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Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia:testicular sperm extraction outcomes

Asian Journal of Andrology 2019年第5期21卷 445-451页

作者： Anne-Laure Barbotin anais dauvergne Agathe Dumont Nassima Ramdane Valerie Mitchell Jean-Marc Rigot Florence Boitrelle Geoffroy Robin CHU Lille Reproductive Biology-Spermiology-CECOS InstituteJeanne de Fla nd re HospitalF-59000 LilleFrance EA4308:Gametogenesis and Gamete Quality Lille UniversityF-59000 LilleFrance CHU Lille Department of AndrologyCalmette HospitalF-59000 LilleFrance CHU Lille Department of Endocrine Gynaecology and Reproductive MedicineJeanne de Flandre HospitalF-59000 LilleFrance CHU Lille Department of BiostatisticsEA2694Lille UniversityF-59000 LilleFrance Fertility Unit Poissy-Saint-Germain-en-Laye General Hospital78303 PoissyFrance.

Cryptorchidism is one of the most frequent causes of nonobstructive azoospermia(NOA)in *** it is well known that spermatogenesis is more impaired in bilateral than in unilateral cryptorchidism,previous studies have only described small cohorts or inhomogeneous ***,we analyzed a cohort of 225 men with only a history of cryptorchidism as sole etiopathogenetic factor for NOA,and compared testicular sperm extraction(TESE)outcomes between men with bilateral versus unilateral *** results show no difference in follicle-stimulating hormone(FSH)levels and testicular volumes between men with a history of bilateral cryptorchidism compared to unilateral cryptorchidism(median:21.3 IU I^-1 vs 19.3 IU I^-1,P=0.306;and 7.2 ml vs 7.9 ml,P=0.543,respectively).In addition,sperm retrieval rates were similar(66.2%vs 60.0%,P=0.353).Using multivariate analysis,we have found that only a low inhibin B level(above the assay's detection limit)was positively associated with successful sperm retrieval(P<0.05).Regarding intracytoplasmic sperm injection outcomes,we found that cumulative pregnancy rate and live birth rate per cycle were not statistically different between the two groups(17.4%vs 27.8%,P=0.070;and 16.1%vs 26.4%,P=0.067,respectively).Unexpectedly,there was no significant difference in hormonal profiles(FSH,luteinizing hormone[LH],testosterone,and inhibin B levels)and TESE outcomes between unilateral versus bilateral *** suggests that a history of unilateral cryptorchidism could reflect a bilateral testicular ***,inhibin B level might be a predictor of successful TESE.

关键词： cryptorchidism in tracytoplasmic sperm in jection non obstructive azoospermia testicular sperm extraction

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