检索结果-南通市图书馆

Nano-Micro Letters 2023年第3期15卷 190-247页

作者： Amjid Rafique Isabel Ferreira Ghulam Abbas ana catarina baptista CENIMAT|I3N Department of Materials ScienceSchool of Science and TechnologyNOVA University LisbonCampus de Caparica2829‑516 CaparicaPortugal

Flexible microelectronic devices have seen an increasing trend toward development of miniaturized,portable,and integrated devices as wearable electronics which have the requirement for being light weight,small in dimension,and *** three-dimensional(3D)and two-dimensional(2D)electronics gadgets fail to effectively comply with these necessities owing to their stiffness and large *** have come up with a new family of one-dimensional(1D)flexible and fiber-based electronic devices(FBEDs)comprising power storage,energy-scavenging,implantable sensing,and flexible displays ***,development and manufacturing are still a challenge owing to their small radius,flexibility,low weight,weave ability and integration in textile *** paper will provide a detailed review on the importance of substrates in electronic devices,intrinsic property requirements,fabrication classification and applications in energy harvesting,energy storage and other flexible electronic ***-and textile-based electronic devices for bulk/scalable fabrications,encapsulation,and testing are reviewed and presented future research ideas to enhance the commercialization of these fiber-based electronics devices.

关键词： Flexible electronics Electronic textiles Energy harvesting Supercapacitors Photovoltaic devices

Addressing soil protection concerns in forest ecosystem management under climate change

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Forest Ecosystems 2020年第3期7卷 432-442页

作者： ana Raquel Rodrigues Brigite Botequim catarina Tavares Patrícia Pécurto JoséGBorges Forest Research Centre School of AgricultureLisbon UniversityTapada da Ajuda1349-017LisbonPortugal

Background: Climate change may strongly influence soil erosion risk, namely through variations in the precipitation pattern. Forests may contribute to mitigate the impacts of climate change on soil erosion and forest managers are thus challenged by the need to define strategies that may protect the soil while addressing the demand for other ecosystem services. Our emphasis is on the development of an approach to assess the impact of silvicultural practices and forest management models on soil erosion risks under climate change. Specifically, we consider the annual variation of the cover-management factor(C) in the Revised Universal Soil Loss Equation over a range of alternative forest management models to estimate the corresponding annual soil losses, under both current and changing climate conditions. We report and discuss results of an application of this approach to a forest area in Northwestern Portugal where erosion control is the most relevant water-related ecosystem ***: Local climate change scenarios will contribute to water erosion processes, mostly by rainfall erosivity *** forest management models provide varying levels of soil protection by trees, resulting in distinct soil loss ***: Results confirm the suitability of the proposed approach to address soil erosion concerns in forest management planning. This approach may help foresters assess management models and the corresponding silvicultural practices according to the water-related services they provide.

关键词： C-factor Erosivity Ecosystem services Forest management Revised universal soil loss equation(RUSLE)

Intranasal delivery of nanostructured lipid carriers,solid lipid nanoparticles and nanoemulsions:A current overview of in vivo studies

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第4期11卷 925-940页

作者： Cláudia Pina Costa Joao Nuno Moreira JoséManuel Sousa Lobo ana catarina Silva UCIBIO/REQUIMTE MedtechLaboratory of Pharmaceutical TechnologyDepartment of Drug SciencesFaculty of PharmacyUniversity of PortoPorto 4050-313Portugal CNC-Center for Neuroscience and Cell Biology Center for Innovative Biomedicine and Biotechnology(CIBB)University of CoimbraFaculty of Medicine(Pólo I)Coimbra 3004-504Portugal UC-University of Coimbra CIBBFaculty of PharmacyPólo Das Ciências da SaúdeCoimbra 3000-548Portugal FP-ENAS(UFP Energy Environment and Health Research Unit)CEBIMED(Biomedical Research Centre)Faculty of Health SciencesUniversity Fernando PessoaPorto 4249-004Portugal

