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Bioactive compounds from mushrooms: Emerging bioresources of food and nutraceuticals

Food Bioscience 2022年第6期50卷 1349-1366页

作者： Harpreet Kour Divjot Kour Satvinder Kour Shaveta singh Syed Azhar Jawad Hashmi Ajar Nath Yadav Krishan Kumar Yash Pal Sharma amrik singh ahluwalia Department of Botany University of JammuJammu180006India Department of Microbiology Akal College of Basic SciencesEternal UniversityBaru SahibSirmaur173101India Department of Biotechnology Dr.Khem Singh Gill Akal College of AgricultureEternal UniversityBaru SahibSirmaur173101India Department of Food Technology Dr.Khem Singh Gill Akal College of AgricultureEternal UniversityBaru SahibSirmaur173101India Department of Botany Akal College of Basic SciencesEternal UniversityBaru SahibSirmaur173101India

Mushrooms have been an indispensable element of the human culture since antiquity and are cherished all over the globe for their nutritive and therapeutic benefits. Being acknowledged as “the new superfood” of the future, they are a cardinal component of human diet for boosting health status and well being. Mushrooms are endowed with antioxidant, antimicrobial, anticancer, prebiotic, antidiabetic, and anti-inflammatory activities, upholding a great therapeutic potential and a huge spectrum of clinical applications. The wide ranges of bioactive compounds including polysaccharides, polysaccharides protein complexes, peptides and proteins, terpenoids and phenolic compounds have been reported from diverse groups of mushroom. Laden with a wealth of nutrients and innumerable biomolecules of therapeutic worth, they are internationally appreciated and envisaged as world's largest untapped resources of dietary supplements. In the recent years, owing to significant healthier lifestyle changes, dietary practices of people and consumers opting for immunity enhancing supplements especially during the COVID-19 pandemic, the yearning for mushroom based nutraceuticals and functional foods is on rise. This review gives comprehensive details on the biodiversity of mushrooms, its nutritional and medicinal importance, secondary metabolites especially of nutraceuticals and pharmaceutical potential, and their role as bioactive agents and application in preparing mushroom based value-added products.

关键词： Anti cancer compounds Bioactive compounds Biodiversity Food industry Mushrooms Nutraceuticals Nutritive value

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Selecting lymph node-positive patients for adjuvant therapy after radical prostatectomy and extended pelvic lymphadenectomy:An outcome analysis of 100 node-positive patients managed without adjuvant therapy

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Current Urology 2022年第4期16卷 232-239页

作者： Ashwin Sunil Tamhankar Saurabh Patil Shanky singh Danny Darlington Carbin Smruti Mokal Puneet ahluwalia Gagan Gautam Urologic Oncology and Robotic Surgery Max Institute of Cancer CareNew Delhi110017India

Objective:The aim of the study is to evaluate the effect of deferred androgen deprivation therapy on biochemical recurrence(BCR)and other survival parameters in node-positive prostate cancer patients after robot-assisted radical prostatectomy with bilateral extended pelvic lymph node dissection(RARP+EPLND).Materials and methods:Of the 453 consecutive RARP procedures performed from 2011 to 2018,100 patients with no prior use of androgen deprivation therapy were found to be lymph node(LN)positive and were observed,with initiation of salvage treatment at the time of BCR *** were divided into 1 or 2 LNs(67)-and more than 2 LNs(33)-positive groups to assess survival ***:At a median follow-up of 21 months(1-70 months),the LN group(p<0.000),preoperative prostate-specific antigen(PSA,p=0.013),tumor volume(TV,p=0.031),and LND(p=0.004)were significantly associated with *** multivariate analysis,only the LN group(p=0.035)and PSA level(p=0.026)were statistically *** estimated BCR-free survival rates in the 1/2 LN group were 37.6%(27%-52.2%),26.5%(16.8%-41.7%),and 19.9%(9.6%-41.0%)at 1,3,and 5 years,respectively,with a hazard of developing BCR of 0.462(0.225-0.948)compared with the more than 2 LN-positive *** 5-year overall survival,cancer-specific,metastasis-free,and local recurrence-free survival rates were 88.4%(73.1%-100%),89.5%(74%-100%),65.1%(46.0%-92.1%),and 94.8%(87.2%-100.0%),respectively,for which none of the factors were *** on cutoff values for PSA,TV,and LND of 30 ng/mL,30%,and 10%,respectively,the 1/2 LN group was substratified,wherein the median BCR-free survival for the low-and intermediate-risk groups was 40 and 12 months,***:Nearly one fourth and one fifth of 1/2 node-positive patients were BCR-free at 3 and 5 years after RARP+*** substratification using PSA,TV,and LN density may help in providing individualized care regarding the initiation of adjuvant therapy.

