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Quality of Diabetes Annual Management in the Internal Medicine Department in Yalgado ouédraogo Teaching Hospital, ouagadougou

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Open Journal of Internal Medicine 2020年第3期10卷 256-262页

作者： oumar Guira amsa ouédraogo Lassané Zoungrana Réné Bognounou Solo Traoré Aline Tondé Joseph Y. Drabo Unité de Formation et de Recherche en Sciences de la Santé Université Joseph Ki Zerbo Ouagadougou Burkina Faso Service de Médecine Interne Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: The periodic management of diabetes improves disease’s prognosis. We aimed to evaluate the quality of diabetes annual management and the effectiveness of its treatment in ouagadougou. Material and Method: It was a cross-sectional and descriptive study, from retrospective records in the internal medicine department, Yalgado ouédraogo Teaching Hospital (CHU-YO). Diabetic patient’s (15 years old and more) files that were registered between January, 2012 and December, 2016 have been analyzed. Files containing less than 80% data were excluded. Data relating to the baseline characteristics of the patients, the therapeutic education dispensation, the clinical and paraclinical assessment of the initial and annual visits at the first year of patient’s follow-up have been collected. The 2007 diabetes management standards of the French “Haute Autorité de Santé” as well as the biological standards of the same instance have been used. The quantitative variables were expressed as means and standard deviations and qualitative variables were expressed as absolute and relative frequencies. Results: 317 patients, including 218 women (68.77%) were studied. The mean age of women was 51.67 ± 12.46 years, and that of men 55.71 ± 10.63. Diabetes was type 2 in 302 (95.26%) patients. The mean duration since the diagnosis of diabetes was 2.9 years. The completeness rate of therapeutic education at the annual visit was 10.46%. That of the clinical examinations was at best 38.17% and 44.23% for the measurement of weight and blood pressure;otherwise it was less than 5%. About the paraclinical data, apart from the measurement of the fasting blood glucose which completeness rate was 71.61%, that of the others exams were less than 10%. At the annual visit, the mean value of HbA1C was 7.5%, and the target for HbA1C was achieved in 47.90% patients. Conclusion: The quality of diabetes annual management is unsatisfying.

关键词： Chronic Disease’s Management Diabetes Sub-Saharan Africa

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Quality of Diabetes Annual Management in the Internal Medicine Department in Yalgado ouédraogo Teaching Hospital, ouagadougou

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Open Journal of Internal Medicine 2020年第3期

作者： oumar Guira amsa ouédraogo Lassané Zoungrana RénéBognounou Solo Traor Aline Tond Joseph Y. Drabo

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Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing Zhang Chun-Lin ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

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Analysis of Chinese Anti-Suit Injunctions in SEP Litigation

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科技与法律（中英文） 2025年第1期 138-148页

作者： ou Fuyong Zhang Xiaoxiao Law School Hunan Normal UniversityChangsha 410081China

In this article,two cases of Standard Essential Patents,ruled by the Supreme People's Court of the People's Republic of China,are presented and *** first Chinese anti-suit injunction in SEP litigation appeared in the first case through the method of behavior preservation,and the second case illustrates a clear intent by the Chinese courts to compete for global royalty rate *** international concerns raised about these cases,it is proved that the anti-suit injunction cases in China do not show any abusive or illegal *** worldwide anti-suit injunctions in China are granted legitimately with legal jurisdiction over the cases,sufficient legal grounds for behavior preservation with the nature of anti-suit injunctions,the necessity of granting worldwide injunctions,and suitable granting *** pieces of advice are proposed for the future application of anti-suit injunctions,including improvements in the predictability of validity scope,consistency of implementation,and clarification of penalties.

