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Assessment of mouse BMMNC DNA damage with a two-tailed comet assay after X-ray and carbon ion total body irradiation

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Nuclear Science and Techniques 2018年第6期29卷 1-8页

作者： Fang Liu Zhuan-Zi Wang Wen-Jian Li Wei Wei Bing-rong dang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 China University of Chinese Academy of Sciences Beijing 100049China

The two-tailed comet assay(2T-comet assay) is a method for simultaneously evaluating DNA single-strand breaks(SSBs) and double-strand breaks(DSBs). In the present study, the endonuclease DNase I and hydrogen peroxide were used to induce DSBs and SSBs in bone marrow mononuclear cells(BMMNCs) from mice, and the damaged DNAs were assessed with a 2T-comet assay. The results demonstrated that this method can detect and discriminate between BMMNC DNA SSBs and DSBs simultaneously. Using this method, we studied DNA damage in BMMNCs from female BALB/c mice after total body irradiation with X-rays and carbon ions. The results indicated that these two types of radiation induced serious DNA damage in BMMNCs in a dose-dependent *** DNA damage induced by carbon ions was more severe than that induced by X-rays at the same dose, and a high dose of carbon ion radiation was more likely to cause death in mice. The DSBs and SSBs induced by X-rays were the highest on the 3rd day post-IR. For carbon ion radiation,DSBs were the most serious on the 3rd day, while SSBs were more obvious on the 3rd day and 13th day *** ratio of DSBs/SSBs was clearly related to the different types of radiation.

关键词： DNA 碳离子损坏彗星尾巴身体金鼠标

Newly-found functions of metformin for the prevention and treatment of age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1274-1280页

作者： Kuan-rong dang Tong Wu Yan-Nian Hui Hong-Jun Du Department of Ophthalmology Xijing HospitalEye Institute of Chinese PLAFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

Metformin(MET),a first-line oral agent used to treat diabetes,exerts its function mainly by activating adenosine monophosphate-activated *** accumulation of oxidized phospholipids in the outer layer of the retina plays a key role in retinal pigment epithelium(RPE)cells death and the formation of choroidal neovascularization(CNV),which mean the development of age-related macular degeneration(AMD).Recent studies have shown that MET can regulate lipid metabolism,inhibit inflammation,and prohibit retinal cell death and CNV formation due to various pathological ***,newly discovered functions of MET that may be used for the prevention and treatment of AMD were reviewed.

关键词： metformin age-related macular degeneration liver X receptor

Effectiveness of urban construction boundaries in Beijing:an assessment

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1285-1295页

作者： Hao-ying HAN Shih-Kung LAI an-rong dang Zong-bo TAN Ci-fang WU College of Public Administration Zhejiang University Hangzhou 310029 China School of Architecture Tsinghua University Beijing 100084 China Department of Real Estate and Built Environment National Taipei University Taipei

Based on the remote sensing (RS) and geographic information system (GIS) analysis of the Landsat multispectral scanner (MSS) and thematic mapper (TM) satellite images of 1983, 1993, and 2005, the present research examined the effectiveness of the urban construction boundaries (UCBs) in containing urban growth within the 6th Ring Road of Beijing Municipality. Three indicators on boundary control were proposed, through which the effectiveness of boundary containment, land inventory sufficiency and illegal adjacent development to the UCBs were explored. The results suggested that, first, the UCBs were limited in effectiveness in containing urban growth; second, the area encompassed by the UCBs might not be designed large enough to accommodate new development. The frustration of the urban growth control through the UCBs mainly resulted from the lack of a transparent system for urban land use planning and control to provide sufficient information, the limitation of the traditional land use prediction method to consider contingencies, and the absence of a mechanism to monitor and adjust the UCBs to respond just in time to urban change.

关键词： Urban construction boundary (UCB) Urban growth boundary City master plan (CMP) Beijing Remote sensing (RS)

Process and Techniques in Developing General Management Plan for Meili Snow Mountains National Park of China

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中国园林 2007年第4期 7-8页

作者： YANG Rui, ZHUANG You-bo, dang An-rong

Meili Snow Mountains (Meili) are sitting at Deqin County, Diqing Tibetan Autonomous State in the extreme edge of Northwest Yunnan Province, and are part of the Three Parallel Rivers World Heritage which is typical of multiple mountainous landforms and the most compressed and extruded gigantic complex orogen across the world, therefore reflects milestones in the evolution of the Earth[1].

