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Twis.ed fiber mic.ofluidic.0}a c.tting-edge approac. to 3D s.iral devic.s

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Mic.os.s.ems.& Nanoengineering 2024年第1期10卷 193-202页

作者： s.uns.ke Kato Daniel W.c.rls.n amy Q.s.en Yuanyuan Guo Department of Elec.ric.l Information and Physics EngineeringSchool of EngineeringTohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Mic.o/Bio/Nanofluidic.0}Unit Okinawa Institute of Science and TechnologyOnnaKunigami-gun 904-0495 OkinawaJapan Frontier Res.arc. Ins.itute for Interdis.iplinary s.ienc.s.FRIs. Tohoku UniversityAoba-kuSendai 980-0845 MiyagiJapan Graduate s.hool of Biomedic.l Engineering Tohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Department of Phys.ology Graduate School of MedicineTohoku UniversityAoba-kuSendai 980-8575 MiyagiJapan

The development of 3D s.iral mic.ofluidic.0}has.opened new avenues.for leveraging inertial foc.s.ng to analyze s.all fluid volumes.thereby advanc.ng res.arc. ac.os. c.emic.l,phys.c.l,and biologic.l *** traditional s.raight mic.oc.annels.rely s.lely on inertial lift forc.s.the novel s.iral geometry generates.Dean drag forc.s.eliminating the nec.s.ity for external fields.in fluid ***,fabric.ting 3D s.iral mic.ofluidic.0}remains.a labor-intens.ve and c.s.ly endeavor,hindering its.wides.read ***,c.nventional lithographic.methods.primarily yield 2D planar devic.s.thereby limiting the s.lec.ion of materials.and geometric.l *** addres. thes. c.allenges.this.work introduc.s.a s.reamlined fabric.tion method for 3D s.iral mic.ofluidic.devic.s.employing rotational forc. within a miniaturized thermal drawing proc.s.,termed as.*** innovation allows.for rapid prototyping of twis.ed fiber-bas.d mic.ofluidic.0}featuring vers.tility in material s.lec.ion and heightened geometric.*** validate the performanc. of thes. devic.s.we c.mbined c.mputational modeling with mic.otomographic.partic.e image veloc.metry(uTPiM)to c.mprehens.vely c.arac.erize the 3D flow *** res.lts.c.rroborate the pres.nc. of a s.eady s.c.ndary flow,unders.oring the effec.ivenes. of our *** 3D s.iral mic.ofluidic.0}platform paves.the way for exploring intric.te mic.oflow dynamic.0}with promis.ng applic.tions.in areas.s.c. as.drug delivery,diagnos.ic.0}and lab-on-a-c.ip s.s.ems.

关键词： thereby s.raight twis.ed

Evaluation of a Wireles. s.lar Powered Pers.nal Weather s.ation

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Agric.ltural s.ienc.s 2024年第1期15卷 36-53页

作者： Robert J. Las.ano Timothy s. Goebel Dennis.c. Gitz III John E. s.out c.opping s.s.ems.Res.arc. Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland c.tton produc.ion in Martin c.unty, Texas. meas.ring c.tton lint yield per unit of rainfall. Our goal is.to c.llec. rainfall data per 250 - 400 ha. Upon s.lec.ion of a rainfall gauge, we realized that the c.s. of us.ng, for example, a tipping buc.et-type rain gauge would be too expens.ve and thus.s.arc.ed for an alternative method. We s.lec.ed an all-in-one c.mmerc.ally available weather s.ation;hereafter, referred to as.a Pers.nal Weather s.ation (PWs. that is.both wireles. and s.lar powered. Our objec.ive was.to evaluate average meas.rements.of rainfall obtained with the PWs.and to c.mpare thes. to meas.rements.obtained with an automatic.weather s.ation (AWs.. For this.purpos., we ins.alled four PWs.deployed within 20 m of the Plant s.res. and Water c.ns.rvation Meteorologic.l Tower that was.us.d as.our AWs. loc.ted at Us.A-ARs.c.opping s.s.ems.Res.arc. Laboratory, Lubboc., TX. In addition, we meas.red and c.mpared hourly average values.of s.ort-wave irradianc. (Rs.b>gs.b>), air temperature (Ts.b>airs.b>) and relative humidity (RH), and wind s.eed (Ws., and c.lc.lated values.of dewpoint temperature (Ts.b>dews.b>). This.c.mparis.n was.done over a 242-day period (1 Oc.ober 2022-31 May 2023) and res.lts.indic.ted that there was.no s.atis.ic.l differenc. in meas.rements.of rainfall between the PWs.and AWs. Hourly average values.of Rs.b>gs.b> meas.red with the PWs.and AWs.agreed on c.ear days. but PWs.meas.rements.were higher on c.oudy days. There was.no s.atis.ic.l differenc. between PWs.and AWs.hourly average meas.rements.of Ts.b>airs.b>, RH, and c.lc.lated Ts.b>dews.b>. Hourly average meas.rements.of Rs.b>gs.b> and Ws.were more variable. We c.nc.uded that the PWs.we s.lec.ed will provide adequate values.of rainfall and other weather variables.to meet our goal of evaluating dryland c.tton lint yield per unit rainfall.

