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Constructing a biofunctionalized 3D-printed gelatin/sodium alginate/chitosan tri-polymer complex scaffold with improvised biological andmechanical properties for bone-tissue engineering

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Bio-Design and Manufacturing 2024年第1期7卷 57-73页

作者： amit kumar Singh Krishna Pramanik amit Biswas Centre of Excellence in Tissue Engineering Department of Biotechnology and Medical EngineeringNational Institute of TechnologyRourkela 769008India

Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering *** present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue *** experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and *** resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)*** studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural *** scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue *** tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of *** enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue *** vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold *** addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its pote

关键词： Scaffold Biomaterial Sodium alginate Chitosan Gelatin 3D printing Tissue engineering

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Applications of phototheranostic nanoagents in photodynamic therapy

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Nano Research 2015年第5期8卷 1373-1394页

作者： Jayeeta Bhaumik amit kumar mittal Avik Banedee Yusuf Chisti Uttam Chand Banerjee Department of Pharmaceutical Technology (Biotechnology) National Institute of Pharmaceutical Education and Research Sector 67 S.A.S. Nagar 160062 India Department of Radiology Dayanand Medical College and Hospital Ludhiana 141001 India School of Engineering Massey University Private Bag 11 222 Palmerston North New Zealand

Nanotherapeutics 在象癌症那样的疾病的治疗有一个增加的角色。在光力学的治疗(太平洋夏季时间) ，治疗学地不活跃的 photosensitizer 混合物被光有选择地激活生产能够杀死 diseased 房间和病原体的分子。一个 phototheranostic 代理... 详细信息

Nanotherapeutics 在象癌症那样的疾病的治疗有一个增加的角色。在光力学的治疗(太平洋夏季时间) ，治疗学地不活跃的 photosensitizer 混合物被光有选择地激活生产能够杀死 diseased 房间和病原体的分子。一个 phototheranostic 代理人能为指向的交货，光成像和疾病的光力学的治疗与能力被定义为单个 nanoentity。恶意的房间，纸巾和微生物引起的 etiologic 代理人能被太平洋夏季时间有效地指向。光力学的治疗是 noninvasive，或最低限度地侵略，并且当健康织物的损坏被最小化，杀死的效果是局部性的，有很少副作用。癌症，粉刺和另外的疾病的各种各样的形式可以被对待。在里面 photosensitizers 的 vivo 功效被把他们纳入能够指向 diseased 地点的 nanostructures 进一步改进。如此的 photosensitizer-functionalized nanostructures，或 nanotherapeutics，为改进 phototheranostic 性能允许成像和治疗学的代理人的地点特定的交货。这评论在诊断和治疗探索 phototheranostic nanostructures 的潜在的应用。

关键词：光动力疗法应用纳米结构光动力学治疗光学成像治疗剂位点特异性光敏剂

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MOALG: A Metaheuristic Hybrid of Multi-Objective Ant Lion Optimizer and Genetic Algorithm for Solving Design Problems

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Computers, Materials & Continua 2024年第3期78卷 3489-3510页

作者： Rashmi Sharma Ashok Pal Nitin mittal Lalit kumar Sreypov Van Yunyoung Nam Mohamed Abouhawwash Department of Mathematics Chandigarh UniversityGharuanMohali140413India Deaprtment of Industry 4.0 Shri Vishwakarma Skill UniversityPalwal121102India Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea Department of Computational Mathematics Science and Engineering(CMSE)College of EngineeringMichigan State UniversityEast LansingMI 48824USA Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt

This study proposes a hybridization of two efficient algorithm’s Multi-objective Ant Lion Optimizer Algorithm(MOALO)which is a multi-objective enhanced version of the Ant Lion Optimizer Algorithm(ALO)and the Genetic Algorithm(GA).MOALO version has been employed to address those problems containing many objectives and an archive has been employed for retaining the non-dominated *** uniqueness of the hybrid is that the operators like mutation and crossover of GA are employed in the archive to update the solutions and later those solutions go through the process of MOALO.A first-time hybrid of these algorithms is employed to solve multi-objective *** hybrid algorithm overcomes the limitation of ALO of getting caught in the local optimum and the requirement of more computational effort to converge *** evaluate the hybridized algorithm’s performance,a set of constrained,unconstrained test problems and engineering design problems were employed and compared with five well-known computational algorithms-MOALO,Multi-objective Crystal Structure Algorithm(MOCryStAl),Multi-objective Particle Swarm Optimization(MOPSO),Multi-objective Multiverse Optimization Algorithm(MOMVO),Multi-objective Salp Swarm Algorithm(MSSA).The outcomes of five performance metrics are statistically analyzed and the most efficient Pareto fronts comparison has been *** proposed hybrid surpasses MOALO based on the results of hypervolume(HV),Spread,and *** primary objective of developing this hybrid approach has been achieved *** proposed approach demonstrates superior performance on the test functions,showcasing robust convergence and comprehensive coverage that surpasses other existing algorithms.

关键词： Multi-objective optimization genetic algorithm ant lion optimizer metaheuristic

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Aerodynamics of a Tandem-Bladed Axial Compressor Rotor under Circumferential Distortion at Different Rotational Speeds

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Journal of Thermal Science 2024年第4期33卷 1340-1356页

作者： amit kumar Jerry T.JOHN A.M.PRADEEP R.A.DAKKERMANS Dragan KOZULOVIC Department of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India Department of Automotive and Aeronautical Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet Propulsion Bundeswehr University Munich85577NeubibergGermany

For most aircraft engines,inflow distortion is *** distortion is known to degrade the aerodynamic performance and stable operating limits of a *** rotor configuration is an arrangement that effectively controls the growth of the boundary layer over the suction surface of the ***,a higher total pressure rise can be achieved through this unconventional design approach involving the splitting of the blade into forward and aft *** is expected that the effect of inlet flow distortion would be more severe for a tandem-rotor design due to the greater flow turning inherent in such ***,this aspect needs to be thoroughly *** present study discusses the effect of circumferential distortion on the tandem-rotor at different rotational ***-annulus RANS simulations using ANSYS CFX are used in the present *** performance of the rotor at a particular flow coefficient and different rotational speeds is *** total pressure and efficiency are observed to drop at lower mass flow rates under the influence of circumferential *** loss region in each blade passage is mainly associated with the blade wake,tip leakage vortex,secondary flow,and boundary ***,their contribution varies from passage to passage,particularly in the distorted *** the lower span,the wake width is found to be higher than that at a higher *** to the redistribution of the mass flow,the circumferential extent reduces at a higher *** the undistorted sector,the strength of the tip leakage vortex is significantly higher at the design rotational speed than at lower *** distortion near the tip region promotes an early vortex breakdown even at the design operating *** adversely affects the total pressure,efficiency,and stall *** clean flow conditions,this phenomenon is only observed near the stall *** the design operating condition,the breakdown of the forward rotor tip l

关键词： tandem rotor circumferential distortion loss tip leakage vortex vortex breakdown diffusion factor aerodynamics of compressor blade

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Clinical outcomes of triceps reflecting anconeus pedicle and olecranon osteotomy approach for distal humerus intercondylar fractures

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World Journal of Orthopedics 2024年第6期15卷 570-577页

作者： Rohit Ailani Sanjeev kumar Bhuyan Brejesh kumar Prasad amit kumar Namrata Dawani Department of Orthopaedics Lovee Shubh HospitalLucknowUttar Pradesh 226002India Department of Orthopaedics Gauhati Medical CollegeGuahati 781032India Department of Orthopaedics ESIC Medical College and HospitalFaridabadHaryana 121001India Department of Orthopaedics All India Institute of Medical SciencesKalyaniWest Bengal 741245India Department of Obstetric and Gynecology Kannauj Medical CollegeKannaujUttar Pradesh 209732India

