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Investigating the Physiological Mechanisms between Resistance Training and Pain Relief in the Cancer Population: A Literature Review

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j.urnal of Cancer Therapy 2023年第2期14卷 80-101页

作者： Yvonne j.ang Peter C. Angeletti amy j. Hoffman College of Arts and Sciences University of Nebraska-Lincoln Lincoln NE USA Nebraska Center for Virology University of Nebraska-Lincoln Lincoln NE USA College of Nursing University of Nebraska Medical Center Omaha Nebraska USA

This literature review examines the mechanisms of how exercise, specifically in the form of resistance training, may lead to pain relief in the cancer population. Primary data from three different cancer populations: breast, prostate, and lung, will be examined. A number of experimental studies have been conducted to confirm the effectiveness of resistance training on pain relief as well as the biochemical pathways that relate to this process. In this review, we will examine 5 randomized controlled trials. For the purposes of this review, pain is defined as physical suffering or discomfort associated with illness. Pain is the body’s natural signal, bringing attention to damage that has been sustained by tissues. However, chronic pain is common in the cancer population, and often serves no good purpose but instead will negatively impact both physical and mental health. The three types of pain: nociceptive, neuropathic, and inflammatory pathways have been investigated, and the knowledge of pain mechanisms allows for the understanding of how it is associated with pain. The purpose of this exploratory literature review is to give insight on how to maximize pain-relieving effects of resistance training. Research has indicated that resistance training modulates pain pathways by upregulating the release of pain-relieving substances including beta-endorphins, anti-inflammatory cytokines, and endocannabinoids. Understanding of the benefits of resistance training may be useful in relieving cancer pain, and reproducing effects of pain-relieving strategies while minimizing the symptoms related to cancer and its treatment.

关键词： Lung Cancer Breast Cancer Prostate Cancer Exercise Physical Activity Cancer Pain Symptoms Pain Relief Resistance Training Pain Relief Biochemical Pathway

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Moving beyond Wastewater:Perspectives on Environmental Surveillance of Infectious Diseases for Public Health Action in Low-Resource Settings

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Environment & Health 2024年第10期2卷 684-687页

作者： j.seth Delgado Vela Sarah E.Philo j.e Brown Mami Taniuchi Molly Cantrell Alexandra Kossik Maya Ramaswamy Sitara SR Aj.ampur Fatma Z.Guerfali Rochelle H.Holm j.hn Scott Meschke Maria Catherine B.Otero amy j.Pickering Mahbubur Rahman Alexander G.Shaw Abhilasha Shrestha Kwanrawee Sirikanchana Vivi Maketa Tevuzula Rolf U.Halden Alexandria B.Boehm Kyle Bibby Department of Civil and Environmental Engineering Duke UniversityDurhamNorth Carolina 27710United States Department of Civil and Environmental Engineering and Earth Sciences University of Notre DameSouth BendIndiana 46556United States Department of Civil and Environmental Engineering University of Southern California Los AngelesCA 90007USA Department of Environmental Sciences and Engineering University of North Carolina at Chapel HillChapel HillNorth Carolina 27599United States Division of Infectious Diseases and International Health University of VirginiaCharlottesvilleVirginia 22903United States Waterborne Disease Prevention Branch U.S.Centers for Disease ControlAtlantaGeorgia 30329United States The Wellcome Trust Research Laboratory Christian Medical CollegeVellore 632004India Laboratory of Transmission Control and Immunobiology of Infections(LTCII)Institut Pasteur de TunisTunis-Belvédère 1002Tunisia UniversitéTunis El Manar Tunis 1002Tunisia Christina Lee Brown Envirome Institute School of MedicineUniversity of LouisvilleLouisvilleKentucky 40202United States Department of Environmental and Occupational Health Sciences School of Public HealthUniversity of WashingtonSeattleWashington 98195United States College of Medicine University of the Philippines ManilaManila 2801Philippines Department of Civil and Environmental Engineering University of CaliforniaBerkeleyBerkeleyCalifornia 94720United States Institute of Epidemiology Disease Control and Research(IEDCR)Dhaka 1212Bangladesh Department of Infectious Disease Epidemiology Imperial College LondonLondon SW72AZU.K. Division of Environmental and Occupational Health Sciences University of Illinois Chicago School of Public HealthChicagoIllinois 60612United States Research Laboratory of Biotechnology Chulabhorn Research InstituteBangkok 10210Thailand Department of Tropical Medicine University of KinshasaKinshasa/DR 63090201Congo School of Sustainable Engineering and the Built Environment Arizona State UniversityTempe

