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Management of pediatric peritonsillar and deep neck infections-cross-sectional retrospective analysis

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第4期5卷 207-214页

作者： ana sousa menezes Daniela Correia Ribeiro Joana Rocha Guimar(a)es António Fontes Lima Luís Dias Department of Otorhinolaryngology-Head and Neck Surgery Hospital De BragaPortugal Department of Otorhinolaryngology Instituto Portugu(e)s de Oncologia Francisco Gentil do PortoPortugal

Objective:Deep neck infections(DNI)are responsible for significant morbidity in children and healthcare *** studies exist specifically addressing the clinical and epidemiologic characterization and management of DNI's in the pediatric *** goal was to analyse the demographic characteristics,clinical presentation,diagnostic and therapeutic approaches of peritonsillar and DNI in pediatric ***:The medical records of patients,aged up to 18 years,admitted for peritonsillar and DNI at our department,from 2011 to 2016,were retrospectively reviewed and compared with the literature ***-eight patients were ***:The mean age was higher in patients with peritonsillar abscess and lower in patients with retropharyngeal and parapharyngeal *** have significantly increased from *** was a seasonal variation for DNI incidence,with a peak incidence in Summer and *** patients included were treated as inpatient and received empirical intravenous antibiotic therapy and steroids regardless of drainage *** and drainage was performed in 72 *** hospital length of stay was higher among patients with retropharyngeal abscess and in the group with *** 2 patients developed complications during hospital *** most common microbiological pattern was monomicrobial and the most commonly isolated pathogens were Streptococcus Pyogenes,Streptococcus Mitisand anaerobic ***:Surgical incision and drainage followed by intravenous antibiotic and steroids proved to be successfull with low morbidity related to surgical ***,in selected cases,medical therapy may be an alternative to surgical management in uncomplicated infections.

关键词： Deep neck infection Abscess Peritonsillar Parapharyngeal Retropharyngeal Microbiology Epidemiology

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza ana Roberta Fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

Short-term effect of physical activity on sleep health:A population-based study using accelerometry

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Journal of Sport and Health Science 2022年第5期11卷 630-638页

作者： Andrea Wendt Inácio Crochemore M.da Silva Helen Goncalves ana menezes Fernando Barros Fernando C.Wehrmeister Post-graduate Program in Epidemiology Federal University of PelotasPelotas 96020-220Brazil

Background:Regular physical activity(PA) is an important behavior in improving sleep ***,the short-term effects of PA on sleep are still *** study aimed to verify the effect of different intensities of PA practiced in different periods of the day on the subsequent sleep night in a population-based cohort of young ***::Prospective analyses were conducted for PA performed during the day and its effect on the following sleep night using data from the22-year follow-up of the 1993 Pelotas Birth Cohort in Brazil(mean age of participants-22.6 years).Wrist-worn accelerometry was usedto measure both PA and sleep *** intensity,we analyzed the sleep effect of light PA(LPA),moderate PA,and vigorous PA,stratified by *** variables were sleep time window(STW;the difference between sleep onset and sleep end),total sleep time(TST;the sum of minutes classified as sleep in STW),and sleep percent(SP;SP=(TST/STW);expressed in percentage).We performed generalized estimating equations using Stata ***::The means of STW,TST,and SP were 443.6 min/day,371.1 min/day,and 84%,*** spent in moderate PA and vigorous PA in the morning and afternoon was not associated with sleep *** men,10 min/day of morning LPA increased TST by2.56 min/*** women,10 min/day of morning LPA increased SP by 0.15 percentage *** LPA also increased SP by 0.09 percentage points for *** PA seems to have an inverse effect on sleep variables for any intensity and both ***::The effect of PA on sleep health is intrinsically related to the period of the day in which it is *** effect magnitude is different between *** better sleep health,it is preferable that PA be performed during the day.