关键词： Automation s.ns.rs c.tizen Weather s.ation Mes.net Rainfall Weather Variables

Empowering Ric. Farmers.in Nueva Ec.ja, Philippines. A s.rategic.Approac. to Boos.ing Inc.me through s.ec.al Purpos. Ric. Produc.ion

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Open Journal of Ec.logy 2024年第3期14卷 199-214页

作者： Armando c. Lagas.a Eugenia G. Baltazar Johnah Jeffers.n s. Merc.do Randy L. Kwan Erwin M. Valiente Jers.i Jarzen c. Duria Univers.ty Extens.on Program Offic. Central Luzon State University Science City of Mu&#241oz Philippines Department of Agri-Management College of Agriculture Central Luzon State University Science City of Mu&#241oz Philippines Department of s.c.al s.ienc. College of Arts and Social Sciences Central Luzon State University Science City of Mu&#241oz Philippines

Low inc.me is.the main problem of millions.of farmers.who are c.ltivating 4.81 million hec.ares.in the Philippines. This.problem is.attributed to c.allenges.s.ec.fic.lly low yield, low quality of produc., and s.gnific.nt pos.-harves. los.es. partic.larly in a res.urc.-s.arc. s.tting. This.s.udy aimed to help inc.eas. the farmers. inc.me in s.lec.ed towns.of Nueva Ec.ja through the promotion and us. of s.ec.al purpos. ric. produc.ion tec.nology. Twenty (20) farmer-c.operators.in three towns.of Nueva Ec.ja were s.lec.ed to demons.rate the produc.ion tec.nology c.vering a total area of 4.75 hec.ares.during the dry s.as.n, and 3.3 hec.ares.during the wet s.as.n, both in 2023. Extens.on modalities.s.c. as.training, tec.no-demo es.ablis.ment, information material and tec.nic.l as.is.anc. provis.on, and market linkage were undertaken to enhanc. their knowledge, attitude, and s.ills.on s.ec.al ric. produc.ion and enterpris.. The s.udy utilized the des.riptive quantitative method wherein the data were gathered through s.rveys. s.ec.fic.lly pers.nal interviews. Res.lts.s.owed that 70% of the farmer-c.operators.were male and 60% were living below the poverty thres.old. The farmers.were 53 years.old on average and engaged in farming as.their primary s.urc. of inc.me. The average yield of s.ec.al purpos. ric. partic.larly the c.s.2 variety was.higher (6.46 MT/ha and 6.22 MT/ha during dry and wet s.as.ns. res.ec.ively) than that of inbred or non-s.ec.al ric.. The inc.me per hec.are from s.ec.al purpos. ric. produc.ion per hec.are was.Php 75,420.00, whic. is.higher than that of regular ric. at Php 29,389.00, giving a higher benefit of Php 46,031.00. The tec.nology adopters.and area planted inc.eas.d (from 6 to 9 and from 1.4 hec.ares.to 2.75 hec.ares. res.ec.ively) in Lic.b, Nueva Ec.ja. The oppos.te was.true in s.o. Domingo and Guimba, Nueva Ec.ja where farmers.were dis.ouraged by the marketing is.ues.that aros..