关键词： Adjuvant therapy Extended pelvic lymph node dissection Prostate cancer Robotic radical prostatectomy

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Chip-based multimodal super-resolution microscopy for histological investigations of cryopreserved tissue sections

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Light(Science & Applications) 2022年第3期11卷 35-51页

作者： Luis E.Villegas-Hernández Vishesh Dubey Mona Nystad Jean-Claude Tinguely David A.Coucheron Firehun T.Dullo Anish Priyadarshi Sebastian Acuña Azeem Ahmad JoséM.Mateos Gery Barmettler Urs Ziegler Åsa Birna Birgisdottir Aud-Malin Karlsson Hovd Kristin Andreassen Fenton Ganesh Acharya Krishna Agarwal Balpreet singh ahluwalia Department of Physics and Technology UiT The Arctic University of NorwayKlokkargårdsbakken N-9019TromsøNorway Department of Clinical Medicine Women’s Health and Perinatology Research GroupUiT The Arctic University of NorwayTromsøNorway Department of Obstetrics and Gynecology University Hospital of North NorwayTromsøNorway Center for Microscopy and Image Analysis University of ZurichZürichSwitzerland Division of Cardiothoracic and Respiratory Medicine University Hospital of North NorwayTromsøNorway Department of Clinical Medicine Clinical Cardiovascular Research GroupUiT The Arctic University of NorwayTromsøNorway Department of Medical Biology RNA and Molecular Pathology Research GroupUiT The Arctic University of NorwayTromsøNorway Division of Obstetrics and Gynecology Department of Clinical ScienceIntervention and TechnologyKarolinska InstituteStockholmSweden

Histology involves the observation of structural features in tissues using a *** diffraction-limited optical microscopes are commonly used in histological investigations,their resolving capabilities are insufficient to visualize details at subcellular *** a novel set of super-resolution optical microscopy techniques can fulfill the resolution demands in such cases,the system complexity,high operating cost,lack of multi-modality,and low-throughput imaging of these methods limit their wide adoption for histological *** this study,we introduce the photonic chip as a feasible high-throughput microscopy platform for super-resolution imaging of histological *** cryopreserved ultrathin tissue sections of human placenta,mouse kidney,pig heart,and zebrafish eye retina prepared by the Tokuyasu method,we demonstrate diverse imaging capabilities of the photonic chip including total internal reflection fluorescence microscopy,intensity fluctuation-based optical nanoscopy,single-molecule localization microscopy,and correlative light-electron *** results validate the photonic chip as a feasible imaging platform for tissue sections and pave the way for the adoption of super-resolution high-throughput multimodal analysis of cryopreserved tissue samples both in research and clinical settings.

关键词： resolution modal feasible

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全膝关节成形术中右心栓塞和急性右心房扩张

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麻醉与镇痛 2009年第4期5卷 43-44页

作者： amrik singh Neal Fleming 王汉兵(译) 杨承祥(校) Department of Anesthesiology and Pain Medicine University of California Davis Medical Center 不详

女性患者，64岁，因慢性膝关节退行性病变伴疼痛在全身麻醉下行全膝关节成形术（TKA），既往有哮喘和高血压病史。按照研究设计，手术中采用经食道超声（TEE）对手术引发的栓子进行定量监测。

关键词：全膝关节成形术右心房膝关节退行性病变急性栓塞高血压病史经食道超声女性患者

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Impact of frailty on endoscopic retrograde cholangiopancreatography outcomes in nonagenarians:A United States national experience

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 148-156页

作者： Sanket Dhirubhai Basida Dushyant singh Dahiya Muhammad Nadeem Yousaf Brinda Basida Bhanu Siva Mohan Pinnam Manesh Kumar Gangwani Hassam Ali Sahib singh Yash R Shah Daksh ahluwalia Mihir Prakash Shah Saurabh Chandan Neil R Sharma Shyam Thakkar Department of Internal Medicine University of Missouri-ColumbiaColumbiaMO 65212United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Division of Gastroenterology and Hepatology University of MissouriColumbiaMO 65212United States Department of Rheumatology Medical College of GeorgiaAugusta UniversityNorth AugustaGA 30912United States Department of Internal Medicine John H.Stroger Hospital of Cook CountyChicagoIL 60612United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology Creighton University School of MedicineOmahaNE 68131United States Division of Interventional Oncology&Surgical Endoscopy GI Oncology Tumor Site TeamParkview Cancer InstituteParkview HealthFort WayneIN 46845United States Section of Gastroenterology&Hepatology West Virginia University School of MedicineMorgantownWV 26505United States