The management of the central nervous system(CNS)disorders is challenging,due to the need of drugs to cross the blood-brain barrier(BBB)and reach the *** the various strategies that have been studied to circumvent this challenge,the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising *** addition,the encapsulation of the drugs in lipid-based nanocarriers,such as solid lipid nanoparticles(SLNs),nanostructured lipid carriers(NLCs)or nanoemulsions(NEs),can improve nose-to-brain transport by increasing the bioavailability and site-specifc *** review provides the state-of-the-art of in vivo studies with lipid-based nanocarriers(SLNs,NLCs and NEs)for nose-to-brain *** on the literature available from the past two years,we present an insight into the different mechanisms that drugs can follow to reach the brain after intranasal *** results of pharmacokinetic and pharmacodynamics studies are reported and a critical analysis of the differences between the anatomy of the nasal cavity of the different animal species used in in vivo studies is carried *** the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear,it appears that the intranasal route together with the use of NLCs,SLNs or NEs is advantageous for targeting drugs to the *** systems have been shown to be more effective for nose-to-brain delivery than other routes or formulations with non-encapsulated drugs,so they are expected to be approved by regulatory authorities in the coming years.

关键词： Nose-to-brain delivery Intranasal administration Nanostructured lipid carriers NLC Solid lipid nanoparticles SLN Nanoemulsions In vivo studies Pharmacokinetic Pharmacodynamics

Dynamics of Droplets of Biological Fluids on Smooth Superhydrophobic Surfaces under Electrostatic Actuation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2016年第2期13卷 220-234页

作者： ana Sofia Moita catarina Laurencia Joana anastacio Ramos Duarte Miguel Franca Prazeres Antonio Luis Nobre Moreira IN+ - Center for Innovation Technology and Policy Research Instituto Superior Tecnico Universidade de Lisboa Av. Rovisco Pais 1049-001 Lisboa Portugal iBB - Institute for Bioengineering and Biosciences Department of Bioengineering Instituto Superior Tecnico Universidade de Lisboa Av. Rovisco Pais 1049-001 Lisboa Portugal

This study describes the dynamic behaviour of droplets of biological liquids on hydrophobic surfaces under electrostatic actuation, to devise sample handling in lab-on-chip diagnostic tools. Bovine Serum Albumin （BSA） is taken as a representative biomolecule, since it is often used in adsorption studies. Green Fluorescence Protein （GFP） is also considered, given its natural fluorescence. Several effects such as sample concentration and pH are discussed. The results show negligible effects of proteins concentration in electrowetting, although increased concentrations endorse passive adsorption mechanisms, which alter the local wettability of the substrates precluding droplet motion. Bioinspired surfaces promote the largest spreading diameter, which is beneficial for droplet motion. However, surface roughness promotes energy dissipation limiting the receding droplet motion. Hence, the most effective approach is altering the surface chemistry. The coating is applied to a surface with a mean roughness smaller than 20 nm and does not alter significantly the topography, thus leading to the so-called smooth superhydrophobic surface. This coating also reduces passive proteins adsorption, as confirmed by Confocal Microscopy （CM）, which is beneficial for droplet motion. Evaluating absorption spectra of protein solutions evidences an increase in protein concentration ascribed to droplet evaporation as confirmed by theoretical analysis and time resolved infrared visualization.

关键词： bioinspired surfaces biofluids electrostatic actuation hydrophobicity adsorption evaporation

Predicting the potential of sludge dewatering liquors to recover nutrients as struvite biominerals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environmental Science and Ecotechnology 2020年第3期3卷 50-59页

作者： Francisco Simoes Robert Colston catarina Rosa-Fernandes Peter Vale Tom Stephenson ana Soares Cranfield Water Science Institute Cranfield UniversityCranfieldMK430ALUK Technology and Development Severn Trent Water LtdAvon HouseSt.Martins RoadCoventryCV36PRUK