Although testing wastewater for public health surveillance has recently received significant attention in the United States,researchers and public health professionals have long realized the tremendous promise of environmental surveillance(ES),defined as tracking pathogens of interest in fecally contaminated surface waters,soil,or fomites,in low-resource settings for public health action.1,2 The power of ES in lowresource settings is most clearly illustrated with the over 30 years of well-established and standardized polio *** part of the Global Polio Eradication Initiative,the World Health Organization(WHO)has accredited 146 laboratories within the Global Polio Lab Network(GPLN).These facilities across 92 countries process over 8,000 wastewater or fecally contaminated surface water samples per year,in addition to over 220,000 stool samples annually.3 The data generated from the GPLN are closely linked to clear public health action related to targeted vaccination *** investment and adoption of ES for polio eradication efforts serves as a use-case for other targets of *** explore the current state of the field,the National Science Foundation-funded Research Coordination Network(RCN)on Wastewater Based Epidemiology for SARS-CoV-2 and Emerging Public Health Threats held a workshop in December 2023 to discuss the opportunities and challenges for ES in low-resource settings(Figure 1).Discussions during the workshop highlighted knowledge gaps,best-practices,target selection,academic/government/private partnerships and overall public health action and sustainability of these programs.

关键词： wastewater Wastewater annually

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A ONE-STOP LOGISTIC SERVICES FRAMEWORK SUPPORTING GLOBAL SUPPLY CHAIN COLLABORATION

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j.urnal of Systems Science and Systems Engineering 2016年第2期25卷 229-253页

作者： amy j.C. Trappey Charles V. Trappey Sandy W.C. Chang W.T. Lee Tun Nien Hsu Department of Industrial Engineering and Engineering Management National Tsing Hua University Hsinchu Taiwan China Department of Management Science National Chiao Tung University Taiwan China Technology Center for Service Industries Industrial Technology Research Institute Taiwan China

A global enterprise must continuously improve the efficiency of logistic operations between supply chain collaborators. Integrating logistic services, resources, and necessary information flows in the supply chain to ensure efficiency and efficacy is critically important to these companies. Global logistic service companies face challenges from their clients to provide logistic services that are cost effective, accurate, and seamlessly integrate material, information and cash flows. In this research, an improved framework for one-stop logistic services is systematically designed, analyzed, and evaluated. The one-stop logistic service framework, defmed in four models, is developed to provide enterprises with integrated and comprehensive services within the global supply chain context. The levels of service importance are assessed using a four categories questionnaire. This research provides a case study of the implementation of one-stop logistic services in the distribution industry and demonstrates the framework operating under different demand conditions. Finally, system dynamics causal evaluation is used to evaluate the advantages of the logistic service framework.

关键词： One-stop logistic services logistic management supply chain management system dynamics modeling

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Protease supplementation reduced the heat increment of feed and improved energy and nitrogen partitioning in broilers fed maize-based diets with supplemental phytase and xylanase

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Animal Nutrition 2022年第3期10卷 19-25页

作者： Klint W.McCafferty Mingan Choct Sosthene Musigwa Natalie K.Morgan Aaron j.Cowieson amy F.Moss USDA-ARS Poultry Research Unit School of Environmental and Rural SciencesMississippi State39762United States University of New England ArmidaleNSW2351Australia DSM Nutritional Products Kaiseraugst4303Switzerland