关键词： Accelerometer Exercise Physical activity Population-based study Sleep health

Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease:two triggers, one disease

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Neural Regeneration Research 2021年第6期16卷 1127-1130页

作者： Sofia Ferreira ana F.Raimundo Regina menezes Ivo C.Martins iBET-Instituto de Biologia Experimental e Tecnológica OeirasPortugal CEDOC-Chronic Diseases Research Center Faculdade de Ciências MédicasUniversidade Nova de LisboaLisboaPortugal ITQB-NOVA Instituto de Tecnologia Química e Biológica António XavierUniversidade Nova de LisboaOeirasPortugal Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

Alzheimer’s disease(AD)is a neurodegenerative disorder that affects millions *** to population ageing,the incidence of AD is *** patients develop cognitive decline and dementia,features for which is known,requiring permanent *** poses a major socio-economic burden on healthcare systems as AD patients’relatives and healthcare workers are forced to cope with rising numbers of affected *** recent advances,AD pathological mechanisms are not fully ***,it is clear that the amyloid beta(Aβ)peptide,which forms amyloid plaques in AD patients’brains,plays a key *** 2 diabetes,the most common form of diabetes,affects hundreds of million people *** amyloid polypeptide(IAPP)is a hormone coproduced and secreted with insulin in pancreatic β-cells,with a key role in diabetes,as it helps regulate glucose levels and control adiposity and *** to Aβ,IAPP is very amyloidogenic,generating intracellular amyloid deposits that causeβ-cell dysfunction and *** is now clear that IAPP can also have a pathological role in AD,decreasing cognitive *** harms the blood-brain barrier,directly interacts and co-deposits with Aβ,promoting diabetes-associated *** can cause a metabolic dysfunction in the brain,leading to other diabetes-related forms of ***,here we discuss IAPP association with diabetes,Aβand dementia,in the context of what we designate a“diabetes brain phenotype”AD *** approach helps to set a conceptual framework for future IAPP-based drugs against AD.

关键词： aggregation Alzheimer amylin amyloid diabetes islet amyloid polypeptide

Bartter's syndrome:clinical findings,genetic causes and therapeutic approach

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World Journal of Pediatrics 2021年第1期17卷 31-39页

作者： Flavia Cristina Carvalho Mrad Sílvia Bouissou Morais Soares Luiz Alberto Wanderley de menezes Silva Pedro Versiani dos Anjos menezes ana Cristina Simoes-e-Silva Interdisciplinary Laboratory of Medical Investigation Faculty of MedicineFederal University of Minas Gerais(UFMG)Av.Alfredo Balena190Room#281Belo HorizonteMG 30130-100Brazil Pediatric Nephrology Unit Faculty of MedicineUFMGBelo HorizonteBrazil

Backgound Bartter's syndrome(BS)is a rare group of salt losing tubulopathies due to the impairment of transport mecha-nisms at the thick ascending limb of the Henle's *** sources Literature reviews and original research articles were collected from database,including PubMed and *** According to the time of onset and symptoms,BS can be classified into antenatal and classic *** studies have identified different subtypes of *** types Ⅰ,Ⅱ and Ⅲ are caused by mutations on genes encoding the luminal Na^(+)-K^(+)-2Cl^(-) co-transporter,the luminal K+ channel ROMK,and the basolateral chloride channel ClC-Kb(CLCNKB),***-of-function mutations of Barttin CLCNK type accessory beta subunit cause BS type Ⅳ*** mutations of CLCNKB and CLCNKA cause BS type Ⅳ*** type Ⅴ consists in a novel transient form characterized by antenatal presentation due to mutations in the MAGE family member *** gain-of-function mutations of the extracellular calcium sensing receptor gene can result in an autosomal dominant condition of *** clinical and biochemical alterations in BS include polyuria,dehydration,hypokalemia,hypochloremic metabolic alka-losis,hyperreninemia,high levels of prostaglandins,normal or low blood pressure,hypercalciuria and failure to *** focuses mainly at correcting dehydration and electrolyte disturbances and in measures to reduce polyuria,including the use of nonsteroidal anti-inflammatory medications to control excessive renal prostaglandin E2 *** Early diagnosis and treatment of BS may prevent long-term consequences such as growth failure,nephrocal-cinosis and end-stage renal disease.

