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Fluoroquinolones-resistant Shigella species in Iranian children:a meta-analysis

World Journal of Pediatrics 2019年第5期15卷 441-453页

作者： Farzad Khademi Amirhossein Sahebkar Department of Microbiology School of MedicineArdabil University of Medical SciencesDaneshgah StreetArdabil ***Iran Biotechnology Research Center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Neurogenic Inflammation Research Center Mashhad University of Medical SciencesMashhadIran School of Pharmacy Mashhad University of Medical SciencesMashhadIran

Background Shigella is one of the most common causes of childhood dysentery along with high rate of morbidity and mortality in both developing and developed countries.According to the World Health Organization(WHO)reports,the prevalence of fluoroquinolones-resistant Shigella species is increasing worldwide which can cause treatment failure of Shigella infections.Since there has not been any comprehensive information on drug-resistant Shigella species in Iran,we conducted the following meta-analysis to raise awareness.Methods We conducted a literature search on antibiotic resistance of Shigella species to collect published studies in Iran using national and international databases.Literature search was performed by up to Jan 30,2019 and eligible studies were included in the meta-analysis by predefined criteria.Results Antimicrobial susceptibility testing using disk diffusion technique was the only used method in all included studies.Antibiotic resistance characteristics of Shigella species against WHO recommended therapeutic regimens were as follows:S.dysenteriae 7%,S.flexneri 3.8%,S.boydii 6.9%and S.sonnei 2.6%to ciprofloxacin,S.dysenteriae 27.9%,S.flexneri 19.3%,S.boydii 15.7%and S.sonnei 9.5%to ceftriaxone and also S.dysenteriae 91.7%,S.flexneri 20.7%,S.boydii 46.7%and S.sonnei 32.3%to azithromycin.Resistance to pivmecillinam has not been investigated in Iran.Conclusions Our findings revealed that ciprofloxacin can still be used as the first-line antibiotic for Shigella infections in Iranian children.However,it seems that second-line antibiotics i.e.,ceftriaxone and azithromycin are not good choices for treatment and thus not recommended.

关键词： Antibiotic resistance Fluoroquinolone Iran Shigella

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Therapeutic potential of trehalose in neurodegenerative diseases:the knowns and unknowns

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Neural Regeneration Research 2021年第10期16卷 2026-2027页

作者： Masoomeh Khalifeh George E.Barreto Amirhossein Sahebkar Department of Medical Biotechnology and Nanotechnology Faculty of MedicineMashhad University of Medical SciencesMashhadIran Department of Biological Sciences Health Research InstituteUniversity of LimerickLimerickIreland Applied Biomedical Research Center Biotechnology Research CenterPharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Polish Mother’s Memorial Hospital Research Institute(PMMHRI) LodzPoland School of Pharmacy Mashhad University of Medical Sciences MashhadIra

Neurodegenerative diseases(NDs)are a growing health problem associated with a high burden due to destructive and longterm clinical effects.Cellular aggregations of misfolded proteins are the most common pathological hallmark of many late-onset NDs called proteinopathies including Parkinson’s disease(PD),Alzheimer’s disease(AD),tauopathies,amyotrophic lateral sclerosis(ALS),and polyglutamine(polyQ)expansion diseases such as Huntington’s disease(HD)and various spinocerebellar ataxias(SCA)such as SCA3(Renna et al.,2010).Misfolded proteins can be generated by posttranslational conjugation(e.g.,hyperphosphorylated tau in AD),or endoproteolytic cleavage(e.g.,amyloidβpeptides)or genetic mutations in specific proteins(such as HTT in HD,α-synuclein in PD,PrPC in prion disease and SOD1 and TDP-43 in ALS)leading to the formation of oligomers.

关键词： Huntington tau Alzheimer

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Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2011年第2期17卷 271-272页

作者： Amirhossein Sahebkar Biotechnology Research Center and School of Pharmacy Mashhad University of Medical Sciences Cardiovascular Research Center Avicenna Research InstituteMashhad University of Medical Sciences Research Center of Chemical Injuries Baqiyatallah University of Medical Sciences

Nonalcoholic fatty liver disease(NAFLD) is one of the most common liver diseases and its prevalence is likely to reach epidemic proportions.According to the"two-stage hypothesis"proposed for the pathophysiology of NAFLD,insulin resistance,oxidative stress and pro-inflammatory cytokines are among the key promoters of the disease. Here,ginger has been hypothesized to prevent NAFLD or blunt its progression via several mechanisms,such as sensitizing insulin effects,activating peroxisome proliferator-activated receptorγwhich induces adiponectin and down-regulates pro-inflammatory cytokines,changing the balance between adiponectin and tumor necrosis factor-αin favor of adiponectin,promoting considerable antioxidant effects and antidyslipidemic properties,and reducing hepatic triglyceride content which can prevent steatosis.The aforementioned mechanisms imply that ginger possesses interesting potentials for serving as a natural supplement for the prevention and treatment of NAFLD.Therefore,conducting trials to explore its benefits in clinical practice is greatly recommended.

