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Isoimperatorin alleviates acetic acid-induced colitis in rats

Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 147-153页

作者： Saied Goodarzi amir hossein abdolghaffari Behnaz Najafi Mostafa Pirali Hamedani Saeed Tavakoli Mahshad Marvi Maryam Baeeri Narguess Yassa Abbas Hadjiakhoondi Mohammad Abdollahi Zahra Tofighi Medicinal Plants Research Center Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran International Campus School of Pharmacy Tehran University of Medical SciencesTehranIran Toxicology and Diseases group The Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehranIran

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis ***:Colitis was induced by intracolonic administration of acetic acid solution(4%v/v)in *** were divided into six groups including the sham group,the negative control group,the dexamethasone-treated group,and the groups treated with isoimperatorin(0.1,1,and 10 mg/kg/d by gavage).The treatments were administered for three days and then colonic status was assessed by macroscopic,histopathological,and biochemical ***:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced *** also significantly reduced myeloperoxidase,TNF-α,IL-1β,and malodialdehyde ***:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

关键词： Isoimperatorin Inflammatory bowel disease Acetic acid Colitis TNF-α IL-1β

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Transmembrane serine protease 2 and angiotensin-converting enzyme 2 anti-inflammatory receptors for COVID-19/inflammatory bowel diseases treatment

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World Journal of Gastroenterology 2021年第46期27卷 7943-7955页

作者： Naser-Aldin Lashgari Nazanin Momeni Roudsari Saeideh Momtaz amir hossein abdolghaffari Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehran ***Iran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKaraj 141554364Iran Toxicology and Diseases Group(TDG) Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)Tehran University of Medical SciencesTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Gastrointestinal Pharmacology Interest Group(GPIG) Universal Scientific Education and Research Network(USERN)Tehran ***Iran

long-term,and relapsing inflammatory *** may spontaneously grow in the colon,and in severe cases may result in tumor lesions such as invasive carcinoma in inflamed regions of the *** epidemiological reports indicate that old age and underlying diseases such as IBD contribute to severity and mortality in patients with coronavirus disease 2019(COVID-19).Currently,the ongoing COVID-19 pandemic caused serious morbidity and mortality *** has also been shown that the transmembrane serine protease 2 is an essential factor for viral activation and viral ***,viral entry causes a'cytokine storm'that induces excessive generation of proinflammatory cytokines/chemokines including interleukin(IL)-6,IL-2,IL-7,tumor necrosis factor-α,and interferon-γ.Future research could concentrate on developing inflammatory immunological responses that are efficient to encounter *** analysis elucidates the role of inflammation and immune responses during IBD infection with COVID-19 and provides a list of possible targets for IBD-regulated therapies in *** from clinical,in vitro,and in vivo studies were collected in English from PubMed,Google Scholar,Scopus,and the Cochrane library until May 2021.

关键词： Inflammatory bowel diseases COVID-19 Transmembrane serine protease 2 Inflammation Pro-inflammatory Immunological responses

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Antioxidant therapy in the management of acute,chronic and post-ERCP pancreatitis:A systematic review

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World Journal of Gastroenterology 2009年第36期15卷 4481-4490页

作者： Seyed Sajad Mohseni Salehi Monfared Hamed Vahidi amir hossein abdolghaffari Shekoufeh Nikfar Mohammad Abdollahi Endocrinology and Metabolism Research Centre Tehran University of Medical Sciences Student Scientific Research Center Tehran University of Medical Science Pharmaceutical Sciences Research Center Tehran University of Medical Sciences Food&Drug Affairs and Food&Drug Laboratory Research Center Ministry of Health&Medical Education Faculty of Pharmacy and Pharmaceutical Sciences Research Center and Endocrinology&Metabolism Research CentreTehran University of Medical Sciences

