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The spindle assembly checkpoint:perspectives in tumorigenesis and cancer therapy

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Frontiers in Biology 2011年第2期6卷 147-155页

作者： Joana BARBOSA ana Vanessa NAScIMeNTO Juliana FARIA Patrícia silva Hassan BOUSBAA centro de Investigação em ciências da Saúde(cIcS) Instituto Superior de Ciências da Saúde-NorteCESPURua Central de Gandra13174585-116 Gandra PRDPortugal

Loss or gain of chromosomes,a condition known as aneuploidy,is a common feature of tumor cells and has therefore been proposed as the driving force for *** chromosomal instability can arise during mitosis as a result of mis-segregation of the duplicated sister chromatids to the two daughter *** normal cells,missegregation is usually prevented by the spindle assembly checkpoint(SAc),a sophisticated surveillance mechanism that inhibits mitotic exit until all chromosomes have successfully achieved bipolar attachment to spindle *** abrogation of SAc activity is lethal to normal as well as to tumor cells,as a consequence of massive chromosome ***,many human aneuploid tumor cells exhibit a weakened SAc activity that allows them to tolerate gains or losses of a small number of chromosomes;and interfering with this SAc residual activity may constitute a suitable strategy to kill cancer *** review focuses on the potential link between SAc and tumorigenesis,and the therapeutic strategy to target the SAc for cancer treatment.

关键词： spindle assembly checkpoint mitosis chromosome instability tumor cancer therapy

The brain as a source and a target of prolactin in mammals

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Neural Regeneration Research 2022年第8期17卷 1695-1702页

作者： ana R.costa-Brito Isabel Gonçalves cecília R.A.Santos cIcS-UBI-Health Sciences Research centre Universidade da Beira InteriorCovilhãPortugal c4-UBI-cloud computing competence centre Universidade da Beira InteriorCovilhãPortugal

Prolactin is a polypeptide hormone associated with an extensive variety of biological *** the roles of prolactin in vertebrates,some were preserved throughout *** is the case of its function in the brain,where prolactin receptors,are expressed in different structures of the central nervous *** the brain,prolactin actions are principally associated with reproduction and parental behavior,and involves the modulation of adult neurogenesis,neuroprotection,and neuroplasticity,especially during pregnancy,thereby preparing the brain to *** is mainly produced by specialized cells in the anterior pituitary ***,during vertebrate evolution many other extrapituitary tissues do also produce prolactin,like the immune system,endothelial cells,reproductive structures and in several regions of the *** review summarizes the relevance of prolactin for brain function,the sources of prolactin in the central nervous system,as well as its local production and secretion.A highlight on the impact of prolactin in human neurological diseases is also provided.

关键词： brain brain disease choroid plexus neurogenesis neuroplasticity neuroprotection prolactin prolactin receptor

Hazardous elements and amorphous nanoparticles in historical estuary coal mining area

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Geoscience Frontiers 2019年第3期10卷 927-939页

作者： ana L.Duarte Kátia DaBoit Marcos L.S.Oliveira elba c.Teixeira Ismael L.Schneider Luis F.O.silva Department of civil and environmental Universidad de la Costa Faculdade Meridional IMeD FePAM-Funda■o estadual de Prote■o Ambiental Henrique Luis Roessler

