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Targeting triple-negative breast cancer:A clinical perspective

Oncology Research 2023年第3期31卷 221-238页

作者： LAZAR S.POPOVIc GORana MATOVINA-BRKO MAJA POPOVIc KEVIN PUNIE ana cVETANOVIc MATTEO LAMBERTINI Department of Medical Oncology Oncology Institute of VojvodinaSremska KamenicaSerbia Faculty of Medicine University of Novi SadNovi SadSerbia Department of General Medical Oncology and Multidisciplinary Breast centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuvenBelgium Department for Oncology Medical Faculty NisUniversity of NisNisSerbia clinic of Oncology Clinical Centre NisNisSerbia Department of Internal Medicine and Medical Sciences(DiMI) School of MedicineUniversity of GenovaGenovaItaly Department of Medical Oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenovaItaly

Triple-negative breast cancer(TNBc)is a disease with often an aggressive course and a poor prognosis compared to other subtypes of breast *** accounts for approximately 10%–15%of all diagnosed breast cancer cases and represents a high unmet need in the *** to just a few years ago,chemotherapy was the only systemic treatment option for this subtype(1).To date,TNBc is considered a heterogeneous *** of the existing classifications is based on the analysis of mRNA expression in 587 TNBc cases,in which Lehman et *** six subtypes of TNBc as follows:two basal-like(BL1 and BL2)subtypes,a mesenchymal(M)subtype,a mesenchymal stem-like(MSL)subtype,an immunomodulatory(IM)subtype,and a luminal androgen receptor(LAR)subtype(2).Later studies have demonstrated that the IM and MSL subtypes do not correlate with independent subtypes but reflect background expression by dense infiltration of tumor-infiltrating lymphocytes(TILs)or stromal *** to this finding,the classification of TNBc has been revised into the following four subtypes:basal 1,basal 2,LAR,and mesenchymal subtypes(3).Over the last years,several new strategies have been investigated for the treatment of patients with *** them,immunotherapy,antibody drug conjugates,new chemotherapy agents,and targeted therapy have been and are currently being *** present article aims to provide an updated overview on the different treatment options that are now available or are still under investigation for patients with TNBc.

关键词： Triple-negative breast cancer Immunotherapy Antibody-drug conjugates Target therapy

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conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity

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cellular & Molecular Immunology 2022年第2期19卷 260-275页

作者： Elena Hernández-García Francisco J.cueto Emma c.L.cook ana Redondo-Urzainqui Sara charro-Zanca Iñaki Robles-Vera Ruth conde-Garrosa Ivana Nikolić Guadalupe Sabio David Sancho Salvador Iborra Department of Immunology Ophthalmology and ENTSchool of MedicineUniversidad Complutense de MadridMadrid 28040Spain centro Nacional de Investigaciones cardiovasculares(cNIc) Madrid 28029Spain

conventional dendritic cells(cDcs)scan and integrate environmental cues in almost every tissue,including exogenous metabolic *** cDcs are critical in maintaining immune balance,their role in preserving energy homeostasis is ***,we showed that Batf3-deficient mice lacking conventional type 1 Dcs(cDc1s)had increased body weight and adiposity during *** led to impaired energy expenditure and glucose tolerance,insulin resistance,dyslipidemia,and liver ***1 deficiency caused adipose tissue inflammation that was preceded by a paucity of NK1.1+invariant NKT(iNKT)***,among antigen-presenting cells,cDc1s exhibited notable induction of IFN-γproduction by iNKT cells,which plays a metabolically protective role in lean adipose ***3L treatment,which expands the dendritic cell(Dc)compartment,mitigated diet-induced obesity and hyperlipidemia in a Batf3-dependent *** effect was partially mediated by NK1.1+*** results reveal a new critical role for the cDc1-iNKT cell axis in the regulation of adipose tissue homeostasis.

