检索结果-南通市图书馆

CRISPR,CAR-T,and NK:Current applications and future perspectives

Genes & Diseases 2024年第4期11卷 246-257页

作者： Mohadeseh Khoshandam hossein Soltaninejad amir Ali Hamidieh Saman hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom branch***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14965/161Iran Department of stem cells technology and Tissue Regeneration Faculty of Interdisciplinary Science and TechnologiesTarbiat Modares UniversityTehran 15614Iran Pediatric Cell Therapy and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran University of Medical SciencesTehran ***Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 15614Iran

Chimeric antigen receptor T(CAR-T)cell therapy represents a breakthrough in personalized cancer *** this regard,synthetic receptors comprised of antigen recognition domains,signaling,and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy *** the success of this approach in refractory B-cell malignancies,the optimal potency of CAR T-cell therapy for many other cancers,particularly solid tumors,has not been *** killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity *** on these studies,many investigations are focused on the accurate designing of CAR T-cells with clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system or other novel gene editing tools that can induce hereditary changes with or without the presence of a double-stranded break into the *** methodologies can be specifically focused on negative controllers of T-cells,induce modifications to a particular gene,and produce reproducible,safe,and powerful allogeneic CAR T-cells for on-demand cancer *** improvement of the CRISPR/Cas9 innovation offers an adaptable and proficient gene-editing capability in activating different pathways to help natural killer cells interact with novel CARs to particularly target tumor *** achievements and future challenges of combining next-generation CRISPR-Cas9 gene editing tools to optimize CAR T-cell and natural killer cell treatment for future clinical trials toward the foundation of modern cancer treatments have been assessed inthis review.

关键词： Cancer CAR T-cell CRISPR Gene editing Immunotherapy NK cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

引用

Genes & Diseases 2024年第1期11卷 268-282页

作者： Mohadeseh Khoshandam hossein Soltaninejad Marziyeh Mousazadeh amir Ali Hamidieh Saman hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom BranchQom ***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14155-6463Iran Faculty of Interdisciplinary Science and Technology Tarbiat Modares UniversityTehran 14117-13116Iran Pediatric Cell and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran UniversityofMedical SciencesTehran14155-6559Iran Department of Nanobiotechnology Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran

CRISPR/Cas9 is an effective gene editing tool with broad applications for the pre-vention or treatment of numerous *** depends on CRiSPR(clustered regularly inter-spaced short palindromic repeats)as a bacterial immune system and plays as a gene editing *** to the higher specificity and efficiency of CRISPR/Cas9 compared to other editing ap-proaches,it has been broadly investigated to treat numerous hereditary and acquired ill-nesses,including cancers,hemolytic diseases,immunodeficiency disorders,cardiovascular diseases,visual maladies,neurodegenerative conditions,and a few X-linked ***/Cas9 system has been used to treat cancers through a variety of approaches,with sta-ble gene editing ***,the applications and clinical trials of CRisPR/Cas9 in various illnesses are *** to its high precision and efficiency,CRISPR/Cas9 strategies may treat gene-related illnesses by deleting,inserting,modifying,or blocking the expression of specific *** most challenging barrier to the in vivo use of CRISPR/Cas9 like off-target effects will be *** use of transfection vehicles for CRISPR/Cas9,including viral vectors(such as an Adeno-associated virus(AAV),and the development of non-viral vectors is also considered.

关键词： Clinical trials CRISPR/Cas9 Gene therapy Non-viral vectors Viral vectors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of rehabilitation strategies for lakes affected by anthropogenic and climatic changes: A case study of the Urmia Lake, Iran

引用

Journal of Arid Land 2024年第6期16卷 752-767页

作者： Seyed Morteza MOUSAVI hossein BABAZADEH Mahdi SARAI-TABRIZI amir KHOSROJERDI Department of Water Science and Engineering Science and Research BranchIslamic Azad UniversityTehran 147789-3855Iran

