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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 686-688页

作者： Paula Taunde ana felicidade lucas Abel Chilundo Rosa Costa Custodio Gabriel Bila Faculty of Veterinary Medicine Eduardo Mondlane University Kyeema Foundation

Objective: To investigate serologically the presence of avian influenza virus(AIV) in backyard chickens from Mandlhakazi district, Southern ***: A total of 439 sera samples from unvaccinated and apparently healthy backyard chickens from 4 villages(Chidenguele, Macuacua. Chizavane, and Nwadjahane) were tested for the presence of AIV antibodies through commercial enzyme-linked immunoabsorbent assay(ELISA) kit used according to manufacturer ***: Anti-AIV antibodies were detected in all villages surveyed. The overall seroprevalence obtained was 32.6%(95% CI 28.2%-37.0%). The highest prevalence of 51.3%(95% CI 42.3%-60.2%) was recorded in Macuacua village, while the lowest prevalence of 13.0%(95% CI 6.2%-19.9%) was found in Chizavane village. The results of logistic regression analyses suggested that chicken being located in Chizavane and Macuacua villages were more unlikely for getting the virus exposure(P<0.05).Conclusions: Our findings suggested that AIV is widespread within backyard chickens in the studied villages. Further research is needed to identify the circulating virus genotypes and determine the potential role of backyard chickens in the zoonotic transmission of AIV in Mozambique.

关键词：鸟的流行性感冒病毒血清学流行后院鸡肉莫桑比克非洲

Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation:A Systematic Review

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Chinese Journal of Integrative Medicine 2023年第3期29卷 268-279页

作者： Guilherme Vinicio de Sousa Silva ana Luiza Vieira Ferreira Guimaraes Lopes Isis Carolina Viali lucas Zannini Medeiros Lima Matheus Ribeiro Bizuti Fabiana Brum Haag Débora Tavares de Resende e Silva Department of Medicine Federal University of Fronteira SulChapecóSanta CatarinaBrazil Department of Nursing Federal University of Fronteira SulChapecóSanta CatarinaBrazil Department of Graduate Studies in Biomedical Sciences Federal University of Fronteira SulChapecóSanta CatarinaBrazil

Cancers have high morbidity and mortality rates *** anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of *** is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis,exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant ***,drugs aimed at autophagy can function as antitumor *** are a class of polyphenolic secondary metabolites commonly found in plants and,consequently,consumed in *** this review,the systematic search strategy was used,which included the search for descriptors"flavonoids"AND"mTOR pathway"AND"cancer"AND"autophagy",in the electronic databases of PubMed,Cochrane Library,Web of Science and Scopus,from January 2011 to January *** current literature demonstrates that flavonoids have anticarcinogenic properties,including inhibition of cell proliferation,induction of apoptosis,autophagy,necrosis,cell cycle arrest,senescence,impaired cell migration,invasion,tumor angiogenesis and reduced resistance to multiple drugs in tumor *** demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition.(Registration ***42021243071 at PROSPERO)

关键词： anti-cancer effects apoptosis cell proliferation cell survival flavonoids

Low cholesterol biosynthesis favors epithelial-to-mesenchymal transition maintenance and influences tumor molecular subtyping and disease-free survival in colon cancer patients

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Cancer Communications 2022年第8期42卷 793-797页

作者： anaïs Aulas Maria Lucia Liberatoscioli Pascal Finetti Olivier Cabaud David JBirnbaum lucas Usclade Daniel Birnbaum François Bertucci Emilie Mamessier Predictive Oncology Laboratory Cancer Research Center of MarseilleInstitut Paoli-Calmettes“Ligue contre le cancer”labelAix-Marseille UniversityMarseille 13009France Department of Digestive Surgery Hospital NordChemin des BourrelyAix-Marseille UniversityMarseille 13015France Department of Medical Oncology Institut Paoli-CalmettesAix-Marseille UniversityMarseille 13009France

Dear Editor,To metastasize,epithelial cancer cells undergo an epithelial-to-mesenchymal transition(EMT)during migration,whereupon they activate a mesenchymal-toepithelial transition(MET)when colonizing the new niche[1].Targeting EMT or MET inducers might thus impair the metastatic process[2,3].However,the identification of genes involved in epithelium-mesenchyme switches(EMS)is difficult in complex samples such as human *** overcome this problem,we used spheroids of a colorectal cancer(CRC)cell line,HT29,to mimic EMS in a controlled environment.