We systematically reviewed the clinical trials which recruited antioxidants in the therapy of pancreatitis and evaluated whether antioxidants improve the outcome of patients with *** bibliographic databases were searched for any studies which investigated the use of antioxidants in the management of acute pancreatitis(AP)or chronic pancreatitis(CP)and in the prevention of post-endoscopic retrograde cholangio-pancreatography(post-ERCP)pancreatitis(PEP)up to February ***-two randomized,placebo-controlled,clinical trials met our criteria and were included in the *** for a cocktail of antioxidants which showed improvement in outcomes in three different clinical trials,the results of the administration of other antioxidants in both AP and CP clinical trials were incongruent and ***,antioxidant therapy including allopurinol and N-acetylcysteine failed to prevent the onset of PEP in almost all *** conclusion,the present data do not support a benefit of antioxidant therapy alone or in combination with conventional therapy in the management of AP,CP or *** double blind,randomized,placebo-controlled clinical trials with large sample size need to be conducted.

关键词：急性胰腺炎抗氧化剂产后管理系统评价治疗慢性临床试验书目数据库

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Mammalian target of rapamycin;novel insight for management of inflammatory bowel diseases

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World Journal of Pharmacology 2022年第1期11卷 1-5页

作者： Naser-Aldin Lashgari Nazanin Momeni Roudsari Saeideh Momtaz amir hossein abdolghaffari Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehran ***Iran Department of Pharmacology Medicinal Plants Research CenterInstitute of Medicinal PlantsACECRKaraj ***Iran Toxicology and Diseases Group(TDG) Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)Tehran University of Medical SciencesTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Gastrointestinal Pharmacology Interest Group(GPIG) Universal Scientific Education and Research Network(USERN)Tehran ***Iran

Inflammatory bowel diseases(IBDs),with blurred etiology,show a rising trend and are of global *** various factors involved in IBD pathogenesis and development,inflammation has been shown to play a major *** of the molecular and cellular pathways that induce IBD is an emerging subject to develop targeted *** target of rapamycin(mTOR)is one the most common receptors of many inflammatory pathways,including that of *** this end,we intend to overview the mTOR inhibitors for their possible efficacy in present and future approaches to treatment of IBD.

关键词： Inflammatory bowel diseases Inflammation Mammalian target of rapamycin Mammalian target of rapamycin inhibitors

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CRISPR,CAR-T,and NK:Current applications and future perspectives

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Genes & Diseases 2024年第4期11卷 246-257页

作者： Mohadeseh Khoshandam hossein Soltaninejad amir Ali Hamidieh Saman hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom branch***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14965/161Iran Department of stem cells technology and Tissue Regeneration Faculty of Interdisciplinary Science and TechnologiesTarbiat Modares UniversityTehran 15614Iran Pediatric Cell Therapy and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran University of Medical SciencesTehran ***Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 15614Iran

Chimeric antigen receptor T(CAR-T)cell therapy represents a breakthrough in personalized cancer *** this regard,synthetic receptors comprised of antigen recognition domains,signaling,and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy *** the success of this approach in refractory B-cell malignancies,the optimal potency of CAR T-cell therapy for many other cancers,particularly solid tumors,has not been *** killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity *** on these studies,many investigations are focused on the accurate designing of CAR T-cells with clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system or other novel gene editing tools that can induce hereditary changes with or without the presence of a double-stranded break into the *** methodologies can be specifically focused on negative controllers of T-cells,induce modifications to a particular gene,and produce reproducible,safe,and powerful allogeneic CAR T-cells for on-demand cancer *** improvement of the CRISPR/Cas9 innovation offers an adaptable and proficient gene-editing capability in activating different pathways to help natural killer cells interact with novel CARs to particularly target tumor *** achievements and future challenges of combining next-generation CRISPR-Cas9 gene editing tools to optimize CAR T-cell and natural killer cell treatment for future clinical trials toward the foundation of modern cancer treatments have been assessed inthis review.