关键词： Bartter's syndrome Hypercalciuria Hypokalemia Metabolic alkalosis Nephrocalcinosis

Diagnostic criteria for autoimmune hepatitis in children: A challenge for pediatric hepatologists

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World Journal of Gastroenterology 2012年第33期18卷 4470-4473页

作者： Priscila menezes Ferri Alexandre Rodrigues Ferreira Débora Marques Miranda ana Cristina Sim■es e Silva Division of Pediatric Gastroenterology and Hepatology Department of Pediatrics School Medicine Federal University of Minas Gerais Minas Gerais 30130-100 Brazil National Institute of Science and Technology of Molecular Medicine Faculty of Medicine Federal University of Minas Gerais Minas Gerais 30130-100 Brazil

Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder that is rare in children and adolescents. AIH has a broad clinical spectrum and a quick response to treatment with corticosteroids and immunosuppressive medication. The available diagnosis criteria have limitations and should be evaluated in pediatric populations. Recently, some studies reported that the 2008 simplified diagnostic criteria for AIH could be used in children with high sensibility and specificity. In addition, the authors reported that globulin and immunoglobulin G levels can be used interchangeably for diagnostic purposes. They also demonstrated that the 2008 simplified criteria fail in identifying patients with fulminant hepatic failure. Here, we discuss the limitations of the use of these criteria in pediatric patients and the requirement of more studies to improve the diagnosis of AIH in children.

关键词：自身免疫性儿童标准诊断肝病肝炎小儿免疫球蛋白G

New translational and experimental insights into the role of proresolving lipid mediators in inflammatory bowel disease

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World Journal of Experimental Medicine 2022年第1期12卷 1-15页

作者： Lívia Bitencourt Pascoal Bruna Biazon Palma Fabio Henrique Mendonça Chaim Marina Moreira de Castro Tiago Andrade Damázio ana Paula menezes de Freitas Franceschini Marciane Milanski Lício AugustoVelloso Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory Colorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Metabolic Disorders School of Applied SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Cell Signaling School of Medical SciencesUniversity of CampinasCampinas 13083-864São PauloBrazil

The resolution of inflammation is an active process,guided by specialized proresolution lipid mediators(SPMs).These mediators originate from polyunsaturated fatty acids,such as *** evidence suggests that the beneficial effects attributed to omega-3 are,at least in part,the result of the immunomodulatory action of the SPMs,which act systemically by overcoming inflammation and repairing tissue damage,without suppressing the immune *** studies suggest that an imbalance in the synthesis and/or activity of these compounds may be associated with the pathogenesis of several inflammatory conditions,such as inflammatory bowel disease(IBD).Thus,this review highlights the advances made in recent years with regard to the endogenous synthesis and the biological role of lipoxins,resolvins,protectins,and maresins,as well as their precursors,in the regulation of inflammation;and provides an update on the participation of these mediators in the development and evolution of IBD and the therapeutic approaches that these immunomodulating substances are involved in this context.

关键词： Pro-resolving lipid mediators Anti-inflammatory cytokines Omega-3 Chronic inflammation Pro-inflammatory cytokines Inflammatory bowel disease

Distal renal tubular acidosis:genetic causes and management

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World Journal of Pediatrics 2019年第5期15卷 422-431页

作者： Sílvia Bouissou Morais Soares Luiz Alberto Wanderley de menezes Silva Flávia Cristina de Carvalho Mrad ana Cristina Simoes e Silva Interdisciplinary Laboratory of Medical Investigation Faculty of MedicineFederal University of Minas Gerais(UFMG)Av.Prof.Alfredo Balena190Room#281Belo HorizonteMG 30130-100Brazil Pediatric Nephrology Unit Faculty of MedicineUFMGBelo HorizonteBrazil