关键词： cancer colon epithelium

Influence of Pt/Ru anodic ratio on the valorization of ethanol by PEM electrocatalytic reforming towards value-added products

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Journal of Energy Chemistry 2021年第5期30卷 264-275页

作者： Alberto Rodriguez-Gomez Fernando Dorado Antonio de lucas-Consuegra ana Raquel de la Osa Chemical Engineering Department Faculty of Chemical Sciences and TechnologyUniversity of Castilla-La Mancha13071 Ciudad RealSpain

The ethanol electro-reforming process was studied over PtRu/C catalysts synthesized by the modified polyol method with different *** particular,this work reports the influence of anodic Pt:Ru ratio(5:1,2:1 and 1:2)on the organic product distribution(acetaldehyde,acetic acid and ethyl acetate)and pure hydrogen generation at different current densities operation *** characterization of the catalysts was made by X-ray diffraction(XRD),temperature-programmed reduction(TPR)and N_(2) adsorption-desorption *** patterns showed that Ru is introduced into the Pt structure,forming an alloy between both ***,the degree of alloy was higher by increasing the Ru *** TPR profiles Pt was found to be properly reduced while Ru was both in metallic state and forming *** electrochemical behaviour of each catalyst towards ethanol electroreforming process was investigated through electrochemical techniques in a half cell and a single proton exchange membrane(PEM)cell *** intermediate Pt:Ru ratio was found to result in high current density and electrochemical surface area(ECSA)values along with lower amounts of adsorbed ***,Ru addition seems to diminish the degree of degradation of the *** on characterization and in agreement with essays carried out in a PEM cell at mild conditions(80℃ and 1 atm),PtRu/C 2:1 anode provided the best electrocatalytic results in terms of current density(740 mA cm^(-2)),hydrogen production and selectivity toward acetic acid(up to 15%apart from acetaldehyde and ethyl acetate)while requiring the lowest energy consumption.

关键词： Ethanol electro-reforming PEM cell Pt:Ru anodic ratio Hydrogen production Value-added liquid product distribution

Acute kidney injury and electrolyte disorders in COVID-19

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World Journal of Virology 2022年第5期11卷 283-292页

作者： Gabriel Martins Nogueira Noel lucas Oliveira Rodrigues Silva ana Flávia Moura Marcelo Augusto Duarte Silveira JoséA Moura-Neto Department of Medicine Bahiana School of Medicine and Public HealthSalvador 40290-000BahiaBrazil Department of Nephrology D’Or Institute for Research and EducationHospital São RafaelSalvador 41253900BahiaBrazil

Acute kidney injury(AKI)and electrolyte disorders are important complications of hospitalized coronavirus disease 2019(COVID-19)*** is thought to occur due to multiple pathophysiological mechanisms,such as multiple organ dysfunction(mainly cardiac and respiratory),direct viral entry in the renal tubules,and cytokine release *** is present in approximately one in every ten hospitalized COVID-19 *** incidence rates of AKI increase in patients who are admitted to the intensive care unit(ICU),with levels higher than 50%.Additionally,renal replacement therapy(RRT)is used in 7%of all AKI cases,but in nearly 20%of patients admitted to an ***-19 patients with AKI are considered moderate-to-severe cases and are managed with multiple interdisciplinary *** acts as a risk factor for mortality in severe acute respiratory syndrome coronavirus 2 infection,especially when RRT is *** disorders are also common manifestations in hospitalized COVID-19 patients,mainly hyponatremia,hypokalemia,and *** occurs due to a combination of syndrome of inappropriate secretion of antidiuretic hormone and gastrointestinal fluid loss from vomiting and *** it comes to hypokalemia,its mechanism is not fully understood but may derive from hyperaldosteronism due to renin angiotensin aldosterone system overstimulation and gastrointestinal fluid loss as *** clinical features of hypokalemia in COVID-19 are similar to those in other *** is the most common electrolyte disorder in COVID-19 and seems to occur because of vitamin D deficiency and parathyroid *** is also highly associated with longer hospital and ICU stay.

