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Preoperative Assessment of Abdominal Adipose Tissue to Predict Microvascular Invasion in Small Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 184-189页

作者： Zongqian Wu Hong Lu Qiao Xie Jie Cheng Kuansheng Ma Xiaofei Hu Liang Tan Huarong Zhang Chen Liu Xiaoming Li ping cai Department of Radiology Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Department of Hepatobiliary Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Department of Neurosurgery Southwest HospitalThird Military Medical University(Army Military Medi-cal University)ChongqingChina Department of Electrical and Computer Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina Institute of Pathology and Southwest Cancer Center Third Military Medical University(Army Military Medical University)ChongqingChina

Background and Aims:Microvascular invasion(MVI)affects recurrence after treatment of small hepatocellular carcinoma(sHCC)of≤3 cm in *** present study aimed to investigate whether abdominal subcutaneous adipose tissue(SAT),visceral adipose tissue(VAT),and intermuscular adipose tissue(IMAT)are associated with MVI in patients with ***:A total of 124 patients with pathologicallyconfirmed sHCC diagnosed on surgical resection at the First Hospital Affiliated to Army Military University were recruited and divided into two groups according to MVI classification criteria(i.e.,MVI-positive or MVI-negative).The SAT,VAT,and IMAT areas at the lumbar 3 vertebral level were imaged with abdominal computed tomography and measured using ImageJ *** association with MVI in sHCC was ***:Of the 124 patients with sHCC,67 were MVIpositive and 57 were *** analysis revealed a significant difference in the abdominal VAT and SAT between the MVI-positive and MVI-negative groups(p<0.05),with an area under the receiver operating characteristic curve of 0.76 and 0.65,***:The results of this study suggest that the areas of abdominal SAT and VAT are of significant clinical value because they can effectively predict the MVI status in patients with sHCC.

关键词： Hepatocellular carcinoma Subcutaneous adipose tissue Visceral adipose tissue Computed tomography

Scanning near-field acoustic microscope and its application

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Science China(Technological Sciences) 2011年第1期54卷 126-130页

作者： XU ping,cai Wei & WANG RongMing Key Laboratory of Micro-nano Measurement-Manipulation and Physics (Ministry of Education) Department of Physics,Beihang University,Beijing 100191,China Key Laboratory of Micro-nano Measurement-Manipulation and Physics (Ministry of Education) Department of Physics Beihang University Beijing China

Scanning near-field acoustic microscope （SNAM） combines the ultrasonic detection technology with scanning near-field microscopy. The main characteristic of such microscope is that the acoustic wave is produced or detected in near-field area whether ultrasonic transducer acts as generator or detector. The resolution of SNAM can reach to nanometer scale. First, two typical SNAMs, scanning electron acoustic Inicroscope and scanning probe acoustic microscope, will be introduced in this paper. The working principle of our homemade SNAM based on a commercial scanning probe microscope will be reported, together with some recent results from this homemade SNAM.

关键词： scanning near-field acoustic microscope ultrasonic detection technology scanning probe microscopy

Dietary Modulation of Glucagon-like Peptide 1 Secretion:insights and innovations

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Food and Health 2024年第2期6卷 42-48页

作者： Qing-Yu Wang Jian-ping cai The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijing 100730China

Glucagon-like peptide-1(GLP-1),a signal peptide hormone produced by enteroendocrine L cells from the distal small intestine and colon,is a crucial regulator of glycemic control,gastric emptying,satiety,and body *** advancements in understanding the dietary modulation of GLP-1 through enteroendocrine L-cells have highlighted the potential of various nutrients in enhancing its endogenous *** review summarizes the current knowledge on food-derived molecules,including macronutrients,polyphenols,other chemicals,and bacterial products,that can modulate GLP-1 *** explores the efficacy and impact of various treatments and the involved signaling pathways,aiming to contribute to developing innovative strategies for enhancing endogenous GLP-1 release.

关键词： GLP-1 intestine enteroendocrine L-cells nutrient bacteria-derived product

Infrared Spectroscopic and Theoretical Studies on Cobalt(Ⅱ) Complex of Maleinitriledithiolate and 4, 4′-Dimethyl-2, 2′-bipyridine

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Wuhan University Journal of Natural Sciences 2002年第1期7卷 87-96页

作者： Peng Zheng-he, cai ping, Fang Chen-jie, Wen Li-li College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China College of Chemistry and Molecular Sciences Wuhan University Wuhan Hubei China

The complete experimental IR spectra and vibrational analysis of the title complex Co(mnt)(dmbpy) were reported in this paper. The results show that the complex molecule has a planar geometry belonging to point group C 2v and ground electronic state with spin quartet. A new method for analyzing vibrational spectra of complicated molecule is established. The essential of this method is to point out main fixed points and pivotal vibrational units in assignment for each fundamental band. Two new symbols η (heaving along the specified direction) and M (midpoint of a bond or unit) were defined for describing the vibrational modes accurately.

