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Probing the Nucleation and Growth Kinetics of Bismuth Nanoparticles via In-situ Transmission Electron Microscopy

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 877-887页

作者：王浪李超凡 ran Maojin yuAN Manman 胡执一 LI yu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Nanostructure Research Centre(NRC) Wuhan University of TechnologyWuhan 430070China Institute of Chemistry Henan Academy of SciencesZhengzhou 450002China Henan Academy of Sciences Zhengzhou 450046China

The nucleation and growth mechanism of nanoparticles is an important theory,which can guide the preparation of ***,it is still lacking in direct observation on the details of the evolution of intermediate state structure during nucleation and *** this work,the evolution process of bismuth nanoparticles induced by electron beam was revealed by in-situ transmission electron microscopy(TEM)at atomic *** experimental results demonstrate that the size,stable surface and crystallographic defect have important influences on the growth of Bi *** non-classical growth paths including single crystal growth and polycrystalline combined growth,as well as,corresponding layer-by-layer growth mechanism along{012}stable crystal plane of Bi nanoparticles with dodecahedron structure were revealed by in-situ TEM *** results provide important guidance and a new approach for in-depth understanding of the nucleation and growth kinetics of nanoparticles.

关键词： bismuth nanoparticles crystal growth transmission electron microscopy in-situ electron microscopy

Left-sided vagus nerve stimulation improves cardiopulmonary resuscitation outcomes in rats as effectively as right-sided vagus nerve stimulation

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World Journal of Emergency Medicine 2021年第4期12卷 309-316页

作者： Wei-jing Shao Ting-ting Shu Shuang Xu Li-cai Liang Jehane Michael Le Grange yu-ran Zhou He Huang yu Cai Qing Zhang Peng Sun Department of Emergency Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Intensive Care Unit Wuhan Hospital of Traditional Chinese MedicineWuhan 430000China Department of Emergency Medicine the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Emergency Medicine Hankou Branch of Central Theater General HospitalWuhan 430070China Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

BACKGROUND: Our group previously reported that right-sided vagus nerve stimulation(RVNS) significantly improved outcomes after cardiopulmonary resuscitation(CPR) in a rat model of cardiac arrest(CA). However, whether left-sided vagus nerve stimulation(LVNS) could achieve the same effect as RVNS in CPR outcomes remains ***: A rat model of CA was established using modified percutaneous epicardial electrical stimulation to induce ventricular fibrillation(VF). Rats were treated with LVNS or RVNS for 30 minutes before the induction of VF. All animals were observed closely within 72 hours after return of spontaneous circulation(ROSC), and their health and behavior were evaluated every 24 ***: Compared with those in the RVNS group, the hemodynamic measurements in the LVNS group decreased more notably. Vagus nerve stimulation(VNS) decreased the serum levels of tumor necrosis factor-alpha(TNF-α) and the arrhythmia score, and attenuated inflammatory infiltration in myocardial tissue after ROSC, regardless of the side of stimulation, compared with findings in the CPR group. Both LVNS and RVNS ameliorated myocardial function and increased the expression of α-7 nicotinic acetylcholine receptor in the myocardium after ROSC. Moreover, a clear improvement in 72-hour survival was shown with VNS pre-treatment, with no significant difference in efficacy when comparing the laterality of stimulation. CONCLUSIONS: LVNS may have similar effects as RVNS on improving outcomes after CPR.

