Non-alcoholic fatty liver disease is not independent risk factor for cardiovascular disease event:A cohort study
作者机构:Department of Social MedicineZanjan University of Medical SciencesZanjan ***Iran Gastrointestinal and Liver Diseases Research CenterIran University of Medical SciencesTehran ***Iran Faculty of ScienceEngineering and ComputingKingston UniversityKingstonLondon KT12EEUnited Kingdom Cancer Theme SEC Faculty Penrhyn RoadKingston UniversityLondon KT12EEUnited Kingdom Department of PulmonologyFirouzgar HospitalIran University of Medical SciencesTehran ***Iran Department of CardiologyIran University of Medical SciencesTehran ***Iran
出 版 物:《World Journal of Hepatology》 (世界肝病学杂志(英文版)(电子版))
年 卷 期:2020年第12卷第6期
页 面:323-331页
学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题:Non-alcoholic fatty liver disease Cardiovascular disease Cohort Type 2 diabetes mellitus Risk factor Follow up
摘 要:BACKGROUND There are no consistent results between previous studies for an independent association between non-alcoholic fatty liver disease(NAFLD)and cardiovascular disease(CVD)*** To determine if there is an independent association between NAFLD and CVD *** In the present study,valid outcome data of 4808 subjects were available for phase 2 of our cohort *** subjects had been followed up for seven years from phase 1,beginning in 2009-2010 to phase 2 during *** and multiple Cox proportional models were used to determine the association between NAFLD in the primary phase of the cohort and subsequent fatal and non-fatal CVD events during *** The incidence of non-fatal CVD events in males with NAFLD was significantly higher(P=0.004)than in males without NAFLD.A positive association was demonstrated between NAFLD and non-fatal CVD events in males(Hazard ratio=1.606;95%CI:1.166-2.212;P=0.004)by the simple Cox proportional hazard model,but no independent association was detected between these in the multiple Cox *** No independent association was detected between NAFLD and *** is likely that diabetes mellitus and age may be the principle mediators in this regard.