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Bone tissue engineering via growth factor delivery:from scaffolds to complex matrices

Regenerative Biomaterials 2018年第4期5卷 197-211页

作者： Tinke-Marie De Witte Lidy E.Fratila-Apachitei amir a.zadpoor Nicholas A.Peppas Department of Biomedical Engineering The University of Texas at AustinAustinTX 78712USA Additive Manufacturing Laboratory Department of Biomechanical EngineeringDelft University of Technology(TU Delft)2628 CD DelftThe Netherlands McKetta Department of Chemical Engineering The University of Texas at AustinAustinTX 78712USA Institute for Biomaterials Drug Delivery and Regenerative MedicineThe University of Texas at AustinAustinTX 78712USA Department of Pediatrics and Department of Surgery and Perioperative CareDell Medical SchoolThe University of Texas at AustinAustinTX 78712USA Division of Molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at AustinAustinTX 78712USA

In recent years,bone tissue engineering has emerged as a promising solution to the limitations of current gold standard treatment options for bone related-disorders such as bone *** tissue engineering provides a scaffold design that mimics the extracellular matrix,providing an architecture that guides the natural bone regeneration *** this period,a new generation of bone tissue engineering scaffolds has been designed and characterized that explores the incorporation of signaling molecules in order to enhance cell recruitment and ingress into the scaffold,as well as osteogenic differentiation and angiogenesis,each of which is crucial to successful bone ***,we outline and critically analyze key characteristics of successful bone tissue engineering *** also explore candidate materials used to fabricate these *** growth factors involved in the highly coordinated process of bone repair are discussed,and the key requirements of a growth factor delivery system are ***,we concentrate on an analysis of scaffold-based growth factor delivery strategies found in the recent *** particular,the incorporation of two-phase systems consisting of growth factor-loaded nanoparticles embedded into scaffolds shows great promise,both by providing sustained release over a therapeutically relevant timeframe and the potential to sequentially deliver multiple growth factors.

关键词： scaffolds bone growth tissue engineering growth factor delivery

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