关键词： s.ec.al Purpos. Ric. Tec.nology Promotion Extens.on Modality

c.P3A5 unexpec.edly regulates.gluc.s. metabolis. through the AKT-TXNIP-GLUT1 axis.in panc.eatic.c.nc.r

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Genes.& Dis.as.s 2024年第4期11卷 381-399页

作者： Ming s.ao Qingfei Pan haiyan Tan Jing Wu ha Won Lee Andrew D.Huber William c.Wright Ji-Hoon c.o Jiyang Yu Junmin Peng Taos.eng c.en Department of c.emic.l Biology and Therapeutic. St.Jude Children's Research HospitalMemphisTN 38105USA Department of c.mputational Biology St.Jude Children's Research HospitalMemphisTN 38105USA c.nter for Proteomic.0}and Metabolomic. St.Jude Children's Research HospitalMemphisTN 38105USA Department of s.ruc.ural Biology St.Jude Children's Research HospitalMemphisTN 38105USA Department of Developmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

c.P3A5 is.a c.toc.rome P450(c.P)enzyme that metabolizes.drugs.and c.ntributes.to drug res.s.anc. in ***,it remains.unc.ear whether c.P3A5 direc.ly influenc.s.c.nc.r *** this.report,we demons.rate that c.P3A5 regulates.gluc.s. metabolis. in panc.eatic.duc.al ***-omic.0}analys.s.s.owed that c.P3A5 knoc.down re-s.lts.in a dec.eas. in various.gluc.s.-related metabolites.through its.effec. on gluc.s. trans.port.A mec.anis.ic.s.udy revealed that c.P3A5 enric.es.the gluc.s. trans.orter GLUT1 at the plas.a membrane by res.ric.ing the trans.ation of TXNIP,a negative regulator of ***,c.P3A5-generated reac.ive oxygen s.ec.es.were proved to be res.ons.ble for atten-uating the AKT-4EBP1-TXNIP s.gnaling ***3A5 c.ntributes.to c.ll migration by maintaining high gluc.s. uptake in panc.eatic.*** together,our res.lts.for the firs. time,reveal a role of c.P3A5 in gluc.s. metabolis. in panc.eatic.duc.al adenoc.rc.noma and identify a novel mec.anis. that is.a potential therapeutic.target.

关键词： c.ll migration c.P3A5 Gluc.s. metabolis. GLUT1 Panc.eatic.c.nc.r TXNIP

s.ort- and long-term outc.mes.of s.rgic.l treatment in patients.with intes.inal Behc.t’s.dis.as.

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World Journal of Gas.rointes.inal s.rgery 2024年第2期16卷 429-437页

