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Circulating Levels of Hypoxia-regulating microRNAs in Systemic Lupus Erythematosus Patients with Hemolytic Anemia

Current medical Science 2022年第6期42卷 1231-1239页

作者： amira m.gamal.eldeen Cinderella A.Fahmy Bassem m.Raafat Fayez Althobaiti Iman H.Bassyouni Roba m.Talaat Clinical Laboratory Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia High Altitude Research Center Prince Sultan Medical ComplexAl-HawiyahTaif UniversityTaif21944Saudi Arabia Cancer Biology and Genetics Laboratory Centre of Excellence for Advanced SciencesNational Research CentreCairo12622Egypt Biochemistry Department National Research CentreCairo12622Egypt Radiological Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Biotechnology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Department of Rheumatology and Rehabilitation Faculty of MedicineCairo UniversityEl-Kasr El-Aini HospitalCairo12613Egypt molecular Biology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)Sadat City UniversitySadat City32897Egypt

Objective microRNAs are fine regulators for gene expression during the post-transcriptional stage in many autoimmune ***(miR-210 and miR-21)play an important role in hypoxia and in inflammation-associated *** lupus erythematosus(SLE)is a chronic systemic autoimmune disease that would potentiate many pathological complications,including hemolytic *** study aimed to investigate the role of hypoxamiRs in SLE/hemolytic anemia *** This work was designed to analyze the circulating levels of↱the miR-210 and miR-21 expressions and hypoxia-inducible factor-1α(HIF-α)in SLE/hemolytic anemia *** activity was evaluated for all patients by SLE Disease Activity Index(SLEDAI).Clinical manifestations/complications and serological/hematological investigations were ***-αconcentration was assayed by ELISA and expression of miR-21 and miR-210 was analyzed by *** The results indicated that the fold change of the miR-210/miR-21 expressions in plasma was significantly elevated in SLE/hemolytic anemia patients.A strong positive correlation between the miR-210 and miR-21 expression levels was also *** the associated-disease complications,hypertension,arthritis,oral ulcers,and serositis were associated with a high circulating miR-210 expression,while the occurrence of renal disorders was associated with the increased miR-21 ***,the HIF-αlevel was remarkably elevated in SLE/hemolytic anemia patients.A high positive correlation was recorded between the HIF-αconcentration and miR-210/miR-21 expression *** occurrence of oral ulcers,arthritis,and hypertension was associated with the increased HIF-α*** the other hand,SLEDAI and white blood cell count were positively correlated with miR-21/*** erythrocyte sedimentation rate was positively correlated with *** The dysregulation of the circulating miR-210/miR-210/HIF-1αlevels in SLE/hemolytic anemia pat

关键词： circulating hypoxamiRs miR-210 and miR-21 hypoxia-inducing factor-1α hemolytic anemia systemic lupus erythematosus

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Adipose tissue-derived mesenchymal stem cells and chitosan/poly(vinyl alcohol)nanofibrous scaffolds for cartilage tissue engineering

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Cell Regeneration 2020年第1期9卷 62-73页

作者： Ghada Nour-eldeen mazen Abdel-Rasheed amira m.EL-Rafei Osama Azmy Gehan T.El-Bassyouni molecular Genetics and Enzymology Department National Research CentreDokkiCairo 12622Egypt Stem Cell Research group Medical Research Centre of ExcellenceNational Research CentreCairo 12622Egypt Reproductive Health Research Department National Research Centre33 El-Buhouth StDokkiCairo 12622Egypt Refractories Ceramics and Building Materials DepartmentNational Research CentreDokkiCairo 12622Egypt