关键词： Dendritic cells NKT Obesity ageing FLT3L

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Neotropical mustelids: fecal metabolome diversity and its potential for taxonomic discrimination

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Integrative Zoology 2023年第3期18卷 518-529页

作者： Lana Resende de ALMEIDA Marina Amaral ALVES ana Maria Obino MASTELLA Rafael GARRETT Maria João Ramos PEREIRA Bird and Mammal Evolution Systematics and Ecology LabPrograma de Pós-Graduação em Biologia AnimalUniversidade Federal do Rio Grande do SulPorto AlegreRio Grande do SulBrazil Programa de Pós-Graduação em Biologia Animal Universidade Federal do Rio Grande do SulPorto AlegreRio Grande do SulBrazil chemistry Institute Metabolomics Laboratory(LabMeta–LADETEC/IQ–UFRJ)Avenida Horácio MacedoFederal University of Rio de JaneiroRio de JaneiroRJBrazil Walter Mors Institute of Research on Natural Products Universidade Federal do Rio de JaneiroRio de JaneiroRJBrazil

chemical proﬁles of non-invasive biological material,such as feces,have great potential to study elusive animals or those with low population ***,we use a metabolomic approach to evaluate Neotropical mustelids as a biological model to describe the diversity of the metabolites present in fecal samples,as well as to evaluate the potential of chemical proﬁles for taxonomic *** collected fecal samples from captive individuals of 5 species of mustelids occurring in Brazil and analyzed them by liquid chromatography coupled to high-resolution mass *** 200 compounds have been annotated;“bile acids,alcohols and derivatives”was the most expressive class in the metabolome of all the *** successfully discriminated 3 taxonomic groups:1—tayra(Eira barbara);2—otters(Lontra longicaudis and Pteronura brasiliensis;1);and 3—grisons(Galictis vittata and Galictis cuja).Several compounds seemed to be associated with food intake and the digestive process,while others were found for theﬁrst time in Neotropical *** concluded that mustelids show high metabolome diversity and that species-speciﬁc identiﬁcation through metabolomic proﬁles is possible,thus contributing to the development and implementation of additional non-invasive approaches in the study of mustelids.

关键词： chemical proﬁles ecology high-resolution mass spectrometry metabolomics Mustelidae

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The heterogeneity-diversity-system performance nexus

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National Science Review 2023年第7期10卷 251-260页

作者： Nico Eisenhauer Gerrit Angst ana E.B.Asato Rémy Beugnon Elisabeth B?nisch Simone cesarz Peter Dietrich Stephanie D.Jurburg Anna-Maria Madaj Rine c.Reuben christian Ristok Marie Sünnemann Huimin Yi carlos A.Guerra Jes Hines German centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig Institute of Biology Leipzig University Institute of Soil Biology and Biogeochemistry Biology Centre of the Czech Academy of Sciences Leipzig Institute for Meteorology Universit?t Leipzig cEFE Univ Montpellier CNRS EPHE IRD Department of Environmental Microbiology Helmholtz Centre for Environmental Research – UFZ

Ever-growing human population and nutritional demands,supply chain disruptions,and advancing climate change have led to the re alization that changes in diversity and system performance are intimately ***,diversity and system performance depend on *** changes in system performance and promoting sustainable living conditions requires transformative ***,we introduce the heterogeneity-diversity-system performance(HDP) nexus as the conceptual basis upon which to formulate transformative *** suggest that managing the heterogeneity of systems will best allow diversity to provide multiple benefits to *** on ecological theory,we pose that the HDP nexus is broadly applicable across systems,disciplines,and sectors,and should thus be considered in future decision making as a way to have a more sustainable global future.

关键词： heterogeneity diversity biodiversity-ecosystem functioning global change homogenization

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analysis of the bacterial community composition in acidic well water used for drinking in Guinea-Bissau,West Africa

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Journal of Environmental Sciences 2014年第8期26卷 1605-1614页

作者： ana Machado Adriano A.Bordalo Laboratory of Hydrobiology and Ecology Institute of Biomedical SciencesUniversity of PortoPorto 4050-313Portugal cIIMAR/cIMAR-Interdisciplinary centre of Marine and Environmental Research University of PortoPorto 4050-123Portugal

Potable water is a resource out of reach for millions worldwide,and the available water may be chemically and microbiologically compromised. This is particularly acute in Africa,where water-networks may be non-existent or restricted to a small fraction of the urban population,as in the case of Guinea-Bissau,West Africa. This study was carried out seasonally in Bolama（11°N）,where unprotected hand-dug wells with acidic water are the sole source of water for the population. We inspected the free-living bacterial community dynamics by automated rRNA intergenic spacer analyses,quantitative polymerase chain reaction and cloning *** results revealed a clear seasonal shift in bacterial assemblage composition and microbial abundance within the same sampling site. Temperature,pH and turbidity,together with the infiltration and percolation of surface water,which takes place in the wet season,seemed to be the driving factors in the shaping and selection of the bacterial community and deterioration of water quality. analysis of 16 S rDNA sequences revealed several potential pathogenic bacteria and uncultured bacteria associated with water and sediments,corroborating the importance of a culture-independent approach in drinking water monitoring.

