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Effect of a hydrogymnastics program on the serum levels of high-sensitivity C-reactive protein amongst elderly women

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Health 2014年第1期6卷 80-85页

作者： Javier Arturo Hall-López Paulina Yesica Ochoa-martínez Edgar Ismael Alarcón-Meza Fernando Israel anaya-Jaramillo ana maría miranda botelho teixeira José Moncada-Jiménez José Carlos Ferreira-Reis Estélio Henrique martin Dantas Centre for Research in Human Movement Sciences University of Costa Rica San Jose Costa Rica Euro-American Network of Human Kinetics (REMH) Rio de Janeiro Brazil Laboratory of Human Motricity Biosciences (LABIMH) Federal University of State of Rio de Janeiro Rio de Janeiro Brazil Faculty of Sports Science and Physical Education University of Coimbra Coimbra Portugal School of Sports Autonomous University of Baja California (UABC) Mexicali Mexico Euro-American Network of Human Kinetics (REMH) Rio de Janeiro Brazil School of Sports Autonomous University of Baja California (UABC) Mexicali MexicoEuro-American Network of Human Kinetics (REMH) Rio de Janeiro Brazil

The aim of this study was to evaluate the effect of a hydrogymnastics training program on highsensitivity C-reactive protein in elderly women. The subjects were randomly divided into the experimental group who participates in the hydrogymnastics training program and the control group who was not involved in the training and remained sedentary. The serum levels of highsensitivity C-reactive protein were determined by immunoturbidimetry using C-reactive protein (CRP), the training protocol consisted of hydrogymnastics sessions 5 times per week during 12 weeks of intervention, executed in a pool of 1.3 meters divided into three phases: a 10-minute warm-up, 30 minutes of aerobic exercise at 50%-60% of maximum heart rate (monitored by heart rate monitor) and a 10-minute cool down. As a statistical method to compare the results between groups of variables pre and post training, the analysis of variance (ANOVA) mixed 2 × 2 (group × measurement) test was done using SPSS version 17. The founds showed significant changes in the level of high-sensitivity C-reactive protein, and a greater percentage decrease of hs-CRP (Δ%= -37%, p = 0.001) in the experimental group in relation to the control ***, it can be inferred that a hydrogymnastics program is effective in reducing the metabolic rate of high-sensitivity C-reactive protein amongst elderly women.

关键词： Elderly hs-CRP Hydrogymnastics

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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： maria Renata Valente Brandão Freire Natália marchesan Bexiga marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares ana Cláudia Camargo miranda Anna Carolina de Alcântara Barbosa marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. teixeira maria Helena marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

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Renin angiotensin system in liver diseases: Friend or foe?

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World Journal of Gastroenterology 2017年第19期23卷 3396-3406页

作者： ana Cristina Simoes e Silva Aline S miranda Natália P Rocha Antonio L teixeira Department of Pediatrics Faculty of MedicineFederal University of Minas Gerais Interdisciplinary Laboratory of Medical Investigation Faculty of MedicineUFMG Laboratory of Neurobiology Department of MorphologyInstitute of Biological SciencesUFMG Neuropsychiatry Program Department of Psychiatry and Behavioral SciencesMcGovern Medical SchoolUniversity of Texas Health Science Center at Houston

In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?*** this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two *** first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver *** this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal *** therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed.

关键词： Renin angiotensin system Angiotensin Ⅱ Angiotensin-(1-7) Hepatic cirrhosis Liver fibrosis Hepatorenal syndrome

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Ecophysiological acclimatization to cyclic water stress in Eucalyptus

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Journal of Forestry Research 2020年第3期31卷 797-806页

作者： Rogerio de Souza Noia Junior Genilda Canuto Amaral Jose Eduardo Macedo Pezzopane mariana Duarte Silva Fonseca ana Paula Camara da Silva Talita miranda teixeira Xavier Department of Biosystems Engineering ESALQ University of Sao PauloPiracicabaSao PauloBrazil Department of Forestry Sciences NEDTEC Federal University of Espirito SantoJero nimo MonteiroEspirito SantoBrazil

Drought is considered the main environmental factor limiting productivity in eucalyptus plantations in Brazil. However, recent studies have reported that exposure to water deficit conditions enables plants to respond to subsequent stresses. Thus, this study investigates the ecophysiological acclimatization of eucalyptus clones submitted to recurrent water deficit cycles. Eucalyptus seedlings were submitted to three recurrent water deficit cycles and anatomical, morphological and physiological changes were analyzed. The results were:(1) Eucalyptus seedlings responded to water deficits by directing carbohydrates to root and stem growth;(2) Size and number of stomata were reduced;(3) Stomatal conductance decreased which allowed the plants to reduce water losses through transpiration,increasing instantaneous water use efficiency;(4) The relationship between gas exchanges and available water contents allowed the seedlings to uptake the retained soil water athigher tensions;and,(5) Physiological recovery from subsequent water deficits became faster. As a result of these changes, the eucalyptus seedlings recovered from the same degree of water stress more rapidly.