Osteoarthritis(OA)has been defined as a chronic inflammatory joint disease characterized by progressive articular cartilage *** growing interest in regenerative medicine,using cell therapy and tissue engineering,where cellular components in combination with engineered scaffolds and bioactive materials were used to induce functional tissue *** the present study,nanofibrous scaffold based on chitosan(CS)/poly(vinyl alcohol)(PVA)were used to develop biologically functionalized biomaterial to mimic the extracellular matrix,allowing the human adipose tissue derived mesenchymal stem cells(ADSCs)to proliferate and differentiate to chondrogenic *** morphology of the nanofibrous mat was examined using field emission scanning electron microscope(FE/SEm).The characteristic functional groups and the nature of the chemical bonds between atoms were evaluated using Fourier transform infrared spectroscopy(FTIR)*** of the seeded cells was morphologically evaluated by scanning electron microscopy and by flow cytometry for the expression of the stem cell surface *** differentiation potential was verified after chondrogenic induction by analyzing the expression of chondrogenic marker genes using real-time(RT PCR).Current study suggest significant potential for the use of ADSCs with the nanofibrous scaffolds in improving the osteoarthritis pathology.

关键词： Adipose tissue mesenchymal stem cells Nanofibrous scaffolds Osteoarthritis Cartilage tissue engineering

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A Weighted multi-Layer Analytics Based model for Emoji Recommendation

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Computers, materials & Continua 2024年第1期78卷 1115-1133页

作者： amira m.Idrees Abdul Lateef marzouq Al-Solami Faculty of Computers and Information Technology Future University in EgyptCairo11835Egypt Alkamil College of Science and Arts University of JeddahJeddah21959Saudi Arabia

The developed system for eye and face detection using Convolutional Neural Networks(CNN)models,followed by eye classification and voice-based assistance,has shown promising potential in enhancing accessibility for individuals with visual *** modular approach implemented in this research allows for a seamless flow of information and assistance between the different components of the *** research significantly contributes to the field of accessibility technology by integrating computer vision,natural language processing,and voice *** leveraging these advancements,the developed system offers a practical and efficient solution for assisting blind *** modular design ensures flexibility,scalability,and ease of integration with existing assistive ***,it is important to acknowledge that further research and improvements are necessary to enhance the system’s accuracy and ***-tuning the CNN models and expanding the training dataset can improve eye and face detection as well as eye classification ***,incorporating real-time responses through sophisticated natural language understanding techniques and expanding the knowledge base of ChatGPT can enhance the system’s ability to provide comprehensive and accurate ***,this research paves the way for the development of more advanced and robust systems for assisting visually impaired *** leveraging cutting-edge technologies and integrating them into amodular framework,this research contributes to creating a more inclusive and accessible society for individuals with visual *** work can focus on refining the system,addressing its limitations,and conducting user studies to evaluate its effectiveness and impact in real-world scenarios.

关键词： Social networks text analytics emoji prediction features extraction information retrieval

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A Proposed Feature Selection Particle Swarm Optimization Adaptation for Intelligent Logistics--A Supply Chain Backlog Elimination Framework

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Computers, materials & Continua 2024年第6期79卷 4081-4105页

作者： Yasser Hachaichi Ayman E.Khedr amira m.Idrees College of Computing and Information Technology at Khulais Department of Information SystemsUniversity of JeddahJeddah21959Saudi Arabia Faculty of Computers and Information Technology Future University in EgyptCairo11835Egypt

The diversity of data sources resulted in seeking effective manipulation and *** challenge that arises from the increasing dimensionality has a negative effect on the computation performance,efficiency,and stability of *** of the most successful optimization algorithms is Particle Swarm Optimization(PSO)which has proved its effectiveness in exploring the highest influencing features in the search space based on its fast convergence and the ability to utilize a small set of parameters in the search *** research proposes an effective enhancement of PSO that tackles the challenge of randomness search which directly enhances PSO *** the other hand,this research proposes a generic intelligent framework for early prediction of orders delay and eliminate orders backlogs which could be considered as an efficient potential solution for raising the supply chain *** proposed adapted algorithm has been applied to a supply chain dataset which minimized the features set from twenty-one features to ten significant *** confirm the proposed algorithm results,the updated data has been examined by eight of the well-known classification algorithms which reached a minimum accuracy percentage equal to 94.3%for random forest and a maximum of 99.0 for Naïve ***,the proposed algorithm adaptation has been compared with other proposed adaptations of PSO from the literature over different *** proposed PSO adaptation reached a higher accuracy compared with the literature ranging from 97.8 to 99.36 which also proved the advancement of the current research.

