Non-alcoholic fatty liver disease is not independent risk factor for cardiovascular disease event:A cohort study

作     者：Nima Motamed Hossein Ajdarkosh Maral Ahmadi Dhayaneethie Perumal G Hossein Ashrafi Mehdi Nikkhah Amir Hossein Faraji Mansooreh Maadi Mahmoodreza Khoonsari Nader Rezaie Behzad Farahani Fahimeh Safarnezhad Tameshkel Mitra Ameli Mahshid Panahi Mohammad Hadi Karbalaie Niya Farhad Zamani 

作者机构：Department of Social MedicineZanjan University of Medical SciencesZanjan ***Iran Gastrointestinal and Liver Diseases Research CenterIran University of Medical SciencesTehran ***Iran Faculty of ScienceEngineering and ComputingKingston UniversityKingstonLondon KT12EEUnited Kingdom Cancer Theme SEC Faculty Penrhyn RoadKingston UniversityLondon KT12EEUnited Kingdom Department of PulmonologyFirouzgar HospitalIran University of Medical SciencesTehran ***Iran Department of CardiologyIran University of Medical SciencesTehran ***Iran 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第6期

页      面：323-331页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Non-alcoholic fatty liver disease Cardiovascular disease Cohort Type 2 diabetes mellitus Risk factor Follow up 

摘      要：BACKGROUND There are no consistent results between previous studies for an independent association between non-alcoholic fatty liver disease(NAFLD)and cardiovascular disease(CVD)*** To determine if there is an independent association between NAFLD and CVD *** In the present study,valid outcome data of 4808 subjects were available for phase 2 of our cohort *** subjects had been followed up for seven years from phase 1,beginning in 2009-2010 to phase 2 during *** and multiple Cox proportional models were used to determine the association between NAFLD in the primary phase of the cohort and subsequent fatal and non-fatal CVD events during *** The incidence of non-fatal CVD events in males with NAFLD was significantly higher(P=0.004)than in males without NAFLD.A positive association was demonstrated between NAFLD and non-fatal CVD events in males(Hazard ratio=1.606;95%CI:1.166-2.212;P=0.004)by the simple Cox proportional hazard model,but no independent association was detected between these in the multiple Cox *** No independent association was detected between NAFLD and *** is likely that diabetes mellitus and age may be the principle mediators in this regard.