关键词： Vagus nerve stimulation Cardiac arrest Tumor necrosis factor-alpha Myocardial function α-7 nicotinic acetylcholine receptor

Synthesis and antitumor activity of α-aminophosphonate derivatives containing thieno[2,3-d]pyrimidines

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Chinese Chemical Letters 2015年第6期26卷 755-758页

作者： Yan-Chun Guo Jing Li Jiao-Li Ma Zhi-ran yu Hai-Wei Wang Wen-Juan Zhu Xin-Cheng Liao yu-Fen Zhao The College of Chemistry and Molecular Engineering The Key Laboratory of Chemical Biology and Organic Chemistry of Henan ProvinceZhengzhou University Department of Chemistry College of Chemistry and Chemical EngineeringThe Key Laboratory for Chemical Biology of Fujian ProvinceXiamen University

Two series of thieno[2,3-d]pyrimidine derivatives were designed and synthesized, in which bioactive α-aminophosphonate subunits were introduced at the N3 position through an N-N bond connection. The in vitro cytotoxic activity of the novel compounds was tested against human esophageal carcinoma cells （EC109）, human hepatocarcinoma cells （HepG2）, human gastric carcinoma cells （MGC-803）, respectively, by the MTT method. The evaluation results revealed that compounds fimb, 6mf, 6mg, 6rid and 6nh exerted the most potent inhibition against HepG2, MGC-803 and EC109 cells, respectively. In particular, compound 6rag presented excellent inhibitory effect against HepG2 （91.2%） and MGC-803 （94.4%） cells.

关键词： α-Aminophosphonate derivatives Thieno[2 3-d]pyrimidine Synthesis Antitumor

坡顶车辆荷载作用下顺向泥岩边坡破坏机理分析

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路基工程 2024年第5期 158-162页

作者：杨瑞娟吁燃苏晓亮段晓冉陈涛贵州省交通规划勘察设计研究院股份有限公司贵阳550081 长江岩土工程有限公司武汉430010

基于贵州某高速公路顺向泥岩边坡,将坡顶车辆荷载考虑为均布静载,采用离散元UDEC软件,研究坡顶荷载大小及作用位置对顺向泥岩边坡变形破坏机理的影响。结果表明:边坡上部岩体先沿层面产生顺层滑移,边坡破坏模式为推移式滑坡;随着坡顶车... 详细信息

基于贵州某高速公路顺向泥岩边坡,将坡顶车辆荷载考虑为均布静载,采用离散元UDEC软件,研究坡顶荷载大小及作用位置对顺向泥岩边坡变形破坏机理的影响。结果表明:边坡上部岩体先沿层面产生顺层滑移,边坡破坏模式为推移式滑坡;随着坡顶车辆荷载的增加,边坡的稳定性系数不断降低,最大位移不断增大,但边坡潜在滑面位置及变形失稳范围基本不变;随着坡顶荷载距坡肩的距离增大,边坡的稳定系数不断增大,最大位移量不断减小,但潜在滑面后缘不断后移,潜在失稳范围增大。

关键词：泥岩边坡坡顶荷载离散元稳定性系数破坏机理变形控制

Ahn Chong Ghee：Yeosu World Expo： Researching into the Worldwide Topic of Sound Development of Ocean and Coast

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今日上海 2012年第5期 23-26页

作者： yu ran

小檗碱通过调节蛋白激酶B缓解对比剂肾病的作用及机制研究

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临床肾脏病杂志 2024年第10期24卷 847-854页

作者：于然肖瑶王万鹏李庆菊陈皓瑜宋坚陈佳佳南京医科大学康达学院附属涟水人民医院中心实验室淮安223400 扬州大学医学院临床学院江苏省中西医结合老年病防治重点实验室扬州225009

