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Ozone action on Streptococcus mutans and Lactobacillus fermentum : A pilot study

World Journal of Stomatology 2013年第1期2卷 18-23页

作者： Joana Marques anabela paula Teresa Gon?alves Manuel Ferreira Eunice Carrilho Faculty of Medicine the University of Coimbra Area of Dentistry Av Bissaya Barreto Blocos de Celas 3000-075 Coimbra Portugal

AIM: To study the effectiveness of ozone in the elimination of cariogenic bacteria, followed with fluoride ***: Sixty extracted teeth free of caries were used, and five groups were constituted. In Group Ⅰ,the teeth were immersed in artificial saliva. In Group Ⅱ,the teeth were inoculated with Streptococcus mutans(S. mutans) and immersed in artificial saliva. In GroupⅢ the teeth were inoculated with Lactobaccilus fermentum(L. fermentum) and immersed in artificial *** Group Ⅳ the teeth were inoculated with S. mutans and L. fermentum and immersed in artificial saliva and the teeth in Group Ⅴ were inoculated with S. mutans and L. fermentum, and were subjected to the application of ozone and to the action of a fluoride mineralizing gel. DIAGNOdent was used to evaluate the caries of the teeth 3 wk after inoculation of bacteria and after that the teeth of Group Ⅴ were subjected to the application of ozone during 60 s, by HealO zone. After the application of ozone, products of the remineralization kit supplied by the manufacturer were applied daily, during 30 d. At the end samples were collected for analysis and evaluation of bacterial activity by polymerase chain reaction. RESULTS: Regarding the value of caries, obtained via DIAGNOdent, in the initial measurement the groups are homogeneous(P = 0.730). There was an increase in DIAGNOdent values, presenting statistical significant difference regarding the initial measurement in all groups(P < 0.001), except in group Ⅰ- only artificial saliva- which shows that the artificial carie model was effective. Comparing the initial and final measurements for each of the 60 teeth, it can be observed that in 9 teeth(15.0%) there was a decrease in values between the two measurements, one(1.7%) retained the same values in the two measurements and in the remaining 50 cases(83.3%) there was increase in values between the initial and final measurements. It should also be noted that in the teeth inoculated with S. mutans

关键词： Dental caries Cariogenic agents Lactobaccilus fermentum Streptococcus mutans Ozone

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^(99m)Tc in the evaluation of microleakage of composite resin restorations with SonicFill^(TM).An in vitro experimental model

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Open Journal of Stomatology 2012年第4期2卷 340-347页

作者： Carrilho Eunice Abrantes Margarida Casalta-Lopes Joao Botelho Filomena paula anabela Ambrósio Pedro Marto Carlos Miguel Rebelo Diana Marques Joana Polido Mário Ferreira Manuel Marques Faculty of Medicine University of CoimbraCoimbraPortugal

Introduction: The composite SonicFillTM (Kerr/Kavo) is indicated for posterior restorations, with a single increment up to 5 mm due to reduced polymerization shrinkage, thus reducing working time. Aim: Evaluation of marginal microleakage with SonicFillTM. Method and Materials: There were sectioned sixty noncarious human molars in the occluso-cervical direction. Class V cavities were prepared on each tooth with gingival margin walls in a standardized way. The specimens were divided into 4 groups: group 1—restored with SonicFillTM (Kerr/Kavo), group 2—restored with FiltekTM SupremeXTE (3M ESPE), group 3—the cavities were not restored;group 4—restored with SonicFillTM (Kerr/Kavo). In groups 1, 2 and 4 the enamel was conditioned with 37% orthophosphoric acid and applied the self-etch adhesive system Clear- fillTM SE BOND (Kuraray). The specimens were stored in distilled water at 37?C for 7 days. After, the specimens, were immersed in a solution of 99mTc-Pertechnetate and the radioactivity was assessed with a gamma camera. The nonparametric Kruskal-Wallis and Mann-Whitney test with Bonferroni correction at a significance level of 5% were used for the statistical analyses. Results: There are significant differences between the positive and negative control groups and between these and experimental groups (p TM and FiltekTM SupremeXTE. Conclusion: The new composite SonicFillTM and FiltekTM SupremeXTE showed no difference concerning dye penetration. The Sonic- FillTM restorative system showed no influence in concerning microleakage.