关键词： Process and Techniques in Developing General Management Plan for Meili Snow Mountains National Park of China VERP

A modified laser-induced choroidal neovascularization animal model with intravitreal oxidized low-density lipoprotein

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1187-1194页

作者： Tong Wu Kuan-rong dang Ya-Fen Wang Bao-Zhen Lyu Wen-Qin Xu Guo-Rui Dou Jian Zhou Yan-Nian Hui Hong-Jun Du Department of Ophthalmology Xijing HospitalEye Institute of Chinese PLAFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Anatomy and Histology and Embryology Xi’an Health SchoolXi’an 710032Shaanxi ProvinceChina The Orbital Disease Institute of the Third Medical Center of PLA General Hospital Beijing100039China

AIM: To investigate whether intravitreal injection of oxidized low-density lipoprotein(OxLDL) can promote laserinduced choroidal neovascularization(CNV) formation in mice and the mechanism involved, thereby to develop a better animal ***: C57BL6/J mice were randomized into three groups. Immediately after CNV induction with 532 nm laser photocoagulation, 1.0 μL of OxLDL [100 μg/m L in phosphate-buffered saline(PBS)] was intravitreally injected, whereas PBS and the same volume low-density lipoprotein(LDL;100 μg/m L in PBS) were injected into the vitreous as controls. Angiogenic and inflammatory cytokines were measured by quantitative real-time polymerase chain reaction(q RT-PCR) and Western blotting(WB) after 5 d, and CNV severity was analyzed by choroid flat mount and immunofluorescence staining after 1wk. In vitro, retinal pigment epithelial(RPE) cell line(ARPE19) were treated with OxLDL(LDL as control) for 8 h. Angiogenic and inflammatory cytokine levels were measured. A specific inhibitor of lectin-like oxidized low-density lipoprotein receptor 1(LOX1) was used to evaluate the role of LOX1 in this ***: At 7 d after intravitreal injection of 1 μL(100 μg/mL) OxLDL, T15-labeled OxLDL was mainly deposited around the CNV area, and the F4/80-labeled macrophages, the CD31-labeled vascular endothelial cells number and CNV area were increased. Meanwhile, WB and qR T-PCR results showed that vascular endothelial growth factor(VEGF), CC chemokine receptor 2(CCR2), interleukin-6(IL-6), IL-1β, and matrix metalloproteinase 9(MMP9) expressions were increased, which was supported by in vitro experiments in RPE cells. LOX1 inhibitors significantly reduced expressions of inflammatory factors IL-1β and VEGF. CONCLUSION: A modified laser-induced CNV animal model is established with intravitreal injection of 1 μL(100 μg/mL) of OxLDL at 7 d, which at least partially through LOX1. This animal model can be used as a simple model for studying the role of OxLDL in age-

关键词： age-related macular degeneration choroidal neovascularization oxidized low-density lipoprotein animal model

Efficacy and safety of atropine at different concentrations in prevention of myopia progression in Asian children: a systematic review and Meta-analysis of randomized clinical trials

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1326-1336页

作者： Xin-Li Wei Tong Wu Kuan-rong dang Ke-Ke Hu Xin-Ting Lu Min Gong Yu-Ru Du Yan-Nian Hui Xue-Min Tian Hong-Jun Du Department of Ophthalmology Eye Institute of Chinese PLAXijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Ophthalmology the Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Ophthalmology the People’s Liberation Army 988th HospitalZhengzhou 450000Henan ProvinceChina