关键词： anti-suit injunction anti-anti-suit injunction FRAND royalty rate jurisdiction SEP

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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

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Anthelmintic activity of Saba senegalensis(***.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 945-949页

作者： Mohamed Bonewendé Belemlilga Aristide Traoré Sylvin ouédraogo Adama Kaboré Hamidou Hamadou Tamboura Innocent Pierre Guissou Laboratoire de Développement du Médicament Centre de recherche sur le médicament Ecole Doctorale de la SantéUniversité de Ouagadougou Ecole Doctorale de Santé Département Médecine Pharmacopée Traditionnelles–Pharmacie (MEPHATRA-Ph) Institut de Recherche en Sciences de la Santé (IRSS/CNRST) Département Productions Animales Institut de l’Environnement et de Recherches Agricoles(INERA/CNRST)

Objective: To evaluate the anthelmintic property of Saba senegalensis(***) Pichon(Apocynaceae)(S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites ***: The lyophilized aqueous decoction of leaves of S. senegalensis at concentrations of 0.10, 1.00, 3.00, 10.00 and 15.00 mg/m L was used on eggs and adult worms of Haemonchus contortus collected from gastrointestinal tract of small ***: The LC_(50) on adult worms was 6.79 mg/m L and 3.25 mg/m L for the leaves of S. senegalensis and the levamisole(reference drug), respectively. Inhibition of hatching assay showed a concentration-dependent manner with an inhibition of 93.63% at the concentration of 15.00 mg/m L of S. ***: These results indicate that the aqueous extract of S. senegalensis possesses an anthelmintic property and may justify its use in traditional medicine for the treatment of gastrointestinal parasites.

关键词： Saba senegalensis Anthelmintic properties Haemonchus contortus In vitro Burkina Faso

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Clinical Evaluation of the Safety and Efficacy of the Phytomedicine APIVIRINE Based on Aqueous Extracts of Dichrostachys glomerata (Forssk.). Chiov. (D. cinerea) in COVID-19 Patients without Signs of Severity

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International Journal of Clinical Medicine 2023年第6期14卷 302-318页

作者： Daouda ouédraogo Grissoum Tarnagda Jean Claude Romaric Pingdwindé ouédraogo Amed Héma Simon Tiendrebéogo Salfo ouédraogo Geoffroy Gueswindé ouédraogo Lazare Belemnaba Noufou ouédraogo Félix Dit Bondo Kini Zékiba Tarnagda Martial ouédraogo Sylvin ouédraogo Service de Pneumologie/Centre Hospitalier Universitaire Yalgado ouédraogo (CHU-YO) Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouaga-dougou Burkina Faso

Background: Since the appearance of the COVID-19 pandemic, several drugs have also been proposed for the treatment of the COVID-19, but the therapeutic effectiveness of those drugs is not satisfactory. This situation has led to the search for therapeutic solutions based on recipes from traditional medicine. Aims: This study aimed to evaluate the clinical safety, efficacy and tolerability of the phytomedicine APIVIRINE in patients with non-severe COVID-19. Methods: Patients were included following defined criteria and followed on an outpatient basis until recovery in accordance with national guidelines for the management of single cases of COVID-19 in Burkina Faso. Vital signs, anthropometric parameters as well as electrocardiographic, hematological and biochemical examinations were measured on D4, D7, D14 and D21. Adverse events were recorded during maintenance. Results: The present study included 45 patients. The clinical signs present at inclusion were mostly cough (44.44%), asthenia (42.22%), headache (40%), and anosmia (35.55%). Dyspnoea and chest pain were less represented in 05 (11.11%) and 06 (13.33%) patients. Cough, dyspnoea, chest pain, fever, sore throat, headache, and nasal obstruction present at inclusion disappeared before Day 4 of treatment. Anosmia and asthenia disappeared before Day 7. At the inclusion visit (Day 1), CRP, WBC, and blood glucose were abnormal in 15 (33.33%), 13 (28.89%), and 11 (24.44%) patients respectively. In addition, 3 (6.66%) patients had elevated creatinine levels. Transaminases Alanine aminotransferase (ALAT) were elevated in 05 (11.11%) patients while Aspartate aminotransferase (ASAT) was elevated in 04 (8.89%) patients. After 4 days of treatment, the cure rate was 33.33% of patients and 48.89% after 7 days. The cumulative cure rate was 86.67% after 14 days of treatment. Conclusion: No serious side effects or allergic reactions were observed during treatment. No clinical complications were observed and all symptoms present r

