hours. Nanoemulsions based transdermal therapeutic systems were found to have similar tackiness but better peel adhesion property than marketed patches. It was found that a nanoemulsion based transdermal patches with smaller size and reduced thickness can have a similar release profile to that of marketed patch with a good F2 value. The incorporated drug was released by the Fickian type of diffusion, as is evident by the slope values of less than 0.5 for the plots of log amount released Vs log time. The slope values of marketed and synthesized patches are 0.4 and 0.16 respectively. The correlation values of marketed and synthesized patches are 0.9941 and 0.9945 respectively. From comparative evaluation of physical parameters and in-vitro release profile, we can conclude that the synthesized nanoemulsion based transdermal patches could be a novel smaller sized transdermal dosage form for effective therapy but additional extradermal tests and experiments should be performed before the formulation is used in humans.

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High Dose Rate (HDR) Brachytherapy for Mycosis Fungoides of the Wrist

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International Journal of Clinical Medicine 2015年第3期6卷 154-157页

作者： gaurav Shukla Virginia Lockamy James Keller Joya Sahu Barbara Pro Onder Alpdogan Wenyin Shi Department of Radiation Oncology Thomas Jefferson University Philadelphia PA USA Department of Dermatology Thomas Jefferson University Philadelphia PA USA Department of Medical Oncology Thomas Jefferson University Philadelphia PA USA

Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma accounting for approximately half of all cutaneous T-cell lymphomas. Radiation therapy is an effective treatment for early stage MF and has been shown to result in long-term disease-free intervals, with even curative potential. Radiation is also effective as palliative treatment for the localized lesion resistant to the topic or other treatments. In the current study, we report using high dose rate (HDR) radiation treatment for a patient with resistant mycosis fungoides involving the wrist. We report a convenient treatment with an ideal radiation dose distribution, and a excellent clinical outcome.

关键词： Mycosis Fungoides Cutaneous T-Cell Lymphoma Radiation Therapy High Dose Rate (HDR)

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远程显示技术增强云用户体验

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今日电子 2013年第3期 44-46,48,49页

作者： Raj Pawate gaurav Agarwal 德州仪器公司

不同的云，不同的需求云计算的各种图示往往采用一团蓬松且不定形的图形，中间贴有“云”字样标签。这多少会产生一些误解，因为实际上云计算是由多个不同层面的云构成的。

关键词：用户体验显示技术远程云计算不定形

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SIMO开关调节器:延长耳戴式和可穿戴设备的电池寿命

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单片机与嵌入式系统应用 2018年第2期18卷 84-85页

作者： Cary Delano gaurav Mital Maxim Integrated移动方案事业部技术团队

耳戴式、可穿戴产品日益成为市场热点,消费者对这些产品也提出了更高要求,要求它们不但体积小巧,而且电池寿命长。显而易见,设备尺寸限制了电池容量。本文介绍如何利用单电感多输出(SIMO)电源转换器技术节省电路板空间。SIMO架构及其稳... 详细信息

耳戴式、可穿戴产品日益成为市场热点,消费者对这些产品也提出了更高要求,要求它们不但体积小巧,而且电池寿命长。显而易见,设备尺寸限制了电池容量。本文介绍如何利用单电感多输出(SIMO)电源转换器技术节省电路板空间。SIMO架构及其稳压器的低静态电流使IC能够有效延长空间受限电子产品的电池寿命。本文将帮助您深入理解SIMO技术及其工作原理,同时您将了解到更多关于电源管理IC(PMIC)的知识,这些IC具有SIMO调节器,能够降低功耗和总体元件数量,同时以不到一半的空间提供与传统方案相同的功能。

关键词：开关调节器电池寿命 SIMO 设备电子产品低静态电流电源转换器工作原理

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Experiments Using Capillary Mat as Ground Heat Exchanger for Ground Source Heat Pump Heating Application

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Energy and Power Engineering 2019年第11期11卷 363-378页

作者： Arif Widiatmojo Shrestha gaurav Takeshi Ishihara Akira Tomigashi Kasumi Yasukawa Youhei Uchida Shohei Kaneko Mayumi Yoshioka Renewable Research Center National Institute of Advanced Industrial Science and Technology Koriyama Japan Japan Oil Gas and Metals National Corporation (JOGMEC) Tokyo Japan

The cooling and heating of spaces are among the largest sources for household’s energy demand. Ground Source Heat Pump (GSHP) is a promising technology to reduce the energy for cooling and heating purposes. However, the major obstacle hindering the utilization of this technology is the high initial cost, especially for the installation of ground coupled heat exchanger. The horizontal closed-loop system offers lower installation cost, as it requires no vertical borehole construction. Instead, the heat exchangers can be installed in shallow trenches that may be excavated, by small excavator or even by human labor. This paper presents the comparison of two different heat exchangers, namely, the capillary mat and the widely used slinky pipe. Both heat exchangers are connected to a heat pump, where continuous heating tests were carried out for 165 hours (~7 days) for each configuration. The purpose of this research is to show the performance of capillary mat in comparison to slinky pipe. Despite during the entire test for capillary mat required 6% higher electricity consumption, compared to slinky heat exchanger, the results still suggest the potential use of capillary mat as alternative to slinky heat exchanger. Additionally, the results also highlight the high hydraulic resistance of installed capillary mat heat exchangers may become the major disadvantage of the capillary mat.