目的探究小檗碱(berberine,BBR)对对比剂肾病(contrast-induced nephropathy,CIN)的作用及潜在机制。方法SD大鼠用于构建大鼠CIN模型,BBR治疗组(model+BBR,M+B)大鼠给予200 mg/kg BBR灌胃治疗,对照组(control,Con)大鼠和模型组(model,Mod)大鼠给予等量生理盐水灌胃。人肾皮质近曲小管上皮细胞(human kidney cortex proximal tubule epithelial cells,HK-2)用于构建CIN体外模型,Con组细胞不进行特殊处理,Mod组细胞使用50 g/L碘佛醇作用24 h,M+B组细胞使用50 g/L碘佛醇和30μmol/L BBR处理24 h。蛋白激酶B(protein kinase B,Akt)激动剂(SC79)和Akt抑制剂(MK2206)用于检测BBR对蛋白激酶B-叉头盒O3-核因子E2相关因子2(protein kinase B-forkhead box O3-nuclear factor erythroid 2-related factor 2,Akt-Foxo3a-Nrf2)调控轴的调节作用。血肌酐(serum creatinine,Scr)检测和HE染色用于评估大鼠肾脏损伤情况。膜联蛋白V-碘化丙啶(annexin V-propidium iodide,Annexin V-PI)染色用于检测各组HK-2细胞凋亡情况。蛋白质印迹法用于检测Akt-Foxo3a-Nrf2调控轴蛋白的表达水平。结果Scr检测结果显示,Mod组大鼠的Scr水平[(58.83±7.96)μmol/L比(23.52±0.78)μmol/L]高于Con组,M+B组Scr水平[(39.64±2.52)μmol/L比(58.83±7.96)μmol/L]低于Mod组(P均<0.05)。HE染色结果显示,Con组大鼠肾脏形态正常,肾小管上皮细胞完好,Mod组大鼠肾脏中肾小管结构受损,大量肾小管上皮细胞死亡,肾小管上皮细胞空泡样变明显,M+B组大鼠肾脏中部分肾小管形态恢复,肾小管上皮细胞空泡样变减少,细胞死亡减少。蛋白质印迹法表明,与Con组相比,在Mod组大鼠和HK-2细胞中磷酸化蛋白激酶B(Phospho-protein kinase B,p-Akt)表达增加,差异均具有统计学意义(P均<0.05);M+B组p-Akt表达较Mod组下降(P<0.05);Annexin V-PI凋亡检测显示,与Con组相比,Mod组中HK-2细胞凋亡[(12.65±1.25)%比(27.44±0.73)%]增加,与Mod组相比,M+B组中HK-2细胞凋亡[(27.44±0.73)%比(24.81±0.49)%]下降(P均<0.05)。与M+B组相比,BBR与Akt激动剂联合治疗组HK-2细胞凋亡[(24.81±0.49)%比(27.50±0.35)%]增加(P<0.05)。与Mod组相比,Akt抑制剂治疗组HK-2细胞凋亡[(27.65±0.56)%比(25.20±0.64)%]减少(P<0.05)。与M+B组相比,MK2206与BBR联合使用能够进一步减少碘佛醇诱导的HK-2细胞凋亡[(24.51±0.52)%比(21.24±0.99)%,P<0.05]。结论BBR通过调控Akt-Foxo3a-Nrf2轴,在体内和体外发挥抑制CIN的作用,该作用机制是p-Akt依赖性的。

关键词：对比剂肾病小檗碱蛋白激酶B 凋亡

多囊卵巢综合征合并不孕患者病耻感现状及影响因素研究

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国际生殖健康／计划生育杂志 2024年第1期43卷 6-10页

作者：罗丽燕金叶史莉韩梅于然宋东红北京大学第三医院妇产科生殖中心 100191

目的:调查育龄期多囊卵巢综合征(polycystic ovary syndrome,PCOS)合并不孕患者病耻感现状,并分析其影响因素。方法:采用方便抽样的方法,于2022年1月—2023年3月应用一般资料调查问卷、女性不孕症患者病耻感量表(Infertility Stigma Sca... 详细信息

目的:调查育龄期多囊卵巢综合征(polycystic ovary syndrome,PCOS)合并不孕患者病耻感现状,并分析其影响因素。方法:采用方便抽样的方法,于2022年1月—2023年3月应用一般资料调查问卷、女性不孕症患者病耻感量表(Infertility Stigma Scale,ISS)、生育压力量表(Fertility Problem Inventory,FPI)对北京大学第三医院生殖中心门诊治疗的PCOS合并不孕患者进行调查。结果:本次共发放问卷269份,有效问卷251份,有效率为93.3%。PCOS合并不孕患者的ISS总分为(61.49±23.25)分,FPI总分为(148.32±31.02)分;ISS总分与FPI总分呈强正相关(r=0.719,P<0.001)。分层回归显示,生育压力是PCOS合并不孕患者病耻感的影响因素,生育压力可独立解释病耻感43.5%的变异。结论:PCOS合并不孕患者病耻感呈中度水平,医护人员应重点关注生育压力大的患者,并根据影响因素制定干预措施,降低患者的病耻感水平。

