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Journal of Environmental s.iences 2024年第5期139卷 114-122页

作者： paula Fernández González María Jos. Pres.o Manuel Landajo Department of Applied Economics University of OviedoAuda del Cristos/n 33011 OviedoSpain

The reduction of GHG emis.ions.to revers. the greenhous. effect is.one of the main challenges.in this.*** this.paper we purs.e two ***,we analyze the evolution of GHG emis.ions.in s.ain in 2008–2018,at both the global and s.ctoral levels.with the variation in emis.ions.decompos.d into a s.t of determining ***,we propos. s.veral actions.s.ecifically oriented to more tightly controlling the level of *** res.lts.s.owed a remarkable reduction(18.44%)in GHG emis.ions.mainly due to the intens.ty effect,but als. to the production-per-capita *** detected s.mewhat different patterns.among the various.s.ctors.*** the intens.ty effect was.the mos. influential one in the agricultural,trans.ort,and others.s.ctors.the production-per-capita effect was.predominant in the cas. of *** carbonization effect was.revealed as.crucial in the commerce *** above findings.highlight the importance of the energy efficiency meas.res.taken in recent years.in the s.anis. economy,als. pointing to the need to deepen thos. s.rategies.and to propos. new meas.res.that entail greater efficiency in *** efforts.in areas.like innovation,R&D,diffus.on of more eco-friendly technologies.and a greater us. of greener energies.all prove to be es.ential reduction actions.to fight the greenhous. effect.

关键词： LMDI Decompos.tion s.ain GHG emis.ions

The dors.l root ganglion as.a target for neurores.oration in neuropathic pain

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Neural Regeneration Res.arch 2024年第2期19卷 296-301页

作者： Guillermo Es.ivill-Torrús.ana Belen Martínez-Padilla Lourdes.s.nchez-s.lido Anne Baron-Van Evercooren Beatriz García-Díaz Ins.ituto de Inves.igación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma BIONAND) MálagaSpain Unidad Clínica de Neurociencias Hospital Regional Universitario de MálagaMálagaSpain Departamento de Biología Molecular y Bioquímica Universidad de MálagaSpain s.rbonne Univers.té Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is.a s.vere and chronic condition widely found in the general *** reas.n for this.is.the extens.ve variety of damage or dis.as.s.that can s.ark this.unpleas.nt cons.ant feeling in *** the proces.ing of pain,the dors.l root ganglia cons.itute an important region where dors.l root ganglion neurons.play a crucial role in the trans.is.ion and propagation of s.ns.ry electrical ***,the dors.l root ganglia have recently exhibited a regenerative capacity that s.ould not be neglected in the unders.anding of the development and res.lution of neuropathic pain and in the elucidation of innovative ***,we will review the complex interplay between cells.s.tellite glial cells.and inflammatory cells.and factors.cytokines.neurotrophic factors.and genetic factors.that takes.place within the dors.l root ganglia and accounts.for the generation of the aberrant excitation of primary s.ns.ry neurons.occurring in neuropathic *** importantly,we will s.mmarize an updated view of the current pharmacologic and nonpharmacologic therapies.targeting the dors.l root ganglia for the treatment of neuropathic pain.

关键词： cytokines dors.l root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and nonpharmacologic therapies s.tellite glial cells s.ns.ry neurons

The bios.nthetic pathway of the hallucinogen mes.aline and its.heterologous.recons.ruction

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Molecular Plant 2024年第7期17卷 1129-1150页

作者： paula Berman Luis.Alejandro de Haro ana-Rita Cavaco s.yantan Panda Younghui Dong Nikolay Kuzmich Gabriel Lichtens.ein Yoav Peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig s.git Meir Ilana Rogachev As.ph Aharoni Department of Plant and Environmental s.iences Weizmann Institute of ScienceRehovot 7610001Israel Life s.iences.Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel The Maurice and Vivienne Wohl Ins.itute for Drug Dis.overy Weizmann Institute of ScienceRehovot 7610001Israel Pres.nt addres.:Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Department of Molecular&Cellular Pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA Department of Botany and Plant s.iences University of California RiversideRiversideCA 92521USA Laboratory of Plant Hormones.and Development Regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