An experiment was conducted to explore the effects of digestible amino acid(dAA)concentrations and supplemental protease on live performance and energy partitioning in *** 308 male broilers(n?288)were distributed into 24 floor pens and offered 1 of 4 dietary treatments with 6 replicates from 1 to 35 d of *** treatments consisted of a 2×2 factorial arrangement with dAA concentrations(standard and reduced[34 g/kg below standard])and supplemental protease(without or with)as the main *** 1,15,28,and 35 d of age,feed and broilerswereweighed to determine live ***20 to 23 d of age,a total of 32 birds(2 birds/chamber,4 replicates)were placed in closed-calorimeter chambers to determine respiratory exchange(heat production,HP),apparent metabolisable energy(AME),retained energy(RE),and net energy(NE).From 29 to 35 d of age,supplemental protease in the reduced-dAA diet decreased broiler feed conversion ratio(FCR)by 5.6 points,whereas protease supplementation in the standard-dAA diet increased FCR by 5.8 *** indirect calorimetry assay revealed that supplemental protease decreased(Pj.***,from 20 to 23 d of age,broilers offered the reduced-dAA diet with supplemental protease had a higher daily body weight gain(BWG)(t10.4%),N intake(t7.1%),and N retention(t8.2%)than those offered the standard-dAA with supplemental *** offered the reduced-dAA without supplemental protease exhibited a 3.6%higher AME-to-crude protein(CP)ratio than those offered other *** supplementation in the standard-and reduced-dAA diets resulted in 2.7%and 5.6%lower AME intake-to-N retention ratios,respectively,compared with the unsupplemented ***-dAA increased(P<0.05)AME intake(t4.8%),RE(t9.8%),NE intake(t5.8%),NE intake-to-CP ratio(t3.0%),and RE fat-to-RE ratio(t8.6%).Protease supplementation increased(P<0.05)respiratory quotient(t1.2%)and N retention-to-N intake ratio(t2.2%),

关键词： Exogenous enzyme Mono-component protease Net energy Amino acid

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Incidence and consequences of varicella in children treated for cancer in Guatemala

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世界儿科杂志:英文版 2016年第3期12卷 320-326页

作者： amy E.Caruso Brown Edwin j.Asturias Mario Melgar Federico A.Antillon-Klussmann Pamela Mettler Myron j.Levin Center for Bioethics and Humanities and Department of Pediatrics SUNY Upstate Medical University Center for Global Health and Department of Epidemiology Colorado School of Public HealthAuroraColoradoUSA National Unit of Pediatric Oncology Guatemala CityGuatemala Department of Biostatistics and Informatics Colorado Biostatistics ConsortiumColorado School of Public HealthAuroraColoradoUSA Section of Pediatric Infectious Diseases Department of PediatricsUniversity of Colorado Denver Anschutz Medical CampusAuroraColoradoUSA

Background:Varicella-zoster virus infection is associated with significant morbidity and mortality in immune-compromised children,despite treatment with antiviral *** varicella vaccine programs have significantly decreased this risk in many highincome countries,but in most low-income and middleincome countries,the burden of varicella in children treated for malignancy is poorly defi ***:We retrospectively reviewed records of children at the National Unit of Pediatric Oncology(UNOP)in Guatemala diagnosed with varicella between j.nuary 2009 and March 2013 in order to calculate incidence of varicella and evaluate morbidity,mortality,treatment interruption,and ***:Fifty-nine cases of varicella were *** was 23.4 cases per 1000 person-years(p-y).66.1%of cases occurred in children with leukemia(median age 5.2 years;interquantile range 3.4-7 years)and 41.0%of these occurred during maintenance *** of exposure was identified for 14/59(23.7%)*** were hospitalized(71.2%)and given intravenous acyclovir(64.4%).Eight(13.6%)children required critical care,and two(3.4%)died from disseminated varicella with multiorgan *** was delayed or omitted due to varicella in 50%.No signifi cant differences in outcomes based on nutritional and immunologic status were *** minimum average cost of treatment per episode was 598.75 ***:Varicella is a significant problem in children treated for cancer in Guatemala,where effective post-exposure prophylaxis is *** the absence of universal varicella vaccination,strategies to improve recognition of exposure and the future use of novel inactivated vaccines currently under investigation in clinical trials could mitigate this burden.

关键词： cancer developing countries immunocompromised host oncology varicella

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Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait

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Translational Neurodegeneration 2015年第1期4卷 205-208页

作者： Gonzalo j.Revuelta Aaron Embry j.rdan j.Elm Chris Gregory amy Delambo Steve Kautz Vanessa K.Hinson Movement Disorders Division Department of NeurologyCollege of MedicineMedical University of South Carolina208B Rutledge AvenueMSC 108CharlestonSC 29425USA Department of Health Sciences and Research Center for Rehabilitation Research in Neurological ConditionsCollege of Health ProfessionsMedical University of South CarolinaCharlestonSCUSA Department of Public Health Sciences College of MedicineMedical University of South CarolinaCharlestonSC 29425USA Ralph H.j.hnson VA Medical Center CharlestonSCUSA