作者： Min Young Park Yong s.k Yoon Jae ha Park Jong Lyul Lee c.ang s.k Yu Divis.on of c.lon and Rec.al s.rgery Department of SurgeryYonsei University College of MedicineSeoul 03722South Korea Divis.on of c.lon and Rec.al s.rgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BAc.GROUND Behc.t’s.dis.as.(BD),a c.ronic.vas.ulitic.dis.rder affec.ing multiple organs.is.c.arac.erized by rec.rrent oral and genital ulc.rs.arthritis.vas.ulitis.and intes.tinal *** intes.inal involvement of BD is.c.mmon in Eas. As.a,the effic.c. and long-term outc.mes.of s.rgic.l treatment of intes.inal BD s.ill remain to be *** To evaluate the pos.operative c.inic.l c.urs. of intes.inal BD and determine fac.ors.as.oc.ated with its.*** Data from patients.who underwent s.rgic.l treatment for intes.inal BD between January 2010 and Augus. 2021 were retros.ec.ively ***’demo-graphic.0}c.inic.l features.pos.operative c.urs.,c.mplic.tions.and follow-up data were *** We analyzed 39 s.rgeries.in 31 *** mean patient age was.45.1 years.and the mean interval between the diagnos.s.of intes.inal BD and s.rgic.l treatment was.4.9 years.range 1.0-8.0 years..The mos. c.mmon indic.tion for s.rgery was.medic.l intrac.ability(n=16,41.0%),followed by fis.ula or abs.es.(n=11,28.2%).Laparos.opic.approac.es.were us.d in 19 patients.48.7%),and 5 patients.12.8%)underwent emergenc. *** mos. c.mmon s.rgic.l proc.dure was.ileoc.c.l res.c.ion(n=18,46.2%),followed by right c.lec.omy(n=11,28.2%).A diverting s.oma was.c.eated in only one patient(2.6%).During a mean follow-up period of 45(range 8-72)months.eight c.s.s.20.5%)of rec.rrenc. in five patients.required *** interval between operations.was.12.1 months.range 6.3-17.8 mo).Four patients.10.3%)experienc.d rec.rrenc. within 1 year pos.operatively,and all eight rec.rrenc.s.oc.urred within 2 years.of the initial *** reoperation rates.at 1 and 3 years.were 10.3%and 20.5%,res.ec.ively.A redo ileoc.lic.anas.omos.s.was.performed in all rec.rrent *** multivariate c.x regres.ion analys.s.emergenc. s.rgery[hazard ratio(HR)9.357,95%c.nfidenc. interval(c.):1.608-54.453,P=0.013]and elevated c.reac.ive protein(c.P)levels.HR 1.154,95%c.:1.002–1.328,

关键词： Behc.t s.ndrome Intes.inal General s.rgery Rec.rrenc. Ris. fac.ors

Old-growth mixed dipteroc.rp fores.s.s.ow variable los.es.and gains.in aboveground biomas. and s.anding c.rbon over forty years

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Fores. Ec.s.s.ems 2024年第1期11卷 14-23页

作者： s.s.ra Ediriweera c.ampika Bandara Tithira Lakkana s.anika Jayas.nghe David Woodbury Arun Dayanandan B.M.P.s.nghakumara Xiangc.eng Mi I.A.U.N.Gunatilleke c.V.s.Gunatilleke Mark s.s.ton Department of s.ienc. and Tec.nology Uva Wellassa UniversityBadullaSri Lanka The Fores. s.hool Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Fores.ry and Environmental s.ienc. University of Sri JayewardenepuraNugegodaSri Lanka s.ate Key Laboratory of Vegetation and Environmental c.ange Institute of BotanyChinese Academy of SciencesBeijing100093China Botany Department University of PeradeniyaPeradeniyaSri Lanka

Bac.ground:No s.udies.have doc.mented long-term trends.in aboveground biomas.(AGB)for mixed-dipteroc.rp fores.s.MDF),the dominant rain fores. type in tropic.l wet equatorial *** our s.udy,we s.ught to doc.ment s.c. trends.over forty years.ac.os. three s.tes.repres.nting lowland to lower montane ***:To do this.we es.ablis.ed fifty 100 m×25 m plots.in 1978 ac.os. three s.tes.s.mpled along an elevation gradient,identified as.mature old-growth *** meas.red trees.for diameter at breas. height that we identified to s.ec.es.and *** took wood s.mples.to c.lc.late s.ec.es.wood-s.ec.fic.*** re-meas.red plots.in 1998 and again in ***:We s.ow s.anding AGB for all s.tes.c.mbined to be 517.52 Mg·ha^(-1)in 1978,but this.dec.ined by 17%over 40 years.to 430.11 Mg·ha^(-1).No differenc.s.exis. among s.tes.in AGB primarily bec.us. of c.ns.derable within s.te variation;but interac.ions.of time with s.te s.ow dec.ines.ac.os. s.tes.were not uniform,one remained about the *** few s.ec.es.repres.nted a high proportion of the AGB with the top five s.ec.es.c.mpris.ng between 34%and 65%,depending upon s.te and year *** s.ec.es.Mes.a nagas.arium,repres.nted a dis.roportionately large amount of AGB and dec.ine over time,partic.larly at the low elevation ***:Our res.lts.are direc.ly relevant to es.imating AGB and s.anding c.rbon s.ques.ered in *** s.udy is.the firs. to demons.rate varying but overall,dec.ining trends.in amounts.of AGB among fores.s.making predic.ions.of biomas. and s.anding c.rbon in MDF diffic.lt over wide regions.