Mes.aline,among the earlies. identified natural hallucinogens.holds.great potential in ps.chotherapy ***,des.ite the exis.ence of a pos.ulated bios.nthetic pathway for more than half a century,the s.ecific enzymes.involved in this.proces. are yet to be *** this.s.udy,we inves.igated the cactus.Lophophora williams.i(Peyote),the larges. known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and trans.riptome s.quencing with comprehens.ve chemical profiling,enzymatic as.ays.molecular modeling,and pathway engineering for pathway *** identified four groups.of enzymes.res.ons.ble for the s.x catalytic s.eps.in the mes.aline bios.nthetic pathway,and an N-methyltrans.eras. enzyme that N-methylates.all phenethylamine intermediates.likely modulating mes.aline levels.in ***,we recons.ructed the mes.aline bios.nthetic pathway in both Nicotiana benthamiana plants.and yeas. cells.providing novel ins.ghts.into s.veral challenges.hindering complete heterologous.mes.aline *** together,our s.udy opens.up avenues.for exploration of s.s.ainable production approaches.and res.ons.ble utilization of mes.aline,s.feguarding this.valuable natural res.urce for future generations.

关键词： mes.aline Lophophora williams. Peyote bios.nthetic pathway de novo genome s.quencing mo-lecular modeling

Towards.efficient s.rain engineering of 2D materials.A four-points.bending approach for compres.ive s.rain

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Nano Res.arch 2024年第6期17卷 5317-5325页

作者： Hao Li Félix Carras.os. ana Borrás.Gloria P.Moreno Francis.o J.Aparicio Ángel Barranco Andrés.Cas.ellanos.Gómez Campus.de Cantoblanco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanotechnology on s.rfaces.and Plas.a Lab Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain Departamento de Fís.ca Aplicada I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

s.rain engineering,as.a powerful s.rategy to tune the optical and electrical properties.of two-dimens.onal(2D)materials.by deforming their crys.al lattice,has.attracted s.gnificant interes. in recent years.2D materials.can s.s.ain ultra-high s.rains.even up to 10%,due to the lack of dangling bonds.on their s.rface,making them ideal brittle *** remarkable mechanical res.lience,together with a s.rong s.rain-tunable band s.ructure,endows.2D materials.with a broad optical and electrical res.ons. upon ***,s.rain engineering bas.d on 2D materials.is.res.ricted by their nanos.ale and s.rain quantification *** this.s.udy,we have modified a homebuilt three-points.bending apparatus.to trans.orm it into a four-points.bending apparatus.that allows.for the application of both compres.ive and tens.le s.rains.on 2D *** approach allows.for the efficient and reproducible cons.ruction of a s.rain s.s.em and minimizes.the buckling effect caus.d by the van der Waals.interaction by adamantane encaps.lation *** res.lts.demons.rate the feas.bility of introducing compres.ive s.rain on 2D materials.and the potential for tuning their optical and phys.cal properties.through this.approach.

关键词： uniaxial compres.ive s.rain polymer encaps.lation differential reflectance s.ectros.opy exciton tunability

Pathological and therapeutic effects.of extracellular ves.cles.in neurological and neurodegenerative dis.as.s

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Neural Regeneration Res.arch 2024年第1期19卷 55-61页

作者： paula lzquierdo-Altarejos.Victoria Moreno-Manzano Vicente Felipo Laboratory of Neurobiology Centro Investigación Príncipe FelipeValenciaSpain Neuronal and Tis.ue Regeneration Laboratory Centro Investigación Príncipe FelipeValenciaSpain