Phosphorus and nutrient recovery from wastewater as mineral salts can support local replenishment of fertilisers and reduce mining,contributing to the circular *** and related streams are rich in nutrients,however;there is need to develop bio-based processes to recover *** study investigates the fractions of phosphorus(P)used by Brevibacterium antiquum to form struvite biominerals(bio-struvite)in wastewater sludge dewatering *** 72h of incubation,25.6 mg P/L were recovered as bio-struvite from 12.4 mg P/L organic plus condensed P and 13.2 mg P/L of *** potential of sludge dewatering liquors to recover nutrients as struvite was investigated by characterising ten types of sludge liquors(originating from primary,secondary sludge,feed to anaerobic digester and digestate,from 3 types of wastewater treatment plants)for their P fractions together with other parameters relevant for *** *** indicated that liquors obtained from primary sludge,feed to anaerobic digesters and digestate were the most suitable to produce biostruvite,as these were found to frequently have a high content of organic and condensed P,between to 276-732 mg P/***,from all the investigated sites,presented a higher potential for bio-struvite production than with conventional struvite *** study demonstrated that *** could convert organic and condensed P into bio-struvite,and this opens up a completely new way to recover forms of phosphorus that are not typically available for nutrient recovery in a single process.

关键词： Biomineralization Centrate Sidestream P-recovery Acid-hydrolysable phosphorus

Network of GRAS transcription factors in plant development,fruit ripening and stress responses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2023年第12期10卷 286-303页

作者： catarina Neves Beatriz Ribeiro Rute Amaro Jesús Expósito Jérôme Grimplet ana Margarida Fortes BioISI-Biosystems and Integrative Sciences Institute Faculty of SciencesUniversity of LisbonCampo Grande1749-016 LisboaPortugal Centro de Investigación y Tecnología Agroalimentaria de Aragón(CITA) Departamento de Ciencia VegetalGobierno de AragónAvda.Montañana 93050059 ZaragozaSpain Instituto Agroalimentario de Aragón-IA2(CITA-Universidad de Zaragoza) Calle Miguel Servet 17750013 ZaragozaSpain

The plant-specific family of GRAS transcription factors has been wide implicated in the regulation of transcriptional reprogramming associated with a diversity of biological functions ranging from plant development processes to stress *** analyses of GRAS transcription factors supported by in silico structural and comparative analyses are emerging and clarifying the regulatory networks associated with their biological *** this review,a detailed analysis of GRAS proteins’structure and biochemical features as revealed by recent discoveries indicated how these characteristics may impact subcellular location,molecular mechanisms,and *** issues associated with GRAS classification into different subfamilies in diverse plant species even in the presence of robust genomic resources are discussed,in particular how it affects assumptions of biological *** into the mechanisms driving evolution of this gene family and how genetic and epigenetic regulation of GRAS contributes to subfunctionalization are ***,this review debates challenges and future perspectives on the application of this complex but promising gene family for crop improvement to cope with challenges of environmental transition.

关键词： function GRAS plant

Testicular prostheses-impact on quality of life and sexual function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第2期26卷 160-164页

作者： ana Sofia Araujo Sara anacleto Ricardo Rodrigues catarina Tinoco Andreia Cardoso Carlos Oliveira Ricardo Leao Department of Urology Braga's HospitalBraga 4710Portugal Faculty of Medicine Coimbra UniversityCoimbra 3000Portugal

Orchiectomy is the recommended treatment for many testicular ***,testicular prosthesis placement is not always performed for different *** this study,we aimed to evaluate patients'opinions and the impact on sexual function and quality of *** retrospective observational single-center study included patients who underwent orchiectomy between January 2014 and December 2020 at the Department of Urology,Braga's Hospital(Braga,Portugal),where testicular implants were always available and the decision to undergo the procedure was made fully independent of *** completed four questionnaires that assessed demographic data,satisfaction,self-esteem,and sexual *** the 96 patients who underwent orchidectomy,59 replied to the questionnaires,and of these patients,86.4%decided to undergo silicone-based testicular prostheses *** remaining 13.6%refused the implant based on concerns about complications(37.5%),because they felt that it was unnecessary(37.5%),or because it was not offered by the doctor(25.0%).Overall,96.1%of these patients were satisfied with the implant;however,25.5%classified it as"too firm".No statistically significant differences were found in sexual function(all P>0.05).However,it can be observed that there are more patients with prostheses presenting normal sexual activity compared to patients without prostheses(74.0%vs 50.0%),and none of them reported severe erectile dysfunction(0 vs 16.7%).Regarding self-esteem,both patients with and without prostheses present very similar average scores with no statistically significant *** present study highlights the highest level of satisfaction among patients who received testicular *** prostheses implantation is a safe procedure that does not hamper sexual function after orchiectomy.

