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Mitochondrial dysfunctions in neurodegenerative diseases:role in disease pathogenesis,strategies for analysis and therapeutic prospects

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Neural Regeneration Research 2022年第4期17卷 754-758页

作者： Federica rey Sara Ottolenghi Gian vincenzo Zuccotti Michele Samaja Stephana Carelli Department of Biomedical and Clinical Sciences“L.Sacco” University of MilanMilanoItaly Paediatric Clinical Research Centre Fondazione“Romeo ed Enrica Invernizzi” University of MilanoMilanoItaly Laboratory of Biochemistry Department of Health SciencesUniversity of MilanMilanoItaly Department of Paediatrics Children’s Hospital“V.Buzzi”MilanoItaly

Fundamental organelles that occur in every cell type with the exception of mammal erythrocytes,the mitochondria are required for multiple pivotal processes that include the production of biological energy,the biosynthesis of reactive oxygen species,the control of calcium homeostasis,and the triggering of cell *** disruption of anyone of these processes has been shown to impact strongly the function of all cells,but especially of *** this review,we discuss the role of the mitochondria impairment in the development of the neurodegenerative diseases Amyotrophic Lateral Sclerosis,Parkinson's disease and Alzheimer's *** highlight how mitochondria disruption revolves around the processes that underlie the mitochondria's life cycle:fusion,fission,production of reactive oxygen species and energy *** genetic and sporadic forms of neurodegenerative diseases are unavoidably accompanied with and often caused by the dysfunction in one or more of the key mitochondrial ***,in order to get in depth insights into their health status in neurodegenerative diseases,we need to focus into innovative strategies aimed at characterizing the various mitochondrial *** techniques include Mitostress,Mitotracker,transmission electron microscopy,oxidative stress assays along with expression measurement of the proteins that maintain the mitochondrial *** will also discuss a panel of approaches aimed at mitigating the mitochondrial *** include canonical drugs,natural compounds,supplements,lifestyle interventions and innovative approaches as mitochondria transplantation and gene *** conclusion,because mitochondria are fundamental organelles necessary for virtually all the cell functions and are severely impaired in neurodegenerative diseases,it is critical to develop novel methods to measure the mitochondrial state,and novel therapeutic strategies aimed at improving their health.

关键词： Alzheimer's disease amyotrophic lateral sclerosis mitochondria mitochondria modulation mitochondrial dysfunction mitochondrial health Mitostress Mitotracker neurodegenerative disease Parkinson's disease

Role of bioengineering structures made of willow cuttings in marly sediment trapping: assessment of three real-size experiments in the Southern French Alps

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Journal of Mountain Science 2018年第2期15卷 225-236页

作者： Freddy rey Univ.Grenoble Alpes Irstea Grenoble

Improving knowledge on the ability of bioengineering structures made of willow cuttings to enhance efficient and sustainable sediment trapping in marly gullies in the Southern French Alps under a mountainous Mediterranean climate, to decreasesediment trapped per experiment, the mean annual values reached 0.25, 0.14 and 0.08 m3 yr-1 in experiments C, A and B, respectively. Maximum values for one structure reached 1.94 m3 per year in experiment C. The significance of the volumes ofsediment yield at their outlets, is a key issue today for the international scientific community working in geosciences and ecology. This study therefore aims to assess three real-size experiments(A, B and C) carried out between 2003 and 2013 in this environment. A total of 157 bioengineering structures using purple and white willow(Salix purpurea and Salix incana)cuttings – which have been shown to resprout and survive more than 2 years after their installation,corresponding to brush layers with brush mats on wooden sills(BLM), 1.2 m wide and 2 m long,installed on the floors of 33 experimental marly gullies, were monitored. The results showed that sediment trapping occurred upstream of the vegetation barriers from the 1 st year *** the depth of sediment trapped per experiment, the mean annual values reached 11.2 cm yr-1 after 3 years in experiment A, 7.7 cm yr-1 after 2–4 years in experiment C and 5.1 cm yr-1 after 5 years in experiment B. Occasionally, BLMs showed that they could trap up to 16 and 15 cm yr-1 in experiments A and C, respectively. Considering the volumes oftrapped sediment and the sustainability of sediment trapping are discussed, and rules for bioengineering strategies are proposed.

关键词： Erosion Marly gully vegetation barriers Ecological engineering Salix

Metformin and colorectal cancer

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BIOCELL 2022年第1期46卷 51-59页

作者： GASTÓN AMABLE EDUARDO MARTÍNEZ-LEÓN MARÍA E.PICCO OSvALDO rey Consejo Nacionalde Investigaciones Científicas y Técnicas Universidad de Buenos AiresInstituto de InmunologíaGenética y MetabolismoFacultadde Farmacia y BioquímicaHospital de Clínicas“Joséde San Martín”Ciudad Autónoma de Buenos AiresCP1120Argentina

