Bone tissue engineering via growth factor delivery:from scaffolds to complex matrices

作     者：Tinke-Marie De Witte Lidy E.Fratila-Apachitei Amir A.Zadpoor Nicholas A.Peppas 

作者机构：Department of Biomedical EngineeringThe University of Texas at AustinAustinTX 78712USA Additive Manufacturing LaboratoryDepartment of Biomechanical EngineeringDelft University of Technology(TU Delft)2628 CD DelftThe Netherlands McKetta Department of Chemical EngineeringThe University of Texas at AustinAustinTX 78712USA Institute for BiomaterialsDrug Delivery and Regenerative MedicineThe University of Texas at AustinAustinTX 78712USA Department of Pediatricsand Department of Surgery and Perioperative CareDell Medical SchoolThe University of Texas at AustinAustinTX 78712USA Division of Molecular Pharmaceutics and Drug DeliveryCollege of PharmacyThe University of Texas at AustinAustinTX 78712USA 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2018年第5卷第4期

页      面：197-211页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 

基　　金：This work was supported by the National Institutes of Health Grant R01-EB022025 the UT-Portugal Collaborative Research program(CoLAB)Intelligent scaffolds for molecular recognition of advanced applications in regenerative medicine 

主　　题：scaffolds bone growth tissue engineering growth factor delivery 

摘      要：In recent years,bone tissue engineering has emerged as a promising solution to the limitations of current gold standard treatment options for bone related-disorders such as bone *** tissue engineering provides a scaffold design that mimics the extracellular matrix,providing an architecture that guides the natural bone regeneration *** this period,a new generation of bone tissue engineering scaffolds has been designed and characterized that explores the incorporation of signaling molecules in order to enhance cell recruitment and ingress into the scaffold,as well as osteogenic differentiation and angiogenesis,each of which is crucial to successful bone ***,we outline and critically analyze key characteristics of successful bone tissue engineering *** also explore candidate materials used to fabricate these *** growth factors involved in the highly coordinated process of bone repair are discussed,and the key requirements of a growth factor delivery system are ***,we concentrate on an analysis of scaffold-based growth factor delivery strategies found in the recent *** particular,the incorporation of two-phase systems consisting of growth factor-loaded nanoparticles embedded into scaffolds shows great promise,both by providing sustained release over a therapeutically relevant timeframe and the potential to sequentially deliver multiple growth factors.