关键词： Optimization particle swarm optimization algorithm feature selection logistics supply chain management backlogs

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Tribological Investigation of HDPE-cuttlebone and HDPE-red Coral Composites

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Journal of Bionic Engineering 2019年第6期16卷 1068-1079页

作者： amira Salem Walid Bensalah Salah mezlini Universite de monastir Ecole Nationale d'Ingenieurs de Monastir(ENIM)Laboratoire de Genie Mecanique(LGM)LR99ES325019MonastirTunisia

In this paper,the tribological properties of cuttlebone(CB)-reinforced high density polyethylene(HDPE)and Red Coral(RC)-reinfbrced HDPE composites were *** composite specimens were prepared with a hot compression molding machine using different weight proportions of fillers blended with *** tribological behavior of the composite disks was studied using pin-on-disk tribometer under dry condition against stainless steel m30NW *** coefficient of friction as well as wear rate were examined to study the effects of the two fillers on the tribological perfonnance of both *** wear tests,different composites were examined using a Scanning Electron microscope(SEm).It was fbund that the use of cuttlebone(CB)and Red Coral(RC)as reinforcement improved the tribological properties of HDPE.

关键词： cuttlebone-reinforced HDPE red coral-reinforced HDPE wear rate friction coefficient wear mechanism

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Empirical investigation to explore potential gains from the amalgamation of phase changing materials(PCms)and wood shavings

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Energy and Built Environment 2021年第3期2卷 315-326页

作者： Adham m.mohammed amira Elnokaly Abdel monteleb m.Aly Department of Architecture Faculty of EngineeringUniversity of AssuitEgypt School of Architecture and the Built Environment University of LincolnUK

The reduction of gained heat,heat peak shifting,and the mitigation of air temperature fluctuations are some desirable properties that are sought after in any thermal insulation *** cannot be overstated that these fac-tors,in addition to others,govern the performance of such systems thus their effect on indoor ambient *** effect of such systems extends also to Heating,Ventilation and Air-conditioning(HVAC)systems that are set up to operate optimally in certain *** literature shows that PCms and natural materials such as wood-shavings can provide efficient passive insulation for buildings,it is evident that such approaches utilise methods that are of a degree of intricacy which require specialist knowledge and complex techniques,such as micro-encapsulation for *** technical and economic aspects in mind,an amalgam of PCm and wood-shavings has been created to be utilised as a feasible thermal *** amalgamation was performed in the simplest of methods,through submerging the wood shavings in *** experimental procedure was devised to test the thermal performance of the amalgam and compare this to the performance of the same un-amalgamated *** analysis revealed that no significant thermal gains would be expected from such ***,a significant reduction in the total weight of the insulation system would be achieved that,in this case,shown to be up to 20.94%.Thus,further reducing possible strains on structural elements due to the application of insulation on *** can be especially beneficial in vernacular architectural approaches where considerably large amounts and thicknesses of insulations are *** addition,cost reduction could be attained as wood shavings are significantly cheaper compared to the cost of PCms.

关键词： PCms Heat peak Heat peak shift Thermal performance Wood shavings By-products

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Solute transport and geochemical modeling of the coastal quaternary aquifer, Delta Dahab Basin, South Sinai, Egypt

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Acta Geochimica 2024年第1期43卷 16-39页

作者： amira Samy mustafa Eissa Seham Shahen moustafa m.Said Rabab m.Abou-shahaba Division of Water Resources and Arid Land Department of HydrogeochemistryDesert Research CenterCairoEgypt Egypt Desalination Research Center of Excellence Desert Research CenterCairoEgypt Center for Water Supply Studies S&E-Physical&Environmental SciencesTexas A&M University Corpus ChristiCorpus ChristiUSA Department of Chemistry Faculty of Science(Girls)Al-Azhar UniversityYousef Abbas StrNasr CityP.O.Box:11754CairoEgypt