In Brazil, intense coal exploitation activities have led to environmental deterioration, including soil mortification, water contamination, loss of ecosystem, and atmospheric contamination. In addition,considerable quantities of sulfur-rich residues are left behind in the mining area; these residues pose grave environmental issues as they undergo sulfide oxidation reactions. When sulfur oxides come in contact with water, extreme acid leachate is produced with great proportions of sulfate, and hazardous elements(Hes), which are identified as coal drainage(cMD). cMD is an environmental pollution challenge, particularly in countries with historic or active coal mines. To prevent cMD formation or its migration, the source must be controlled; however, this may not be feasible at many locations. In such scenarios, the mine water should be collected, treated, and discharged. In this study, data from 2005 to2010 was gathered on the geochemistry of 11 cMD discharges from ten different mines. There are several concerns and questions on the formation of nanominerals in mine acid drainage and on their reactions and interfaces. The detailed mineralogical and geochemical data presented in this paper were derived from previous studies on the coal mine areas in Brazil. Oxyhydroxides, sulfates, and nanoparticles in these areas possibly go through structural transformations depending on their size and formation conditions. The geochemistry of Fe-precipitates(such as jarosite, goethite, and hematite) existent in the cMD-generating coal areas and those that could be considered as a potential source of hazardous elements(Hes)(e.g., cr) were also studied because these precipitates are relatively stable in extremely low pH conditions. To simplify and improve poorly ordered iron, strontium, and aluminum phase characterization, field emission scanning electron microscopy(Fe-SeM), high-resolution transmission electron microscopy(HR-TeM), micro-Raman spectroscopy, and X-ray diffraction(XRD) a

关键词： Brazilian coal mining environmental impacts Minerals

Prevalence of sarcopenia using different methods in patients with non-alcoholic fatty liver disease

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World Journal of Hepatology 2022年第8期14卷 1643-1651页

作者： Naiade Silveira Almeida Raquel Rocha claudineia Almeida de Souza ana carolina Sirelli da cruz Bruna dos Reis Ribeiro Luiza Valois Vieira carla Daltro Rafael silva Manoel Sarno Helma Pinchemel cotrim Programa de Pós-Graduação em Medicina e Saúde Universidade Federal da BahiaSalvador 40110-060BABrazil Departamento de ciência da Nutrição Escola de NutriçãoUniversidade Federal da BahiaSalvador 40110-060Brazil caliper clínica e escola de Imagem Salvador 41810-012Brazil

BAcKGROUND Sarcopenia is a clinical condition associated with several liver diseases and it includes non-alcoholic fatty liver disease(NAFLD)in its broad spectrum as steatosis,steatohepatitis and ***,the criteria to define sarcopenia are diverse,and even those established in consensus have been discussed regarding their performance in making an accurate *** To evaluate the prevalence of sarcopenia,using different methods,in patients with NAFLD,and its association with clinical-anthropometric *** This was an observational study of outpatients with *** was defined by the european Working Group consensus on Sarcopenia in Older People of 2010(eWGSOP1)and 2018(eWGSOP2).The skeletal muscle index was used to estimate muscle mass,handgrip strength was assessed using the dynamometer and physical performance by walking a distance of four meters at usual walking *** non-invasive fibrosis scores,fibrosis-4(FIB-4)index and Aspartate aminotransferase to platelet ratio index(APRI),were used to assess the absence and presence of *** Fifty-seven individuals with NAFLD were evaluated,the mean age(SD)was 52.7(11.3)years and 75.4%were *** assessed by FIB-4 and APRI was observed in 3.7%and 16.6%of patients with NAFLD,*** diagnosis of sarcopenia was identified only by eWGSOP1 in 3.5%of NAFLD patients,and the prevalence of probable/pre-sarcopenia was higher using the eWGSOP2 consensus at 26.3%,when compared to 1.8%with *** defined by eWGSOP1,was associated with grade I steatosis,but without overweight(Pciation between sarcopenia and fibrosis was not observed(P>0.05).eWGSOP2 showed a greater number of patients with probable sarcopenia,and who were overweight(12(80.0%)),with a higher degree of steatosis[11(73.3%)and presence of fibrosis(1(6.7%),FIB-4 and 3(20.0%),APRI]compared to eWGSOP1[1(100%),0(0.0%),0(0.0%),FIB-4 and 0(0.0%),APRI,respectively].cONcLUSION The presen

关键词： Non-alcoholic fatty liver disease Sarcopenia Muscle strength Physical performance Liver fibrosis

Development of hepatorenal syndrome in bile duct ligated rats

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World Journal of Gastroenterology 2008年第28期14卷 4505-4511页