Colorecal cancer(CRC)is one of the main causes of cancer-related mortality in the deweloped world despite recent developments in detection and treatment Several epidemiologial studis indicate that metformin,a widdy prescribed antidiabetic drug,exerts a protective effect on different cancers incuding ***,a recent double blind placebo controlled,randomized trial showed that metformin significantly decreased colorectal adenoma *** exploring the medhanism of action of metformin in cells derived from different types of ancers reported many efects including rapiratory chain complex 1 inhibition,Akt phosphorylation inhibition,ATP depltion,PKA activation and Wnt signaling ***,many of these results were obtained employing metformin at concentrations several fold higher than those achieved in target tissuas in diabetic patients receiving therapeutic recommended doses of *** contrast,recent studies obtained with metformin at concentrations compatible with those detected in human intestins revealed that metformin dicit responses that targetβ-catenin,PI3KAkt,E-adherin,pl20-catenin and focal adhesion kinase which are key molecules and signaling pathways associated to colorectal cancar *** brief review revisit several know aspects as well as nowd ones on the effects of metformin on cancer cells.

关键词： Metformin β-Catenin E-Cadherin Colorectal cancer AMPK PI3K/AKT FAK

Synthetic gauge fields for ultracold atoms

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National Science Review 2016年第2期3卷 166-167页

作者： Ana Maria rey JILA NIST and Department of PhysicsUniversity of Colorado

Ultracold gases are remarkably versatile and controllable systems with untapped potential to emulate a variety of quantum phenomena[1].Atoms are,however,electrically neutral and therefore it is highly desirable to make them behave as charged *** capability has recently been demonstrated in a series of recent experiments[2-4].Although many challenges remain ahead,

关键词： Synthetic gauge fields for ultracold atoms

Reference penile size measurement and correlation with other anthropometric dimensions:a prospective study in 800 men

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Asian Journal of Andrology 2022年第6期24卷 620-623页

作者： Martina Sole Ignacio Tobia Gonzalezi Martin Compagnucci Guadalupe Colucci Marcos Dalvit Bernardo Chiconi Omar A Layus Guillermo Gueglio Gaston rey-valzacchi Department of Urology at Hospital Italiano Buenos Aires C1199ABBArgentina Department of Urology at Sanatorio Allende Cordoba 5000Argentina Department of Urology at Hospital Privado de la Comunidad Mar del Plata 7600Argentina Department of Urology at Hospital Central Mendoza 5500Argentina

virility and sexual pleasure have long been associated with penile size and this,in turn,has typically been linked to some anthropometric measurements,such as foot size or height,leading to various misconceptions from both men and *** intention is to estimate penile size parameters in Argentina and evaluate the correlation between penile size and certain anthropometric *** is a cross-sectional,descriptive,multicenter,and observational *** patients who underwent a urological procedure were included in four hospitals located in different regions of the *** anthropometric measurements were obtained:height,weight,penile circumference,flaccid and stretched length,and foot length.A total of 8o0 patients were *** left foot was 26.4 *** flaccid penile length was 11.4(95%confidence interval[CI]:8-14)cm,and mean penile circumference was 10.1(95%CI:8-12)***,mean stretched penis was 15.2(95%CI:11-18.5)*** can confirm that estimates of the average penile measurements in Argentina are flaccid penis length of 11.4 cm,penile circumference of 10.1 cm,and stretching the penis to the maximum in flaccidity of 15.2 *** between flaccid penis length,stretched out,penile circumference,height,weight,and length of the left foot were evaluated,finding low or no correlation between those mentioned,exceptforflaccidand stretched length.

关键词： anthropometric measurements micropenis penile percentile

A Joint Optimization Algorithm for Renewable Energy System

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Intelligent Automation & Soft Computing 2023年第5期36卷 1979-1989页

作者： Imran Khan Firdaus Muhammad-Sukki Jorge Alfredo Ardila rey Abdullahi Abubakar Mas’ud Saud Jazaa Alshammari DagØivind Madsen Department of Electrical Engineering University of Engineering and TechnologyPeshawar814Pakistan School of Engineering&the Built Environment Edinburgh Napier UniversityMerchiston Campus10 Colinton RoadEdinburghEH105DTScotlandUK Department of Electrical Engineering Federico Santa María Technical UniversitySantiago8940000Chile Department of Electrical and Electronics Engineering Jubail Industrial CollegeP O Box 10099Jubail 31961Saudi Arabia University of South-Eastern Norway Bredalsveien143511HønefossNorway

Energy sustainability is a hot topic in both scientiﬁc and political *** date,two alternative approaches to this issue are being *** peo-ple believe that increasing power consumption is necessary for countries’economic and social progress,while others are more concerned with maintaining carbon consumption under set *** establish a secure,sustainable,and economical energy system while mitigating the consequences of climate change,most governments are currently pushing renewable growth *** mar-kets are meant to provide consumers with dependable electricity at the lowest pos-sible cost.A proﬁt-maximization optimal decision model is created in the electric power market with the combined wind,solar units,loads,and energy storage sys-tems,based on the bidding mechanism in the electricity market and operational *** model utterly considers the technological limits of new energy units and storages,as well as the involvement of new energy and electric vehicles in market bidding through power generation strategy and the output arrangement of the virtual power plant’s coordinated *** accuracy and validity of the optimal decision-making model of combined wind,solar units,loads,and energy storage systems are validated using numerical *** multi-operating scenarios,the effects of renewable energy output changes on joint sys-tem bidding techniques are compared.