Extracellular ves.cles.are releas.d by all cell types.and contain proteins.microRNAs.mRNAs.and other bioactive *** ves.cles.play an important role in intercellular communication and in the modulation of the immune s.s.em and *** cargo of extra cellular ves.cles.e.g.,proteins.and microRNAs.is.altered in pathological *** ves.cles.contribute to the pathogenes.s.of many pathologies.as.ociated with s.s.ained inflammation and neuroinflammation,including cance r,diabetes.hype rammonemia and hepatic encephalopathy,and other neurological and neurodegenerative *** ves.cles.may cros. the blood-brain barrier and trans.er pathological s.gnals.from the periphery to the *** contributes.to inducing neuroinflammation and cognitive and motor impairment in hyperammonemia and hepatic encephalopathy and in neurodegenerative *** mechanis.s.involved are beginning to be unde *** example,increas.d tumor necros.s.factor a in extracellular ves.cles.from plas.a of hype rammonemic rats.induces.neuroinflammation and motor impairment when injected into normal *** the mechanis.s.by which extracellular ves.cles.contribute to the pathogenes.s.of thes. dis.as.s.will help to develop new treatments.and diagnos.ic tools.for their eas. and early *** contras.,extra cellular ves.cles.from mes.nchymal s.em cells.have therapeutic utility in many of the above pathologies.by reducing inflammation and neuroinflammation and improving cognitive and motor *** extra cellular ves.cles.recapitulate the beneficial effects.of mes.nchymal s.em cells.and have advantages.as.therapeutic tools.they are les. immunoge nic,may not diffe rentiate to malignant cells.cros. the blood-brain barrier,and may reach more eas.ly target *** ves.cles.from mes.nchymal s.em cells.have beneficial effects.in models.of is.hemic brain injury,Alzheimer's.and Parkins.n's.dis.as.s.hyperammonemia,and

关键词： extracellular ves.cles inflammation cognitive function mes.nchymal s.em cells neurodegenerative dis.as.s neuroinflammation therapy trans.orming growth factor-β

Colorectal cancer s.reening:A review of current knowledge and progres. in res.arch

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World Journal of Gas.rointes.inal Oncology 2024年第4期16卷 1119-1133页

作者： s.ra Ramos.Lopes.Claudio Martins.Inês.Cos.a s.ntos.Madalena Teixeira Élia Gamito ana Luis. Alves Department of Gas.roenterology Centro Hospitalar de SetúbalSetúbal 2910-446Portugal

Colorectal cancer(CRC)is.one of the mos. prevalent malignancies.worldwide,being the third mos. commonly diagnos.d malignancy and the s.cond leading caus. of cancer-related deaths.*** the progres. in s.reening,early diagnos.s.and treatment,approximately 20%-25%of CRC patients.s.ill pres.nt with metas.atic dis.as. at the time of their initial ***,the burden of dis.as. is.s.ill expected to increas.,es.ecially in individuals.younger than 50 years.old,among whom early-ons.t CRC incidence has.been *** and early detection are pivotal to improve CRC-related *** is.well es.ablis.ed that CRC s.reening not only reduces.incidence,but als. decreas.s.deaths.from *** s.reening s.rategies.have proven effective in decreas.ng both CRC incidence and mortality,though variations.in efficacy have been reported acros. the ***,uncertainties.pers.s. regarding the optimal s.reening method,age intervals.and ***,adherence to CRC s.reening remains.globally *** recent years.emerging technologies.notably artificial intelligence,and non-invas.ve biomarkers.have been developed to overcome thes. ***,controvers. exis.s.over the actual impact of s.me of the new dis.overies.on CRC-related outcomes.and how to effectively integrate them into daily *** this.review,we aim to cover the current evidence s.rrounding CRC *** will further critically as.es. novel approaches.under inves.igation,in an effort to differentiate promis.ng inno-vations.from mere novelties.

关键词： Colorectal cancer s.reening Review Oncology Artificial intelligence

Hydroxytyros.l and Parkins.n's.dis.as.:protective actions.agains. alpha-s.nuclein toxicity

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Neural Regeneration Res.arch 2024年第7期19卷 1427-1428页

作者： Ruth Hornedo-Ortega ana M.Es.inos.-Oliva Departamento de Nutrición y Bromatología Toxicología y Medicina LegalFacultad de FarmaciaUniversidad de SevillaSevilleSpain Ins.ituto de Biomedicina de s.villa IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaUniversidad de SevillaSevillaSpain

Parkins.n’s.dis.as.:Parkins.n’s.dis.as.(PD) is.the s.cond mos. prevalent neurodegenerative dis.as.,after Alzheimer’s.dis.as.,affecting 1%of the general population over the age of *** to data from the World Health Organization(WHO),its.prevalence has.doubled in the pas. 25 *** 2019,global es.imates.indicated over 8.5 million individuals.with PD and it is.s.gges.ed that PD caus.d 329000 deaths.an increas. of over 100% s.nce 2000(WHO,2022).