Over the last three decades,more than half of the world's large lakes and wetlands have experienced significant shrinkage,primarily due to climate change and extensive water consumption for agriculture and other human *** desiccation of lakes leads to severe environmental,economic,and social *** Lake,located in northwestern Iran and representing a vital natural ecosystem,has experienced a volume reduction of over 90.0%.Our research evaluated diverse water management strategies within the Urmia Lake basin and prospects of inter-basin water *** study focused on strategies to safeguard the environmental water rights of the Urmia Lake by utilizing the modeling and simulating(MODSIM)*** model simulated changes in the lake's water volume under various *** included diverting water from incoming rivers,cutting agricultural water use by 40.0%,releasing dam water in non-agricultural seasons,treated wastewater utilization,and inter-basin *** hierarchy process(AHP)was utilized to analyze the simulation *** opinions with AHP analysis,acted as a multi-criteria decision-making tool to evaluate the simulation and determine the optimal water supply source priority for the Urmia *** findings underscore the critical importance of reducing agricultural water consumption as the foremost step in preserving the *** this,inter-basin water transfers are suggested,with a detailed consideration of the inherent challenges and limitations faced by the source *** is imperative to conduct assessments on the impacts of these transfers on the downstream users and the potential environmental risks,advocating for a diplomatic and cooperative approach with adjacent *** study also aims to forecast the volumes of water that can be transferred under different climatic conditions—drought,normal,and wet years—to inform strategic water management planning for the Urmia *** to our proj

关键词： climate change drought lake ecological level agricultural water demand inter-basin water transfer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Limb Lengthening and Reconstruction Society orthopedic surgeons in the United States:An analysis of geographical distribution,academic,leadership,and demographic characteristics

引用

World Journal of Orthopedics 2024年第2期15卷 147-155页

作者： amir Human Hoveidaei Reza Niakan Seyed hossein hosseini-Asl Abijith Annasamudram Janet D Conway International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States Student Research Committee Shiraz University of Medical SciencesShiraz 73Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran

BACKGROUND The Limb Lengthening and Reconstruction Society(LLRS)is a premier orthopedic specialty organization that promotes limb reconstruction for all *** membership characteristics,however,are poorly *** study delineates orthopedic surgeon LLRS members’demographic traits,academic achievement,leadership attainment,and geographical distribution across the United *** To inform aspiring orthopedic professionals,as well as to promote growth and diversity in both the LLRS organization and overarching *** This cross-sectional study examined United States LLRS members’academic,leadership,demographic,and geographical *** reviewing the 2023 LLRS member directory,Google search results were matched to the listings and appended to the compiled *** and ethnicity were evaluated visually utilizing retrieved *** Hirsch index(H-index)of academic activity,residency and fellowship training,other graduate degrees,leadership positions,practice type(academic or non-academic),and spoken languages were *** members per state and capita determined geographic *** Mann Whitney U test was applied to compare H-index between males and females,as well as to assess member differences pertaining to affiliation with academic vs non-academic practice *** The study included 101 orthopedic surgeons,78(77.23%)Caucasian and 23(22.77%)non-Caucasian,79(78.22%)male and 22(21.78%)*** with DO degrees comprised only 3.96%(4)of the cohort,while the vast majority held MDs[96.04%(97)].Mean H-index was 10.55,with male surgeons having a significantly higher score(P=0.002).Most orthopedic surgeons(88.12%,)practiced in academic *** those professionals who occupied leadership positions,14%were women,while 86%were ***,19(37.25%)United States regions and the District of Columbia lacked an LLRS-member orthopedic *** per capita rate across the United States was 0.30 LLRS orthopedic

关键词： Limb lengthening and reconstruction Orthopedic surgeon demographics Orthopedic surgeon societal membership Orthopedic fellowships

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-alcoholic fatty liver disease is not independent risk factor for cardiovascular disease event:A cohort study