关键词：脂肪肝病过氧化物酶体增殖物激活受体酒精性自然肝疾病胰岛素抵抗姜疗效

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Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases

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Neural Regeneration Research 2022年第8期17卷 1675-1684页

作者： Fatemeh Zahedipour Seyede Atefe Hosseini Neil C.Henney George E.Barreto Amirhossein Sahebkar Department of Medical Biotechnology School of MedicineMashhad University of Medical SciencesMashhadIran Student Research Committee Faculty of MedicineMashhad University of Medical SciencesMashhadIran Pharmacy&Biomolecular Sciences Liverpool John Moores UniversityLiverpoolUK Department of Biological Sciences University of LimerickLimerickIreland Health Research Institute University of LimerickLimerickIreland Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran Biotechnology Research Center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Polish Mother’s Memorial Hospital Research Institute(PMMHRI) LodzPoland School of Pharmacy Mashhad University of Medical SciencesMashhadIran

Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders.Tumor necrosis factor alpha has been reported to play a major role in the central nervous system in Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral sclerosis and many other neurodegenerative diseases.Therefore,a potent proinflammatory/proapoptotic tumor necrosis factor alpha could be a strong candidate for targeted therapy.Plant derivatives have now become promising candidates as therapeutic agents because of their antioxidant and chemical characteristics,and anti-inflammatory features.Recently,phytochemicals including flavonoids,terpenoids,alkaloids,and lignans have generated interest as tumor necrosis factor alpha inhibitor candidates for a number of diseases involving inflammation within the nervous system.In this review,we discuss how phytochemicals as tumor necrosis factor alpha inhibitors are a therapeutic strategy targeting neurodegeneration.

关键词： brain central nervous system cytokine herbal medicine inflammation neurodegenerative diseases phytochemicals tumor necrosis factor-alpha

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Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial

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Journal of Traditional Chinese Medicine 2015年第6期35卷 632-636页

作者： Yunes Panahi Hossein Khedmat Ghasem Valizadegan Reza Mohtashami Amirhossein Sahebkar Chemical Injuries Research Center Baqiyatallah University of Medical Sciences Baqiyatallah Research Center for Gastroenterology and Liver Diseases Baqiyatallah University of Medical Sciences Baqiyatallah University of Medical Sciences Medicine Quran and Hadith Research CenterBaqiyatallah University of Medical Sciences Biotechnology Research Center Mashhad University of Medical Sciences Metabolic Research Centre Royal Perth HospitalSchool of Medicine and PharmacologyUniversity of Western Australia

OBJECTIVE: To investigate the use of Aloe vera(A.vera) for the treatment of gastroesophageal reflux disease(GERD) symptoms and compare its effects with those of omeprazole and ranitidine.METHODS: In this pilot, randomized controlled trial, 79 subjects were allocated to A. vera syrup(standardized to 5.0 mg polysaccharide per m L of syrup)at a dose of 10 m L/d, omeprazole capsule(20 g/d)or ranitidine tablet(150 mg in a fasted state in the morning and 150 mg 30 min before sleep at night)for a period of 4 weeks. The frequencies of eight main symptoms of GERD(heartburn, food regurgitation, flatulence, belching, dysphagia, nausea,vomiting and acid regurgitation) were assessed at weeks 2 and 4 of the trial.RESULTS: A. vera was safe and well tolerated and reduced the frequencies of all the assessed GERD symptoms, with no adverse events requiring withdrawal.CONCLUSION: A. vera may provide a safe and effective treatment for reducing the symptoms of GERD.