关键词： Cancer CAR T-cell CRISPR Gene editing Immunotherapy NK cell

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Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

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Genes & Diseases 2024年第1期11卷 268-282页

作者： Mohadeseh Khoshandam hossein Soltaninejad Marziyeh Mousazadeh amir Ali Hamidieh Saman hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom BranchQom ***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14155-6463Iran Faculty of Interdisciplinary Science and Technology Tarbiat Modares UniversityTehran 14117-13116Iran Pediatric Cell and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran UniversityofMedical SciencesTehran14155-6559Iran Department of Nanobiotechnology Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran

CRISPR/Cas9 is an effective gene editing tool with broad applications for the pre-vention or treatment of numerous *** depends on CRiSPR(clustered regularly inter-spaced short palindromic repeats)as a bacterial immune system and plays as a gene editing *** to the higher specificity and efficiency of CRISPR/Cas9 compared to other editing ap-proaches,it has been broadly investigated to treat numerous hereditary and acquired ill-nesses,including cancers,hemolytic diseases,immunodeficiency disorders,cardiovascular diseases,visual maladies,neurodegenerative conditions,and a few X-linked ***/Cas9 system has been used to treat cancers through a variety of approaches,with sta-ble gene editing ***,the applications and clinical trials of CRisPR/Cas9 in various illnesses are *** to its high precision and efficiency,CRISPR/Cas9 strategies may treat gene-related illnesses by deleting,inserting,modifying,or blocking the expression of specific *** most challenging barrier to the in vivo use of CRISPR/Cas9 like off-target effects will be *** use of transfection vehicles for CRISPR/Cas9,including viral vectors(such as an Adeno-associated virus(AAV),and the development of non-viral vectors is also considered.

关键词： Clinical trials CRISPR/Cas9 Gene therapy Non-viral vectors Viral vectors

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Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways

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World Journal of Gastroenterology 2020年第24期26卷 3365-3400页

作者： Aida Kamalian Masoud Sohrabi Asl Mahsa Dolatshahi Khashayar Afshari Shiva Shamshiri Nazanin Momeni Roudsari Saeideh Momtaz Roja Rahimi Mohammad Abdollahi amir hossein abdolghaffari Department of Medicine Tehran University of Medical SciencesTehran ***Iran Students'Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Department of Traditional Pharmacy School of Persian MedicineTehran University of Medical SciencesTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehran ***Iran Medicinal Plants Research Center Institute of Medicinal PlantsACECRTehran ***Iran Toxicology and Diseases Group(TDG) Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)and Department of Toxicology and PharmacologySchool of PharmacyTehran University of Medical SciencesTehran ***Iran Gastrointestinal Pharmacology Interest Group Universal Scientific Education and Research NetworkTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran

Inflammatory bowel disease(IBD)refers to a group of disorders characterized by chronic inflammation of the gastrointestinal(GI)*** elevated levels of nitric oxide(NO)in serum and affected tissues;mainly synthesized by the inducible nitric oxide synthase(iNOS)enzyme;can exacerbate GI inflammation and is one of the major biomarkers of GI *** natural and synthetic agents are able to ameliorate GI inflammation and decrease iNOS expression to the extent comparable with some IBD ***,the purpose of this study was to gather a list of natural or synthetic mediators capable of modulating IBD through the NO *** databases including Google Scholar and PubMed were searched from 1980 to May *** found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factorκB(NF-κB)and JAK/STAT signaling *** and probiotics can also alter the GI microbiota and reduce NO expression in IBD models through a broad array of mechanisms.A number of synthetic molecules have been found to suppress NO expression either dependent on the NF-κB signaling pathway(i.e.,dexamethasone,pioglitazone,tropisetron)or independent from this pathway(i.e.,nicotine,prednisolone,celecoxib,β-adrenoceptor antagonists).Co-administration of natural and synthetic agents can affect the tissue level of NO and may improve IBD symptoms mainly by modulating the Toll like receptor-4 and NF-κB signaling pathways.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Nitric oxide Nuclear factor-κB Natural or synthetic mediators

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The protective effect of a standardized hydroalcoholic extract of Prosopis farcta (Banks & Sol.) ***. fruit in a rat model for experimental ulcerative colitis

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Traditional Medicine Research 2021年第5期6卷 1-9页