AIM:To assess the efficacy versus the adverse effects of various concentrations of atropine in the prevention of myopia in Asian ***:Databases(PubMed,EMBASE,the Cochrane Library and Web of science)were comprehensively searched from inception to April *** of studies included were randomized clinical trials(RCTs).The published languages were limited to *** researchers assessed the quality of included studies independently using Cochrane risk of bias tool based on the Cochrane Handbook for Systematic Reviews of *** plots and Egger’s test were used for detection of publication ***-analyses were conducted using STATA(version 15.0;StataCorp).RESULTS:A total of 15 RCTs involving 2268 patients were included in the *** the atropine group,spherical equivalent progressed at a significantly lower rate[weighted mean difference(WMD)=0.39,95%confidence interval(CI):0.23,0.54]than in the control group.A WMD of 0.15 mm was associated with less axial elongation(95%CI-0.19,-0.10).Different doses showed statistically significant differences(P<0.05)and an improved effect could result from a higher *** in photopic pupil size and mesopic pupil size in atropine group is 0.70 mm(95%CI:0.33,1.06)and 0.38 mm(95%CI:0.22,0.54)more than the control *** the present Meta-analysis,no changes in accommodative amplitude(AA)were associated with atropine *** administration increased the risk of adverse effects by 1.37 ***:Concentrations of less than 1%atropine are able to effectively retard diopter and axis growth of myopia in Asian children in a dose-dependent ***,it caused pupil enlargement,but induced no change in the AA within this *** study is required to determine the dosage needed to achieve maximum efficacy and minimal side effects.

关键词： atropine myopia Asian children Meta-analysis

The Flow Measurement of Multiphase Flow Based on the Conductance Sensor

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Modern Instrumentation 2012年第4期1卷 35-40页

作者： Rui-rong dang Dong-Sheng Zhao Li-Pin Li Guang Yin Key Laboratory of Photoelectric Logging and Detecting of Oil and Gas Ministry of Education

Oil-gas-water three-phase flow in the pipe is commonly encountered in the petroleum and nature gas industry. Its flow patterns are complex and always changeable, so it’s difficult to be measured and is becoming one of the most important subjects. Moreover, most of the oil fields in China are in such a high water fraction period that measures must be taken to meet the needs of the actual production. A conductance sensor which is widely used in the measurements of oil-water two-phase flow is used to measure the flow rate of the three-phase flow based on the research of the characteristics and the correlation theory, and a new technical solution which is suitable for measuring the oil-gas-water three-phase flow is established. A series of tests demonstrate that it’s feasible to use the conductance sensor in the measurements of oil- gas-water three-phase flow.

关键词： Correlation Measurement Technology Conductance sensor Flow Measurement Three-Phase Flow

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混合噪声图像的去噪算法研究及FPGA实现

电子测量技术 2021年第16期44卷 135-140页

作者：陈伟党榕西安科技大学通信与信息工程学院西安710600

针对数字图像中常见的混合噪声以及边缘轮廓模糊的问题,提出一种修正的阿尔法均值滤波与边缘增强算法相结合的图像预处理算法。修正的阿尔法均值滤波算法首先对像素矩阵中的像素值统计排序,其次去除定量的最大值和最小值,再次求取像素... 详细信息

针对数字图像中常见的混合噪声以及边缘轮廓模糊的问题,提出一种修正的阿尔法均值滤波与边缘增强算法相结合的图像预处理算法。修正的阿尔法均值滤波算法首先对像素矩阵中的像素值统计排序,其次去除定量的最大值和最小值,再次求取像素矩阵中剩余像素点的均值,最后用求取的均值代替原始中心点的像素值从而实现图像去噪。边缘增强算法首先使用Sobel算子定位图像边缘信息,提取图像的边缘后,将边缘叠加于去噪图像,最终实现图像的边缘复合增强。经验证,随着噪声密度的不断增加,该算法相比于传统算法始终保持着较小的均方误差值,且均方误差的增长率约为31%。结果表明,该算法有效滤除了数字图像的混合噪声,增强了边缘信息,同时满足图像降噪系统的实时性要求。

关键词：修正的阿尔法均值滤波边缘增强 Sobel算子 CMOS图像传感器

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基于资源等待图的死锁检测算法

计算机应用与软件 2007年第6期24卷 149-151页

作者：党荣陈斌渭南师范学院财务处陕西渭南714000 渭南师范学院数学系陕西渭南714000

死锁是操作系统、数据库系统以及通信网络中经常出现的现象。分析了使用资源分配图和进程等待图完成死锁检测的不足,提出了资源等待图的概念,并给出了基于资源等待图进行死锁检测的方法,该算法能够完成当资源类含有多个实例时的死锁检测。

关键词：资源分配图进程等待图资源等待图死锁检测