作者： Regina M Pereira Robson AS dos Santos eduardo A Oliveira Virgínia HR Leite Filipi Lc Dias Alysson S Rezende Lincoln P costa Lucíola S Barcelos Mauro M Teixeira ana c.istina sim■es e silva Departamento de ciências Biológicas Centro Universitário de Belo Horizonte-UNIBHAv.Mário WerneckBelo HorizonteMinas Gerais 30150-281Brazil Laboratório de Hipertenso Departamento de Fisiologia e BiofísicaInstituto de Ciências Biológicas (ICB)Universidade Federal de Minas Gerais (UFMG)Av.Antonio Carlos6627Belo HorizonteMinas Gerais 30150-281Brazil Departamento de Pediatria Faculdade de MedicinaUFMGAv.Alfredo Balena 190Belo HorizonteMinas Gerais 30150-281Brazil Departamento de anatomia Patológica Faculdade de MedicinaUFMGAv.Alfredo Balena 190Belo HorizonteMinas Gerais 30150-281Brazil Laboratório de Imunofarmacologia Departamento de Bioquímica e ImunologiaICBUFMGAv.Antonio Carlos 6627Belo HorizonteMinas Gerais 30150-281Brazil

AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. MeTHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. ResULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. cONcLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS.

关键词：胆管结扎肾素高血压蛋白原酶肾功能

effect of ce-base mischmetal addition on the microstructure and mechanical properties of hot-rolled ZK60 alloy

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Journal of Magnesium and Alloys 2021年第3期9卷 995-1006页

作者： e.P.silva R.H.Buzolin F.Marques F.Soldera U.Alfaro H.c.Pinto Institute of engineering Science and Technology(IECT)Federal University of Vales do Jequitinhonha e Mucuri(UFVJM)JanaúbaMGBrazil São carlos School of engineering(eesc) University of São Paulo(USP)Department of Materials EngineeringCEP 13563-120 São Carlos-SPBrazil christian Doppler Laboratory for Design of high-performance alloys by thermomechanical processing Kopernikusgasse 24/I8010 GrazAustria Technische Universität Graz(TU Graz) Institute of Materials ScienceJoining and FormingKopernikusgasse 24/I8010 GrazAustria Institute of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbrueckenGermany German Aerospace center(DLR)Institute of Materials Research Linder Höhe51147 CologneGermany

Mg-Zn-Zr(ZK)alloys exhibit notably high mechanical strength amongst all magnesium alloy ***,due to the formation of low melting point Mg_3Zn_7-precipitates,these alloys are susceptible to hot cracking,thus compromising their metallurgical *** addition of rare earths to ZK alloys is an alternative to form higher melting point intermetallic compounds,speed up dynamic recrystallization,refine grain size,enhance corrosion resistance and extend the service temperature due to improved creep *** work deals with the effect of ce-base mischmetal addition on the hot rolling behaviour of as-cast ZK60 *** microstructure investigation conducted using electron microscopy and X-Ray diffraction shows that precipitation of Mg_(7)Zn_(3) intermetallics occur during hot rolling,whereas no further precipitation is observed for the ZK60-Mm *** fragmentation of the intermetallic compounds occur during hot rolling and finer particles of Mg_(7)Zn_(3) are observed for the ZK60,whereas Mg_(7)Zn_(3) and Mg Zn_(2) ce intermetallics are formed in the alloy modified with mischmetal addition.A higher fraction of dynamically recrystallized grains is observed for the ZK60-Mm in comparison to the *** recrystallization takes place in ZK60 with the formation of sub-grains near to the intermetallics and the addition of mischmetal promotes the occurrence of discontinuous recrystallization with the nucleation of new grains close to the *** mechanical strength and,in particular,the ductility of the hot-rolled alloys are notably improved when compared to the same alloys in the as-cast *** mechanical strength is,however,higher for the ZK60 *** solid solution strengthening,softer Mg Zn_(2) ce intermetallics and more extensive recrystallization contribute to reduce the mechanical strength of *** in both alloys are initiated at coarse intermetallics and propagate through intermetallic-rich regions.