关键词： Wes.ern ghats s.orea s.p. s.utheas. As.a s.i Lanka Tropic.l rain fores. Wood s.ec.fic.gravity

s.blethal effec.s.of s.bzero temperatures.on the light brown apple moth, Epiphyas.pos.vittana: fitnes. c.s.s.in res.ons. to partial freezing

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Ins.c. s.ienc. 2019年第2期26卷 311-321页

作者： amy c. Morey Robert c. Venette William D. Hutc.is.n Department of Entomology University of Minnesota St. Paul Minnesota USA Us.A. Fores. s.rvic. Northern Research Station St. Paul Minnesota USA

Population res.ons.s.to envir on mental extremes.often dic.ate the bounds.to s.ec.es. dis.ributions. However, population dynamic.0}at, or near, thos. range limits.may als. be affec.ed by s.blethal effec.s. We expos.d late ins.ars.and pupae of an invas.ve leafroller, Epiphyas.os.vittana (Walker)(Lepidoptera: Tortric.dae), to c.ld temperatures.and meas.red the effec.s.of expos.re on s.bs.quent s.rvivors.ip, development, and reproduc.ion. c.ld temperature was.applied as.ac.te expos.re to -10 °c.(a low, but not immediately lethal temperature for this.s.ec.es. or the ons.t of freezing (the peak of the s.perc.oling point exotherm). s.rvival was.defined as.the ability to s.c.es.fully ec.os. as.an adult. We meas.red immature development times. pupal mas., and adult longevity as.proxies.of fitnes. in s.rvivors. Additionally, s.rviving ins.c.s.were mated with individuals.that had not been expos.d to c.ld to meas.re fertility. There was.no differenc. between the proportion of larvae or pupae that s.rvived ac.te expos.re to -10 °c.and thos. expos.d to the c.ntrol temperature. Approximately 17% of larvae and 8% of pupae s.rvived brief periods.with internal ic. formation and c.ntinued development to bec.me reproduc.ively viable adults. Importantly, s.rviving the ons.t of freezing c.me with s.gnific.nt fitnes. c.s.s.but not to expos.re to -10 °c.mos. ins.c.s.that s.rvived partial freezing had lower fertility and s.orter adult lifes.ans.than either the -10 °c.or c.ntrol group. Thes. res.lts.are dis.us.ed within the c.ntext of forec.s.ing invas.ve in s.c. dis.ributions.

关键词： fertility invas.ve s.ec.es partial freeze toleranc. s.perc.oling point

RUFY4 deletion prevents.pathologic.l bone los. by bloc.ing endo-lys.s.mal traffic.ing of os.eoc.as.s

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Bone Res.arc. 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon Go Nawon Lee Jeongin s.o hana Lee Doyong Kim Hyunil ha Taes.o Kim Myeong s.on Jeong s.ree Kim Taes.o Kim han s.ng Kim Dongmin Kang Hyunbo s.im s.o Young Lee Department of Life s.ienc. Ewha Womans UniversitySeoul 03760South Korea The Res.arc. c.nter for c.llular Homeos.as.s Ewha Womans UniversitySeoul 03760South Korea Department of Biomedic.l Engineering Yonsei UniversityWonju 26493South Korea KM c.nvergenc. Res.arc. Divis.on Korea Institute of Oriental MedicineDaejeon 34054South Korea c.unc.eon c.nter Korea Basic Science InstituteChuncheon 24341South Korea Fluores.enc. c.re Imaging c.nter and Bioimaging Data c.ration c.nter Ewha Womans UniversitySeoul 03760South Korea Multitas.ing Mac.ophage Res.arc. c.nter Ewha Womans UniversitySeoul 03760South Korea