关键词： Posterior resin Composites Composite Restorations Polymerization Stress Polymerization Shrinkage Microleakage Thermocycling

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E2F transcription factors and their complementary roles during DNA damage responses

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Molecular Plant 2023年第9期16卷 1373-1375页

作者： paula Casati Centro de Estudios Fotosinteticos y Bioquimicos(CEFOBl) Universidad Nacional de RosarioSuipacha 5312000 RosarioArgentina

E2F transcription factors(TF)comprise a family of proteins that regulate the expression of genes required for S-phase progression,among *** genome encodes six E2F TFs(E2FA–F),which are classified as typical(E2FA–C)and atypical(E2FD–F)depending on their ability to interact with two DP interaction proteins(DPa and DPb)(Sablowski and Gutierrez,2022).While E2FA–C need to heterodimerize with either DPa or DPb to function,E2FD–F act independently of DP ***,the retinoblastoma-related1(RBR1)protein also binds and inhibits the typical E2F/DP TF complexes when bound to the promoter of genes,repressing their expression in the absence of a signal to enter a new cell *** general,E2FA and E2FB are considered transcriptional activators,while E2FC is generally considered a repressor of cell proliferation(Sablowski and Gutierrez,2022).In addition,it is well documented that E2FB at least,and probably E2FA,can also stimulate the G2/M transition.

关键词： damage E2F complementary

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3D City Models as a Visual Support Tool for the Analysis of Buildings Seismic Vulnerability: The Case of Lisbon

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International Journal of Disaster Risk Science 2017年第3期8卷 308-325页

作者： paula Redweik paula Teves-Costa Inês Vilas-Boas Teresa Santos Instituto Dom Luiz Faculdade de CiênciasUniversidade de Lisboa ESRI Portugal CICS.NOVA–Centro Interdisciplinar de Ciências Sociais Faculdade de Ciências Sociais e HumanasUniversidade Nova de Lisboa

3D city models associate a database of a city to a rigorous geospatial representation that is close to the visible reality by combining appearance, geometry, and semantics. As such, these models may include tools that convey attribute analysis, not only at the statistical level but also in terms of visual appearance of the objects, thus allowing the generation of new knowledge about a phenomenon or its effects. Lisbon is a city with a moderate level of seismic risk, and has been hit in the past by strong earthquakes. Several seismic vulnerability studies of buildings have been carried out in Lisbon. These studies generate different scenarios that consider the magnitude and source location of potential earthquakes. The results of these studies were presented as maps obtained from crossing information contained in 2D layers and presented in a GIS environment. In the present study a seismic vulnerability assessment of Lisbon's buildings held in 2D is extended to the third dimension, which refines the resolution and the set of parameters and explores the gains of spatial analysis in 3D representations. The numerous parameters that contribute to assess seismic vulnerability of buildings may be analyzed individually or simultaneously as well as in multiple seismic scenarios. Although covering all residential buildings in Lisbon, the application of the 3Dcity model is demonstrated with more detail in three pilot areas.

关键词： 3D-GIS 3D models Building vulnerability Lisbon Seismic scenarios

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Striatum-specific mechanisms regulate neuronal cell cycle re-entry:the choice between life and death

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Neural Regeneration Research 2023年第3期18卷 523-524页

作者： paula Dietrich Ioannis Dragatsis Department of Physiology The University of TennesseeHealth Science CenterMemphisTNUSA

Mitochondria dysfunction occurs in the aging brain as well as in several neurodegenerative disorders and predisposes neuronal cells to enhanced sensitivity to *** particular,defects in any of the mitochondria respiratory chain complexes lead to impaired adenosine triphosphate production resulting in diseases that often affect the central nervous *** instance,innate deficits in succinate dehydrogenase(SDH)mitochondria respiratory chain complex II activity caused by genetic mutations in SDH subunits lead to early-onset neurodegeneration(Jain-Ghai et al.,2013),while several adult-onset genetic neurodegenerative disorders are associated with variable levels of complex II deficiency in the central nervous system(Túnez et al.,2010).Also,chemically induced complex II deficiency leads to neurodegeneration.