关键词： Aloe vera Gastroesophageal reflux dis-ease Complementary therapies Treatment out-come Randomized controlled trial

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Antibiotic resistance of Neisseria species in Iran: A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2019年第1期12卷 8-13页

作者： Farzad Khademi Amirhossein Sahebkar Department of Microbiology School of Medicine Ardabil University of Medical Sciences Biotechnology Research Center Pharmaceutical Technology Institute Mashhad University of Medical Sciences Neurogenic Inflammation Research Center Mashhad University of Medical Sciences School of Pharmacy Mashhad University of Medical Sciences

Objective: To estimate the prevalence of antibiotic resistance of Neisseria species in Iran. Methods: A systematic and electronic search using relevant keywords in major national and international databases was performed until 6th July, 2018 in order to find studies reporting the prevalence of antibiotic resistance of Neisseria species in Iran. Results: A total of nine studies were found to be eligible based on predefined inclusion and exclusion criteria. Our analysis indicated that the prevalence of Neisseria gonorrhoeae resistance to different antibiotics was as follows: 66.9% to penicillin, 59.1% to ciprofloxacin, 11.1% to ceftriaxone, 21.6% to spectinomycin, 13.8% to cefixime, 82.4% to co-trimoxazole, 52.7% to tetracycline, 29.9% to gentamicin, 87.5% to ampicillin, 11.1% to azithromycin, 2.2% to chloramphenicol, 50.1% to cefepime and 50.0% to vancomycin. Antimicrobial resistance rates of Neisseria meningitidis was as follows: 30.0% to penicillin, 33.3% to amoxicillin, 33.3% to cephalexin, 55.6% to ampicillin and 0.0% to ciprofloxacin, ceftriaxone, cefotaxime, amikacin, co-trimoxazole, gentamicin, kanamycin, chloramphenicol and ceftizoxime. Conclusion: Neisseria gonorrhoeae and Neisseria meningitidis isolates of Iran show resistance to different types of antibiotics. Therefore, care should be exercised for the use of penicillin, ciprofloxacin, co-trimoxazole, tetracycline, gentamicin, ampicillin, cefepime and vancomycin for gonococcal infections, and also with respect to the use of penicillin, amoxicillin, ampicillin and cephalexin for meningococcal infections in Iran.

关键词： Antibiotic Neisseria Resistance Meta-analysis Iran

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An Investigation of the Effects of Curcumin on Anxiety and Depression in Obese Individuals:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2015年第5期21卷 332-338页

作者： Habibollah Esmaily Amirhossein Sahebkar Mehrdad Iranshahi Shiva Ganjali Akram Mohammadi Gordon Ferns Majid Ghayour-Mobarhan Department of Biostatistics and Epidemiology Research Health CenterSchool of HealthMashhad University of Medical Sciences Neurogenic Inflammation Research Center Mashhad University of Medical Sciences Biotechnology Research Center Mashhad University of Medical Sciences Department of Modern Sciences and Technologies Mashhad University of Medical Sciences Cardiovascular Research Center Mashhad University of Medical Sciences Division of Medical Education Rm 342Mayfield HouseUniversity of Brighton Biochemistry of Nutrition Research Center Mashhad University of Medical Sciences

Objective： To investigate the effectiveness of curcumin, a natural polyphenolic compound with antioxidant and anti-inflammatory activities, on the frequency of symptoms of anxiety and depression in obese individuals. Methods： In this double blind, cross-over trial, 30 obese subjects were randomized to receive either curcumin （1 g/day） or placebo for a period of 30 days. Following a wash-out interval of 2 weeks, each subject was crossed over to the alternative regimen for a further 30 days. Severity of anxiety and depression was assessed at baseline and at weeks 4, 6 and 10 of the trial using the Beck Anxiety Inventory （BAI） and Beck Depression Inventory （BDI） scales, respectively. Results： Mean BAI score was found to be significantly reduced following curcumin therapy （P=0.03）. However, curcumin supplementation did not exert any significant impact on BDI scores （P=0.7）. Conclusion： Curcumin has a potential anti-anxiety effect in individuals with obesity.

关键词： Curcuma Ionga curcumin phenolic psychological disorders Beck Anxiety Inventory scale BeckDepression Inventory scale

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Distribution and variability of n-alkanes in waxes of conifers

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Journal of Forestry Research 2019年第2期30卷 429-433页

作者： Mohamad Hassanzadeh-Khayyat Maryam Akaberi Hamideh Moalemzadeh Haghighi Amirhossein Sahebkar Seyed Ahmad Emami Pharmaceutical Research Centre Department of Medicinal Chemistry School of Pharmacy Mashhad University of Medical Sciences Student Research Committee Department of Pharmacognosy School of Pharmacy Mashhad University of Medical Sciences Biotechnology Research Center Pharmaceutical Technology Institute Mashhad University of Medical Sciences Neurogenic Inflammation Research Center Mashhad University of Medical Sciences School of Pharmacy Mashhad University of Medical Sciences Department of Pharmacognosy School of PharmacyMashhad University of Medical Sciences

Epicuticular waxes have vital roles in the growth and development of plants and in defense. Conifers have a considerable amount of waxes on their cones and leaves.Here we characterized the n-alkane composition of Iranian conifers, including Juniperus oblonga, J. foetidissima, J.sabina, J. communis subsp. hemisphaerica, J. excelsa,Cupressus sempervirens, Platycladus orientalis from Cupressaceae and Taxus baccata from Taxaceae for the first time using GC-FID analyses. In the waxes, 25 n-alkane homologs with chain lengths ranging from C7 to C32 were identified. Short-chain n-alkanes were dominant in almost all samples with some exceptions. Complementary studies to elucidate complete wax constituents of Iranian conifers and n-alkane distribution pattern as a function of geographical and bioclimatic variables are recommended.