关键词： Carbon partition Drought Gas exchange Morpho-physiological changes Photosynthetic apparatus

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Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital

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World Journal of Clinical Cases 2023年第8期11卷 1761-1770页

作者： Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior maria Teresa Araújo de Lorenzo Barcia Renata de Amorim marques AndréBezerra botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes teixeira Cláudio Lima Souza Lucas miranda marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Hospital Geral de Vitória da Conquista Vitória da Conquista 45030-160BahiaBrazil Departamento de Ciências da Saúde Universidade Estadual do Sudoeste da Bahia(UESB)Vitória da Conquista 45083-900BahiaBrazil Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern *** that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and *** To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease *** This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian *** The patients had a median age of 65.60±15.78 *** was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the *** least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with *** and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective *** This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected *** associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features.

关键词： COVID-19 Epidemiology Symptoms Comorbidities Laboratory parameters

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Resting energy expenditure in cirrhotic patients with and without hepatocellular carcinoma

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2021年第1期12卷 1-12页

作者： ana Cristhina Henz Claudio Augusto marroni Daniella miranda da Silva Joise Munari teixeira ThiagoThoméSilveira Shaiane Ferreira Andresa ThoméSilveira Natalia Perin Schmidt Jessica Taina Stein Roberta Goulart Rayn Sabrina Alves Fernandes Department of Nutrition Centro Universitário Metodista(IPA)Porto Alegre 90420-060RSBrazil Department of Gastroenterology and Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 91760470RSBrazil Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90050170RSBrazil Postgraduate Program in Medicine HepatologyUniversidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90050170RSBrazil Hepatology Graduate Program Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90050170RSBrazil

BACKGROUND The diagnosis of malnutrition in patients with independent hepatocellular carcinoma(HCC)varies from 20%to 50%,is related to important complications and has a direct impact on the *** of the resting energy expenditure(REE)has become an important parameter in this population,as it allows therapeutic adjustments to recover their nutritional *** REE in cirrhosis,with and without HCC,is not clearly defined,and requires the identification and definition of the best nutritional *** To evaluate the REE of patients with cirrhosis,with and without *** This is a prospective observational study evaluating the REE of 118 patients,33 with cirrhosis and hepatocellular carcinoma and a control group of 85 patients with cirrhosis without HCC,using indirect calorimetry(IC),bioimpedance,and predictive *** The REE determined by IC in cirrhotic patients with HCC was 1643±364 and in those without HCC was 1526±277(P=0.064).The REE value as assessed by bioimpedance was 1529±501 for those with HCC and 1660±385 for those without HCC(P=0.136).When comparing the values of REE determined by IC and predictive formulas in cirrhotics with HCC,it was observed that only the formulas of the Food and Agriculture Organization(FAO)/World Health Organization(WHO)(1985)and Cunningham(1980)presented values similar to those determined by *** comparing the REE values determined by IC and predictive formulas in cirrhotics without HCC,it was observed that the formulas of Schofield(1985),FAO/WHO(1985),WHO(2000),Institute of Medicine(IOM)(2005)and Katch and McArdie(1996)presented values similar to those determined by *** The FAO/WHO formula(1985)could be used for cirrhotic patients with or without HCC;as it is the one with the values closest to those obtained by IC in these cirrhotic patients.

关键词： Carcinoma Hepatocellular Liver cirrhosis Calorimetry Indirect Rest energy expenditure

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Chemical Composition and Allelopathic Activity of the Essential Oil from Callistemon viminalis(Myrtaceae)Blossoms on Lettuce(Lactuca sativa L.)Seedlings

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American Journal of Plant Sciences 2014年第24期5卷 3551-3557页

作者： Christiane maria de Oliveira maria das Gracas Cardoso ana Cristina da Silva Figueiredo maria Laene Moreira de Carvalho Cintia Alvarenga Santos Fraga de miranda Luiz Roberto marques Albuquerque David Lee Nelson marcos de Souza Gomes Lucilene Fernandes Silva Juliana de Andrade Santiago maria Luisa teixeira Rafaela Magalhaes Brandao Department of Chemistry Federal University of LavrasLavrasBrazil Centro de Biotecnologia Vegetal/IBB Departamento de Biologia VegetalFaculdade de Ciencias de LisboaUniversidade de LisboaLisbonPortugal Department of Agriculture Federal University of LavrasLavrasBrazil Federal University of Valleys Jequitinhonha and Mucuri DiamantinaBrazil

The extraction of essential oils was performed by using the technique of hydrodistillation modified Clevenger apparatus, identification and quantification of the constituents was achieved by Gas Chromatography coupled to Mass Spectrometry, and Gas Chromatography equipped with a flame ionization detector. Assessment of allelopathic activity was evaluated with the use of the method that assesses the direct contact of essential oils on germination and vigor of lettuce seeds. The major constituents that characterize the essential oil from the flowers of Callistemon viminalis were 1, 8-cineole, α-pinene and limonene at concentrations of 66.9%, 16.0% and 10.0%, respectively. The essential oil presented allelopathic activity at intensities that varied proportionately to the concentration of the essential oil, with a reduction in the percentage of germination and the germination speed index (GSI) of lettuce seeds and in the dry mass and length of shoots and roots of lettuce seedlings.

关键词： Biological Activity Myrtaceae Allelopathy

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