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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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亲子孝道观念冲突与青少年子女抑郁的关系

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心理学报 2025年第1期57卷 58-70页

作者：郭筱琳张艺凡关岳琳罗良北京师范大学中国基础教育质量监测协同创新中心北京师范大学心理学部北京100875

孝道是维系家庭关系的基本准则,对子女心理健康具有重要影响。但家庭中父母和子女的孝道观念可能存在冲突,其对子女的心理意义尚未可知。本文探讨了亲子孝道观念冲突与青少年子女抑郁的关系,并关注不同亲子性别组合间的差异。基于对332... 详细信息

孝道是维系家庭关系的基本准则,对子女心理健康具有重要影响。但家庭中父母和子女的孝道观念可能存在冲突,其对子女的心理意义尚未可知。本文探讨了亲子孝道观念冲突与青少年子女抑郁的关系,并关注不同亲子性别组合间的差异。基于对3321名青少年及其父亲和母亲的间隔2年的问卷调查纵向数据,采用多项式回归和响应面分析方法得到如下结果:(1)当父母和子女孝道观念不存在冲突时,相互性和权威性孝道的水平对子女抑郁不具有预测作用。(2)当父母和子女孝道观念存在冲突时,与父亲在相互性和权威性孝道上的冲突对儿子的抑郁水平有消极预测作用,与父亲及母亲在相互性和权威性孝道上的冲突对女儿的抑郁水平有消极预测作用。这表明,当亲子间在孝道上不存在冲突时,孝道本身的类型及水平与子女抑郁无关,但儿子与父亲以及女儿与父母在孝道上的冲突则可能诱发子女抑郁。

关键词：孝道观念冲突青少年抑郁性别差异响应面分析

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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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Biological Systems:Reliable Functions out of Randomness

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Journal of Systems Science & Complexity 2021年第5期34卷 2036-2047页

作者： XIE liang-liang University of Waterloo WaterlooOntarioCanada.Email:llxie@uwaterloo.ca.

What makes biological systems different from man-made systems?One distinction is explored in this paper:Biological systems achieve reliable functions through randomness,i.e.,by both mitigating and exploiting the effects of *** fundamental reason for biological systems to take such a random approach is the randomness of the microscopic world,which is dramatically different from the macroscopic world we are familiar *** substantiate the idea,bacterial chemotaxis is used as an example.

关键词： Bacterial chemotaxis biological systems feedback randomness reliable functions

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Unraveling the mechanism of action of Shangxia liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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紧邻在建城市轨道交通特别保护区开口基坑支护实践

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山西建筑 2025年第2期51卷 77-81页

作者：吴亮无锡市建筑设计研究院有限责任公司江苏无锡214001

基坑北侧距离济南市在建城市轨道交通R2线特别保护区仅1.9 m,特别保护区内严禁支护结构进入,务必在该有限的空间内实现支护桩和止水桩的布置,因此济南市常规的桩锚支护体系难以应用。基坑南侧为先开挖到底的居住地块基坑,因其邻近本基... 详细信息

基坑北侧距离济南市在建城市轨道交通R2线特别保护区仅1.9 m,特别保护区内严禁支护结构进入,务必在该有限的空间内实现支护桩和止水桩的布置,因此济南市常规的桩锚支护体系难以应用。基坑南侧为先开挖到底的居住地块基坑,因其邻近本基坑侧采用放坡支护,导致本基坑在南侧形成开口,难以满足支撑支点设置要求。通过在居住地块侧设置专门的支撑传力结构作为支座,在解决支撑支点设置问题的同时还增加了地下室的实际使用面积,使本基坑成为R2线特别保护区边首个采用钢管支撑的地下2层深基坑,在确保基坑本身安全的同时,满足了R2线的建设控制要求。

关键词：城市轨道交通特别保护区基坑支护钢管支撑支撑传力结构

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新型悬臂式掘进机横轴截割头的研制

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煤矿机械 2025年第1期46卷 60-62页

作者：董良中国煤炭科工集团太原研究院有限公司太原030006 煤矿采掘机械装备国家工程实验室太原030006 山西天地煤机装备有限公司太原030006

作为煤矿采掘机械中破岩落煤的关键部件,横轴式截割头相比纵轴式截割头在硬岩截割时具有更好的破岩效率和适应性。相比山特维克AHM105横轴截割头结构,通过在联接结构、头体结构、齿座结构、大端结构等方面的创新,采用八方结构联接、前... 详细信息