The wadi dahab delta is in a dry, arid coastal zone within Egypt’s south Sinai Peninsula’s eastern portion. The primary water source is the Quaternary coastal alluvial aquifer. The groundwater salinity varies from 890to 8213 mg/L, with a mean value of 3417 mg/L. The dissolved major ions have been used to calculate the seawater mixing index(SWmI) using a linear equation that discriminates the groundwater mostly affected by water–rock interaction(SWmI 1>) and other samples mixed with Seawater(SWmI mposition of groundwater for specifically chosen groundwater samples ranges from-0.645‰ to +5.212‰ for δ^(18)O and from-9.582‰ to + 22.778‰ for δ^(2)H, where the seawater represented by a Red Sea water sample(δ^(18)O + 1.64‰-δ^(2)H + 9.80‰) and reject brine water are considerably enriched the isotopic groundwater values. The geochemical NETPATH model constrained by the dissolved significant ions, isotopes, and the rock aquifer forming minerals as phases indicate the mixing percent with the seawater ranges from 9% to 97% of seawater from 91% to 3% of original recharge water. According to the SEAWAT 3-D flow models, seawater has penetrated the Northeastern Dahab delta aquifer, with the intrusion zone extending1500 m inland. The salt dissolution, upwelling of saline water, recharge from the upstream mountain block, and seawater encroachment are the primary aspects contributing to the deterioration of groundwater quality. These findings may have significance for effective groundwater withdrawal management in arid locations worldwide with similar hydrogeological systems.

关键词： Groundwater geochemistry Seawater intrusion Solute transport SEAWAT

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Therapeutic Effect of Dimethyl Dimethoxy Biphenyl Dicarboxylate on Collagen-Induced Arthritis in Rats

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Chinese Journal of Integrative medicine 2015年第11期21卷 846-854页

作者： Roba m Talaat amira S Abo-EI-Atta Sabah m Farou Karima I EI-Dosoky molecular Biology Department Genetic Engineering and Biotechnology Research InstituteMenofia UniversitySadat Branch Pathology Department Faculty of MedicineTanta University

Objective： To study the effect of oral administration of dimethyl dimethoxy biphenyl dicarboxylate （DDB） on adjusting angiogeneic/inflammatory mediators and ameliorating the pathology of bones in rats with collagen-induced arthritis （CIA）. methods： Wistar rat model of CIA was set up using bovine collagen type H. Fifty rats were divided into five groups randomly： normal, CIA model, DDB treatment, methotrexate （mTX） treatment, and combined DDB＋mTX treatment. Ankle joints of rats were imaged with digital X-ray machine to show the destruction of joints. Fore and hind paw and knee joints were removed above the ankle joint then processed for haematoxylin and eosin staining. Plasma levels of vascular endothelial growth factor （VEGF）, platelet derived growth factor, interleukin-8 （IL-8）, IL-4, tumor necrosis factor α （TNF-α）, and cyclooxygenase-2 （COX-2） were quantified by enzyme-linked immunosorbent assay. Nitric oxide levels were detected by Griess reagent. Results： Compared with the CIA model group, a remarkable reduction in various angiogenic （VEGF and IL-8） and inflammatory mediators （TNF-α, IL-4 and COX-2） after treatment with DDB either alone or combined with mTX （P〈0.05 or P〈0.01）. Histopathological and X-ray findings were confirmatory to the observed DDB anti-arthritic effect. The DDB-treated group showed amelioration in signs of arthritis which appeared essentially similar to normal. Conclusion： Our data shed light on the therapeutic efficacy of DDB in experimental rheumatoid arthritis （RA） compared with a choice drug （mTX） and it may be offered as a second-line drug in the treatment of RA.