关键词： Gymnosperms Iranian conifers Epicuticular waxes Cupressaceae Taxaceae

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Helicobacter pylori infection and susceptibility to cardiac syndrome X:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2021年第2期9卷 208-219页

作者： Mohsen Karbalaei Amirhossein Sahebkar Masoud Keikha Department of Microbiology and Virology Faculty of MedicineJiroft University of Medical SciencesJiroft 43317803Iran Biotechnology Research Center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran Department of Microbiology and Virology Faculty of MedicineMashhad University of Medical SciencesMashhad ***Iran

BACKGROUND Cardiac syndrome X(CSX)is characterized by persistent angina with normal coronary arteries.Several pathophysiologic mechanisms have been introduced,particularly Helicobacter pylori(H.pylori)infection.AIM To investigate the association between H.pylori infection and CSX.METHODS All studies related to H.pylori infection and CSX were evaluated by comprehensive searches of global databases such as ISI Web of Knowledge,PubMed,Scopus,EMBASE,and Google scholar.Statistical analyses of selected articles were evaluated based on the summary odds ratio(OR).Finally,heterogeneity and publication bias were estimated using the I2 statistic and Cochrane Q-test as well as Begg’s and Egger’s tests.RESULTS A total of 11 studies met our inclusion criteria and 1435 patients(63%female,and 37%male)were reviewed.A significant association was observed between female patients and this syndrome(P=0.02).Our results showed a positive association between infection with this pathogen and presence of CSX(OR:5.65;95%confidence interval[CI]:4.17-7.64;I2:82.20).However,no significant association was observed with cagA-positive H. pylori strains and this syndrome (OR: 0.97;0.56-1.70 with 95%CI). Given the heterogeneity and publication bias, the resultsneed to confirmed by further prospective investigation.CONCLUSIONBased on our results, H. pylori infection is associated with an increased risk ofCSX. This bacterium appears to play a major role in the pathogenesis of CXS byinducing persistent inflammation.

关键词： Helicobacter pylori Cardiac syndrome X Cardiovascular disease Infection Meta-analysis Coronary diseases

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Corrosion and corrosion-fatigue behavior of magnesium metal matrix composites for bio-implant applications:A review

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Journal of Magnesium and Alloys 2023年第4期11卷 1125-1161页

作者： Hassan Delavar amirhossein Jabbari Mostahsan Hamdy Ibrahim School of Mechanical Engineering Iran University of Science and TechnologyTehranIran Department of Mechanical Engineering Sharif University of TechnologyTehranIran Mechanical Engineering Department University of Tennessee at ChattanoogaChattanoogaTN 37403USA

Recently,the topic of bioresorbable metals,with much focus on magnesium for bone implant applications,has been an area of considerable investigation.Indeed,it could be argued that magnesium is the most promising biodegradable material currently being studied for use as an orthopedic skeletal fixation and joint replacement hardware.However,the fast degradation rate of magnesium-based materials in the physiological environment negatively affects their mechanical integrity and hence limits their biomedical use.The most critical conditions may occur when the implant is subjected to a corrosive physiological environment and a fluctuating load during daily activities.Hence,numerous studies have been published on the synthesis,alloying,and coating of magnesium to control degradation rate and increase strength and durability.Among the materials and strategies employed to achieve these goals,magnesium-based biocomposites have exhibited superior mechanical properties and acceptable biocompatibility.However,there is a lack of understanding of their corrosion and corrosion-fatigue behavior.Such understanding is necessary to qualify these new materials for various bio-implant applications.To this end,this paper reviews the recent advances in the corrosion and corrosion-fatigue behavior of magnesium-based biocomposites.It also provides a comprehensive discussion of different factors that influence the biocompatibility,corrosion,fatigue,and corrosion-fatigue of magnesium-based biocomposites as potential implant materials.This study emphasizes that despite the abundance of various studies on the corrosion behavior of magnesium-based biocomposites,there is an imperative need for more fatigue and corrosion-fatigue studies.

关键词： Magnesium biocomposites Biodegradable implants Corrosion Fatigue Corrosion-fatigue

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