BACKGROUND The preferred treatment for distal humeral intercondylar fractures is open reduction and internal *** there is consensus about the posterior approach,several posterior approaches have been *** is debatable as to which approach is *** To compare triceps reflecting anconeus pedicle(TRAP)and olecranon osteotomy approaches for internal fixation of distal humeral intercondylar *** In total,40 cases of Arbeitsgemeinschaft für Osteosynthesefragen/Association of the Study of Internal Fixation type C,closed,and Gustilo type I intercondylar humeral fractures were *** ranged in age from 18 years to 70 *** patients were randomized into two groups:TRAP group and olecranon osteotomy group,with 20 cases in *** were followed up at 6 wk,3 months,6 months,and 12 *** outcomes were measured in terms of flexion-extension arc,Disabilities of Arm,Shoulder and Hand score,and Mayo Elbow Performance *** The mean age was 43.2 years in the TRAP group and 37.5 years in the olecranon osteotomy *** mean operative time and mean duration of hospital stay in the TRAP group were significantly higher than in the olecranon osteotomy group(119.5 vs 111.5 min and 9.85 vs 5.45 d,respectively).The mean arc of flexion-extension,Disabilities of Arm,Shoulder and Hand score,and Mayo Elbow Performance Score were comparable without any significant difference in the groups at the 12-month follow-up(107.0 vs 106.2,18.3 vs 15.7,and 84.2 vs 86.2,respectively).Ulnar paresthesia and superficial infections were comparable in both groups(2 cases vs 3 cases and 3 cases vs 2 cases,respectively).Hardware prominence was significantly higher in the olecranon osteotomy group,mostly due to tension band *** Both approaches were equivalent,but there is a need for further study including higher numbers of subjects and longer study duration to prove the benefits of one approach over the other.

关键词： Elbow joint Humeral fracture Osteotomy Internal Fracture fixation

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Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

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Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra Kashyap Nidhi Varshney Tarun Prakash Verma Ajay kumar Jain Debi Chatterji Vinod kumar amit Mishra Awanish kumar Hem Chandra Jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(***)is the strongest known risk factor for gastric cancer(GC).*** is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that *** infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

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Transcranial direct current stimulation as early augmentation in adolescent obsessive compulsive disorder:A pilot proof-of-concept randomized control trial

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World Journal of Clinical Pediatrics 2024年第2期13卷 161-170页

作者： Aditya Agrawal Vivek Agarwal Sujita kumar Kar amit Arya Department of Psychiatry King George Medical UniversityUttar PradeshLucknow 226003India

BACKGROUND Transcranial direct current stimulation(tDCS)is proven to be safe in treating various neurological conditions in children and *** is also an effective method in the treatment of OCD in *** To assess the safety and efficacy of tDCS as an add-on therapy in drug-naive adolescents with *** We studied drug-naïve adolescents with OCD,using a Children’s Yale-Brown obsessive-compulsive scale(CY-BOCS)scale to assess their *** active and sham groups were given fluoxetine,and we applied cathode and anode over the supplementary motor area and deltoid for 20 min in 10 *** occurred at 2,6,and 12 wk using *** Eighteen adolescents completed the study(10-active,8-sham group).CY-BOCS scores from baseline to 12 wk reduced significantly in both groups but change at baseline to 2 wk was significant in the active group *** mean change at 2 wk was more in the active group(11.8±7.77 vs 5.25±2.22,P=0.056).Adverse effects between the groups were *** tDCS is safe and well tolerated for the treatment of OCD in ***,there is a need for further studies with a larger sample population to confirm the effectiveness of tDCS as early augmentation in OCD in this population.

关键词： Adolescents Early augmentation Obsessive compulsive disorder Safety Transcranial direct current stimulation

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Recent progress in carbonaceous materials based Z-scheme and Sscheme heterojunctions for photocatalytic clean energy generation

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新型炭材料(中英文) 2024年

作者： Sahil Rana amit kumar Wang Tong-tong Gaurav Sharma Pooja Dhiman Alberto García-Penas Interdisciplinary and Innovate Research Xi'an University of Architecture and Technology Departamento de Ciencia e Ingeniería de Materiales e Ingeniería Química (IAAB) Universidad Carlos III de Madrid International Research Centre of Nanotechnology for Himalayan Sustainability (IRCNHS) Shoolini University