关键词： COVID-19 SARS-CoV-2 Acute kidney injury Electrolyte disorders Renal dialysis

Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 998-1010页

作者： Manoela Dias Susi de Matos Lourenco Caroline lucas Trevizani Rasmussen Spencer Luis Marques Payao ana Flavia Teixeira Rossi ana Elizabete Silva Juliana Garcia de Oliveira-Cucolo Department of Graduate-Level Research USCSacred Heart UniversityBauru 17011-970SPBrazil Department of Genetics and Molecular Biology FAMEMA-Marilia Medical SchoolMarília 17519-030SPBrazil Department of Biology Sao Paulo State University-UNESPSao Jose do Rio Preto 15054-000SPBrazil Department of Molecular Biological and Genetics and Molecular Biology Research Unit-UPGEMFaculty of Medicine of Sao Jose do Rio Preto-FAMERPSao Jose do Rio Preto 15090-000SPBrazil

BACKGROUND Toll-like receptors(TLRs)are the first line of host defense,and are involved in Helicobacter pylori(***)recognition and activation of both inflammatory and carcinogenic *** presence of single nucleotide polymorphisms(SNPs)in genes that activate the immune response may modulate the risk of precancerous lesions and gastric cancer(GC).Among them,Toll-like receptor 9(TLR9)polymorphisms have emerged with a risk factor of infectious diseases and cancer,however the studies are still *** To evaluate whether TLR9 rs5743836 and rs187084 SNPs contribute to the risk of gastric carcinogenesis,and its influence on mRNA *** A case-control study was conducted to evaluate two TLR9 SNPs(TLR9-1237 TCrs5743836 and TLR9-1486 CT-rs187084)in chronic gastritis(CG)and GC patients.A total of 609 DNA samples of peripheral blood[248 CG,161 GC,and 200 samples from healthy individuals(C)]were genotyped by polymerase chain reaction-restriction fragment length *** samples were tested for the *** infection using Hpx1 and Hpx2 *** polymerase chain reaction by TaqMan?assay was used to quantify TLR9 mRNA from fresh gastric tissues(48 GC,26 CG,and 14 C).RESULTS For TLR9-1237,the TC+CC or CC genotypes were associated with a higher risk of GC than C[recessive model odds ratio(OR)=5.01,95%confidence interval(CI):2.52-9.94,P<0.0001],and the CG(recessive model OR=4.63;95%CI:2.44-8.79,P<0.0001)*** TLR9-1486,an association between the CT+TT genotypes and increased risk of both GC(dominant model OR=2.72,95%CI:1.57-4.72,P<0.0001)and CG(dominant model OR=1.79,95%CI:1.15-2.79,P=0.0094)was observed when compared to the C ***,the presence of TLR9-1237 TC/CC+TLR9-1486 CC genotypes potentiate the risk for this neoplasm(OR=18.57;95%CI:5.06-68.15,P<0.0001).The TLR9 mRNA level was significantly higher in the GC group(RQ=9.24,P<0.0001)in relation to the CG group(RQ=1.55,P=0.0010)and normal mucosa(RQ=1.0).When the sa

关键词： Toll-like receptor 9 Helicobacter pylori Gastric cancer Chronic gastritis Polymorphisms Gene expression

Menopause and cognitive impairment:A narrative review of current knowledge

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World Journal of Psychiatry 2021年第8期11卷 412-428页