关键词： Magnesium alloys Hot rolling Mischmetal Recrystallization Microstructure Mechanical properties

epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5404-5416页

作者： catarina Macedo-silva Vera Miranda-Gonçalves Nuno Tiago Tavares Daniela Barros-silva Joana Lencart João Lobo Ângelo Oliveira Margareta Pcorreia Lucia Altucci carmen Jerónimo cancer Biology&epigenetics Group Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Precision Medicine University of Campania“Luigi Vanvitelli”80138NaplesItaly Department of Pathology and Molecular Immunology ICBAS-School of Medicine&Biomedical SciencesUniversity of PortoR.Jorge de Viterbo Ferreira 2284050-313PortoPortugal Medical Physics Radiobiology and Radiation Protection Group-Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Medical Physics Portuguese Oncology Institute of Porto4200-072PortoPortugal Department of Pathology Portuguese Oncology Institute of PortoPortoPortugal Department of Radiation Oncology Portuguese Oncology Institute of PortoPortoPortugal BIOGeM Molecular Biology and Genetics Research Institute83100AvellinoItaly IeOS Institute of Endocrinology and Oncology80100NaplesItaly

external beam radiotherapy(RT)is a leading first-line therapy for prostate cancer(Pca),and,in recent years,significant advances have been ***,RT resistance can arise and result in long-term recurrence or disease progression in the worst-case ***,making crucial the discovery of new targets for Pca ***,we generated a radioresistant Pca cell line,and found p53 to be highly expressed in radioresistant Pca cells,as well as in Pca patients with recurrent/disease progression submitted to *** dissection revealed that RT could promote p53 expression via epigenetic ***,a decrease of H3K27me3 occupancy at TP53 gene promoter,due to increased KDM6B activity,was observed in radioresistant Pca ***,p53 is essential for efficient DNA damage signaling response and cell recovery upon stress induction by prolonged fractionated ***,KDM6B inhibition by GSK-J4 significantly decreased p53 expression,consequently attenuating the radioresistant phenotype of Pca cells and hampering in vivo 3D tumor ***,this work contributes to improve the understanding of p53 as a mediator of signaling transduction in DNA damage repair,as well as the impact of epigenetic targeting for Pca radiosensitization.

关键词： TP53 damage cancer

Fiber cavity Ring Down and Gain Amplification effect

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Photonic Sensors 2016年第4期6卷 324-327页

作者： Susana silva Regina MAGALHAes Rosa ana PeReZ-HeRReRA Manuel LOPeZ-AMO M. B. MARQUes O. FRAZAO IINesc Tec Rua do Campo Alegre 687 4169-007 Porto Portugal Dept. de Fisica e Astronomia da Faculdade de ciencias da Universidade do Porto Rua do Campo Alegre 687 4169-007 Porto Portugal public University of Navarra Dept. of Electric and Electronic Engineering Campus de Arrosadla Pamplona Spain.

The effect of an erbium-doped fiber amplifier （eDFA） placed inside the fiber ring of a cavity ring down （cRD） configuration is studied. The limitations and advantages of this configuration are discussed, and the study of the ring-down time as a function of the current applied and gain to the eDFA is also presented. In this case, the power fluctuations in the output signal are strongly dependent on the cavity ring-down time with the eDFA gain.

关键词： cavity ring down eDFA multimode laser optical fibers.

Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni ana Júlio celestino Santos-Buelga ana M.Gonzalez-Paramas Patrícia Filipe Patricia Rijo Sofia A.costa Lima Salette Reis Angela Fernandes Isabel c.F.R.Ferreira Virginia Fernandez-Ruiz Patricia Morales Guido Flamini Lotfi Achour Pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia cBIOS-Research center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal centro de Investigacao de Montanha(cIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly center for Marine Sciences(ccMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-esI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with ec_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SeM and spherical polymeric nanoparticles with a smooth surface were *** and DSc were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA