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Soil Pore Characterization Using Free Software and a Portable Optical Microscope

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Pedosphere 2013年第4期23卷 503-510页

作者： l. F. PIRES F. S. BORGES S. PASSONI A. B. pereira Department of Physics State University of Ponta Grossa (UEPG) Department of Soil Science State University of Ponta Grossa (UEPG)

Total porosity （TP）, determined by image analysis, pore type and pore size distribution were evaluated on impregnated soil blocks from an undisturbed Brazilian sandy loam soil using a digital portable optical microscope. The free software Image J （version 1.40g） was used for image analysis. Procedures for soil image collection and analysis were presented. The image analysis allowed the evaluation of pore sizes with diameters ranging from 20 to 〉 1 000 μm. The following types of pores were also obtained： rounded, elongated and intermediate. The results M[owed the characterization of the soil as moderately porous （TP = 21.6%）. Rounded, intermediate and elongated pores were responsible for 11.6%, 31.7% and 56.7% of TP. In relation to pore size 51.1% of TP was in the 100-500μm size class and a third of TP came from the pores larger than 500μm.

关键词： image analysis soil porosity soil structure pore size distribution

Rietveld refinement and optical properties of SrWO_4:Eu^(3+) powders prepared by the non-hydrolytic sol-gel method

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Journal of Rare Earths 2015年第2期33卷 113-128页

作者： P.F.S.pereira I.C.Nogueira E.longo E.J.Nassar I.l.V.Rosa l.S.Cavalcante Chemistry Institute University of the State of Sao Paulo Julio de Mesquita Filho-UNESP Francisco DegniAraraquara-SP 14800-900 Brazil lIEC-Chemistry Department Federal University of Sao Carlos Via Washington Luis Km 235Sao Carlos-SP 13565-905 Brazil University of Franca-UNIFRAN Via Dr.Armando Sales de OliveiraNo.201 Franca-SP 14404-600 Brazil CCN-DQ-GERATEC University of the State of Piauí Joao Cabral 2231 P.O.Box 391Terezina PI 64002-150 Brazil

We investigated the effect of annealing time on the structure and optical properties of Sr WO4：Eu^3＋ powders prepared by the non-hydrolytic sol-gel method and heat treated at 800 ℃ for 2,4,8 and 16 *** and differential thermal analyses revealed that Sr WO4：Eu^3＋ powders were obtained at about 800 ℃.X-ray diffraction patterns and Rietveld refinement data confirmed that all powders had a scheelite-type tetragonal ***-Raman and Fourier transform infrared spectra indicated structural order at short range and anti-symmetric stretching vibrations of O-W-O bonds associated with tetrahedral[WO4]*** properties were investigated by ultraviolet-visible（UV-vis）diffuse reflectance,and photoluminescence（Pl）data which provided the evolution of quantum efficiency（η）and lifetime（τ）.UV-vis spectroscopy evidenced intermediate energy levels within the band gap of Sr WO4：Eu^3＋ *** properties validated that the Eu^3＋ electric-dipole（^5D0→^7F2）transition in Pl emission spectra was dominant which proved that Eu^3＋ ions were positioned in a site without an inversion center.[（^5D0→^7F2）/（^5D0→^7F1）]band ratios showed that Eu^3＋ ions were located in a low symmetry *** Pl emission,ηandτproved the dependence on the annealing time in the behavior of Sr WO4：Eu3＋powders with a higher relative emission Pl intensity as well as higherηandτvalues related to other samples when heat treated at 800℃ for 8 h.

关键词： SrWO4 Rietveld refinement optical band gap Eu^(3+) +-rare earth luminescence

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

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Military Medical Research 2023年第5期10卷 699-725页

作者： Daniela lopes Joana lopes Miguel pereira-Silva Diana Peixoto Navid Rabiee Francisco Veiga Omid Moradi Zhan-Hu Guo Xiang-Dong Wang Joao Conde Pooyan Makvandi ana Claudia Paiva-Santos Department of Pharmaceutical Technology Faculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal REQUIMTE/lAQV Group of Pharmaceutical TechnologyFaculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000-548 CoimbraPortugal School of Engineering Macquarie UniversitySydneyNsW 2109Australia Centre for Molecular Medicine and Innovative Therapeutics Murdoch UniversityPerthWA 6150Australia Department of Chemistry Shahr-e-Qods BranchIslamic Azad UniversityTehran 374-37515Iran lntegrated Composites laboratory(iCl) Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK Department of Pulmonary and Critical Care Medicine Zhongshan HospitalFudan University Shanghai Medical CollegeShanghai 200032China Faculdade de Ciencias Medicas NOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal Centre for Toxicogenomics and Human Health GeneticsOncology and Human ToxicologyFaculdade de Ciencias MedicasNOVA Medical SchoolUniversidade Nova de Lisboa1169-056 LisbonPortugal school of Engineering Institute for Bioengineeringthe University of EdinburghEdinburgh EH93JLUK.

A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes,such as natural cell membranes or subcellular structure-derived *** strategy endows cloaked nanomaterials with improved interfacial properties,superior cell targeting,immune evasion potential,and prolonged duration of systemic ***,we summarize recent advances in the production and application of exosomal membrane-coated *** structure,properties,and manner in which exosomes communicate with cells are first *** is followed by a discussion of the types of exosomes and their fabrication *** then discuss the applications of biomimetic exosomes and membrane-cloaked nanocarriers in tissue engineering,regenerative medicine,imaging,and the treatment of neurodegenerative ***,we appraise the current challenges associated with the clinical translation of biomimetic exosomal membrane-surface-engineered nanovehicles and evaluate the future of this technology.

关键词： Biomimetic Cell membrane coating Exosome Exosomal-membrane-coated nanoparticle Extracellular vesicle(EV)

Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models

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World Journal of Hepatology 2022年第4期14卷 719-728页

作者： Milena lima Rodrigues Tatiane Priscila Santos Rodrigues da luz Caroline louise Diniz pereira Andrea Dória Batista ana lúcia Coutinho Domingues Ricardo Oliveira Silva Edmundo Pessoa lopes Programa de Pós-Graduação em Medicina Tropical Centro de Ciências MédicasUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil Programa de Pós-Graduação em Química Centro de Ciências Exatas e da NaturezaUniversidade Federal de PernambucoRecife 50670-740PernambucoBrazil Hospital das Clínicas Departamento de Medicina ClínicaUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil

BACKGROUND The evaluation of periportal fibrosis(PPF)is essential for a prognostic assessment of patients with Schistosomiasis *** WHO Niamey Protocol defines patterns of fibrosis from abdominal ultrasonography,^(1)H-nuclear magnetic resonance(NMR)-based metabonomics has been employed to assess liver fibrosis in some *** To build 1H-NMR-based metabonomics models(MM)to discriminate mild from significant periportal PPF and identify differences in the metabolite *** A prospective cross-sectional study was performed on schistosomiasis patients at a University Hospital in Northeastern *** evaluated 41 serum samples from 10 patients with mild PPF(C Niamey pattern)and 31 patients with significant PPF(D/E/F Niamey patterns).MM were built using partial least squares-discriminant analysis(PlS-DA)and orthogonal projections to latent structures discriminant analysis(OPlS-DA)*** PlS-DA and OPlS-DA resulted in discrimination between mild and significant PPF groups with R2 and Q2 values of 0.80 and 0.38 and 0.72 and 0.42 for each model,*** OPlS-DA model presented accuracy,sensitivity,and specificity values of 92.7%,90.3%,and 100%to discriminate significant *** metabolites identified as responsible by discrimination were:Nacetylglucosamines,alanine,glycolaldehyde,carbohydrates,and *** MMs discriminated mild from significant PPF patterns in patients with Schistosomiasis mansoni through identification of differences in serum metabolites profiles.

关键词： Metabolomics Portal hypertension Schistosoma mansoni Biomarkers Neglected disease Nuclear magnetic resonance

Cutaneous leishmaniasis in an indigenous infant with Down’s syndrome: A case report

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Asian Pacific Journal of Tropical Medicine 2019年第12期12卷 574-576页

作者： Fernanda Fresneda Villibor Geracina Marchesini ana lúcia Roselino Ribeiro RenataOliveira Guaré Centro Universitário Tocantinense Presidente Antonio Carlos AraguaínaTocantinsBrasil Programa de Pós Graduacao em Odontologia Universidade Cruzeiro do SulSao PauloSao PauloBrasil Hospital de Doencas Tropicais AraguaínaTocantinsBrasil Faculdade de Ciencias do Tocantins AraguaínaTocantinsBrasil

Rationale: leishmaniasis, caused by the protozoan leishmania and transmitted by sandflies, is endemic to the tropical and subtropical areas of Brazil. It is one of the neglected tropical diseases in the world. Patient concerns: A 20-month-old indigenous infant with severe malnutrition and Down’s syndrome presented with a facial ulcer for 5 months. Diagnosis: Giemsa staining of scraped ulcer tissues indicated the presence of the amastigote form of leishmania sp., and positive Montenegro’s intradermal test helped in diagnosing the condition as cutaneous leishmaniasis. Interventions: The child was hospitalized and received intravenous treatment for cutaneous leishmaniasis(1 mg/kg/day of amphotericin B). Outcomes: The condition was cured with amphotericin B(1 mg/kg/day for 14 d). lessons: Because of infanticide practices in indigenous cultures, indigenous infants with Down’s syndrome rarely survive. Thus, no similar case has been reported in the literature.

关键词： Cutaneous leishmaniasis Indigenous Down’s syndrome Immune deficiencies

SARS-CoV-2 consequences for mental health:Neuroinflammatory pathways linking COVID-19 to anxiety and depression

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World Journal of Psychiatry 2022年第7期12卷 874-883页

作者： Anna Julie de Mello Morgana Moretti ana lúcia S Rodrigues Department of Biochemistry Universidade Federal de Santa CatarinaFlorianópolis 88040-200Brazil

The coronavirus disease 2019(COVID-19)pandemic has been linked to an increased prevalence of mental health disorders,particularly anxiety and ***,the COVID-19 pandemic has caused stress in people worldwide due to several factors,including fear of infection;social isolation;difficulty in adapting to new routines;lack of coping methods;high exposure to social media,misinformation,and fake reports;economic impact of the measures implemented to slow the contagion and concerns regarding the disease ***-19 patients have elevated levels of pro-inflammatory cytokines,such as interleukin(Il)-1β,Il-6,and tumor necrosis factor-α,and other inflammation-related ***,invasion of the central nervous system by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)may potentially contribute to neuroinflammatory alterations in infected ***,a consequence of psychological stress due to the COVID-19 pandemic,may also play a role in the development of anxiety and depressive symptoms in the general *** that neuroinflammation plays a significant role in the pathophysiology of depression and anxiety,this study investigated the effects of SARS-CoV-2 on mental health and focused on the impact of the COVID-19 pandemic on the neuroinflammatory pathways.

关键词： Anxiety disorders COVID-19 pandemic Depression Mental health Neuroinflammation Stress

An Outlook on Implantable Biosensors for Personalized Medicine

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Engineering 2021年第12期7卷 1696-1699页

作者： Rita Rebelo ana Isabel Barbosa Vitor M.Correlo Rui l.Reis Research Institute on Biomaterials Biodegradablesand BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineBarcoGuimarães 4805-017Portugal ICVS/3B’s-PT Government-Associated laboratory BragaGuimarães 4710-057Portugal

Biosensors are a fast-growing field,as they have been shown to be very helpful in our daily life,playing roles in industries such as agriculture,food safety,homeland security,bioprocessing,environmental monitoring,and industrial *** these,the application of biosensing in medicine and biomedical engineering may have the highest potential for growth and for affecting human quality of life in the near *** potential is driven by the need for new and improved devices and technologies with improved sensitivity,specificity,reliability,and biocompatibility.

关键词： Outlook specificity playing

Seaweeds’nutraceutical and biomedical potential in cancer therapy:a concise review

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 189-212页

作者： João Cotas Diana Pacheco ana M.M.Gonçalves Paulo Silva loïc G.Carvalho leonel pereira University of Coimbra MARE-Marine and Environmental Sciences CentreDepartment of Life SciencesCalçada Martim de FreitasCoimbra 3000-456Portugal Department of Biology and CESAM University of AveiroAveiro 3810-193Portugal UCIBIO-REQUIMTE Departamento de QuímicaFaculdade de Ciências e TecnologiaUniversidade Nova de LisboaCaparica 2829-516Portugal The James Hutton Institute Dundee DD25DAScotlandUK Heriot-Watt University Edinburgh EH144ASScotlandUK.

Seaweeds have been a food source since ancient times(600 BC)and are still widely used in Asia,mainly in traditional Chinese medicine and Japanese folk ***,seaweed compounds and extracts have been gaining interest from the biomedical and pharmaceutical market *** have been referenced as feasible solutions in finding new potential compounds and therapies in prevention,control,and reduction of cancer development due to the multirole of some bioactive components(e.g,phenolic compounds and sulphated polysaccharides).Moreover,seaweeds are rich in important health-promoting molecules[such as poly and highly unsaturated fatty acids(PUFAs and HUFAs),essential amino acids,vitamins,and dietary fibers]and minerals(calcium,iron,iodine,magnesium,phosphorus,potassium,zinc,copper,manganese,selenium,and fluoride).In this review,the potential therapeutic effects of seaweed in the prevention and treatment of cancer are approached,as well as nutraceutical properties of seaweed to promote cell homeostasis.

关键词： Seaweed compounds nutraceutical bioactive molecules cancer prevention cancer treatment

Amyotrophic lateral sclerosis: a complex syndrome that needs an integrated research approach

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Neural Regeneration Research 2019年第2期14卷 193-196页

作者： Javier Riancho Francisco J.Gil-Bea ana Santurtun Adolfo lópez de Munaín Service of Neurology Hospital Sierrallana-Idival CIBERNED (Center for Networked Biomedical Research on Neurodegenerative Diseases Ministry of Economy and Competitiveness Institute Carlos Ⅲ) Neurosciences Area Institute Biodonostia Department of Physiology and Pharmacology University of Cantabria-Idival Department of Neurology University Hospital Donostia Department of Neurosciences University of the Basque Country Universidad País Vasco-Euskal Herria Unibertsitatea

Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to mutations in causative genes, while the vast majority of amyotrophic lateral sclerosis cases are considered to be sporadic, resulting from the interaction between genes and environmental factors in predisposed individuals. During the past few years, dozens of drugs have been postulated as promising strategies for the disease after showing some beneficial effects in preclinical cellular and murine models. However, the translation into clinical practice has been largely unsuccessful and the compounds failed when were tested in clinical trials. This might be explained, at least partially, by the enormous complexity of the disease both from clinico-epidemiological and a pathogenic points of view. In this review, we will briefly comment on the complexity of the disease focusing on some recent findings, and we will suggest how amyotrophic lateral sclerosis research might be reoriented to foster the advance in the diagnostic and therapeutic questions.

关键词： amyotrophic lateral sclerosis AlS environment epidemiology genes phenotype therapy