Carbonaceous materials including carbon nanotubes/nanofibers, graphene, graphene oxide, reduced graphene oxide,graphyne, graphdiyne, carbon quantum dots and fullerenes have gained considerable attention in the recent years for their unique properties such as high conductivity, excellent stability and biocompatibility. The integration of these carbonaceous materials into Zscheme and S-scheme heterojunctions has emerged as a transformative strategy to enhance the photocatalytic efficiency for energy conversion applications. This review delves into the fundamental principles of clean energy generation such as photocatalytic H2generation and CO2reduction, elucidating their respective mechanisms and advantages. Furthermore, various types of carbonaceous materials, their synthesis and construction of Z-scheme and S-scheme heterojunctions are discussed emphasizing their role in promoting charge separation, reducing recombination losses and extending the spectral response range. With the focus on solar fuel production,the recent advancements in carbonaceous based Z-scheme and S-scheme heterojunctions are discussed and summarized for photocatalytic H2generation and CO2reduction. Lastly, the current bottlenecks and challenges in the field of carbonaceous based photocatalysts are discussed with the valuable insights for future development in this particular field.

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Therapeutic potential and pharmacological mechanism of visnagin

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Journal of Integrative Medicine 2024年第4期22卷 399-412页

作者： Poonam Yadav Sumeet kumar Singh Sayantap Datta Saloni Verma Aarti Verma Arnab Rakshit Anjana Bali Jasvinder Singh Bhatti amit Khurana Umashanker Navik Department of Pharmacology School of Health SciencesCentral University of PunjabBathindaPunjab 151401India Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTX 77204-5000USA Department of Human Genetics and Molecular Medicine School of Health SciencesCentral University of PunjabBathindaPunjab 151401India

Visnagin is a furanochromone and one of the most important compound in the Ammi visnaga(L.)Lam(a synonym of Visnaga daucoides Gaertn.)plant,which is used to cure various *** investigations into the bioactive properties of visnagin have been studied to *** literature on visnagin demonstrates its biological properties,including anti-inflammatory,anti-diabetic,and beneficial effects in cardiovascular and renal ***,visnagin improves sperm quality parameters,stimulates steroidogenesis,and increases serum gonadotropins and testosterone levels,while decreasing proinflammatory cytokines,oxidative damage,genomic instability,and it modulates ***,visnagin has emerged as an exciting lead for further research,owing to its potential in various unmet clinical *** current review summarized its basic structure,pharmacokinetics,and pharmacological effects,focusing on its mechanisms of *** review will help to understand the potential of visnagin as an alternative treatment strategy for several diseases and provide insight into research topics that need further exploration for visnagin’s safe clinical use.

关键词： Visnagin Phytochemical Anti-inflammatory Ammi visnaga L. Visnaga daucoides Gaertn Cancer

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石墨炔:一种用于合成水污染物有效吸附剂的新型炭材料

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新型炭材料（中英文） 2024年第2期39卷 173-200页

作者： Gaurav Sharma Yaksha Verma amit kumar Pooja Dhiman WANG Tong-tong Florian JStadler 深圳大学材料科学与工程学院深圳市高分子科学与技术重点实验室广东省功能材料界面工程研究中心南山区生物高分子与安全性评价重点实验室广东深圳518055 International Research Centre of Nanotechnology for Himalayan Sustainability(IRCNHS) Shoolini UniversityHimachal Pradesh 173229India 西安建筑科技大学跨学科与创新研究院陕西西安710055

石墨炔(GDY)是一种新生的二维材料,其在去除水溶液中污染物的研究方面引起了广泛关注。GDY是sp和sp2杂化碳原子的框架,其在二维对称网络中存在苯环和二乙基键,因此具有优异的共轭性、独特的可调谐电子性能、以及优异的化学和热稳定性。... 详细信息

石墨炔(GDY)是一种新生的二维材料,其在去除水溶液中污染物的研究方面引起了广泛关注。GDY是sp和sp2杂化碳原子的框架,其在二维对称网络中存在苯环和二乙基键,因此具有优异的共轭性、独特的可调谐电子性能、以及优异的化学和热稳定性。GDY的分子中有C≡C键,且具有均匀分布的三角形孔,可提供更多的反应位点和多种反应路径。因而,GDY具有吸附性,其作为吸附剂时在去除污染水中的油、有机污染物、染料和金属方面表现优异。在已发表的文献中,GDY被用作吸附剂的报道十分有限。本文综述了GDY的合成方法、GDY作为吸附剂的应用以及GDY基吸附剂的表征,并展望了GDY在污染物修复中的应用前景。

关键词：石墨炔合成吸附污染物合理机制

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