Background:Freezing of gait(FoG)is a common and debilitating condition in Parkinson’s disease(PD)associated with executive dysfunction.A subtype of FoG does not respond to dopaminergic therapy and may be related to noradrenergic *** pilot study explores the effects of atomoxetine on gait in PD patients with dopaunresponsive FoG using a novel paradigm for obj.ctive gait ***:Ten patients with PD and dopa-unresponsive FoG were enrolled in this eight-week open label pilot *** included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning,while performing a dual ***,and subj.ctive assessments of gait,quality of life,and safety were also *** primary outcome was a validated subj.ctive assessment for FoG(FOG-Q).Atomoxetine was well tolerated,however,no significant change was observed in the primary *** gait analysis protocol correlated well with clinical scales,but not with subj.ctive *** patients were more likely to increase gait velocity(p=0.033),and improved in other clinical ***:Obj.ctive gait analysis protocols assessing gait while dual tasking are feasible and useful for this patient population,and may be superior correlates of FoG severity than subj.ctive *** findings can inform future trials in this population.

关键词： Parkinson’s disease Freezing of gait Noradrenaline Atomoxetine Dopa-response

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Delayed gastric emptying following pancreaticoduodenectomy:Incidence,risk factors,and healthcare utilization

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World j.urnal of Gastrointestinal Surgery 2017年第3期9卷 73-81页

作者： Somala Mohammed George Van Buren II amy Mc Elhany Eric j.Silberfein William E Fisher Elkins Pancreas Center Michael E DeBakey Department of SurgeryBaylor College of MedicineHoustonTX 77030United States

AIM To characterize incidence and risk factors for delayed gastric emptying(DGE) following pancreaticoduodenectomy and examine its implications on healthcare utilization. METHODS A prospectively-maintained database was reviewed. DGE was classified using International Study Group of Pancreatic Surgery criteria. Patients who developed DGE and those who did not were compared. RESULTS Two hundred and seventy-six patients underwent pancreaticoduodenectomy(PD)(> 80% pyloruspreserving, antecolic-reconstruction). DGE developed in 49 patients(17.8%): 5.1% grade B, 3.6% grade C. Demographic, clinical, and operative variables were similar between patients with DGE and those without. DGE patients were more likely to present multiplecomplications(32.6% vs 4.4%, ≥ 3 complications, P < 0.001), including postoperative pancreatic fistula(POPF)(42.9% vs 18.9%, P = 0.001) and intra-abdominal abscess(IAA)(16.3% vs 4.0%, P = 0.012). Patients with DGE had longer hospital stay(median, 12 d vs 7 d, P < 0.001) and were more likely to require transitional care upon discharge(24.5% vs 6.6%, P < 0.001). On multivariate analysis, predictors for DGE included POPF [OR = 3.39(1.35-8.52), P = 0.009] and IAA [OR = 1.51(1.03-2.22), P = 0.035].CONCLUSION Although DGE occurred in < 20% of patients after PD, it was associated with increased healthcare utilization. Patients with POPF and IAA were at risk for DGE. Anticipating DGE can help individualize care and allocate resources to high-risk patients.

关键词： Delayed gastric emptying Pancreaticoduodenectomy Post-operative pancreatic fistula

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Risk Factors for Failure of OPAT （Outpatient Parenteral Antimicrobial Therapy） in Veterans with Staphylococcus aureus Bacteremia

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j.urnal of Pharmacy and Pharmacology 2016年第6期4卷 241-247页

作者： j.hn j. Veillette Leslie Bittner Marion j. Skalweit Usha Stiefel Christopher j. Burant amy A.Hirsch Sharanie Sims Pharmacy Service Louis Stokes Cleveland Department of Veterans Affairs Medical Center (LSCDVAMC) Cleveland OH USA Medicine Service LSCDV.4MC Cleveland OH USA Case Western Reserve University School of Medicine Cleveland OH USA Cleveland Geriatric Research Education and Clinical Center (GRECC) LSCDVAMC Cleveland OH USA Case Western Reserve University Frances Payne Bolton School of Nursing Cleveland OH USA