关键词： orchiectomy patient satisfaction quality of life sexual dysfunction sexual health testicular prostheses

Targeting of Pollen Tubes to Ovules Is Dependent on Nitric Oxide （NO） Signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2008年第4期1卷 703-714页

作者： ana Margarida Prado Renato Colaco Nuno Moreno ana catarina Silva Jose A. Feijo Instituto Gulbenkian de Ciencla Centro de Blologia do Desenvolvimento PT-2780-156 Oeiras Portugal Universidade de Lisboa Faculdade de Clencias Dept Biologia Vegetal Campo Grande Ed.C2. PT-1749-016 Lisboa Portugal

The guidance signals that drive pollen tube navigation inside the pistil and micropyle targeting are still, to a great extent, unknown. Previous studies in vitro showed that nitric oxide （NO） works as a negative chemotropic cue for pollen tube growth in lily （Lilium Iongiflorum）. Furthermore, Arabidopsis thaliana Atnosl mutant plants, which show de- fective NO production, have reduced fertility. Here, we focus in the role of NO in the process of pollen-pistil communication, using Arabidopsis in-vivo and lily semi-vivo assays. Cross-pollination between wild-type and Atnosl plants shows that the mutation affects the pistil tissues in a way that is compatible with abnormal pollen tube guidance. Moreover, DAF- 2DA staining for NO in kanadi floral mutants showed the presence of NO in an asymmetric restricted area around the micropyle. The pollen-pistil interaction transcriptome indicates a time-course-specific modulation of transcripts of AtNOS1 and two Nitrate Reductases （nrl and nr2）, which collectively are thought to trigger a putative NO signaling pathway. Semivivo assays with isolated ovules and lily pollen further showed that NO is necessary for micropyle targeting to occur. This evidence is supported by CPTIO treatment with subsequent formation of balloon tips in pollen tubes facing ovules. Activation of calcium influx in pollen tubes partially rescued normal pollen tube morphology, suggesting that this pathway is also dependent on Ca^2＋ signaling. A role of NO in modulating Ca^2＋ signaling was further substantiated by direct imaging the cytosolic free Ca^2＋ concentration during NO-induced re-orientation, where two peaks of Ca^2＋ occur--one during the slowdown/stop response, the second during re-orientation and growth resumption. Taken together, these results provide evidence for the participation of NO signaling events during pollen-pistil interaction. Of special relevance, NO seems to directly affect the targeting of pollen tubes to the ovule＇s micropyle by modu

关键词： pollen tubes NO fertilization guidance calcium signaling

Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2021年第1期8卷 73-82页

作者： Isabel Pereira Jose Eduardo Pereira Luis Maltez Alexandra Rodrigues catarina Rodrigues Manuela Oliveira Dina MSilva ana Rita Caseiro Justina Prada ana Colette Mauricio Jose Domingos Santos Miguel Gama CEB Centre of Biological EngineeingUniversity of MinhoCampus de GualtarBraga 4710-057Portugal CECAV Animal and Veterinary Research CentreUniversity of Trias-os-Montes e Alto DouroVila Real 5001-801Portugal Department of Veterinary Sciences University of Tras-os-Montes e Alto DouroVila Real 5001-801Portugal Bios ckin Molecular and Cell Therapies S.A.Laboratorio CriovidaTecMaiaRua Engenheiro Frederico Ulrich 2650Moreira da Maia 4470-605Portugal Departamento de Clinicas Veterinarias Instituto de Ciencias Biomedicas de Abel Salazar(ICBAS)Universidade do Porto(UP)Rua de Jorge Viterbo Ferreiran°228Porto 4050-313Portugal Centro de Estudos de Ciencia Animal(CECA) Instituto de CienciasTecnologias e Agroambiente da Universidade do Porto(ICETA)Rua D.Manuel IApartado 55142Porto 4051-401 Portugal Centro de Investigaqao Vasco da Gama(CIVG)/Escola Universitaria Vasco da Gama(EUVG) Avenida Jose R.Sousa Femandesn°197 LordemaoCoimbra 3020-210Portugal REQUIMTE/LAQV Departamento de Engenharia Metalurgica e MateriaisFaculdade de EngenhariaUniversidade do PortoRua Dr Roberto FriasPorto 4200-495Portugal

