Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases

作     者：Fatemeh Zahedipour Seyede Atefe Hosseini Neil C.Henney George E.Barreto Amirhossein Sahebkar Fatemeh Zahedipour;Seyede Atefe Hosseini;Neil C.Henney;George E.Barreto;Amirhossein Sahebkar

作者机构：Department of Medical BiotechnologySchool of MedicineMashhad University of Medical SciencesMashhadIran Student Research CommitteeFaculty of MedicineMashhad University of Medical SciencesMashhadIran Pharmacy&Biomolecular SciencesLiverpool John Moores UniversityLiverpoolUK Department of Biological SciencesUniversity of LimerickLimerickIreland Health Research InstituteUniversity of LimerickLimerickIreland Applied Biomedical Research CenterMashhad University of Medical SciencesMashhadIran Biotechnology Research CenterPharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Polish Mother’s Memorial Hospital Research Institute(PMMHRI)LodzPoland School of PharmacyMashhad University of Medical SciencesMashhadIran 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第8期

页      面：1675-1684页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：brain central nervous system cytokine herbal medicine inflammation neurodegenerative diseases phytochemicals tumor necrosis factor-alpha 

摘      要：Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders.Tumor necrosis factor alpha has been reported to play a major role in the central nervous system in Alzheimer’s disease,Parkinson’s disease and amyotrophic lateral sclerosis and many other neurodegenerative diseases.Therefore,a potent proinflammatory/proapoptotic tumor necrosis factor alpha could be a strong candidate for targeted therapy.Plant derivatives have now become promising candidates as therapeutic agents because of their antioxidant and chemical characteristics,and anti-inflammatory features.Recently,phytochemicals including flavonoids,terpenoids,alkaloids,and lignans have generated interest as tumor necrosis factor alpha inhibitor candidates for a number of diseases involving inflammation within the nervous system.In this review,we discuss how phytochemicals as tumor necrosis factor alpha inhibitors are a therapeutic strategy targeting neurodegeneration.