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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： ana Milena Silva Olaya Fernanda Martins Almeida ana maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Phylogeny of the Acarosporaceae(Lecanoromycetes,Ascomycota,Fungi)and the evolution of carbonized ascomata

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Fungal Diversity 2015年第4期73卷 145-158页

作者： Martin Westberg ana M.millanes Kerry Knudsen Mats Wedin Department of Botany Swedish Museum of Natural HistoryP.O.Box 50007SE-10405 StockholmSweden Departamento de Biología y Geología Universidad Rey Juan CarlosE-28933 MóstolesSpain Department of Ecology Faculty of Environmental SciencesKamýcká129Prague CZ-16521Czech Republic

The phylogeny of the Acarosporaceae(Lecanoromycetes,Acarosporomycetidae,Acarosporales)is investigated using data from three molecular markers;nuclear ITS-LSU rDNA,mitochondrial SSU andβ-*** is shown to be constituted by six main clades;Myriospora,Timdalia,Pleopsidium,a clade composed by BAcarospora^rhizobola and BA.^terricola,the poorly supported Sarcogyne clade(including several Polysporina and Acarospora species)and the Acarospora clade(including the type of Polysporina,***,and several other Polysporina species).The common ancestor of the Acarosporaceae did not produce strongly black pigmented(carbonized or melanized)ascomata,but this trait has arisen secondarily and independently numerous times in the evolution of the *** number of changes in character states of both carbonized epihymenium and carbonized exciple are considerably more than the minimum *** genera Sarcogyne and Polysporina—largely circumscribed based on the presence of black pigmented ascomata—are shown to be distinctly *** presence of green algae in the ascoma margin(lecanorine or lecideine ascomata)may vary even within single species.

关键词： Convergent evolution Lichens Lichenized fungi Lichenicolous

Oxygen-evolving SnO_(2)-based Ceramic Anodes in Aluminium Electrolysis

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Chemical Research in Chinese Universities 2014年第5期30卷 800-805页

作者： POPESCU ana-maria Ilie Murgulescu Institute of Physical Chemistry of the Romanian Academy 060021-Bucharest Romania

This study deals with SnO2-based ceramic anodes doped with Sb203 and CuO, aiming at contributing new data regarding their electrochemical behavior in cryolite melts. The performances of the anodes were evaluated by anodic polarization, cyclic voltammetry, and current efficiency and corrosion measurements. The investigation proves that the anodic process of SnO2-based inert anodes occurs at a low overvoltage and the oxygen discharge takes place in one step with an exchange of two electrons. The current efficiency and corrosion were proved to be dependent on the electrolysis parameters and composition of electrolysis bath. For a long term electrolysis, the dissolution of the anode in the cryolite-alumina melt produced small aluminium contamination（ca. 0.2%, mass fraction）.

关键词： Inert anode Aluminium electrolysis Polarization Voltammetry

Perspective on automated in vivo drug screening using the chodl mutant zebrafish line

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Neural Regeneration Research 2022年第11期17卷 2437-2438页

作者： ana-maria Oprisoreanu Center for Regenerative Therapies Dresden(CRTD) TU Dresden

Since the early 2000s, the popularity of zebrafish in in vivo drug screening has shown a substantial *** zebrafish has become an important screening tool covering a wide range of tissue-specific pathologies and diseas... 详细信息

关键词： fish vivo screening

Synthetic gauge fields for ultracold atoms

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National Science Review 2016年第2期3卷 166-167页

作者： ana maria Rey JILA NIST and Department of PhysicsUniversity of Colorado

Ultracold gases are remarkably versatile and controllable systems with untapped potential to emulate a variety of quantum phenomena[1].Atoms are,however,electrically neutral and therefore it is highly desirable to make them behave as charged *** capability has recently been demonstrated in a series of recent experiments[2-4].Although many challenges remain ahead,

关键词： Synthetic gauge fields for ultracold atoms

Insights on Chemical and Natech Risk Management in Japan and South Korea:A Review of Current Practices

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International Journal of Disaster Risk Science 2022年第3期13卷 359-371页

作者： Hyejeong Park ana maria Cruz Disaster Prevention Research Institute Kyoto UniversityKyoto611-0011Japan

A growing number of natural hazard-triggered technological accidents(Natech)has been reported by several researchers,and this trend is expected to continue due to climate *** a result,some governments have initiated direct efforts to manage Natech risks,particularly in the United States and ***,two surveys conducted by the Organisation for Economic Co-operation and Development(OECD)in 2009 and 2017 found that there was a lack of proper risk management and risk governance for Natech among OECD member states,including Japan and South *** study aimed to identify relevant regulations and practical considerations for chemical and Natech risk management from government perspectives in Japan and South *** article provides a review of the current state of risk management,emergency response,and risk communication on chemical and Natech risk management in the two countries,and concludes with a discussion of some of the issues that require improvement of the current chemical risk *** practices for chemical risk management in Japan and South Korea point to the possibility of improvements in dealing with the Natech *** practical lessons will be valuable for improving the capacity for dealing with challenges in chemical and Natech risk management.

关键词： Chemical accidents Government perspectives Japan Natech Risk governance Risk management South Korea

Structure and heat capacity of the NaCeF_4 compound

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Journal of Rare Earths 2013年第9期31卷 911-915页

作者： Virgil Constantin ana-maria Popescu "Ilie Murgulescu" Institute of Physical Chemistry of the Romanian Academy Splaiul Independentei 202 st.060021BucharestRomania

This work continued our general research program on obtaining metallic cerium by electrodeposition from NaCeF4 dis-solved in different molten fluorides. The structure of NaCeF4 （cubic or hexagonal depending on the way of preparation） was estab-lished by DTA analysis, IR spectra and X-ray diffraction. The heat capacity （Cp） of NaCeF4 was measured by differential scanning calorimetry in the temperature range of 300-1093 K using the“step-method”. The Cp was fitted by an equation with a satisfactory re-sult. Heat capacity was compared with that calculated from the Neumann-Kopp rule （NKR） and the deviations observed were consis-tent with the stability of the NaCeF4 compound.

关键词： cerium compounds structure heat capacity NaCeF4 rare earths

Current Efficiency, Corrosion and Structural Changes in SnO2-Sb2O3-CuO Inert Anodes for Aluminium Electrolysis

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Chinese Journal of Chemical Physics 2014年第3期27卷 368-372页

作者： ana-maria Popescu Virgil Constantin Ilie Mur&ulescu Institute of Physical Chemistry of the Romanian Academy Splaiul Independentei 202060021 Bucharest Romania

A systematic study was conducted on current efficiency （CE）, corrosion and structural changes in SnO2-based inert anodes （made of 96wt%SnO2＋2wt%Sb2O3＋2wt%CuO） on a laboratory Hall-Heroult aluminium cell. The influence of operating parameters and electrolyte composition on the CE and corrosion process were evaluated. The CE was found to be more than 90% and catastrophic corrosion took place at low percent of Al2O3, high percent of LiF, low cryolite ratio and high current densities. From all the structural changes that took place in the SnO2-based inert anodes, we assumed that the most important contribution was due to the migration of CuO towards the outer limits of the constituent grains of SnO2 based ceramic. The complex process occurred during the formation of various phases and their sintering ability both directly depended on Cu/Sb molar ratio.

关键词： Inert anode Aluminium electrowinning Current efficiency