关键词： rheumatoid arthritis collagen-induced arthritis dimethyl dimethoxy biphenyl dicarboxylate angiogenesis inflammation

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Reproductive cycle,sexual maturity and fecundity of Nemipterus furcosus(Valenciennes,1830)

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Aquaculture and Fisheries 2021年第4期6卷 424-431页

作者： mustafizur m.Rahman amira F.Samat Institute of Oceanography and maritime Studies International Islamic University Malaysia(IIUM)Kg.Cherok PalohKuantanPahang26160Malaysia Department of marine Science IIUMJalan Sultan Ahmad ShahBandar Indera MahkotaKuantanPahang25200Malaysia Universiti malaysia Perlis Sungai ChuchuhPadang BesarPerlis02100Malaysia

Understanding the reproductive biology particularly sexual maturity,reproductive cycle and fecundity of fish is useful for fisheries ***,there is no information about reproductive biology of Nemipterus *** study addresses this deficit for *** conducted a 12-month study to understand the reproductive biology particularly the sex ratio,sexual maturity,fecundity and reproductive cycle of *** at the east coast of peninsular *** indicated that ratios of male and female were statistically similar up to 19.0 cm TL(total length).male outnumbered female above 19.0 cm TL(Pmean fecundity of 102,477±43,580(standard deviation).male and female fish reached first sexual maturation at almost same size,15.8 and 15.6 cm,*** information is needed to determine the lowest acceptable harvest length of this fish under the management aim to enter all female fish for reproduction minimum one time in their *** estimated the reproductive period of *** applying oocytes diameter,histological examination of ovaries and monthly mean *** of these methods gave a consistent result about spawning season,which appeared to be from march to July with peaks in march and *** on this result,*** spawners can be protected during march to July for entering the reproductive *** from artificial breeding,the results of this study might facilitate future efforts at fine-tuning fishing effort for a proper management of ***.

关键词： Gonadal histology Sexual maturity Nemipterus furcosus Oocytes diameter South China Sea

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mineralogy and Geochemistry of Uraniferous Sandstones in Fault Zone,Wadi El Sahu Area,Southwestern Sinai,Egypt:Implications for Provenance,Weathering and Tectonic Setting

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Acta Geologica Sinica(English Edition) 2021年第3期95卷 830-845页

作者： Osama R.SALLAm Hamed ImIRA amira m.El TOHAmY Abd Elhadi AABBAS Nuclear materials Authority El-Maadi Cairo P.O.Box:530Egypt

Paleozoic rocks in the Wadi El Sahu area are affected by many major faults in different directions.A reverse fault trending NE-SW is exposed for about 300 m of its length as it cuts through the Abu Hamata and Adedia formations on the south side of Wadi El Sahu.A secondary ascending hydrothermal solution carrying heavy metals and radioactive minerals passed through the fault plain and the surrounding fractures,forming mineralized and radioactive *** mineralized zone thickness ranges from 60 cm to 200 cm along the fault *** rocks were analyzed radiometrically using a portable gamma-ray spectrometer,chemically by employing ICP-ES and ICP-mS,as well as mineralogically by both binocular and Environmental Scanning Electron *** content was also determined by fire *** and U contents reached up to 2682 and 1216 ppm,*** investigations indicated the presence of uraninite,torbernite,autunite,sklodowskite,kasolite as uranium minerals,thorite as a thorium mineral,monazite,allanite and xenotime as REE-bearing minerals,zircon and columbite as accessory minerals,gold and nickel as precious and base metals,in addition to cassiterite,chalcopyrite,chalcocite and *** REE and U contents are attributed to the circulation of epigenetic U and REE-bearing hydrothermal solutions along the fault plain and its surrounding *** alteration processes could then be confirmed by the presence of the m-type tetrad effect in the REE-patterns of the ferruginous *** non-chondritic ratio of Nb/Ta,Zr/Hf and Y/Ho in the studied sandstone may be attributed to the tetrad *** Ce and Eu anomaly with unusual REE-patterns was represented by the presence of conjugated m-W tetrad effects,indicating either the dual effect of hydrothermal solutions or groundwater with *** results clarify that the tetrad-effects could be used as evidence for the environment of deposition and as an indication for gold minerali

关键词： uranium gold RREs tetrad effect

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