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Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways

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World Journal of Gastroenterology 2020年第24期26卷 3365-3400页

作者： Aida Kamalian Masoud Sohrabi Asl Mahsa Dolatshahi Khashayar Afshari Shiva Shamshiri Nazanin Momeni Roudsari Saeideh Momtaz Roja Rahimi Mohammad Abdollahi amir hossein Abdolghaffari Department of Medicine Tehran University of Medical SciencesTehran ***Iran Students'Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Department of Traditional Pharmacy School of Persian MedicineTehran University of Medical SciencesTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehran ***Iran Medicinal Plants Research Center Institute of Medicinal PlantsACECRTehran ***Iran Toxicology and Diseases Group(TDG) Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)and Department of Toxicology and PharmacologySchool of PharmacyTehran University of Medical SciencesTehran ***Iran Gastrointestinal Pharmacology Interest Group Universal Scientific Education and Research NetworkTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran

Inflammatory bowel disease(IBD)refers to a group of disorders characterized by chronic inflammation of the gastrointestinal(GI)*** elevated levels of nitric oxide(NO)in serum and affected tissues;mainly synthesized by the inducible nitric oxide synthase(iNOS)enzyme;can exacerbate GI inflammation and is one of the major biomarkers of GI *** natural and synthetic agents are able to ameliorate GI inflammation and decrease iNOS expression to the extent comparable with some IBD ***,the purpose of this study was to gather a list of natural or synthetic mediators capable of modulating IBD through the NO *** databases including Google Scholar and PubMed were searched from 1980 to May *** found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factorκB(NF-κB)and JAK/STAT signaling *** and probiotics can also alter the GI microbiota and reduce NO expression in IBD models through a broad array of mechanisms.A number of synthetic molecules have been found to suppress NO expression either dependent on the NF-κB signaling pathway(i.e.,dexamethasone,pioglitazone,tropisetron)or independent from this pathway(i.e.,nicotine,prednisolone,celecoxib,β-adrenoceptor antagonists).Co-administration of natural and synthetic agents can affect the tissue level of NO and may improve IBD symptoms mainly by modulating the Toll like receptor-4 and NF-κB signaling pathways.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Nitric oxide Nuclear factor-κB Natural or synthetic mediators

二氧化硅包覆NiFe_2O_4担载Preyssler杂多酸用于合成双(二氢嘧啶酮)苯和3,4-二氢嘧啶-2(1H)-酮（英文）

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催化学报 2015年第3期36卷 299-307页

作者： hossein Eshghi Ali Javid amir Khojastehnezhad Farid Moeinpour Fatemeh F. Bamoharram Mehdi Bakavoli Masoud Mirzaei Department of Chemistry Faculty of Sciences Ferdowsi University of Mashhad Mashhad Iran Department of Chemistry Ahvaz Branch Islamic Azad University Ahvaz Iran Department of Chemistry Bandar Abbas Branch Islamic Azad University Bandar Abbas *** Iran Department of Chemistry College of Science Mashhad Branch Islamic Azad University Mashhad Iran

A novel magnetic acidic catalyst comprising Preyssler(H14[Na P5W30O110]) heteropoly acid support‐ed on silica coated nickel ferrite nanoparticles (Ni Fe2O4@Si O2) was *** catalyst was characterized by Fourier transform infrared,scanning electron microscopy,transmission electron microscopy,X‐ray diffraction,energy dispersive spectrum,VSM and particle size *** catalytic activity was investigated for the synthesis of bis(dihydropyrimidinone)benzene and 3,4‐dihydropyrimidin‐2(1H)‐ones derivatives by the Biginelli *** the catalyst,the reac‐tions occurred in less than 1 h with good to excellent *** importantly,the catalyst was easily separated from the reaction mixture by an external magnet and reused at least five times without degradation in the activity.