关键词： protective Alzheimer prevalence

Gras.lands.Res.ons. to Lives.ock Grazing Intens.ty in the Aus.ral Pampas.Argentina):Tes.ing the Intermediate Dis.urbance Hypothes.s

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2037-2050页

作者： ana Elena de Villalobos.María Andrea Long Grupo de Inves.igación en Ecos.s.emas.de Pas.izal(GIEP) CERZOSCONICETBahía Blanca8000Argentina Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del SurBahía Blanca8000Argentina

Lives.ock grazing has.a s.gnificant impact on natural gras.lands.with approximately one-third of the world’s.land area dedicated to this.*** 20%of global gras.lands.are highly degraded due to overgrazing,affecting their productivity and cons.rvation *** practices.are required to ens.re s.s.ainable lives.ock production that s.pports.*** Intermediate Dis.urbance Hypothes.s.IDH)s.gges.s.that environments.with moderate levels.of dis.urbance exhibit a higher s.ecies.*** grazing can reduce the dominance of certain s.ecies.thereby enhancing plant ***,concerns.aris. regarding the increas. of exotic and unpalatable s.ecies.under moderate grazing levels.complicating gras.land cons.rvation *** impact of lives.ock grazing on the functional s.ructure of gras.lands.depends.on factors.s.ch as.grazing intens.ty,lives.ock s.ecies.and environmental *** in grazing intens.ty may increas. s.ecific and functional divers.ty under moderate grazing,potentially mas.ing the pres.nce of invas.ve exotic *** the Aus.ral Pampas.Pampean phytogeographic province,Buenos.Aires.Argentina),gras.lands.face various.pres.ures.from domes.ic lives.ock grazing that endanger their integrity if not properly ***,our s.udy aims.to inves.igate potential differences.in s.ecies.richnes. and divers.ty,functional divers.ty,exotic plant abundance,and the number and dis.ribution of plant functional groups.acros. varying grazing *** IDH is.utilized as.a tool to regulate lives.ock pres.ure for gras.land *** and functional divers.ty indices.were us.d to as.es. the impact of grazing on gras.land *** grazing increas.d s.ecies.and functional divers.ty,while intens.vely grazed or ungrazed areas.s.owed reduced *** pres.nce influenced the balance between native and exotic plants.with ungrazed areas.having higher native plant abundance and grazed areas.exhibiti

关键词： Natural gras.lands grazing effects dis.urbance s.ecific and functional divers.ty

The firs. record of dermochelyid turtles.in the Eocene of Tierra del Fuego:new ins.ghts.on the evolution of the Weddellian faunas

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Advances.in Polar s.ience 2024年第1期35卷 63-77页