作者： Ali Akbar Safari Mohammad Sharifzadeh Gholamreza Hassanzadeh Mohammad-Reza Delnavazi􀏰 Mohammad Mahdi Ahmadian-Attari amir hossein abdolghaffari Maryam Baeeri Mehran Mirabzadeh Ardakani Department of Traditional Pharmacy School of Persian MedicineTehran University of Medical SciencesTehranIran Department of Pharmacology and Toxicology Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Anatomy School of MedicineTehran University of Medical SciencesTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran Evidence-based Phytotherapy and Complementary Medicine Research Center Alborz University of Medical SciencesKarajIran Department of Pharmacognosy Faculty of PharmacyAlborz University of Medical SciencesKarajIran Department of Toxicology&Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRTehranIran Toxicology and Diseases Group(TDG) Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)Faculty of PharmacyTehran University of Medical SciencesTehranIran GI Pharmacology Interest Group(GPIG) Universal Scientific Education and Research Network(USERN)TehranIran Pharmaceutical Sciences Research Center Tehran University of Medical SciencesTehranIran

Background:Investigating new therapies for inflammatory bowel disease among natural products has recently been gaining *** Prosopis farcta has repeatedly been mentioned in traditional Persian medicine as a therapeutic option for inflammatory bowel disease,no evidence-based investigations have been conducted on this *** aim of this study was to assess the impact of *** on acetic acid-induced colitis in ***:A hydroalcoholic extract of *** fruits was ***-six adult Wistar rats were divided into six groups,and colitis was induced in five groups,except the sham group,using acetic acid *** animals received distinctive daily doses of ***(50,75,and 100 mg/kg/day,p.o.)and dexamethasone(1 mg/kg/day,i.p.)as standard treatment for two progressive days,starting from colitis *** and histopathological examinations were performed on inflamed colonic *** concentrations of interleukin-1βand tumor necrosis factor-αwere assessed using enzyme-linked immunosorbent assay *** identify the role of oxidative stress in ulcerative colitis,the levels of malondialdehyde and myeloperoxidase were measured in colon ***:Treatment with all concentrations of *** attenuated inflammation and ulcers compared with saline treatment in the control group(P<0.01 for 50 mg/kg;P<0.001 for 75 and 100 mg/kg/day).The best suppression of tumor necrosis factor-αand interleukin-1βwas observed at a dose of 100 mg/kg ***(P<0.001).This dose showed the best effect in reducing myeloperoxidase and malondialdehyde in ulcerative colitis-induced rats(P<0.001).Conclusion:*** can be considered a promising candidate for treating ulcerative colitis;thus,it requires further confirmation by clinical trials.

关键词： Prosopis farcta colitis interleukin-1β tumor necrosis factor malondialdehyde traditional Persian medicine

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Assessment of rehabilitation strategies for lakes affected by anthropogenic and climatic changes: A case study of the Urmia Lake, Iran

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Journal of Arid Land 2024年第6期16卷 752-767页

作者： Seyed Morteza MOUSAVI hossein BABAZADEH Mahdi SARAI-TABRIZI amir KHOSROJERDI Department of Water Science and Engineering Science and Research BranchIslamic Azad UniversityTehran 147789-3855Iran

Over the last three decades,more than half of the world's large lakes and wetlands have experienced significant shrinkage,primarily due to climate change and extensive water consumption for agriculture and other human *** desiccation of lakes leads to severe environmental,economic,and social *** Lake,located in northwestern Iran and representing a vital natural ecosystem,has experienced a volume reduction of over 90.0%.Our research evaluated diverse water management strategies within the Urmia Lake basin and prospects of inter-basin water *** study focused on strategies to safeguard the environmental water rights of the Urmia Lake by utilizing the modeling and simulating(MODSIM)*** model simulated changes in the lake's water volume under various *** included diverting water from incoming rivers,cutting agricultural water use by 40.0%,releasing dam water in non-agricultural seasons,treated wastewater utilization,and inter-basin *** hierarchy process(AHP)was utilized to analyze the simulation *** opinions with AHP analysis,acted as a multi-criteria decision-making tool to evaluate the simulation and determine the optimal water supply source priority for the Urmia *** findings underscore the critical importance of reducing agricultural water consumption as the foremost step in preserving the *** this,inter-basin water transfers are suggested,with a detailed consideration of the inherent challenges and limitations faced by the source *** is imperative to conduct assessments on the impacts of these transfers on the downstream users and the potential environmental risks,advocating for a diplomatic and cooperative approach with adjacent *** study also aims to forecast the volumes of water that can be transferred under different climatic conditions—drought,normal,and wet years—to inform strategic water management planning for the Urmia *** to our proj

