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Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2018年第7期8卷 352-359页

作者： amit d.kandhare Anwesha A.Mukherjee Subhash L.Bodhankar department of Pharmacology Poona College of Pharmacy Bharati Vidyapeeth Deemed University

Objective: To evaluate the protective effect of morin against pentylenetetrazol(PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice(18-22 g) was used to induce convulsions by intraperitoneal(i.p.) administration of PTZ(90 mg/kg). Mice were either pretreated with morin(10, 20 and 40 mg/kg) or vehicle(distilled water, 10 mg/kg) 45 min before PTZ administration. Various behavioral and biochemical parameters were assessed. Results: PTZ administration resulted in significant production(Pd mortality in mice. PTZ-induced increase in the duration of convulsion, onset of convulsion and mortality was inhibited significantly by morin(20 and 40 mg/kg) administration. The PTZinduced decrease in brain GABA, dopamine and Na+K+ATPase levels and increase in xanthine oxidase activity were inhibited significantly by morin(20 and 40 mg/kg) treatment. The increased levels of malondialdehyde and nitric oxide level were significantly decreased by morin(20 and 40 mg/kg) treatment. Also, reduced levels of superoxide dismutase and glutathione were increased significantly by morin treatment. Conclusions: Results of the present study indicate that morin showed its anti-convulsant effect via modulating the levels of brain GABA, Na^+K^+ATPase, and oxido-nitrosative stress. Thus, morin can be a potential candidate for further clinical evaluations as an anti-epileptic agent.

关键词： Brain GABA Epilepsy Morin Nitric oxide Pentylenetetrazol Oxidative stress Xanthine oxidase

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Effect of hydroalcoholic extract of Hibiscus rosa sinensis *** in experimental colitis in rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 337-344页

作者： amit d kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed University department of Homeopathic Pharmacy Homeopathic Medical CollegeBharati Vidyapeeth Deemed University

Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar ***: The animals were administered with 2 mL acetic acid(4%) via intra *** animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg *** control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOd),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MdA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MdA,NO and TNF-α It caused significant decreased level of SOd and *** with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOd and GSH at a dose of 100 and 200 mg/kg in acetic acid induced ***:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α.

关键词： Acetic acid Hibiscus rosa sinensis Inflammatory bowel disease Inflammatory cytokine Nitrite/nitrate Oxidative stress Ulcerative colitis Prednisolone

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