引用

World Journal of Hepatology 2020年第6期12卷 323-331页

作者： Nima Motamed hossein Ajdarkosh Maral Ahmadi Dhayaneethie Perumal G hossein Ashrafi Mehdi Nikkhah amir hossein faraji Mansooreh Maadi Mahmoodreza Khoonsari Nader Rezaie Behzad Farahani Fahimeh Safarnezhad Tameshkel Mitra Ameli Mahshid Panahi Mohammad Hadi Karbalaie Niya Farhad Zamani Department of Social Medicine Zanjan University of Medical SciencesZanjan ***Iran Gastrointestinal and Liver Diseases Research Center Iran University of Medical SciencesTehran ***Iran Faculty of Science Engineering and ComputingKingston UniversityKingstonLondon KT12EEUnited Kingdom Cancer Theme SEC Faculty Penrhyn Road Kingston UniversityLondon KT12EEUnited Kingdom Department of Pulmonology Firouzgar HospitalIran University of Medical SciencesTehran ***Iran Department of Cardiology Iran University of Medical SciencesTehran ***Iran

BACKGROUND There are no consistent results between previous studies for an independent association between non-alcoholic fatty liver disease(NAFLD)and cardiovascular disease(CVD)*** To determine if there is an independent association between NAFLD and CVD *** In the present study,valid outcome data of 4808 subjects were available for phase 2 of our cohort *** subjects had been followed up for seven years from phase 1,beginning in 2009-2010 to phase 2 during *** and multiple Cox proportional models were used to determine the association between NAFLD in the primary phase of the cohort and subsequent fatal and non-fatal CVD events during *** The incidence of non-fatal CVD events in males with NAFLD was significantly higher(P=0.004)than in males without NAFLD.A positive association was demonstrated between NAFLD and non-fatal CVD events in males(Hazard ratio=1.606;95%CI:1.166-2.212;P=0.004)by the simple Cox proportional hazard model,but no independent association was detected between these in the multiple Cox *** No independent association was detected between NAFLD and *** is likely that diabetes mellitus and age may be the principle mediators in this regard.

关键词： Non-alcoholic fatty liver disease Cardiovascular disease Cohort Type 2 diabetes mellitus Risk factor Follow up

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isoimperatorin alleviates acetic acid-induced colitis in rats

引用

Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 147-153页

作者： Saied Goodarzi amir hossein Abdolghaffari Behnaz Najafi Mostafa Pirali Hamedani Saeed Tavakoli Mahshad Marvi Maryam Baeeri Narguess Yassa Abbas Hadjiakhoondi Mohammad Abdollahi Zahra Tofighi Medicinal Plants Research Center Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran International Campus School of Pharmacy Tehran University of Medical SciencesTehranIran Toxicology and Diseases group The Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehranIran

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis ***:Colitis was induced by intracolonic administration of acetic acid solution(4%v/v)in *** were divided into six groups including the sham group,the negative control group,the dexamethasone-treated group,and the groups treated with isoimperatorin(0.1,1,and 10 mg/kg/d by gavage).The treatments were administered for three days and then colonic status was assessed by macroscopic,histopathological,and biochemical ***:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced *** also significantly reduced myeloperoxidase,TNF-α,IL-1β,and malodialdehyde ***:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

关键词： Isoimperatorin Inflammatory bowel disease Acetic acid Colitis TNF-α IL-1β

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

引用

World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi amir hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi Mohammad-Mahdi Salarabedi Syed Azizur Rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi Mohammad Ahmadvand Wael M Abdel-Rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhancing the Robustness of Visual Object Tracking via Style Transfer

引用

Computers, Materials & Continua 2022年第1期70卷 981-997页

作者： Abdollah amirkhani amir hossein Barshooi amir Ebrahimi School of Automotive Engineering Iran University of Science and TechnologyTehran16846-13114Iran School of Electrical Engineering and Computing The University of NewcastleCallaghan2308Australia