作为煤矿采掘机械中破岩落煤的关键部件,横轴式截割头相比纵轴式截割头在硬岩截割时具有更好的破岩效率和适应性。相比山特维克AHM105横轴截割头结构,通过在联接结构、头体结构、齿座结构、大端结构等方面的创新,采用八方结构联接、前后截割头体结合防剪切销组焊、J形坡口齿座、一体化耐磨头体大端等结构,成功研制了新型悬臂式掘进机横轴截割头,通过井下应用验证了该截割头在截割全岩过程中具有较高的可靠性和稳定性。研究内容为横轴式截割头的研发和创新提供了参考,具有一定的实用和推广价值。

关键词：悬臂式掘进机横轴式截割头研制

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大罐笼载胶轮车用液压自动阻车器的开发

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煤矿机械 2025年第1期46卷 128-130页

作者：张良徐州煤矿安全设备制造有限责任公司江苏徐州221011

针对传统大罐笼内的胶轮车阻车器多为手动阻车,提出了一种无轨胶轮车用液压自动阻车器。该液压阻车器采用液压自动控制,无须工人进罐操作,安全、可靠,为立井大罐笼载无轨胶轮车的运输安全提供了保障。

关键词：阻车器液压自动无轨胶轮车大罐笼

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组织工程技术修复颞下颌关节:问题与挑战

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中国组织工程研究 2025年第22期29卷 4804-4812页

作者：赖鹏宇梁冉沈山暨南大学口腔医学院广东省广州市510632

背景:颞下颌关节疾病的传统疗法受限于疾病严重程度和个体差异。相比之下,组织工程作为一种新兴治疗方法,可以根据患者具体情况定制个性化治疗方案,减少手术过程中的不确定性,提高治疗效果。目的:综述组织工程修复颞下颌关节的最新研究... 详细信息

背景:颞下颌关节疾病的传统疗法受限于疾病严重程度和个体差异。相比之下,组织工程作为一种新兴治疗方法,可以根据患者具体情况定制个性化治疗方案,减少手术过程中的不确定性,提高治疗效果。目的:综述组织工程修复颞下颌关节的最新研究成果和进展。方法:以“颞下颌关节,组织工程,种子细胞,支架,生长因子,动物模型”为中文检索词,以“temporomandibular joint,tissue engineering,seed cell,scaffold,growth factor,animal model”为英文检索词,分别在PubMed数据库和中国知网进行文献检索,检索时限为各数据库建库时间至2024年3月。通过分析和阅读文献进行筛选,按照排除筛选标准纳入文献,最终纳入57篇文献进行综述。结果与结论:(1)随着生物学、材料学与工程学等技术的发展,颞下颌关节组织工程己取得较大进展,例如种子细胞的筛选、新型支架的开发、生长因子作用机制的探索、多种动物模型的构建等,目前大多数研究尚处于体外实验阶段,动物实验等体内研究尚未大规模开展,组织工程修复颞下颌关节的临床应用还需更多证据支持。(2)尽管颞下颌关节组织工程研究仍存在许多问题和挑战等待解决,依然展现出广阔的临床应用前景,有望在将来成为颞下颌关节疾病出色高效的治疗方式。

关键词：组织工程颞下颌关节软骨缺损种子细胞支架水凝胶脱细胞外基质生长因子外泌体动物模型

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Study of thermal decoherence of harmonic oscillators

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原子与分子物理学报 2025年第5期42卷 108-114页

作者： LI Jian ZHOU Gao-liang YAN Zheng-Xin LIU Wei WANG Zhao-Qi College of Science Xi’an University of Science and TechnologyXi’an 710054China

The thermal decoherence of harmonic oscillators is investigated *** quantum system presented here is a one-dimensional oscillator with angular frequency,which is surrounded by a thermal bath of environmental *** are various environmental oscillators with different angular frequency(below an ultraviolet cutoff).At the beginning,the quantum system is a pure state and the environmental oscillators are in thermodynamic equilibrium with *** a period,the system-environment interactions inspire significant decoherence of the quantum *** decoherence is displayed by explicit calculations of the purity and von Neumann entropy of the quantum *** is worth noting that the decoherence could be significant even in the weak coupling and low temperature case due to the large amount of environmental degrees of *** the decoherence process is inspired between the quantum system and an ordinary thermal environment here,the thermal decoherence result is quite general.

关键词： Quantum decoherence Grand canonical ensemble Oscillators

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