关键词：二氢嘧啶酮催化合成纳米颗粒镍铁二氧化硅扫描电子显微镜透射电子显微镜反应混合物

Predicting the Two-Phase Liquid-Solid Drag Model Using the Calculus of Variation

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Journal of Applied Mathematics and Physics 2018年第1期6卷 103-113页

作者： Hamid Reza Nazif amir hossein Javadi Neda Fallahnezhad Department of Mechanical Engineering Imam Khomeini International University (IKIU) Qazvin Iran

The simplified momentum equations of the two-phase flow have been adopted as the basic assumptions in this study. For vessels of small diameter, the shear stress becomes important and the friction pressure drop proposed by Ergun considers this effect by involving the wall effect. By replacing the Ergun pressure drop and the first order velocity term for particles drag model in the momentum equations, the relation for the drag coefficient versus the volume fraction is obtained. The calculus of variations is used with certain restriction for extremization of this drag coefficient. An analytical correlation for the drag coefficient is obtained depending on the volume fraction of “fluid particles”. The drag function obtained in previous studies does not match with the empirical data in the bed volume fraction range of [0.45 to 0.59]. Therefore, the function is modified and the results are better adjusted with the empirical data.

关键词： Calculus of Variations Drag Coefficient Ergun Pressure Drop Fluidization

Non-alcoholic fatty liver disease is not independent risk factor for cardiovascular disease event:A cohort study

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World Journal of Hepatology 2020年第6期12卷 323-331页

作者： Nima Motamed hossein Ajdarkosh Maral Ahmadi Dhayaneethie Perumal G hossein Ashrafi Mehdi Nikkhah amir hossein Faraji Mansooreh Maadi Mahmoodreza Khoonsari Nader Rezaie Behzad Farahani Fahimeh Safarnezhad Tameshkel Mitra Ameli Mahshid Panahi Mohammad Hadi Karbalaie Niya Farhad Zamani Department of Social Medicine Zanjan University of Medical SciencesZanjan ***Iran Gastrointestinal and Liver Diseases Research Center Iran University of Medical SciencesTehran ***Iran Faculty of Science Engineering and ComputingKingston UniversityKingstonLondon KT12EEUnited Kingdom Cancer Theme SEC Faculty Penrhyn Road Kingston UniversityLondon KT12EEUnited Kingdom Department of Pulmonology Firouzgar HospitalIran University of Medical SciencesTehran ***Iran Department of Cardiology Iran University of Medical SciencesTehran ***Iran

BACKGROUND There are no consistent results between previous studies for an independent association between non-alcoholic fatty liver disease(NAFLD)and cardiovascular disease(CVD)*** To determine if there is an independent association between NAFLD and CVD *** In the present study,valid outcome data of 4808 subjects were available for phase 2 of our cohort *** subjects had been followed up for seven years from phase 1,beginning in 2009-2010 to phase 2 during *** and multiple Cox proportional models were used to determine the association between NAFLD in the primary phase of the cohort and subsequent fatal and non-fatal CVD events during *** The incidence of non-fatal CVD events in males with NAFLD was significantly higher(P=0.004)than in males without NAFLD.A positive association was demonstrated between NAFLD and non-fatal CVD events in males(Hazard ratio=1.606;95%CI:1.166-2.212;P=0.004)by the simple Cox proportional hazard model,but no independent association was detected between these in the multiple Cox *** No independent association was detected between NAFLD and *** is likely that diabetes mellitus and age may be the principle mediators in this regard.

关键词： Non-alcoholic fatty liver disease Cardiovascular disease Cohort Type 2 diabetes mellitus Risk factor Follow up

Genetic Predisposition to Numerous Large Ulcerating Basal Cell Carcinomas and Response to Immune Therapy

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International Journal of Dermatology and Venereology 2021年第2期4卷 70-75页