The performance and accuracy of computer vision systems are affected by noise in different *** numerous solutions and algorithms have been presented for dealing with every type of noise,a comprehensive technique that can cover all the diverse noises and mitigate their damaging effects on the performance and precision of various systems is still *** this paper,we have focused on the stability and robustness of one computer vision branch(i.e.,visual object tracking).We have demonstrated that,without imposing a heavy computational load on a model or changing its algorithms,the drop in the performance and accuracy of a system when it is exposed to an unseen noise-laden test dataset can be prevented by simply applying the style transfer technique on the train dataset and training the model with a combination of these and the original untrained *** verify our proposed approach,it is applied on a generic object tracker by using regression *** method’s validity is confirmed by testing it on an exclusive benchmark comprising 50 image sequences,with each sequence containing 15 types of noise at five different intensity *** OPE curves obtained show a 40%increase in the robustness of the proposed object tracker against noise,compared to the other trackers considered.

关键词： Style transfer visual object tracking robustness corruption

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy efficiency of small buildings with smart cooling system in the summer

引用

Frontiers in Energy 2022年第4期16卷 651-660页

作者： Yazdan DANESHVAR Majid SABZEHPARVAR Seyed amir hossein HASHEMI Department of Civil Engineering Qazvin BranchIslamic Azad UniversityQazvin 314199-15195Iran Department of Industrial Engineering Collage of EngineeringKaraj BranchIslamic Azad UniversityKaraj 31499-68111Iran

In this paper,a novel cooling control strategy as part of the smart energy system that can balance thermal comfort against building energy consumption by using the sensing and machine programming technology was *** this goal,a general form of a building was coupled by the smart cooling system(SCS)and the consumption of energy with thermal comfort cooling of persons simulated by using the EnergyPlus software and compared with similar buildings without *** the beginning of the research,using the data from a survey in a randomly selected group of hundreds and by analyzing and verifying the results of the specific relationship between the different groups of people in the statistical society,the body mass index(BMI)and their thermal comfort temperature were obtained,and the sample building was modeled using the EnergyPlus *** result show that if an intelligent ventilation system that can calculate the thermal comfort temperature was used in accordance with the BMI of persons,it can save up to 35%of the cooling load of the building yearly.

关键词： smart home heating and cooling systems saving energy optimal consumption of energy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Towards digital architecture,engineering,and construction(AEC)industry through virtual design and construction(VDC)and digital twin

引用

Energy and Built Environment 2023年第2期4卷 169-178页

作者： Hamed Nabizadeh Rafsanjani amir hossein Nabizadeh School of Engineering and Applied Sciences Western Kentucky UniversityBowling GreenKY 42101United States Kerman University of Medical science KermanIran/INESC-ID/ISTUniversity of LisbonLisbon 1000-029Portugal

The architecture,engineering,and construction(AEC)industry is undergoing a substantial change,and the tech-nological advancements are shaping the future of this *** years,numerous tools have been developed based on building information modeling(BIM)and the Internet of Things(IoT)to manage a variety of tasks and activities within different construction and operational phases in the AEC ***,with the advent of novel internet-enabled technologies in providing the ability of real-time connectivity,researchers have started to develop virtual design and construction(VDC)and digital twin approaches to remotely monitor,control,and optimize different work progresses and activities in real-time at any work level in the AEC *** paper presents a reference model to illustrates the main advantages and applications of VDC and digital twin,and to demonstrate their trends and anticipated cost savings in the AEC industry at a global *** technological advancements along with augmented reality(AR)and virtual reality(VR)can offer the unique benefit of real-time monitoring of the current status as well as predicting the future of any physical structure at any level of *** global demand and usage of these technological advancements will lead to great cost savings in the AEC industry which would be US$950 million in design and construction and US$400 million in operation and maintenance phases in the non-residential AEC industry in *** paper also discusses the future challenges of VDC and digital twin in the *** a main line of future research,these technologies can simultaneously be utilized with artificial intelligence to enable human-centered decision making to automate and optimize work *** integrations of VDC,digital twin,artificial intelligence,and human-centered approaches will shape the future of the AEC industry and provide numerous research opportunities in this domain.

关键词： Virtual design and construction Digital twin BIM IoT Artificial intelligence Augmented reality Virtual reality AEC industry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：