关键词：多囊卵巢综合征不育,女(雌)性影响因素分析病耻感心理压力

单室与四室井筒式地下连续墙竖向承载特性研究

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山西建筑 2024年第8期50卷 78-82页

作者：吴郡何泽平解维佳阙木泰冉玉重庆三峡学院重庆404100 重庆市万州建筑工程集团有限公司重庆404100

以井筒式地下连续墙为研究对象,采用数值模拟的研究方法,应用弹性本构模型,考虑墙土界面的参数影响,对单室和四室井筒式地下连续墙基础的沉降特性、内外侧摩阻力、端阻力、土芯顶部反力及其荷载分担比进行分析和研究。研究表明:外摩阻... 详细信息

以井筒式地下连续墙为研究对象,采用数值模拟的研究方法,应用弹性本构模型,考虑墙土界面的参数影响,对单室和四室井筒式地下连续墙基础的沉降特性、内外侧摩阻力、端阻力、土芯顶部反力及其荷载分担比进行分析和研究。研究表明:外摩阻力主要由墙身深度范围内的外侧下部土体提供,内摩阻力主要由土芯下部土体提供;外摩阻力自上而下发挥作用,而内摩阻力自下而上发挥作用。随着荷载的增加,单室井筒式地下连续墙的外侧摩阻力的荷载分担比逐渐减小,而端承反力、内侧摩阻力和土芯顶反力的荷载分担比都在增加,而四室井筒式地下连续墙的外侧摩阻力、墙端反力、土芯顶反力都在减小,仅有内摩阻力的荷载分担比在增加。

关键词：井筒式地下连续墙沉降内摩阻力外摩阻力荷载分担比

Improved magnetic anisotropy of Co-based multilayer film with nitrogen dopant

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Rare Metals 2021年第10期40卷 2855-2861页

作者： Ling-ran yu Xiu-Lan Xu yun-Long Jia Xuan Geng Xu-Jie Ma Yi-Fei Ma Yong-Hui Zan Chun Feng Jiao Teng School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China

Modulating the magnetic anisotropy of ferromagnetic thin films is crucial for constructing high-density and energy efficient magnetic memory devices. Ta/W(N)/Co/Pt multilayers were deposited on silicon substrates by magnetron sputtering at room temperature. The influences of N dopant on the magnetic anisotropy of the multilayers were investigated by preparing the sample with N incorporation. The results indicate that when sputtering W target with only argon gas(Ar), Ta/W/Co/Pt sample shows inplane magnetic anisotropy(IMA). When sputtering W target at a different amount of N_(2) and Ar atmosphere, it can induce perpendicular magnetic anisotropy(PMA) for proper N-doped Ta/W(N)/Co/Pt sample. When the gas flow ratio of Ar:N_(2) is 16:6, the effective magnetic anisotropy constant reach its maximum value of 1.68×10^(5) J·m^(-3),which enhanced by about 400% than our past works(annealing treatment is necessary to induce PMA in Pt/Co/MgO system). X-ray diffraction(XRD) and X-ray reflection(XRR) results demonstrate that N dopants can effectively promote the formation of b-W phase and reduce the roughness of W(N)/Co interface, which are beneficial for PMA. X-ray electron spectroscopy(XPS) analysis reveals that N doping redistributes Co charges, nitrogen ions participate in electron allocation of Co and attract some electrons of Co to form orbital hybridization between Co3 d and N 2 p. This may be another important reason for the PMA formation.

关键词： Magnetic multilayers N dopants Perpendicular magnetic anisotropy X-ray electron spectroscopy