The development of injectable bone substitutes(IBS)have obtained great importance in the bone re-generation field,as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular *** this scenario,the association of injectable hydrogels and bone graft granules is emerging as a well-established ***,in situ forming hydrogels have arisen as a new IBS *** in situ forming and injectable dextrin-based hydrogel(HG)was developed,aiming to act as a carrier of granular bone substitutes and bioactive *** this work,the HG was associated to a granular bone substitute(Bonelike)and implanted in goat critical-sized calvarial defects(14mm)for 3,6 and *** results showed that HG improved the han-dling properties of the Bonelike granules and did not affect its osteoconductive features,neither impairing the bone regener ation *** multipotent mesenchymal stromal cells from the umbilical cord,extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the *** bioactive agents did not enhance the new bone formation significantly under the conditions tested,according to micro-computed tomography and histological analysis.

关键词： polysaccharide injec table hydrogel granular ceramics Bonelike' bone regen eration calvarial defect

Alpha-1 antitrypsin deficiency and Pi^(*)Z allele as important co-factors in the development of liver fibrosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第8期16卷 1099-1110页

作者： ana Isabel Ferreira catarina Guimarães Vitor Macedo Silva Sofia Xavier Joana Magalhães JoséCotter Department of Gastroenterology Hospital da Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal Life and Health Sciences Research Institute/3B’s PT Government Associate LaboratoryBraga 4710-057Portugal Department of Pulmonology Hospital Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal

BACKGROUND Alpha-1 antitrypsin deficiency(AATD)is a codominant autosomal hereditary condition that predisposes patients to the development of lung and/or liver disease,and Pi*Z allele is the most clinically relevant *** To evaluate the impact of clinical parameters and AATD phenotypes,particularly the Pi*Z allele,in liver *** Cross-sectional cohort study including consecutive patients with AATD followed in Pulmonology or Hepatology *** Included 69 patients,49.3%had Pi*MZ phenotype and 10.1%Pi**** age≥55 years,age at diagnosis≥41 years and AAT at diagnosis<77 mg/dL predicted a nonalcoholic fatty liver disease fibrosis score(NFS)not excluding advanced fibrosis[area under the curve(AUC)=0.840,P<0.001;AUC=0.836,P<0.001;AUC=0.681,P=0.025].An age≥50 years and age at diagnosis≥41 years predicted a fibrosis-4 index of moderate to advanced fibrosis(AUC=0.831,P<0.001;AUC=0.795,P<0.001).Patients with hypertension,type 2 diabetes mellitus(DM),dyslipidaemia,metabolic syndrome,and regular alcohol consumption were more likely to have a NFS not excluding advanced fibrosis(P<0.001,P=0.002,P=0.008,P<0.001,P=0.033).Patients with at least one Pi*Z allele and type 2 DM were 8 times more likely to have liver stiffness measurement≥7.1 kPa(P=0.040).CONCLUSION Risk factors for liver disease in AATD included an age≥50 years,age at diagnosis≥41 years,metabolic risk factors,regular alcohol consumption,at least one Pi*Z allele,and AAT value at diagnosis<77 mg/*** created an algorithm for liver disease screening in AATD patients to use in primary care,selecting those to be referred to Hepatology consultation.

关键词： Alpha-1 antitrypsin deficiency Liver fibrosis Nonalcoholic fatty liver disease fibrosis score Fibrosis-4 index Liver stiffness measurement