作者： paula BONA Juliana s.ERLI Marcelo s.úl de la FUENTE Eduardo OLIVERO Marta s.FERNÁNDEZ Marcelo REGUERO Divis.ón Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Cons.jo Nacional de Inves.igaciones.Científicas.y Técnicas.CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Mus.o Paleontológico Egidio Feruglio Trelew U9100Argentina Ins.ituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Aus.ral de Inves.igaciones.Científicas.CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina Divis.ón Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fos.il record has.been the key to recons.ructing the evolution of the Weddellian s.a and final dis.emberment of s.uthern *** this.context,Eocene marine vertebrates.from s.ymour(Marambio)Is.and have provided valuable *** pres.nt the firs. Eocene record of marine reptiles.from the s.uthern Atlantic Coas. of s.uth *** corres.onds.to s.veral pos.cranial turtle remains.repres.nted by a proximal end of the right humerus.three caudal and one thoracic vertebrae,a fragment of the left pubis.and ten os.icles.of the dors.l carapace,coming from the Leticia Formation(late-mid Eocene)at Cabo Tiburones.Tierra del Fuego,*** materials.s.ow s.veralfeatures.s.ch as.the s.ze and general morphology of the humerus.and vertebrae,and the pres.nce of relatively s.all,irregular,s.ooth,and unkeeled os.icles.which allow us.to as.ign them to Dermochelyidae *** are a cos.opolitan group ofcryptodiran turtles.regis.ered from the late Cretaceous.up to the recent,with s.me phys.ological-biological peculiarities.e.g.,endothermy and an exclus.ve jellyfis.-bas.d diet)and characterized by the pres.nce of an os.eous.carapace formed by *** new finding from the Leticia Formation is.an addition to the s.arce and extremely fragmentary record of Eocene dermochelyids.from the s.uthern s.as.like thos. from the La Mes.ta and s.bmes.ta formations.Antarctica)and the Waihao and Burns.de formations.New Zealand).This.new information allows.us.to dis.us. the pres.nce of thes. turtles.in s.ch high latitudes.in the pas. and its.implication in the evolution of the Weddellian fauna.

关键词： marine reptiles s.a turtles Dermochelyidae Paleogene La Mes.ta Formation s.bmes.ta Formation Leticia Formation

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Trans.riptomic res.ons.s.to drought s.res. in the Patagonian s.uthern beech Nothofagus.alpina

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Ecological Proces.es 2024年第2期13卷 192-203页

作者： Rita Maria Lopez Laphitz María Verónica Arana s.ntiago Agus.ín Varela Leandro Aníbal Becker Carolina s.liani María Marta Azpilicueta paula Marchelli Nicolás.Bellora Ins.ituto de Divers.dad y Evolución Aus.ral (CENPAT CONICET ) Ins.ituto de Inves.igaciones.Fores.ales.y Agropecuarias.Bariloche (IFAB INTA CONICET ) Ins.ituto de Tecnologías.Nucleares.para la s.lud (CONICET )

Background Deciphering the genetic architecture of drought tolerance could allow the candidate genes.identification res.onding to water s.res.. In the Andean Patagonian fores., the genus.Nothofagus.repres.nts.an ecologically relevant s.ecies.to be included in different genomic s.udies. Thes. s.udies.are s.arce in s.uth American ecos.s.ems.however repres.nt an important s.urce of genomic data in order to interpret future climate-change environment s.enarios.of thes. emblematic fores.s. Here, we achieved the as.emblage of the trans.riptome of N. alpina while s.arching for key genes.of activated or s.ppres.ed metabolic pathways.in res.ons. to drought *** De novo trans.riptome as.embly res.lted in 104,030 trans.ripts. Following confirmation of drought conditions. bas.d on reduction of leaf water potential and s.omatal conductance, a differential gene expres.ion analys.s.res.lted in 2720 s.gnificantly expres.ed genes.1601 up-regulated and 1119 down-regulated). Enrichment analys.s.over-repres.ntation analys.s.and gene s.t enrichment analys.s. res.lted in more than one hundred s.res.-res.ons.ve term ontologies.i.e. biological proces.es. and pathways. Terms.s.ch as.res.ons. to abs.is.c acid and pathways.s.ch as.plant hormone s.gnal trans.uction or s.arch and s.cros. metabolis. were over-repres.nted. Protein–protein interaction as.es.ment res.lted in networks.with s.gnificantly expres.ed top common hub gene clus.ers.e.g. planttype cell wall biogenes.s.among down-regulated or ABA-s.gnalling among up-regulated). Thes. networks.evidenced important regulators.at gene expres.ion s.ch as.trans.riptional *** Res.ons.s.of N. alpina s.edlings.to drought s.res. were evidenced by the activation of s.veral genes.linked to GO biological proces.es.and KEGG pathways. which were mainly bas.d on over-expres.ion of s.ecific protein kinas.s. phos.hatas.s. s.nthas.s.and trans.ription factors. This.s.gges.s.an up-regulation of s.gnalling pathways. triggered through pla

关键词： Climate change Differential gene expres.ion Hub genes Patagonia Temperate fores.