关键词： Cobalt(Ⅱ) complex infrared spectrum new method to analyze vibrational spectra quantum chemical calculation

Silencing profilin-1 inhibits gastric cancer progression via integrin β1/focal adhesion kinase pathway modulation

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World Journal of Gastroenterology 2015年第8期21卷 2323-2335页

作者： Ya-Jun Cheng Zhen-Xin Zhu Jian-Sheng Zhou Zun-Qi Hu Jian-Peng Zhang Qing-ping cai Liang-Hua Wang Gastrointestinal Surgery Department Shanghai Changzheng Hospital Second Military Medical University Biochemistry and Molecular Biology Department Second Military Medical University

AIM:To investigate the role of profilin-1(PFN1)in gastric cancer and the underlying ***:Immunohistochemical analysis,quan-titative real-time polymerase chain reaction(q RTPCR)and Western blot were performed to detect PFN1expression in clinical gastric carcinoma and adjacent tissues,and the association of PFN1 expression with patient clinicopathological characteristics was ***1 was knocked down to investigate the role of this protein in cell proliferation and metastasis in the SGC-7901 cell *** explore the underlying mechanisms,the expression of integrinβ1 and the activity of focal adhesion kinase(FAK)and the downstream proteins extracellular-regulated kinase(ERK)1/2,P38 mitogen-activated protein kinase(MAPK),phosphatidylinositol 3-kinase(PI3K),AKT and mammalian target of rapamycin(m TOR)were measured through Western blot or q RT-PCR ***(FN),a ligand of integrinβ1,was used to verify the correlation between alterations in the integrinβ1/FAK pathway and changes in tumor cell aggressiveness upon PFN1 ***:Immunohistochemical,Western blot and q RT-PCR analyses revealed that PFN1 expression was higher at both the protein and m RNA levels in gastric carcinoma tissues compared with the adjacent *** addition,high PFN1 expression(53/75,70.4%)was correlated with tumor infiltration,lymph node metastasis and TNM stage in gastric cancer,but not with gender,age,location,tumor size,or histological *** vitro experiments showed that PFN1knockdown inhibited the proliferation of SGC-7901cells through the induction G0/G1 *** PFN1 inhibited cell migration and invasion and downregulated the expression of matrix metalloproteinase(MMP)-2 and ***,silencing PFN1 reduced the expression of integrinβ1 at the protein level and inhibited the activity of FAK,and the downstream effectors ERK1/2,P38MAPK,PI3K,AKT and m ***-promoted cell proliferation and metastasis via the integrinβ1/FAK pathwa

关键词： Gastric cancer Profilin-1 Integrin β1 Focaladhesio

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强非线性振动系统极限环振幅控制研究

振动与冲击 2013年第9期32卷 110-112页

作者：蔡萍唐驾时湖南大学机械与运载工程学院长沙410082 漳州师范学院数学与信息科学系福建漳州363000

研究一类强非线性振动系统极限环振幅控制。利用改进的多尺度法求解系统极限环振幅表达式;构造几类线性、非线性反馈控制器,获得反馈系数与极限环振幅的近似解析关系;通过选择适当的反馈系数,可对极限环振幅进行控制;讨论并比较不同控... 详细信息

研究一类强非线性振动系统极限环振幅控制。利用改进的多尺度法求解系统极限环振幅表达式;构造几类线性、非线性反馈控制器,获得反馈系数与极限环振幅的近似解析关系;通过选择适当的反馈系数,可对极限环振幅进行控制;讨论并比较不同控制器的控制效果;数值模拟结果验证了幅值预测的正确性与控制的有效性。对较大参数ε仍具有较高精确度。

关键词：强非线性极限环振幅控制改进多尺度法

Lipid-lowering effects of oleanolic acid in hyperlipidemic patients

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Chinese Journal of Natural Medicines 2018年第5期16卷 339-346页

作者： LUO Han-Qiong SHEN Jie CHEN cai-ping MA Xiao LIN Chao OUYANG Qiong XUAN Chun-Xiao LIU Jine SUN Hong-Bin LIU Jun Jiangsu Key Laboratory of Drug Screening and Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease China Pharmaceutical University First Affiliated Hospital Nanjing Medical University