作者： Délio Marques Conde Roberto Carmignani Verdade ana L R Valadares lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva Department of Gynecology and Obstetrics Federal University of GoiásGoiânia 74605-050GoiásBrazil Department of Obstetrics and Gynecology School of Medical SciencesState University of CampinasCampinas 13083-881São PauloBrazil Department of Medical Psychology and Psychiatry-Geriatric Psychiatry and Neuropsychiatric Division State University of CampinasCampinas 13083-887São PauloBrazil

A severe impairment of cognitive function characterizes *** cognitive impairment represents a transition between normal cognition and *** frequency of cognitive changes is higher in women than in *** on this fact,hormonal factors likely contribute to cognitive *** this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially ***,a tendency toward worsened cognitive performance has been reported in women during *** symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen *** therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal *** studies conducted to date have reported conflicting results regarding the effects of HT on *** article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive *** present and discuss the findings of the central observational and interventional studies on HT and cognition.

关键词： Menopause Cognition Dementia Estrogens Hot flashes Cognitive decline

The effects of an experimental drought on the ecophysiology and fruiting phenology of a tropical rainforest palm

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Journal of Plant Ecology 2020年第6期13卷 744-753页

作者： Nara O.Vogado Michael J.Liddell Susan G.W.Laurance Mason J.Campbell Alexander W.Cheesman Jayden E.Engert ana C.Palma Françoise Y.Ishida lucas A.Cernusak Centre for Tropical Environmental and Sustainability Science College of Science and EngineeringJames Cook UniversityCairnsAustralia College of Life and Environmental Sciences University of ExeterExeter EX44RJDevonUK

据预测,人为气候变化将季节性地增加平均温度和降雨。热带雨林物种将如何应对这种气候变化仍不确定。本研究分析了对澳大利亚昆士兰北部丹特里雨林的一种澳大利亚特有棕榈(Normambya normanbyi)进行4年降雨实验的影响,目的是了解模拟降... 详细信息

据预测,人为气候变化将季节性地增加平均温度和降雨。热带雨林物种将如何应对这种气候变化仍不确定。本研究分析了对澳大利亚昆士兰北部丹特里雨林的一种澳大利亚特有棕榈(Normambya normanbyi)进行4年降雨实验的影响,目的是了解模拟降雨减少对物种生理过程和果实物候的影响。我们考察了这种本地丰富的棕榈的果实物候和生理生态学特性,以确定该物种对干旱的生态响应。2015年5月,通过排涝实验,降低了约30%的土壤水分有效性。我们总共监测了8年(2009–2018年)的月度果实活性,包括排涝实验开始之前的4年。在最近几年的研究中,我们测量了干、湿两季幼嫩和成熟叶片的光合速率、气孔导度和碳稳定同位素等生理参数。研究结果表明,所有棕榈树的月度果实活性主要受光周期、平均太阳辐射和平均温度的驱动。然而,暴露于较低土壤水分的植株,其果实活性、光合速率和气孔导度均显著下降。我们还发现这些生理表现受到排涝实验、季节以及两者的相互作用的影响。2018年观察到排涝实验的棕榈的果实活力有所恢复,土壤浅层水分也有所增加(与前几年相比)。我们的研究结果表明,像***这样的棕榈树对未来的气候变化非常敏感,建议对其进行长期监测,以确定其对种群规模的影响。

关键词：气候变化水分利用效率稳定同位素季节性生殖物候

No independent associations between physical activity and clinical outcomes among hospitalized patients with moderate to severe COVID-19

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Journal of Sport and Health Science 2021年第6期10卷 690-696页

作者： ana J.Pinto Karla F.Goessler Alan L.Fernandes Igor H.Murai lucas P.Sales Bruna Z.Reis Mayara Diniz Santos Hamilton Roschel Rosa M.R.Pereira Bruno Gualano Applied Physiology and Nutrition Research Group School of Physical Education and SportClinical Hospital HCFMUSPSchool of Medicine FMUSPUniversity of Sao PauloSao PauloSP 01246903Brazil Rheumatology Division Clinical Hospital HCFMUSPSchool of Medicine FMUSPUniversity of Sao PauloSao PauloSP 01246903Brazil Food Research Center University of Sao PauloSao PauloSP 05508080Brazil