Background Distal renal tubular acidosis(dRTA)is a kidney tubulopathy that causes a state of normal anion gap metabolic acidosis due to impairment of urine *** review aims to summarize the etiology,pathophysiology,clinical findings,diagnosis and therapeutic approach of dRTA,with emphasis on genetic causes of *** sources Literature reviews and original research articles from databases,including PubMed and Google *** searching was performed to identify additional studies about *** dRTA is characterized as the dysfunction of the distal urinary acidification,leading to metabolic *** pediatric patients,the most frequent etiology of dRTA is the genetic alteration of genes responsible for the codification of distal tubule channels,whereas,in adult patients,dRTA is more commonly secondary to autoimmune diseases,use of medications and *** with dRTA exhibit failure to thrive and important laboratory alterations,which are used to define the *** oral alkali and potassium supplementation can correct the biochemical defects,improve clinical manifestations and avoid nephrolithiasis and *** dRTA is a multifactorial disease leading to several clinical *** and laboratory alterations can be corrected by alkali replacement therapy.

关键词： Renal tubular acidosis Distal tubule physiology Metabolic acidosis Gene mutations Proton pump

Clinical Trial Demonstrates Efficacy of Transcranial Direct Current Stimulation (tDCS) in Improving Pain Management from Post-Laminectomy Syndrome

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Pain Studies and Treatment 2023年第4期11卷 27-42页

作者： Marilia Capuço Oliveira Fernanda menezes de Faria Gerardo Maria de Araújo Filho ana Carolina Gonçalves Olmos Demosthenes Santana Silva Junior Camila Souza Alves Cosmo Department of Neurological Sciences Psyquiatry and Medical Psychology Faculdade de Medicina de S&#227o José do Rio Preto S&#227o Paulo Brazil

Chronic pain, a multidimensional experience affecting individuals’ sensory, cognitive, and emotional aspects, significantly impacts their quality of life. Post-laminectomy syndrome, a condition characterized by persistent back pain following spinal surgery, often leads to disability and increased healthcare utilization. Methods: This randomized, controlled, blind clinical trial aimed to investigate the efficacy of Transcranial Direct Current Stimulation (tDCS) in managing pain from post-laminectomy syndrome in patients. Twenty-four participants were assigned to three groups: sham stimulation, active stimulation over primary motor cortex (M1), or stimulation over dorsolateral prefrontal cortex (DLPFC). Stimulation was administered for five consecutive days, 20 minutes per session, using a current of 1.5 mA through 25 cm2 electrodes. Pain intensity was assessed using Visual analog Scale (VAS) before, during, and after intervention. Results: An ANOVA model demonstrates significant reduction in pain intensity compared to baseline in VAS, (F(7, 285) = 12.292;p 0.001;Power = 1.000;η2p = 0.534), in tDCS applied to M1, after five days of intervention. After stimulation, a significant improvement was observed in WHOQoL-Bref Quality of life item 1 (p = 0.04), considering statistical significant difference p 0.05. Correlation between the variables: quality of life, depression, anxiety and pain also demonstrates reduction in depression and anxiety according to Beck’s Depression and Anxiety Inventories (BDI and BAI), p 0.05. This effect was not observed in DLPFC stimulation group. Patients who believed they received active stimulation, in sham group, demonstrated potential for effective blinding. Conclusion: The tDCS applied to primary motor cortex effectively improved pain management and psychiatry symptoms in post-laminectomy syndrome patients. The technique’s low cost, ease of use, and high tolerability make it a promising adjuvant therapy for chronic pain conditio

关键词： Non-Invasive Neuromodulation Transcranial Direct Current Stimulation Post-Laminectomy Syndrome Chronic Pain