作者： Bahar Dasgeb Leila Youssefian amir hossein Saeidian Jun Kang Wenyin Shi Elizabeth Shoenberg Adam Ertel Paolo Fortina Hassan Vahidnezhad Jouni Uitto Department of Surgical Oncology Rutgers Cancer Institute of New JerseyNew BrunswickNJ 08903USA Department of Dermatology and Cutaneous Biology Sidney Kimmel Medical Collegeand Jefferson Institute of Molecular MedicineThomas Jefferson UniversityPhiladelphiaPA 19107USA Genetics Genomics and Cancer Biology PhD ProgramThomas Jefferson UniversityPhiladelphiaPA 19107USA Department of Radiation Oncology Thomas Jefferson UniversityPhiladelphiaPAUSA Department of Internal Medicine Mercy Medical CenterBaltimoreMD 21202USA Department of Cancer Biology Sidney Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphiaPA 19107USA

Objective:Well-defined germ-line mutations in thePTCH1 gene are associated with syndromic multiple basal cell carcinomas(BCCs).Here,we used whole exome sequencing(WES)to identify the role of patched-1 in patients with multiple,unusually large ***:A 72-year old patient presenting with numerous BCCs progressing to large ulcerating lesions was *** was used to identify the pathogenic gene ***:Genetic work-up by WES identified a homozygousPTCH1 nonsense mutation in the tumor tissue but not present in her blood cells or in non-lesional *** addition,heterozygous missense mutations were identified in three cancer-associated genes(EPHB2,RET,andGALNT12)in blood cells as well as in lesional and non-lesional *** also tested systemic immune therapy as a potentially beneficial approach to treat patients with numerous large BCCs on scatted areas of involvement.A rapid and sustained response to nivolumab was noted,suggesting that it is an efficacious drug for long-term therapeutic ***:PTCH1,EPHB2,RET,andGALNT12 may potentially contribute to the synergistic oncogene driven malignant transformation manifesting as multiple,unusually large BCCs.

关键词： immune therapy malignant transformation gene-susceptibility non-syndromic basal cell carcinoma PTCH1 skin neoplasms

Optimization of the fully grouted rock bolts for load transfer enhancement

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International Journal of Mining Science and Technology 2015年第5期25卷 707-712页

作者： Ghadimi Mostafa Shahriar Korosh Jalalifar hossein Department of Mining Engineering Tehran Science and Research BranchIslamic Azad University Faculty of Mining Metallurgy and Petroleum EngineeringAmir Kabir University of Technology Department of Petroleum and Mining Engineering Environmental and Energy Research CenterShahidBahonar University of Kerman

The purpose of this study is to investigate the role of bolt profile configuration in load transfer capacity between the bolt and ***,five types of rock bolts are used with different *** rock bolts are modeled by ANSYS *** show that profile rock bolt T_3 and T_ with load capacity 180 and 195 kN in the jointed rocks,are the optimum ***,the performances of the selected profiles are examined in Tabas Coal Mine by FLAC *** is good subscription between the results of numerical modeling and instrumentation reading such as tells tale,sonic extensometer and strain gauge rock *** to the finding of this study,the proposed pattern of rock bolts,on 7 + 6 patterns per meter with 2 flexi bolt(4 m) for support gate road.

关键词：全长粘结式锚杆优化配置荷载传递强化 FLAC软件配置文件 ANSYS 负荷转移

COCM: Class Based Optimized Congestion Management Protocol for Healthcare Wireless Sensor Networks

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Wireless Sensor Network 2013年第7期5卷 137-149页

作者： Abbas Ali Rezaee Mohammad hossein Yaghmaee amir Masoud Rahmani Department of Computer Engineering Ferdowsi University of Mashhad Mashhad Iran Department of Computer Engineering Science and Research Branch Islamic Azad University Tehran Iran