关键词： climate change drought lake ecological level agricultural water demand inter-basin water transfer

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Antioxidant therapy in acute,chronic and post-endoscopic retrograde cholangiopancreatography pancreatitis:An updated systematic review and meta-analysis

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World Journal of Gastroenterology 2015年第30期21卷 9189-9208页

作者： Maziar Gooshe amir hossein abdolghaffari Shekoufeh Nikfar Parvin Mahdaviani Mohammad Abdollahi Department of Toxicology and Pharmacology Faculty of Pharmacyand Pharmaceutical Sciences Research Centerand Endocrinology and Metabolism Research CenterEndocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical Sciences Pharmacology and Applied Medicine Department of Medicinal Plants Research CenterInstitute of Medicinal PlantsACECRKaraj 31375369Iran International Campus ICTUMSTehran University of Medical Sciences Department of Pharmacoeconomics and Pharmaceutical Administration Faculty of PharmacyTehran University of Medical Sciences Department of Pharmaceutics Faculty of PharmacyTehran University of Medical Sciences

AIM:To investigate the efficacy and adverse effects of antioxidant therapy in acute pancreatitis(AP),chronic pancreatitis(CP) and post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP).METHODS:Pub Med,Scopus,Google Scholar,Cochrane library database,and Evidence-based medicine/clinical trials published before August 2014 were searched. Clinical and laboratory outcomes of randomized trials of antioxidant therapy in patients with AP,CP and PEP were included. The methodological quality of the trials was assessed by the Jadad score based on the description of randomization,blinding,and dropouts(withdrawals). The results of the studies were pooled and meta-analyzed to provide estimates of the efficacy of antioxidant ***:Thirty four trials out of 1069 potentially relevant studies with data for 4898 patients wereeligible for inclusion. Antioxidant therapy significantly reduced the length of hospital stay in AP patients {mean difference-2.59 d(95%CI:-4.25-(-0.93)],P = 0.002}. Although,antioxidant therapy had no significant effect on serum C reactive protein(CRP) after 5-7 d in AP patients [mean difference-9.57(95%CI:-40.61-21.48,P = 0.55],it significantly reduced serum CRP after 10 d {mean difference-45.16 [95%CI:-89.99-(-0.33)],P = 0.048}. In addition,antioxidant therapy had no significant effect on CP-induced pain [mean difference-2.13(95%CI:-5.87-1.6),P = 0.26]. Antioxidant therapy had no significant effects on the incidence of all types of PEP [mean difference 1.05(95%CI:0.74-1.5),P = 0.78],severe PEP [mean difference 0.92(95%CI:0.43-1.97),P = 0.83],moderate PEP [mean difference 0.82(95%CI:0.54-1.23),P = 0.33],and mild PEP [mean difference 1.33(95%CI:0.99-1.78),P = 0.06]. Furthermore,while antioxidant therapy had no significant effect on serum amylase after less than 8 h sampling [mean difference-20.61(95%CI:-143.61-102.39),P = 0.74],it significantly reduced serum amylase close to 24-h sampling {mean difference-16.13 [95%CI:-22.98-(-9.28)],P <

关键词： Acute pancreatitis Chronic pancreatitis Post-endoscopic retrograde cholangiopancreatographypancreatitis Antioxidants Meta-analysis

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