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an essential therapeutic tool for biliary and pancreatic *** and elderly patients,especially those aged≥90 years are generally considered a higher-risk population for ERCP-related *** To investigate outcomes of ERCP in the Non-agenarian population(≥90 years)concerning *** This is a cohort study using the 2018-2020 National Readmission *** aged≥90 were identified who underwent ERCP,using the international classification of diseases-10 code with clinical *** Hopkins’s adjusted clinical groups frailty indicator was used to classify patients as frail and *** primary outcome was mortality,and the secondary outcomes were morbidity and the 30 d readmission rate related to *** used univariate and multivariate regression models for *** A total of 9448 patients were admitted for any indications of *** and non-frail patients were 3445(36.46%)and 6003(63.53%)*** for ERCP were Choledocholithiasis(74.84%),Biliary pancreatitis(9.19%),Pancreatico-biliary cancer(7.6%),Biliary stricture(4.84%),and Cholangitis(1.51%).Mortality rates were higher in frail group[adjusted odds ratio(aOR)=1.68,P=0.02].The Intra-procedural complications were insigni-ficant between the two groups which included bleeding(aOR=0.72,P=0.67),accidental punctures/lacerations(aOR=0.77,P=0.5),and mechanical ventilation rates(aOR=1.19,P=0.6).Post-ERCP complication rate was similar for bleeding(aOR=0.72,P=0.41)and post-ERCP pancreatitis(aOR=1.4,P=0.44).Frail patients had a longer length of stay(6.7 d vs 5.5 d)and higher mean total charges of hospitalization($78807 vs$71392)compared to controls(P<0.001).The 30 d all-cause readmission rates between frail and non-frail patients were similar(P=0.96).CONCLUSION There was a significantly higher mortality risk and healthcare burden amongst nonagenarian frail patients undergoing ERCP compared

关键词： Endoscopic retrograde cholangiopancreatography Nonagenarians Frailty Mortality Healthcare burden

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跨国CEO眼中的2012年投资环境

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博鳌观察 2012年第1期 128-132页

作者：项兵 Motek singh ahluwalia Michael Andrew Stewart A.Baker 谢国民傅成玉 Natarajan Chandrasekaran 平手晴彦艾尔克·霍克斯特洪起俊雷夫·约翰森罗伯特·金米特 K.K.Modi 蒋亚飞梁稳根西室泰三卢英德鲍尔森李润雨三村明夫马蔚华宫内义彦武藤敏郎庄睿思 Malvinder singh Ramadorai Subramanian 赵国华 Artem Volynets 长江商学院印度计划委员会毕马威美国世强律师事务所泰国正大集团中国石油化工集团公司印度塔塔信息技术有限公司日本武田药品荷兰皇家孚宝董事会韩国韩华集团瑞典爱立信德勤跨境投资中心印度Modi公司华为技术有限公司中国三一集团东京证券交易所百事可乐日本新日铁中国招商银行日本欧力士集团日本大和总研 GE 印度南新制药法国施耐德电气集团俄罗斯En+

跨国公司是对外直接投资的主要表现形式,他们亦是当今经济全球化发展中最重要的商业单元。跨国公司CEO们对2012年全球投资环境的研判,很具参考价值。同时,对于全球化未来的战略性发展,来自第一线的各国CEO们,也有自己独特的看法。4月2...

跨国公司是对外直接投资的主要表现形式,他们亦是当今经济全球化发展中最重要的商业单元。跨国公司CEO们对2012年全球投资环境的研判,很具参考价值。同时,对于全球化未来的战略性发展,来自第一线的各国CEO们,也有自己独特的看法。4月2日上午,博鳌亚洲论坛年会上呈现了一场精彩的闭门会,美国前财政部长鲍尔森和长江商学院院长项兵,召集了全球20余家跨国公司的CEO们,一起分析研判了2012年全球对外直接投资(FDI)的投资环境和可能的投资机会。

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