Wireless Sensor Networks (WSNs) consist of numerous sensor nodes which can be used in many new emerging applications like healthcare. One of the major challenges in healthcare environments is to manage congestion, because in applications, such as medical emergencies or patients remote monitoring, transmitted data is important and critical. So it is essential in the first place to avoid congestion as much as possible and in cases when congestion avoidance is not possible, to control the congestion. In this paper, a class based congestion management protocol has been proposed for healthcare applications. We distinguish between sensitive, non-sensitive and control traffics, and service the input traffics based on their priority and quality of service requirements (QoS). The proposed protocol which is called COCM avoids congestion in the first step using multipath routing. The proposed AQM algorithm uses separate virtual queue's condition on a single physical queue to accept or drop the incoming packets. In cases where input traffic rate increases and congestion cannot be avoided, it mitigates congestion by using an optimized congestion control algorithm. This paper deals with parameters like end to end delay, packet loss, energy consumption, lifetime and fairness which are important in healthcare applications. The performance of COCM was evaluated using the OPNET simulator. Simulation results indicated that COCM achieves its goals.

关键词： Wireless Sensor Networks Active Queue Management Congestion Control Healthcare Multi Path Routing

A new analytical solution for calculation the displacement and shear stress of fully grouted rock bolts and numerical verifications

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International Journal of Mining Science and Technology 2016年第6期26卷 1073-1079页

作者： Ghadimi Mostafa Shariar Koroush Jalalifar hossein Department of Mining Engineering Science and Research Branch Islamic Azad University Tehran *** Iran Faculty of Mining Metallurgy and Petroleum Engineering Amir Kabir University of Technology Tehran 158754413 Iran Department of Petroleum and Mining Engineering Shahid Bahonar University of Kerman Kerman *** Iran

In presence of difficult conditions in coal mining roadways, an adequate stabilization of the excavation boundary is required to ensure a safe progress of the construction. The stabilization of the roadways can be improved by fully grouted rock bolt, offering properties optimal to the purpose and versatility in use. Investigations of load transfer between the bolt and grout indicate that the bolt profile shape and spacing play an important role in improving the shear strength between the bolt and the surrounding strata. This study proposes a new analytical solution for calculation displacement and shear stress in a fully encapsulated rock bolt in jointed rocks. The main characteristics of the analytical solution consider the bolt profile and jump plane under pull test conditions. The performance of the proposed analytical solution, for three types of different bolt profile configurations, is validated by ANSYS software. The results show there is a good agreement between analytical and numerical methods. Studies indicate that the rate of displacement and shear stress from the bolt to the rock exponentially decayed. This exponential reduction in displacement and shear stress are dependent on the bolt characteristics such as: rib height, rib spacing, rib width and grout thickness, material and joint properties.

关键词：锚杆应力剪切应力解析解位移数值验证灌浆计算回采巷道

Automatic Guidance of an Agricultural Tractor along with the Side Shift Control of the Attached Row Crop Cultivator

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Journal of Agricultural Science and Technology(B) 2012年第1期2卷 151-158页

作者： Javad Robati hossein Navid Mahdi Rezaei amir Rikhtehgar Ghiasi Faculty of Agricultural University of Tabriz Tabriz lran Faculty of Mechanical Engineering Sahand University of Technology Tabriz Iran Faculty of Computer and Electrical Engineering University of Tabriz Tabriz Iran

This paper presents the automatic guidance system of an agricultural tractor and the side shift control of the attached row crop cultivator using electro-hydraulic actuators. In order to simulate the dynamic behaviour of the tractor along with the attached cultivator, the modified bicycle model was adopted. Steering angle sensor, fibre optic gyroscope (FOG) and RTK-DGPS technologies are assumed for measurements of the steering angle, yaw rate and the lateral position of the tractor, respectively. The kinematics model was used for the implement. In this study four cascade controllers were designed and simulated for tractor guidance which consists of PD, PD, P and PID controllers. Other PI and PID controllers also had been designed for implement side shifting purpose. Then, these two systems were combined and the performance of the whole system was evaluated through the simulation results. According to the results tractor reaches the desired path after less than 10 seconds. Simulations showed that the maximum deviation of the tractor from the desired path was about 5 cm within this period. And the cultivator blades would follow the predetermined path with steady state error of about 5 cm too.

关键词：农用拖拉机制导系统侧移控制中耕机 PID控制器 GPS定位技术运动学模型转向角度