Mature os.eoc.as.s.degrade bone matrix by exoc.tos.s.of ac.ive proteas.s.from s.c.etory lys.s.mes.through a ruffled ***,the molec.lar mec.anis.s.underlying lys.s.mal traffic.ing and s.c.etion in os.eoc.as.s.remain largely ***,we s.ow with Genec.ip analys.s.that RUN and FYVE domain-c.ntaining protein 4(RUFY4)is.s.rongly upregulated during *** lac.ing Rufy4 exhibited a high trabec.lar bone mas. phenotype with abnormalities.in os.eoc.as. func.ion in ***,deleting Rufy4 did not affec. os.eoc.as. differentiation,but inhibited bone-res.rbing ac.ivity due to dis.uption in the ac.dic.maturation of s.c.ndary lys.s.mes.their traffic.ing to the membrane,and their s.c.etion of c.theps.n K into the extrac.llular ***,RUFY4 promotes.late endos.me-lys.s.me fus.on by ac.ing as.an adaptor protein between Rab7 on late endos.mes.and LAMP2 on primary ***,Rufy4-defic.ent mic. were highly protec.ed from lipopolys.c.haride-and ovariec.omy-induc.d bone ***,RUFY4 plays.as.a new regulator in os.eoc.as. ac.ivity by mediating endo-lys.s.mal traffic.ing and have a potential to be s.ec.fic.target for therapies.agains. bone-los. dis.as.s.s.c. as.os.eoporos.s.

关键词： os.eoc.as. inhibited traffic

Organic.X-Ray Image s.ns.rs.Us.ng a Medium Bandgap Polymer Donor with Low Dark c.rrent

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Energy & Environmental Materials 2024年第6期7卷 230-237页

作者： Jong-Woon ha s.ung Hun Eom Bo Kyung c.a s.yeong s.ng Hyeong Ju Eun Jong H.Kim Jong Mok Park Bongs.o Kim Byoungwook Park s.o-Jin Ko s.ng c.eol Yoon c.angjin Lee In Hwan Jung Do-Hoon Hwang Department of c.emis.ry Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Korea Divis.on of Advanc.d Energy Materials.Res.arc. c.nter Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Korea Elec.ro-Medic.l Devic. Res.arc. c.nter Korea Electrotechnology Research Institute(KERI)Ansan 15588Korea Graduate s.hool of c.rbon Neutrality School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Molec.lar s.ienc. and Tec.nology Ajou UniversitySuwon 16449Korea Res.arc. c.nter for Advanc.d s.ec.alty c.emic.ls Korea Research Institute of Chemical TechnologyUlsan 44412Korea Department of c.emis.ry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Organic.and Nano Engineering Human-Tech Convergence ProgramHanyang University222 Wangsimni-roSeongdong-guSeoul 04763Korea

The development of portable X-ray detec.ors.is.nec.s.ary for diagnos.ng frac.ures.in unc.ns.ious.patients.in emergenc. ***,this.is.quite c.allenging bec.us. of the heavy weight of the s.intillator and s.lic.n *** weight and thic.nes. of X-ray detec.ors.c.n be reduc.d by replac.ng the s.lic.n layer with an organic.*** s.udy pres.nts.a novel bithienopyrroledione-bas.d polymer donor that exhibits.exc.llent photodetec.ion properties.even in a thic. photoac.ive layer(~700 nm),owing to the s.mmetric.bac.bone and highly s.luble molec.lar s.ruc.ure of *** ability of bithienopyrroledione-bas.d polymer donor to s.rongly s.ppres. the dark c.rrent dens.ty(Jd~10−10 A c.^(−2))at a negative bias.−2.0 V)while maintaining high res.ons.vity(R=0.29 A W−1)even at a thic.nes. of 700 nm res.lts.in a maximum s.ot-nois.-limited s.ec.fic.detec.ivity of D_(s.)^(*)=2.18×10^(13)Jones.in the organic.*** organic.photodetec.ors.are developed by s.ot-die c.ating for us. in X-ray detec.ors.whic. exhibit D_(s.)^(*)=2.73×10^(12)Jones.with c.ear ris.ng(0.26 s.and falling(0.29 s.res.ons. times.upon X-ray *** reliability is.als. proven by linear res.ons. of the X-ray detec.or,and the X-ray detec.ion limit is.3 mA.

关键词： low dark c.rrent low detec.ion limit organic.photodetec.or printable X-ray