关键词： Water quality Microbial community ARISA qPcR Drinking water Africa

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Targeting of Pollen Tubes to Ovules Is Dependent on Nitric Oxide （NO） Signaling

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Molecular Plant 2008年第4期1卷 703-714页

作者： ana Margarida Prado Renato colaco Nuno Moreno ana catarina Silva Jose A. Feijo Instituto Gulbenkian de ciencla Centro de Blologia do Desenvolvimento PT-2780-156 Oeiras Portugal Universidade de Lisboa Faculdade de Clencias Dept Biologia Vegetal Campo Grande Ed.C2. PT-1749-016 Lisboa Portugal

The guidance signals that drive pollen tube navigation inside the pistil and micropyle targeting are still, to a great extent, unknown. Previous studies in vitro showed that nitric oxide （NO） works as a negative chemotropic cue for pollen tube growth in lily （Lilium Iongiflorum）. Furthermore, Arabidopsis thaliana Atnosl mutant plants, which show de- fective NO production, have reduced fertility. Here, we focus in the role of NO in the process of pollen-pistil communication, using Arabidopsis in-vivo and lily semi-vivo assays. cross-pollination between wild-type and Atnosl plants shows that the mutation affects the pistil tissues in a way that is compatible with abnormal pollen tube guidance. Moreover, DAF- 2DA staining for NO in kanadi floral mutants showed the presence of NO in an asymmetric restricted area around the micropyle. The pollen-pistil interaction transcriptome indicates a time-course-specific modulation of transcripts of AtNOS1 and two Nitrate Reductases （nrl and nr2）, which collectively are thought to trigger a putative NO signaling pathway. Semivivo assays with isolated ovules and lily pollen further showed that NO is necessary for micropyle targeting to occur. This evidence is supported by cPTIO treatment with subsequent formation of balloon tips in pollen tubes facing ovules. Activation of calcium influx in pollen tubes partially rescued normal pollen tube morphology, suggesting that this pathway is also dependent on ca^2＋ signaling. A role of NO in modulating ca^2＋ signaling was further substantiated by direct imaging the cytosolic free ca^2＋ concentration during NO-induced re-orientation, where two peaks of ca^2＋ occur--one during the slowdown/stop response, the second during re-orientation and growth resumption. Taken together, these results provide evidence for the participation of NO signaling events during pollen-pistil interaction. Of special relevance, NO seems to directly affect the targeting of pollen tubes to the ovule＇s micropyle by modu

关键词： pollen tubes NO fertilization guidance calcium signaling

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The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae

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Molecular Plant 2023年第3期16卷 549-570页

作者： Haixiu Li Song Wu Ruoxi Lin Yiren Xiao ana Luisa Malaco Morotti Ya Wang Meytal Galilee Haowen Qin Tao Huang Yong Zhao Xun Zhou Jun Yang Qing Zhao Angelos K.Kanellis cathie Martin Evangelos c.Tatsis National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of chinese Academy of Sciences Beijing 100049China Novogene Bioinformatics Institute BeijingChina Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghai 201602 Group of Biotechnology of Pharmaceutical Plants Lab.of PharmacognosyDepartment of Pharmaceutical SciencesAristotle University of Thessaloniki54124 ThessalonikiGreece John Innes centre Norwich NR47UHUK cEPAMS-cAS-JIc centre of Excellence for Plant and Microbial Sciences Shanghai 200032China