关键词： SDH impaired cycle

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Forecasting patient demand at urgent care clinics using explainable machine learning

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 712-733页

作者： Teo Susnjak paula Maddigan School of Mathematical and Computational Sciences Massey UniversityAucklandNew Zealand

Urgent care clinics and emergency departments around the world periodically suffer from extended wait times beyond patient expectations due to surges in patient *** delays arising from inadequate staffing levels during these periods have been linked with adverse clinical *** research into forecasting patient flows has mostly used statistical *** studies have also predominately focussed on short‐term forecasts,which have limited practicality for the resourcing of medical *** study joins an emerging body of work which seeks to explore the potential of machine learning algorithms to generate accurate forecasts of patient *** research uses datasets covering 10 years from two large urgent care clinics to develop long‐term patient flow forecasts up to one quarter ahead using a range of state‐of‐the‐art algo-rithms.A distinctive feature of this study is the use of eXplainable Artificial Intelligence(XAI)tools like Shapely and LIME that enable an in‐depth analysis of the behaviour of the models,which would otherwise be *** analysis tools enabled us to explore the ability of the models to adapt to the volatility in patient demand during the COVID‐19 pandemic lockdowns and to identify the most impactful variables,resulting in valuable insights into their *** results showed that a novel combination of advanced univariate models like Prophet as well as gradient boosting,into an ensemble,delivered the most accurate and consistent solutions on *** approach generated improvements in the range of 16%-30%over the existing in‐house methods for esti-mating the daily patient flows 90 days ahead.

关键词： data mining explainable AI forecasting machine learning patient flow urgent care clinics

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Systemic mastocytosis: A rare cause of non-cirrhotic portal hypertension

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World Journal of Gastroenterology 2016年第28期22卷 6559-6564页

作者： Cláudio Martins Cristina Teixeira Suzane Ribeiro Daniel Trabulo Cláudia Cardoso Joao Mangualde Ricardo Freire élia Gamito Ana Luísa Alves Isabelle Cremers Cecília Alves anabela Neves Ana paula Oliveira Department of Gastroenterology Setubal Hospital Center - Sao Bernardo Hospital 2910 Setubal Portugal Department of Pathology Setubal Hospital Center - Sao Bernardo Hospital 2910 Setubal Portugal Department of Hematology Setubal Hospital Center - Sao Bernardo Hospital 2910 Setubal Portugal

Mastocytosis is a clonal neoplastic disorder of the mast cells(MC) that can be limited to the skin(cutaneous mastocytosis) or involve one or more extracutaneous organs(systemic mastocytosis). The clinical manifestations of mastocytosis are heterogeneous ranging from indolent disease with a long-term survival to a highly aggressive neoplasm with survival of about 6 mo. Although liver involvement in aggressive systemic mastocytosis(ASM) is relatively common, the development of portal hypertension with or without cirrhosis is rare. We report a case of ASM without skin involvement in a 72-year-old caucasian male who presented with non-cirrhotic portal hypertension based on clinical, analytical, imagiological and endoscopic findings. Given the hematological picture, the correct diagnosis was established based on ancillary tests for MC using bone marrow aspirates and biopsy. Extensive involvement of the liver and gastrointestinal tract was histologically documented. The disease progressed rapidly and severe pancytopenia and recurrent upper gastrointestinal bleeding became the dominant problem. This case illustrates the challenge in establishing a diagnosis of ASM especially when the clinical picture is atypical and without skin involvement. Gastroenterologists should consider infiltrative disease, particularly systemic mastocytosis, as a differential diagnosis in a clinical case of portal hypertension of unknown etiology.