Background:Regular physical activity(PA)has been postulated to improve,or at least maintain,immunity across the life ***,the link between physical(in)activity and coronavirus disease 2019(COVID-19)remains to be *** small-scale prospective cohort study is nested within a randomized controlled trial aimed to investigate the possible associations between PA levels and clinical outcomes among hospitalized patients with moderate to severe ***:Hospitalized patients with COVID-19(mean age:54.9 years)were recruited from the Clinical Hospital of the School of Medicine of the University of Sao Paulo(a quaternary referral teaching hospital)and from Ibirapuera Field Hospital,both located in Sao Paulo,*** level was assessed using the Baecke Questionnaire of Habitual Physical *** primary outcome was hospital length of *** secondary outcomes were mortality,admission to the intensive care unit(ICU),and mechanical ventilation ***:The median hospital length of stay was 7.0§4.0 days,median§IQR;3.3%of patients died,13.8%were admitted to the ICU,and 8.6%required mechanical *** linear regression models showed that PA indices were not associated with hospital length of stay(work index:b=-0.57(95%confidence interval(95%CI):-1.80 to 0.65),p=0.355;sport index:b=0.43(95%CI:-0.94 to 1.80),p=0.536;leisure-time index:b=1.18(95%CI:-0.22 to 2.59),p=0.099;and total activity index:b=0.20(95%CI:-0.48 to 0.87),p=0.563).None of the PA indices were associated with mortality,admission to the ICU,or mechanical ventilation requirement(all p>0.050).Conclusion:Among hospitalized patients with COVID-19,PA did not independently associate with hospital length of stay or any other clinically relevant *** findings should be interpreted as meaning that,among already hospitalized patients with more severe forms of COVID-19,being active is a potential protective factor likely outweighed by a cluster of comorbidities(e.

关键词： Hospital length of stay Lifestyle Physical inactivity Prognosis SARS-CoV-2

Bioinformatics analysis of NprR-NprX Quorum-Sensing System of <i>Bacillus thuringiensis</i>Isolates from the Papaloapan Region, Oaxaca-Mexico

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Advances in Biological Chemistry 2015年第7期5卷 293-304页

作者： Humberto Rafael Bravo-D Alain Cruz-Nolasco Luis Raúl Gutiérrez-lucas ana Karin Navarro-Mtz División de Estudios de Posgrado Universidad del Papaloapan Circuito Central 200 Parque Industrial Tuxtepec Oaxaca México Instituto de Biotecnología Universidad del Papaloapan Circuito Central 200 Parque Industrial Tuxtepec Oaxaca México

Quorum sensing is a chemical communication process that bacteria use to regulate collective behaviors. In Gram-positive bacteria, oligopeptides (called autoinducers) are the signaling molecules to elicit quorum sensing. In Bacillus thuringiensis, NprR is a transcriptional regulator whose activity depends on the NprX signalling peptide. Bacillus thuringiensis is closely related to Bacillus cereus and Bacillus anthracis. The principal difference between them is that Bacillus thuringiensis is the only one that produced Cry protein. The aim of this study is to explore the relation of nprR and 16S rRNA genes in Bacillus thurin-giensis. Phylogenetic trees of nucleotide sequences of nprR and 16S rRNA genes were built. Sequences of fourteen new isolates from Papaloapan region were included in those phylo-genetic trees. In order to identify the isolates, a simple and fast methodology considering the Cry protein formation was used. The 16S rRNA phylogenetic tree allows identify eight isolates as Bacillus thuringiensis and the others as Bacillus spp. The nprR phylogenetic tree does not match with the 16S rRNA phylogenetic tree. This confirms that nprR is not a molecular marker for evolution. Most of the new isolates have the same NprR sequence (WTSDIVG). However, the SKPDIVG is the most common NprR sequence in thuringiensis species.

关键词： Quorum-Sensing Bacillus thuringiensis NprR-NprX Phylogenetic Tree