Oleanolic acid(OA) is a pentacyclic triterpenoid compound extracted from olea europaeal, a traditional Chinese medicine herb. OA has been used in the clinic as a hepatoprotective medicine in China since 1970 s. In our previous study, we observed that OA could ameliorate hyperlipidemia in animal models. In the present study, we conducted a small-scale clinical trial to evaluate the hypolipidemia effect of OA in hyperlipidemic patients. Hyperlipidemic patients were administrated with OA for four weeks(4 tablets once, three times a day). The blood samples of the patients were collected before and after OA treatment. The biological parameters were measured. Furthermore, three patients' blood samples were studied with DNA microarray. After OA administration, the TC, TG, and HDLC levels in serum decreased significantly. DNA microarray analysis results showed that the expressions of 21 m RNAs were significantly changed after OA treatment. Bioinformatics analysis showed 17 m RNAs were up-regulated and 4 m RNAs were down-regulated significantly after OA treatment. Five m RNAs(CACNA1 B, FCN, STEAP3, AMPH, and NR6 A1) were selected to validate the expression levels by q RT-PCR. Therefore, OA administration differentially regulated the expression of genes involved in lipid metabolism. The data showed a clinical evidence that OA could improve hyperlipidemia and also unveiled a new insight into the molecular mechanisms underlying the pharmacological effect of OA on hyperlipidemia.

关键词： Oleanolic acid Hyperlipidemia DNA microarray Pathway analysis Clinic

Evaluation of the efficacy of Tian dan shu gan rehabilitation exercise in improving the short-term quality of life of patients with acute myocardial infarction after percutaneous coronary intervention

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Frontiers of Nursing 2022年第4期9卷 389-394页

作者： Jia-Yan Qu Jing-Bo Lu Yong-Hong Shen Rong Yao cai-ping Meng Li-Yuan Rong Department of Nursing Yueyang Hospital of Integrated Traditional Chinese Medicine and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Objective:To evaluate the efficacy of Tian dan shu gan rehabilitation exercise in improving the short-term survival quality of patients after percutaneous coronary intervention(PCI)and explore whether patients’symptoms,physical function,cognitive function,and psychosocial function are improved after this ***:Patients with acute myocardial infarction who underwent PCI in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine from August to November 2020 were selected.A total of 110 patients were selected by the convenience sampling *** in the control group were given routine nursing measures after PCI for coronary heart disease,and patients in the experimental group received Tian dan shu gan rehabilitation exercise in addition to routine ***:After 3 wk,the quality of life in the experimental group was improved compared with that in the control group,and the differences in symptom scores,physical functions,cognitive functions,and psychosocial functions were statistically significant(P<0.01).After 3 wk of Tian dan shu gan rehabilitation exercise,patients with body mass index(BMI)between 27 and 29.9 had the highest score of body function,which was statistically significantly better compared with that of other groups(P<0.001).Patients who had remained bachelors for a long period of time had the highest score of symptoms,which was statistically significant compared with the other groups(P<0.001).The nursing satisfaction of the experimental group was 96.3%.Conclusions:Tian dan shu gan rehabilitation exercise was effective in improving the short-term quality of life of patients with acute myocardial infarction after PCI,and the nursing satisfaction rate was high,use of which should be further extended to more clinical patients.

关键词： patients routine coronary

Preparation and Magnetic Properties of Submicron CrO2 Thin Film on Poly-crystal TiO2 Film

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Chemical Research in Chinese Universities 2013年第3期29卷 600-602页

作者： YUAN Ju-jun WEN Ge-hui ZHAO Qiang FAN Yin-bo ZHANG cai-ping ZHANG Xian-ke YU Hua-jun XIE Ying-mao College of Physics and Electronics Gannan Normal University Ganzhou 341000 P. R. China State Key Laboratory of Superhard Materials Jilin University Changchun 130012 P. R. China Institute of Optoelectronic Materials and Technology Gannan Normal University Ganzhou 341000 P. R. China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Chengdu 610054 P. R. China

The submicron chromium dioxide（CrO2） thin film was fabricated on a poly-crystal titania（TiO2） film using Si wafers as substrates by atmospheric pressure chemical vapor deposition（CVD） method. X-Ray diffraction patterns show that the CrO2 films were pure rutile structure. Scanning electron microscopy（SEM） images indicate that the CrO2 films consisted of submicron grains with a grain size of 250--750 rim. The magnetic researches reveal that the magnetic easy axis is parallel to the films, and at room temperature, the CrO2 films show linear magnetoresistance.

关键词： CrO2 film TiO2 film Chemical vapor deposition(CVD) Magnetic property Half-metal ferromagnet