关键词： Systemic mastocytosis Mast cells Non-cirrhotic portal hypertension Upper gastrointestinal bleeding Cladribine

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King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da Silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix Castro Silverio Leonardo Macedo Garcia Mauro Martins Teixeira Daniele da Gloria Souza paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of Surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

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Impact of weather conditions and building design on contaminant infiltration from crawl spaces in Swedish schools-Numerical modeling using Monte Carlo method

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Building Simulation 2022年第5期15卷 845-858页

作者： Fredrik Domhagen paula Wahlgren Carl-Eric Hagentoft Department for Architecture and Civil Engineering Division of Building TechnologyChalmers University of TechnologySE-41296GothenburgSweden

Some Swedish school buildings built in the 1960s and 1970s experience indoor air quality problems,where the contaminants are suspected to come from the crawl space underneath the *** poor indoor air quality causes discomfort among pupils and *** an exhaust fan to maintain a negative pressure difference in the crawl space relative to indoors or increasing the ventilation in the classroom are two examples of common measures taken to improve the indoor air ***,these measures are not always effective,and sometimes the school building has to be *** relation between pressure distribution,contaminant concentration in the classroom,outdoor temperature,wind,mechanical ventilation,and air leakage distribution is complex.A better understanding of these relations is crucial for making decisions on the most efficient measure to improve the indoor air *** this paper,a model for contaminant infiltration from the crawl space is used together with the Monte Carlo method to study these *** are performed for several cases where different building shapes,building orientations,shielding conditions,and geographical locations are *** show,for example,that for a building with an imbalanced ventilation system,air is leaking from the crawl space to the classroom for the majority of cases and that concentration levels in the classroom are usually the highest during mild and calm days.

关键词： airtightness air permeability Monte Carlo method infiltration model crawl space indoor air quality

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Numerical Approach of a Coupled Pressure-Saturation Model Describing Oil-Water Flow in Porous Media

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Communications on Applied Mathematics and Computation 2023年第2期5卷 946-964页

作者： paula Luna Arturo Hidalgo ISIS Neutron and Muon Source Rutherford Appleton LaboratoryDidcot OX110QXUK Departamento de Ingeniería Geológica y Minera Escuela Técnica Superior de Ingenieros de Minas y EnergíaCenter for Computational SimulationUniversidad Politécnica de MadridRíos Rosas2128003 MadridSpain

Two-phase flow in porous media is a very active field of research,due to its important applications in groundwater pollution,CO_(2)sequestration,or oil and gas production from petroleum reservoirs,just to name a few of *** flow equations,which make use of Darcy's law,for describing the movement of two immiscible fluids in a porous medium,are among the most relevant mathematical models in reservoir *** work aims to solve a fractional flow model formed by an elliptic equation,representing the spatial distribution of the pressure,and a hyperbolic equation describing the space-time evolution of water *** numerical solution of the elliptic part is obtained using a finite-element(FE)scheme,while the hyperbolic equation is solved by means of two dif-ferent numerical approaches,both in the finite-volume(FV)*** is based on a monotonic upstream-centered scheme for conservation laws(MUSCL)-Hancock scheme,whereas the other makes use of a weighted essentially non-oscillatory(ENO)*** both cases,a first-order centered(FORCE)-αnumerical scheme is applied for inter-cell flux reconstruction,which constitutes a new contribution in the field of fractional flow models describing oil-water movement.A relevant feature of this work is the study of the effect of the parameterαon the numerical solution of the models *** also show that,in the FORCE-αmethod,when the parameterαincreases,the errors diminish and the order of accuracy is more properly attained,as verified using a manufactured solution technique.

关键词： Two-phase flow Reservoir simulation Porous media FORCE-α Finite volume

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