To identify risk factors for failure of OPAT （outpatient parenteral antimicrobial therapy） among veterans with SAB （Staphylococcus aureus bacteremia）, a retrospective review was conducted of all patients receiving OPAT for SAB between 01/2011-09/2013 at a large, tertiary-care VA （Veterans＇ Affairs） medical center. Treatment failure was defined as incomplete therapy, therapy extension, infection relapse, or hospital admission or surgical intervention within 60 days of therapy completion. Of 118 SAB patients treated with OPAT, 101 met inclusion criteria. Treatment failure occurred in 36 （35.6%） patients. In multivariate analysis, heart failure （OR 3.67; CI 1.13-12.0）, previous OPAT （OR 14.1; CI 2.02-97.8）, immunosuppression （OR 10.5; CI 1.74-63.3）, and treatment with daptomycin （OR 9.56; CI 1.89-48.4） were independently associated with failure. A trend toward lower failure rates was seen in the community living center, a VA long-term care facility possessing its own infectious diseases consultation service. In veterans with SAB, specific health factors were associated with higher rates of OPAT failure. Given the morbidity and cost of SAB treatment failures, similar analyses may benefit other large OPAT programs to optimize the selection of patients and settings in which successful treatment will most likely occur.

关键词： Risk factors failure OPAT Staphylococcus aureus bacteremia.

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Hormonally modulated migraine is associated with single-nucleotide polymorphisms within genes involved in dopamine metabolism

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Open j.urnal of Genetics 2013年第2期3卷 38-45页

作者： amy K. Sullivan Elizabeth j. Atkinson F. Michael Cutrer Division of Biomedical Statistics and Informatics Mayo Clinic Rochester USA Division of Headache Mayo Clinic Rochester USA

Migraine is a complex trait in which multiple genetic loci, as well as environmental factors, likely contribute to its clinical manifestation. Many genetic associations reported in previous studies either have not been replicated to date or showed only marginal statistical significance, possibly due to the genetic heterogeneity of the common forms of migraine. One maj.r phenotypic and possibly genetically identifiable migraine subgroup consists of women whose attacks are influenced by fluctuation in gonadal hormones. We hypothesized that for these women, the association between migraine attacks and the menstrual cycle might be attributable to an increased prevalence of genetic polymorphisms in the hypothalamic-pituitary-gonadal axis. We selected 21 such polymerphisms previously reported to be associated with the common forms of migraine and genotyped 1740 individuals (1132 migraineurs) to determine whether any of these selected polymorphisms occurred more frequently in females with hormonally modulated migraine. We were able to confirm the association of migraine with 3 genetic polymorphisms seen in previous studies (rs4680 [COMT], rs2283265 [DRD2], and rs7131056 [DRD2]). Interestingly, we found 2 additional genetic polymorphisms (rs2070762 [TH] and rs6356 [TH]) to be associated with migraine when defining the phenotype as hormonally modulated migraine.

关键词： Genetic Polymorphism Headache Hypothalamic Hormone Menstrual Cycle Menstruation

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Genomic location of Gb1, a unique gene conferring wheat resistance to greenbug biotype F

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作物学报:英文版 2023年第5期11卷 1595-1599页

作者： Xiangyang Xu Genqiao Li Guihua Bai Brett FCarver Ruolin Bian amy Bernardo j.cott Armstrong USDA-ARS Wheat Peanutand Other Field Crop Research UnitStillwaterOK 74075USA USDA-ARS Hard Winter Wheat Genetics Research Unit ManhattanKS 66506USA Department of Agronomy Kansas State UniversityManhattanKS 66506USA Department of Plant and Soil Sciences Oklahoma State UniversityStillwaterOK 74078USA

Greenbug(Schizaphis graminum, Rondani) is a serious insect pest in many wheat growing regions and has been infesting cereal crops in the USA for over a century. Continuous occurrence of new greenbug biotypes makes it essential to explore all greenbug resistant sources available to manage this pest. Gb1, a recessive greenbug resistance gene in DS28A, confers resistance to several economically important greenbug biotypes and is the only gene found to be resistant to greenbug biotype F. A set of 174 F_(2:3)lines from the cross DS28A × Custer was evaluated for resistance to greenbug biotype F in 2020 and 2022. Selective genotyping of the corresponding F_(2) population using single nucleotide polymorphism(SNP) markers generated by genotyping-by-sequencing(GBS) led to the identification of a candidate genomic region for Gb1. Thus, SSR markers previously mapped in this region were used to genotype the entire F2population,and kompetitive allele specific PCR(KASP) markers were also developed from SNPs in the target ***1 was placed in the terminal region of the short arm of chromosome 1A, and its location was confirmed in a second population derived from the cross DS28A × PI 697274. The combined data analysis from the two mapping populations delimited Gb1 to a < 1 Mb interval between 13,328,200 and 14,241,426 bp on1AS.

关键词： Wheat Greenbug resistance gene Gb1 KASP markers Linkage analysis Genotyping-by-sequencing

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