关键词： APIVIRINE COVID-19 Clinical Study Safety

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光照不均匀条件下无人机航拍低照度图像增强方法

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现代电子技术 2025年第01期48卷 55-59页

作者：黄静欧余韬桂林电子科技大学计算机工程学院

增强图像时高低频参数未增强，没有更好地保留图像的细节和平衡图像的亮度，因此，提出一种光照不均匀条件下无人机航拍低照度图像增强方法。首先通过高斯滤波预处理无人机航拍图像，实现无人机航拍图像中的噪声抑制，将预处理后的图像... 详细信息

增强图像时高低频参数未增强，没有更好地保留图像的细节和平衡图像的亮度，因此，提出一种光照不均匀条件下无人机航拍低照度图像增强方法。首先通过高斯滤波预处理无人机航拍图像，实现无人机航拍图像中的噪声抑制，将预处理后的图像通过小波分解得到图像的高频参数和低频参数，分别通过双边滤波算法、软阈值方法和直方图对图像的低频参数和高频参数进行增强，采用小波重构对增强后的图像高频参数和低频参数进行重构，得到增强后的无人机航拍图像。通过实验验证，该方法能够实现一种效果较好的图像增强，在原始图像基础上，通过文中方法增强原始亮度8.14%、对比度提高了37.90%以及清晰度增加了31.01%，使得图像的整体质量得到了显著提升，为后续的图像分析、处理提供了更加准确、丰富的信息。

关键词：无人机航拍低照度图像增强高斯滤波小波分解与重构双边滤波算法软阈值方法

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Microbial Quality and Molecular Identification of Enterotoxigenic Staphylococcus Strains Isolated from Dried, Smoked, and Braised Fish Sold in ouagadougou Markets

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Advances in Microbiology 2024年第1期14卷 59-76页

作者： Arouna ouédraogo Ganamé Abasse ouédraogo Henri Sidabéwindin ouédraogo François Tchoumbougnang Cheikna Zongo Aly Savadogo Laboratoire de Biochimie et d’Immunologie Appliqué es (LABIA) Universit&eacute Joseph Ki-Zerbo Ouagadougou Burkina Faso Laboratoire de Valorisation et Contrô le de Qualit&eacute Institut des Sciences Halieutiques Universit&eacute de Douala Douala Cameroon

Background: The investigation of toxin genes in strains involved in staphylococcal food poisoning contributes to food safety. The aim of this study was to isolate and identify enterotoxigenic Staphylococcus strains from dried, smoked, and braised fish sold in ouagadougou markets. Methodology: Staphylococci were isolated using standard microbiology methods. Staphylococcus strains were identified using API Staph kit (Reference # 20500, BioMerieux S.A., Marcy l'Etoile, France). The molecular identification of isolated Staphylococcus aureus strains was specifically confirmed by PCR using the Staur4 and Staur6 primers. The genes encoding enterotoxins, enterotoxin-like toxins, exfoliative toxins, and TSST-1 toxin were detected by multiplex PCR using specific primers from Inquaba Biotec West Africa Ltd, Africa's Genomics Company. Results: The results of the microbiological quality assessment indicated that most of the samples analyzed were found to be of unsatisfactory microbiological quality according to the Staphylococcus aureus microbiological criteria (m = 102). Overall, only 12.55% of samples were satisfactory, while 97.45% were unsatisfactory. The STAPH API gallery allowed the identification of the following species: Staphylococcus aureus, Staphylococcus xylosus, Staphylococcus lugdunensis, Staphylococcus hominis, Staphylococcus haemolyticus, Staphylococcus lentus, Staphylococcus sciuri and Staphylococcus capitis. Of the 108 Staphylococcus isolates, 81 (75%) showed at least one (1) toxin gene. Among the 21 toxin genes tested in this study, 20 genes were detected in all strains analyzed. The staphylococcal toxin genes detected were present in both Staphylococcus aureus and the other coagulase-negative strains isolated in this study. In addition, these genes are found individually or in association in certain strains. The most frequent genes detected in toxin gene-positive strains were: the tsst-1 gene in 45 isolated strains (41.7%), sei (16/14.8%), seg (13/12%), ser (

关键词： Fish Stapholocuccus Toxin Genes ouagadougou

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