The presence of anticancer clerodane diterpenoids is a chemotaxonomic marker for the traditional chinese medicinal plant Scutellaria barbata,although the molecular mechanisms behind clerodane biosynthesis are ***,we report a high-quality assembly of the 414.98 Mb genome of *** into 13 *** phylogenomic and biochemical data,we mapped the plastidial metabolism of kaurene(gibberellins),abietane,and clerodane diterpenes in three species of the family Lamiaceae(Scutellaria barbata,Scutellaria baicalensis,and Salvia splendens),facilitating the identification of genes involved in the biosynthesis of the clerodanes,kolavenol,and *** show that clerodane biosynthesis evolved through recruitment and neofunctionalization of genes from gibberellin and abietane *** the assumed monophyletic origin of clerodane biosynthesis,which is widespread in species of the Lamiaceae,our data show distinct evolutionary lineages and suggest polyphyletic origins of clerodane biosynthesis in the family *** study not only provides significant insights into the evolution of clerodane biosynthetic pathways in the mint family,Lamiaceae,but also will facilitate the production of anticancer clerodanes through future metabolic engineering efforts.

关键词： Scutellaria barbata genome clerodane diterpenoids biosynthesis specialized metabolism evolution

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Light-induced halide segregation in perovskites with wrinkled morphology

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Journal of Energy chemistry 2022年第8期31卷 83-88,I0003页

作者： Eduardo G.Machado Paulo E.Marchezi Eralci M.Therézio Josécarlos Germino Rodrigo Szostak caique Sde Brito Yara G.Gobato Ernesto c.Pereira Michael F.Toney Raphael Nagao ana Flávia Nogueira Institute of chemistry University of CampinasCampinas 13083-970 SPBrazil center for Innovation on New Energies University of CampinasCampinas 13083-970SPBrazil Institute of Physics Federal University of Mato GrossoCuiaba 78060-900MTBrazil Department of Physics Federal University of Sao CarlosSao Carlos 13565-905SPBrazil Department of Physics and i3N–Institute for Nanostructures Nanomodulation and NanofabricationUniversity of AveiroAveiro 3810-193Portugal Department of chemistry Federal University of Sao CarlosSao Carlos 13565-905SPBrazil Renewable and Sustainable Energy Institute(RASEI) University of Colorado BoulderBoulder CO 80309ColoradoUnited States of America

In this work, it is proposed that, upon light incidence, a halide segregation event takes place, where iodine anions move towards the hills of a wrinkled mixed-halide perovskite.

关键词： halide perovskite iodine

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Approach to persistent ascites after liver transplantation

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World Journal of Hepatology 2022年第9期14卷 1739-1746页

作者： ana Ostojic Igor Petrovic Hrvoje Silovski Iva Kosuta Maja Sremac Anna Mrzljak Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia Department of Hepatobiliary Surgery and Transplantation University Hospital Center ZagrebZagreb 10000Croatia Department of Intensive care Medicine University Hospital Center ZagrebZagreb 10000Croatia

Persistent ascites(PA)after liver transplantation(LT),commonly defined as ascites lasting more than 4 wk after LT,can be expected in up to 7%of *** being relatively rare,it is associated with worse clinical outcomes,including higher 1-year *** cause of PA can be divided into vascular,hepatic,or *** causes of PA include hepatic outflow and inflow obstructions,which are usually successfully *** modifiable hepatic causes,recurrent hepatitis c and acute cellular rejection are the leading *** predictors for PA,the presence of ascites,refractory ascites,hepatorenal syndrome type 1,spontaneous bacterial peritonitis,hepatic encephalopathy,and prolonged ischemic time significantly influence the development of PA after *** initial approach to patients with PA should be to diagnose the treatable cause of *** stepwise approach in evaluating PA includes diagnostic paracentesis,ultrasound with Doppler,and an echocardiogram when a cardiac cause is ***,a percutaneous or transjugular liver biopsy should be performed in cases where the diagnosis is *** of unknown cause should be treated with diuretics and paracentesis,while transjugular intrahepatic portosystemic shunt and splenic artery embolization are treatment methods in patients with refractory ascites after LT.

关键词： Liver transplantation Liver transplantation complications,Ascites Hepatic graft inflow obstructions Hepatic graft outflow obstructions Acute cellular rejection

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iHola,amigos! 7th ed. 7th Edition

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2008年

作者： ana c. Jarvis

来源：畅想之星图书光盘版（南... 评论

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