关键词： Horizontal Heat Exchanger Ground Source Heat Pump Capillary Mat

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印度鬼堡日出之前日落之后,严禁停留!

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环球人文地理 2017年第3期 104-111页

作者：梁嗣麒 Varun gaurav

据说一旦进入鬼堡,人们就会产生一种难以名状的奇怪感,仿佛受到某种恶意的窥探和监视。但城堡中的诡秘情状不止于此,有人看到古人的幽灵在城堡中游荡,有人听到惨厉的尖叫从城堡里传出,更有人称,夜晚待在城堡里的人被鬼怪所惑,全都消失... 详细信息

据说一旦进入鬼堡,人们就会产生一种难以名状的奇怪感,仿佛受到某种恶意的窥探和监视。但城堡中的诡秘情状不止于此,有人看到古人的幽灵在城堡中游荡,有人听到惨厉的尖叫从城堡里传出,更有人称,夜晚待在城堡里的人被鬼怪所惑,全都消失在黑暗之中……

关键词：日出之前考古调查象头神

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以人力资本和信息技术重塑社保经办机构

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中国社会保障 2017年第4期 34-36页

作者：张占力 gaurav Gujra 中国社科院世界社保研究中心

综观全球，社会保障经办机构似乎到了一个临界点：即社保经办机构初始设计是在一个较为稳定的法律环境之中，接受参保人员大量纸质申请材料以满足其简单服务需求，但这一现状面临巨大挑战。宏观经济和人口转变、

关键词：社保经办机构信息技术人力资本法律环境社会保障服务需求申请材料参保人员

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3T magnetic resonance neurography of pudendal nerve with cadaveric dissection correlation

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World Journal of Radiology 2016年第7期8卷 700-706页

作者： Avneesh Chhabra Courtney A McKenna Vibhor Wadhwa gaurav K Thawait John A Carrino Gary P Lees A Lee Dellon Musculoskeletal Radiology University of Texas Southwestern Medical Center the Russell H.Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Department of Art As Applied to Medicine Johns Hopkins University Department of Radiology University of Arkansas for Medical Sciences Department of Radiology and Imaging Hospital for Special Surgery Department of Plastic Surgery and Neurosurgery Johns Hopkins University School of Medicine

AIM: To evaluate the pudendal nerve segments that could be identified on magnetic resonance neurography(MRN) before and after surgical marking of different nerve ***: The hypothesis for this study was that pudendal nerve and its branches would be more easily seen after the surgical nerve marking. Institutional board approval was obtained. One male and one female cadaver pelvis were obtained from the anatomy board and were scanned using 3 Tesla MRI scanner using MR neurography sequences. All possible pudendal nerve branches were identified. The cadavers were then sent to the autopsy lab and were surgically dissected by a peripheral nerve surgeon and an anatomist to identify the pudendal nerve branches. Radiological markers were placed along the course of the pudendal nerve and its branches. The cadavers were then closed and rescanned using the same MRN protocol as the premarking scan. The remaining pudendal nerve branches were attempted to be identified using the radiological markers. All scans were read by an experienced musculoskeletal ***: The pre-marking MR Neurography scans clearly showed the pudendal nerve at its exit from the lumbosacral plexus in the sciatic notch, at the level of the ischial spine and in the Alcock's Canal in both cadavers. Additionally, the right hemorrhoidal branch could be identified in the male pelvis cadaver. The perineal and distal genital branches could not be identified. On post-marking scans, the markers were used as identifiable structures. The location of the perineal branch, the hemorroidal branch and the dorsal nerve to penis(in male cadaver)/clitoris(in female cadaver) could be seen. However, the visualization of these branches was suboptimal. The contralateral corresponding nerves were poorly seen despite marking on the surgical side. The nerve was best seen on axial T1W and T2W SPAIR images. The proximal segment could be seen well on 3D DW PSIF sequence. T2W SPACE was not very useful in visualizat

关键词： Pudendal nerve Cadaver Magnetic resonance neurography Chronic pelvic pain

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