关键词： Renewable energy optimizationalgorithm electricity market decision-making

Protein-Repairing Methionine Sulfoxide Reductases in Photosynthetic Organisms： Gene Organization, Reduction Mechanisms, and Physiological Roles

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Molecular Plant 2009年第2期2卷 202-217页

作者： Lionel Tarrago Edith Laugier Pascal rey CEA DSV IBEB Laboratoire d'Ecophysiologie Moleculaire des Plantes B~timent 161 SBVME CEA-Cadarache 13108 Saint-Paul-lez-Durance Cedex France

Methionine oxidation to methionine sulfoxide （MetSO） is reversed by two types of methionine sulfoxide reducrases （MSRs）, A and B, specific to the S- and R-diastereomers of MetSO, respectively. MSR genes are found in most organisms from bacteria to human. In the current review, we first compare the organization of the MSR gene families in photosynthetic organisms from cyanobacteria to higher plants. The analysis reveals that MSRs constitute complex families in higher plants, bryophytes, and algae compared to cyanobacteria and all non-photosynthetic organisms. We also perform a classification, based on gene number and structure, position of redox-active cysteines and predicted sub-cellular localization. The various catalytic mechanisms and potential physiological electron donors involved in the regeneration of MSR activity are then de- scribed. Data available from higher plants reveal that MSRs fulfill an essential physiological function during environmental constraints through a role in protein repair and in protection against oxidative damage. Taking into consideration the ex- pression patterns of MSR genes in plants and the known roles of these genes in non-photosynthetic cells, other functions of MSRs are discussed during specific developmental stages and ageing in photosynthetic organisms.

关键词： Genome methionine methionine sulfoxide reductase oxidation photosynthetic organisms protein repair.

Synthetic neurosteroids on brain protection

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Neural Regeneration Research 2015年第1期10卷 17-21页

作者： Mariana rey Héctor Coirini Laboratorio de Neurobiología Instituto de Biología y Medicina Experimental (IBYME-CONICET) Vuelta de Obligado 2490 (C1428ADN) Ciudad Autónoma de Buenos AiresArgentina Departamento de Bioquímica Humana Facultad de MedicinaUniversidad de Buenos Aires Paraguay 2155 Ciudad Autónoma de Buenos AiresArgentina

Neurosteroids, like allopregnanolone and pregnanolone, are endogenous regulators of neuronal excitability. Inside the brain, they are highly selective and potent modulators of GABAA receptor activity. Their anticonvulsant, anesthetics and anxiolytic properties are useful for the treatments of several neurological and psychiatric disorders via reducing the risks of side effects obtained with the commercial drugs. The principal disadvantages of endogenous neurosteroids adminis- tration are their rapid metabolism and their low oral bioavailability. Synthetic steroids analogues with major stability or endogenous neurosteroids stimulation synthesis might constitute prom- ising novel strategies for the treatment of several disorders. Numerous studies indicate that the 3ct-hydroxyl configuration is the key for binding and activity, but modifications in the steroid nucleus may emphasize different pharmacophores. So far, several synthetic steroids have been developed with successful neurosteroid-like effects. In this work, we summarize the properties of various synthetic steroids probed in trials throughout the analysis of several neurosteroids-like actions.

关键词： allopregnanolone synthetic steroids GABAA receptor neuroprotection cerebral cortex hippocampus

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疲劳评估中结构计算的不确定性传播

Journal of Marine Science and Application 2022年第4期21卷 55-66页

作者： Ludovic Mell valentine rey Franck Schoefs Benjamin Rocher Nantes Université École Centrale NantesCNRSGeMUMR 6183F-44000 NantesFrance Chantiers de l’Atlantique Avenue Bourdelle-CS90180St-Nazaire CEDEX 44613France

Offshore wind substations are subjected to uncertain loads from waves,wind and *** states are composed of irregular waves which statistics are usually *** loads may induce fatigue failure of some structural components of the *** combining fatigue damage computed through numerical simulations for each sea state endured by the structure,it is possible to assess fatigue failure of the structure over the whole deployment ***,the influence of the discretization error on the fatigue damage is rarely *** is possible to estimate the discretization error on the quantity of interest computed at the structural detail suspected to ***,the relation between this local quantity of interest and the fatigue damage is *** this paper,a method that allows propagating error bounds towards fatigue damage is *** increasing computational burden,computing discretization error bounds is a useful output of finite element *** can be utilized to either validate mesh choice or guide remeshing in case where potential error on the fatigue damage is too *** method is applied to an offshore wind substation developped by Chantiers de l’Atlantique using two discretization error estimators in a single sea state.

关键词： Offshore wind turbines Uncertainty propagation Fatigue damage Discretization error